{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:33:25Z","timestamp":1793126005316,"version":"4.5.0"},"reference-count":148,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2018\/07366-4"],"award-info":[{"award-number":["2018\/07366-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["201808426-0"],"award-info":[{"award-number":["201808426-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["406396\/2021-3"],"award-info":[{"award-number":["406396\/2021-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"H.U. and a FAPESP (Brazil)-Conicyt (Chile)","award":["2018\/07366-4"],"award-info":[{"award-number":["2018\/07366-4"]}]},{"name":"H.U. and a FAPESP (Brazil)-Conicyt (Chile)","award":["201808426-0"],"award-info":[{"award-number":["201808426-0"]}]},{"name":"H.U. and a FAPESP (Brazil)-Conicyt (Chile)","award":["406396\/2021-3"],"award-info":[{"award-number":["406396\/2021-3"]}]},{"name":"National Council for Scientific and Technological Development","award":["2018\/07366-4"],"award-info":[{"award-number":["2018\/07366-4"]}]},{"name":"National Council for Scientific and Technological Development","award":["201808426-0"],"award-info":[{"award-number":["201808426-0"]}]},{"name":"National Council for Scientific and Technological Development","award":["406396\/2021-3"],"award-info":[{"award-number":["406396\/2021-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Cannabis sativa is one of the first medicinal plants used by humans. Its medical use remains controversial because it is a psychotropic drug whose use has been banned. Recently, however, some countries have approved its use, including for recreational and medical purposes, and have allowed the scientific study of its compounds. Cannabis is characterized by the production of special types of natural products called phytocannabinoids that are synthesized exclusively by this genus. Phytocannabinoids and endocannabinoids are chemically different, but both pharmacologically modulate CB1, CB2, GRP55, GRP119 and TRPV1 receptor activities, involving activities such as memory, sleep, mood, appetite and motor regulation, pain sensation, neuroinflammation, neurogenesis and apoptosis. \u03949-tetrahydrocannabinol (THC) and cannabidiol (CBD) are phytocannabinoids with greater pharmacological potential, including anti-inflammatory, neuroprotective and anticonvulsant activities. Cannabidiol is showing promising results for the treatment of COVID-19, due to its capability of acting on the unleashed cytokine storm, on the proteins necessary for both virus entry and replication and on the neurological consequences of patients who have been infected by the virus. Here, we summarize the latest knowledge regarding the advantages of using cannabinoids in the treatment of COVID-19.<\/jats:p>","DOI":"10.3390\/life12122117","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T02:16:41Z","timestamp":1671157001000},"page":"2117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment"],"prefix":"10.3390","volume":"12","author":[{"given":"Rebeca","family":"P\u00e9rez","sequence":"first","affiliation":[{"name":"Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita","family":"Glaser","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, Av. Prof. Lineu Prestes 748, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-1763","authenticated-orcid":false,"given":"Cecilia","family":"Villegas","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Burgos","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Facultad de Ciencias, Universidad Santo Tomas, Temuco 4780000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-3815","authenticated-orcid":false,"given":"Henning","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, Av. Prof. Lineu Prestes 748, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-4984","authenticated-orcid":false,"given":"Cristian","family":"Paz","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","first-page":"307","article-title":"Aplicaciones terap\u00e9uticas por acci\u00f3n de los cannabinoides","volume":"155","year":"2019","journal-title":"Gac. M\u00e9dica M\u00e9xico"},{"key":"ref_2","first-page":"49","article-title":"Uso medicinal de la Marihuana","volume":"31","year":"2019","journal-title":"Anest. 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