{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:29:07Z","timestamp":1788398947063,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taichung Armed Forces General Hospital","award":["803TB110579"],"award-info":[{"award-number":["803TB110579"]}]},{"name":"Taichung Armed Forces General Hospital","award":["NCHU-CSMU 11006"],"award-info":[{"award-number":["NCHU-CSMU 11006"]}]},{"name":"Taichung Armed Forces General Hospital","award":["KSVGH110-101"],"award-info":[{"award-number":["KSVGH110-101"]}]},{"name":"National Chung Hsing University and Chung Shan Medical University Hospital","award":["803TB110579"],"award-info":[{"award-number":["803TB110579"]}]},{"name":"National Chung Hsing University and Chung Shan Medical University Hospital","award":["NCHU-CSMU 11006"],"award-info":[{"award-number":["NCHU-CSMU 11006"]}]},{"name":"National Chung Hsing University and Chung Shan Medical University Hospital","award":["KSVGH110-101"],"award-info":[{"award-number":["KSVGH110-101"]}]},{"name":"Kaohsiung Veterans General Hospital","award":["803TB110579"],"award-info":[{"award-number":["803TB110579"]}]},{"name":"Kaohsiung Veterans General Hospital","award":["NCHU-CSMU 11006"],"award-info":[{"award-number":["NCHU-CSMU 11006"]}]},{"name":"Kaohsiung Veterans General Hospital","award":["KSVGH110-101"],"award-info":[{"award-number":["KSVGH110-101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Isorhamnetin (IRh), which has a wide range of pharmacological effects, is one of the most significant active components in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L. It protects the heart and brain, in addition to possessing anti-tumor, anti-inflammatory, antioxidant, organ protection, and anti-obesity properties. We sought to assess IRh\u2019s anti-psoriatic activity, explore its immunomodulatory properties in reducing the severity of psoriatic symptoms, and evaluate its potential immunotherapeutic effects. We used IRh to treat imiquimod (IMQ)-induced psoriasis in BALB\/C mice and examined the underlying mechanisms. The outcomes demonstrated that IRh reduced epidermal hyperplasia, lowered PASI scores, and improved histopathological psoriasiform lesions in IMQ-induced mice. IRh attenuated the accumulation of malondialdehyde (MDA), and also reversed the reduction caused by IMQ of superoxide dismutase (SOD) and catalase (CAT) in skin tissues. Additionally, IRh effectively inhibited IMQ\u2019s ability to increase proinflammatory cytokines such as TNF-\u03b1, IL-6, IL-17A, and transcription factor NF-\u03baB. Furthermore, IRh significantly reduced the percentage of Th1 and Th17 in the spleens of mice treated with IMQ and suppressed the maturation of splenic dendritic cells. Overall, our research suggests that IRh protects against oxidative stress and inflammation in the pathogenesis of psoriasis, with potential for the development of new and potent medication for the treatment of psoriasis.<\/jats:p>","DOI":"10.3390\/life12122107","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T02:20:57Z","timestamp":1671070857000},"page":"2107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mechanisms and Effects of Isorhamnetin on Imiquimod-Induced Psoriasiform Dermatitis in Mice"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-2000","authenticated-orcid":false,"given":"Chieh-Shan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Division of Dermatology, Pingtung Veterans General Hospital, Pingtung 900, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Chao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung 402, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Collage of Life Science, Inservice Master Program in Life Science, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-274X","authenticated-orcid":false,"given":"Deng-Ho","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung 41152, Taiwan"},{"name":"Division of Rheumatology, Immunology, Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/nm.3016","article-title":"Hiding under the skin: Interleukin-17-producing gammadelta T cells go under the skin?","volume":"18","author":"Becher","year":"2012","journal-title":"Nat. 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