{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:22:23Z","timestamp":1780446143639,"version":"3.54.1"},"reference-count":16,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IVATHERM SA","award":["01\/10.01.2022"],"award-info":[{"award-number":["01\/10.01.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Oily, acne-prone skin is a common skin type which may be monitored in vivo using reflectance confocal microscopy (RCM). The aim of the study was to assess the feasibility of RCM in evaluating the effectiveness of a topical combination of alpha- and beta-hydroxy acids, anti-inflammatory and antibacterial molecules, and Herculane thermal water on acne-prone skin. Thirty-five subjects with oily, acne-prone skin were prescribed topical combination products and were evaluated by clinical, Wood\u2019s lamp, and RCM imaging at baseline and after 28 days. At 28 days, the RCM-evaluated number of dilated infundibula, infundibula filled with keratotic material, and infundibula with thickened bright borders, as well as the density of the inflammatory infiltrate, were significantly decreased. Wood\u2019s light images at 28 days showed a significantly reduced number of C. acnes-colonized infundibula, and both the median area and the intensity of the red-orange fluorescence were decreased. The reduction in the clinical score was concurrent with the improvement in the RCM parameters, suggesting that this non-invasive imaging technique is appropriate for efficiency evaluations of topical acne treatments.<\/jats:p>","DOI":"10.3390\/life12121973","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T03:28:49Z","timestamp":1669606129000},"page":"1973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Feasibility of Reflectance Confocal Microscopy Monitoring in Oily, Acne-Prone Facial Skin Treated with a Topical Combination of Alpha and Beta-Hydroxy Acids, Anti-Inflammatory Molecules, and Herculane Thermal Water: A Blinded, One-Month Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-0817","authenticated-orcid":false,"given":"Mihai","family":"Lupu","sequence":"first","affiliation":[{"name":"Department of Dermatology, MEDAS Medical Center, 030442 Bucharest, Romania"},{"name":"Department of Dermatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Malciu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5671-9378","authenticated-orcid":false,"given":"Vlad Mihai","family":"Voiculescu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Napolitano, M., Fabbrocini, G., Martora, F., Picone, V., Morelli, P., and Patruno, C. (2021). Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases. Cells, 10.","DOI":"10.3390\/cells10123559"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-3083.2011.04374.x","article-title":"European Evidence-based (S3) Guidelines for the Treatment of Acne","volume":"26","author":"Nast","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_4","first-page":"22","article-title":"In-vivo effectiveness of adapalene 0.1%\/benzoyl peroxide 2.5% gel on antibiotic-sensitive and resistant Propionibacterium acnes","volume":"4","author":"Leyden","year":"2011","journal-title":"J. Clin. Aesthetic Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF02850266","article-title":"Potential anti-inflammatory effects of topical retinoids and retinoid analogues","volume":"19","author":"Wolf","year":"2002","journal-title":"Adv. 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