{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:58:02Z","timestamp":1793318282542,"version":"4.5.0"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of Russia","doi-asserted-by":"publisher","award":["121030100227-7"],"award-info":[{"award-number":["121030100227-7"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Background: Two Caucasian blueberries Vaccinium myrtillus L. and Vaccinium arctostaphylos L. are famous berry bushes growing in the Caucasus region and used to treat neurological diseases, but the chemistry and bioactivity of leaf extracts are still poorly studied. (2) Methods: Phenolic compounds of V. myrtillus and V. arctostaphylos leaf extracts were profiled and quantified by HPLC\u2013PDA\u2013ESI\u2013tQ\u2013MS. The neurotropic potential of Vaccinium extracts was studied using the model of middle cerebral artery permanent occlusion to determine cerebral blood flow, the area of the brain tissue necrosis, and antioxidant enzyme activity (including superoxide dismutase, succinate dehydrogenase, and cytochrome C oxidase), as well as the concentration of TBARS. (3) Results: Hydroxycinnamates and flavonoids were identified in the leaves of V. myrtillus and V. arctostaphylos, and the dominant metabolite of both extracts was 5-O-caffeoylquinic acid in the amount of 105\u2013226 mg\/g. The studied extracts enhanced the cerebral hemodynamics and decreased the frequency of necrotic and lipooxidative processes in the brain tissue, accompanied by an increase in the activity of antioxidant enzymes. The positive effect of V. arctostaphylos was stronger and exceeded the effectiveness of Ginkgo biloba standardized extract. (4) Conclusion: The leaf extracts of Caucasian blueberries V. myrtillus and V. arctostaphylos as a new source of hydroxycinnamates demonstrated a protective effect of the brain ischemia pathology and can be used as therapeutic agents to treat neurological diseases.<\/jats:p>","DOI":"10.3390\/life12122079","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T03:02:37Z","timestamp":1670814157000},"page":"2079","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Caucasian Blueberry: Comparative Study of Phenolic Compounds and Neuroprotective and Antioxidant Potential of Vaccinium\u00a0myrtillus and Vaccinium\u00a0arctostaphylos Leaves"],"prefix":"10.3390","volume":"12","author":[{"given":"Arnold A.","family":"Shamilov","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Botany and Technology of Phytopreparations, Pyatigorsk Medical-Pharmaceutical Institute, Branch of Volgograd State Medical University, Ministry of Health of Russian Federation, 11 Kalinina Avenue, 357500 Pyatigorsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-1061","authenticated-orcid":false,"given":"Daniil N.","family":"Olennikov","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, 6 Sakhyanovoy Street, 670047 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitryi I.","family":"Pozdnyakov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Pyatigorsk Medical-Pharmaceutical Institute, Branch of Volgograd State Medical University, Ministry of Health of Russian Federation, 11 Kalinina Avenue, 357500 Pyatigorsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina N.","family":"Bubenchikova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Botany, Kursk State Medical University, Ministry of Health of Russian Federation, 3 Karl Marks Street, 305000 Kursk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina R.","family":"Garsiya","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Botany and Technology of Phytopreparations, Pyatigorsk Medical-Pharmaceutical Institute, Branch of Volgograd State Medical University, Ministry of Health of Russian Federation, 11 Kalinina Avenue, 357500 Pyatigorsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Larskii","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Pyatigorsk Medical-Pharmaceutical Institute, Branch of Volgograd State Medical University, Ministry of Health of Russian Federation, 11 Kalinina Avenue, 357500 Pyatigorsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,11]]},"reference":[{"key":"ref_1","unstructured":"(2022, November 12). 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