{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:08:27Z","timestamp":1762074507115,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sunchon National University Research Fund in 2022","award":["2022-0282","NRF-2020R1I1A 3071908"],"award-info":[{"award-number":["2022-0282","NRF-2020R1I1A 3071908"]}]},{"DOI":"10.13039\/501100001321","name":"Ministry of Education of Korea","doi-asserted-by":"publisher","award":["2022-0282","NRF-2020R1I1A 3071908"],"award-info":[{"award-number":["2022-0282","NRF-2020R1I1A 3071908"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Background: Osteoporosis is a disease in which bones are weakened and fractured easily because of various factors. It is mainly observed in elderly and postmenopausal women, and it continues to carry high economic costs in aging societies. Normal bone maintains a healthy state through a balanced process of osteoclast suppression and osteoblast activation; (2) Methods: In this study, osteoclast inhibition was induced by inhibiting osteoclast differentiation using ginseng protopanaxadiol-enriched rice (PPD-rice) seed extract. To analyze the effect of PPD-rice extract on the inhibition of osteoclast differentiation, bone marrow macrophages extracted from mice were treated with PPD-rice and Dongjin seed (non-transformed rice) extracts and analyzed for the inhibition of osteoclast differentiation; (3) Results: The results illustrated that PPD-rice extract reduced the transcription and translation of NFATc1, a modulator of osteoclast formation, decreased the mRNA expression of various osteoclast differentiation marker genes, and reduced osteoclast activity. Moreover, the bone resorptive activity of osteoclasts was diminished by PPD-rice extract on Osteo Assay plates; (4) Conclusions: Based on these results, PPD-rice extract is a useful candidate therapeutic agent for suppressing osteoclasts, an important component of osteoporosis, and it could be used as an ingredient in health supplements.<\/jats:p>","DOI":"10.3390\/life12111886","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T02:28:58Z","timestamp":1668479338000},"page":"1886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibitory Effects of Protopanaxadiol-Producing Transgenic Rice Seed Extracts on RANKL-Induced Osteoclast Differentiation"],"prefix":"10.3390","volume":"12","author":[{"given":"Yongjin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-4923","authenticated-orcid":false,"given":"Vipada","family":"Kantayos","sequence":"additional","affiliation":[{"name":"Department of Agricultural Life Science, Sunchon National University, Suncheon 57922, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Agricultural Life Science, Sunchon National University, Suncheon 57922, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui-Shik","family":"Rha","sequence":"additional","affiliation":[{"name":"Department of Agricultural Life Science, Sunchon National University, Suncheon 57922, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Jin","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-0842","authenticated-orcid":false,"given":"So-Hyeon","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Agricultural Life Science, Sunchon National University, Suncheon 57922, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12861","DOI":"10.1111\/acel.12861","article-title":"Trends in age-related disease burden and healthcare utilization","volume":"18","author":"Mortari","year":"2019","journal-title":"Aging Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nrd916","article-title":"Discoveries, drugs and skeletal disorders","volume":"1","author":"Goltzman","year":"2002","journal-title":"Nat. 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