{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T03:17:03Z","timestamp":1786763823199,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Severe aortic stenosis (AS) is the most common valve disease in the elderly and is associated with poor prognosis if treated only medically. AS causes chronic pressure overload, concentric left ventricular (LV) hypertrophy, myocardial stiffness, and diastolic dysfunction. This adverse remodeling also affects the left atrium (LA), which dilates and develops myocardial fibrosis, with a reduction in intrinsic function and a consequent high risk of the development of atrial fibrillation. Speckle-tracking echocardiography is able to detect myocardial dysfunction before other conventional parameters, such as LV ejection fraction, and also predict clinical outcomes. This review aims at describing LV and LA remodeling in AS and before and after aortic valve replacement and the usefulness of myocardial strain analysis in this clinical setting.<\/jats:p>","DOI":"10.3390\/life12122074","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T03:02:37Z","timestamp":1670814157000},"page":"2074","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Left Atrial Remodeling in Response to Aortic Valve Replacement: Pathophysiology and Myocardial Strain Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Matteo","family":"Lisi","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"},{"name":"Department of Cardiovascular Disease\u2014AUSL Romagna, Division of Cardiology, Ospedale S. Maria Delle Croci, Viale Randi 5, 48121 Ravenna, Italy"},{"name":"Institute of Public Health and Clinical Medicine and Heart Centre, Ume\u00e5 University, 90187 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-141X","authenticated-orcid":false,"given":"Maria Concetta","family":"Pastore","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Fiorio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease\u2014AUSL Romagna, Division of Cardiology, Ospedale S. Maria Delle Croci, Viale Randi 5, 48121 Ravenna, Italy"},{"name":"Cardiology Unit and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cameli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Elena","family":"Mandoli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Maria","family":"Righini","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Cavigli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"D\u2019Ascenzi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Focardi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rubboli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease\u2014AUSL Romagna, Division of Cardiology, Ospedale S. Maria Delle Croci, Viale Randi 5, 48121 Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[{"name":"Cardiology Unit and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Mondillo","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Henein","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Medicine and Heart Centre, Ume\u00e5 University, 90187 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: A population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM199907153410302","article-title":"Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly","volume":"341","author":"Otto","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMe0807001","article-title":"Calcific aortic stenosis--time to look more closely at the valve","volume":"359","author":"Otto","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_5","first-page":"254","article-title":"Focus update on the echocardiographic assessment of aortic valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"18","author":"Baumgartner","year":"2017","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0002-9149(79)90235-2","article-title":"Ventricular function and coronary hemodynamics in hypertensive heart disease","volume":"44","author":"Strauer","year":"1979","journal-title":"Am. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10554-015-0638-6","article-title":"Left atrial function in volume versus pressure overloaded left atrium","volume":"31","author":"Henein","year":"2015","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.38.1S5.V-61","article-title":"Aortic stenosis","volume":"38","author":"Ross","year":"1968","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a selfexpanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.jacc.2015.03.014","article-title":"Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve stenosis: 1-Year results from the all-comers NOTION randomized clinical trial","volume":"65","author":"Thyregod","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/hrt.81.2.111","article-title":"Normal long axis function","volume":"81","author":"Henein","year":"1999","journal-title":"Heart"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(09)60211-7","article-title":"Aortic stenosis","volume":"373","author":"Carabello","year":"2009","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/heartjnl-2017-311506","article-title":"The role and clinical implications of diastolic dysfunction in aortic stenosis","volume":"103","author":"Kampaktsis","year":"2017","journal-title":"Heart"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: Biomedical research from bench to bedside","volume":"19","author":"Gyongyosi","year":"2017","journal-title":"Eur. J. Heart Fail"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s10741-022-10214-0","article-title":"Detection of myocardial fibrosis by speckle-tracking echocardiography: From prediction to clinical applications","volume":"27","author":"Lisi","year":"2022","journal-title":"Heart Fail. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1136\/heartjnl-2019-315560","article-title":"Myocardial fibrosis: Why image, how to image and clinical implications","volume":"105","author":"Bing","year":"2019","journal-title":"Heart"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.echo.2011.04.014","article-title":"Early detection of left atrial strain abnormalities by speckle-tracking in hypertensive and diabetic patients with normal left atrial size","volume":"24","author":"Mondillo","year":"2011","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.1464","article-title":"Left atrial strain and compliance in the diagnostic evaluation of heart failure with preserved ejection fraction","volume":"21","author":"Reddy","year":"2019","journal-title":"Eur. J. Heart Fail"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.echo.2018.08.012","article-title":"Left atrial function predicts cardiovascular events in patients with chronic heart failure with reduced ejection fraction","volume":"32","author":"Malagoli","year":"2019","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.jcmg.2020.04.031","article-title":"Left atrial strain as a predictor of new-onset atrial fibrillation in patients with heart failure","volume":"13","author":"Park","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/echo.15074","article-title":"Peak atrial longitudinal strain is predictive of atrial fibrillation in patients with chronic obstructive pulmonary disease and coronary artery disease","volume":"38","author":"Pavasini","year":"2021","journal-title":"Echocardiography"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.amjcard.2012.10.049","article-title":"Usefulness of atrial deformation analysis to predict left atrial fibrosis and endocardial thickness in patients undergoing mitral valve operations for severe mitral regurgitation secondary to mitral valve prolapse","volume":"111","author":"Cameli","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/ehjci\/jeab106","article-title":"Left atrial strain by speckle tracking predicts atrial fibrosis in patients undergoing heart transplantation","volume":"23","author":"Lisi","year":"2021","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/echo.13485","article-title":"Changes in myocardial deformation after transcatheter and surgical aortic valve replacement","volume":"34","author":"Garg","year":"2017","journal-title":"Echocardiography"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/ejechocard\/jeq026","article-title":"Valve replacement for aortic stenosis normalizes subendocardial function in patients with normal ejection fraction","volume":"11","author":"Lindqvist","year":"2010","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.echo.2006.11.003","article-title":"Impact of left ventricular loading conditions on myocardial deformation parameters: Analysis of early and late changes of myocardial deformation parameters after aortic valve replacement","volume":"20","author":"Becker","year":"2007","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.amjcard.2010.11.032","article-title":"Relation of myocardial mechanics in severe aortic stenosis to left ventricular ejection fraction and response to aortic valve replacement","volume":"107","author":"Carasso","year":"2011","journal-title":"Am J Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ahj.2009.07.008","article-title":"Differential effects of afterload on left ventricular long- and short-axis function: Insights from a clinical model of patients with aortic valve stenosis undergoing aortic valve replacement","volume":"158","author":"Carasso","year":"2009","journal-title":"Am. Heart J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1540-8175.2012.01808.x","article-title":"Early improvement of the regional and global ventricle function estimated by two-dimensional speckle tracking echocardiography after percutaneous aortic valve implantation speckle tracking after CoreValve implantation","volume":"30","author":"Delgado","year":"2013","journal-title":"Echocardiography"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-7120-10-15","article-title":"Acute regional improvement of myocardial function after interventional transfemoral aortic valve replacement in aortic stenosis: A speckle tracking echocardiography study","volume":"10","author":"Schattke","year":"2012","journal-title":"Cardiovasc. Ultrasound"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.echo.2012.12.006","article-title":"Left ventricular global systolic longitudinal deformation and prognosis 1 year after femoral and apical transcatheter aortic valve implantation","volume":"26","author":"Andersen","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/ehjci\/jet166","article-title":"Recovery of left ventricular and left atrial mechanics in various entities of aortic stenosis 12 months after TAVI","volume":"15","author":"Spethmann","year":"2014","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1093\/eurheartj\/ehp351","article-title":"Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement","volume":"30","author":"Delgado","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1161\/CIRCULATIONAHA.109.929893","article-title":"Comparison between transcatheter and surgical prosthetic valve implantation in patients with severe aortic stenosis and reduced left ventricular ejection fraction","volume":"122","author":"Clavel","year":"2010","journal-title":"Circulation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s10554-012-0175-5","article-title":"Improvement of left ventricular longitudinal systolic function after transcatheter aortic valve implantation: A speckle-tracking prospective study","volume":"29","author":"Cameli","year":"2013","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.ijcard.2012.04.057","article-title":"Severity of aortic stenosis predicts early post-operative normalization of left atrial size and function detected by myocardial strain","volume":"167","author":"Lisi","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10554-013-0265-z","article-title":"Left atrial remodelling in patients undergoing transcatheter aortic valve implantation: A speckle-tracking prospective, longitudinal study","volume":"29","author":"Cameli","year":"2013","journal-title":"Int J Cardiovasc. Imaging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/ehjci\/jev230","article-title":"Prognostic value of left atrial reservoir function in patients with severe aortic stenosis: A 2D speckle-tracking echocardiographic study","volume":"17","author":"Galli","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000514665","article-title":"The Prognostic Value of Left Atrial Global Longitudinal Strain and Left Atrial Phasic Volumes in Patients Undergoing Transcatheter Valve Implantation for Severe Aortic Stenosis","volume":"146","author":"Weber","year":"2021","journal-title":"Cardiology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e006615","DOI":"10.1161\/JAHA.117.006615","article-title":"Left Atrial Volume and Mortality in Patients with Aortic Stenosis","volume":"6","author":"Rusinaru","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10554-013-0323-6","article-title":"Pre-operative left atrial strain predicts post-operative atrial fibrillation in patients undergoing aortic valve replacement for aortic stenosis","volume":"30","author":"Cameli","year":"2014","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/europace\/euab095","article-title":"Role of pre-operative transthoracic echocardiography in predicting post-operative atrial fibrillation after cardiac surgery: A systematic review of the literature and meta-analysis","volume":"23","author":"Kawczynski","year":"2021","journal-title":"Europace"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/echo.13368","article-title":"Left atrium function by 2D speckle tracking in aortic valve disease","volume":"33","author":"Eugenia","year":"2016","journal-title":"Echocardiography"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s10554-017-1211-2","article-title":"Left atrial dysfunction as a determinant of pulmonary hypertension in patients with severe aortic stenosis and preserved left ventricular ejection fraction","volume":"33","author":"Calin","year":"2017","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.echo.2004.06.019","article-title":"Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function","volume":"17","author":"Leitman","year":"2004","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-7120-10-4","article-title":"Novel echocardiographic techniques to assess left atrial size, anatomy and function","volume":"10","author":"Cameli","year":"2012","journal-title":"Cardiovasc. Ultrasound"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-7120-7-6","article-title":"Feasibility and reference values of left atrial longitudinal strain imaging by two-dimensional speckle tracking","volume":"7","author":"Cameli","year":"2009","journal-title":"Cardiovasc. 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