{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:31:38Z","timestamp":1772620298953,"version":"3.50.1"},"reference-count":6,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["#075-15-2020-800"],"award-info":[{"award-number":["#075-15-2020-800"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Orthostatic hypotension is a complex medical problem with various underlying pathogenic mechanisms and limited modalities for its correction. Since transcutaneous spinal cord stimulation (t-SCS) leads to immediate blood pressure (BP) elevation in a supine position, we suggested that t-SCS may attenuate blood pressure drops in orthostasis. We aimed to evaluate the hemodynamic effects of t-SCS during tilt testing in a feasibility study in three patients with documented orthostatic hypotension. Four sessions on two different days of tilt testing on and off t-SCS were performed on each patient. While tilting with t-SCS off showed typical significant BP drops in every patient, active t-SCS resulted in systemic vascular resistance (SVR) elevation in all patients and significantly higher values of systolic and diastolic BP in two patients. T-SCS requires further investigation on a larger patient population. However, our preliminary results demonstrate its ability for SVR and BP elevation in subjects with severe orthostatic hypotension.<\/jats:p>","DOI":"10.3390\/life13010026","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T02:36:46Z","timestamp":1671763006000},"page":"26","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcutaneous Spinal Cord Stimulation Attenuates Blood Pressure Drops in Orthostasis"],"prefix":"10.3390","volume":"13","author":[{"given":"Natalia N.","family":"Beliaeva","sequence":"first","affiliation":[{"name":"Almazov National Medical Research Centre, 2 Akkuratova Str., St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-5253","authenticated-orcid":false,"given":"Tatiana R.","family":"Moshonkina","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, 2 Akkuratova Str., St. Petersburg 197341, Russia"},{"name":"Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarova enb., St. Petersburg 199034, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-439X","authenticated-orcid":false,"given":"Oleg V.","family":"Mamontov","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, 2 Akkuratova Str., St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena N.","family":"Zharova","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, 2 Akkuratova Str., St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3246-5948","authenticated-orcid":false,"given":"Heber Ivan","family":"Condori Leandro","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, 2 Akkuratova Str., St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3878-8783","authenticated-orcid":false,"given":"Nigar Z.","family":"Gasimova","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, 2 Akkuratova Str., St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-9141","authenticated-orcid":false,"given":"Evgeny N.","family":"Mikhaylov","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, 2 Akkuratova Str., St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1089\/neu.2017.5082","article-title":"An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury","volume":"35","author":"Phillips","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1056\/NEJMoa2112809","article-title":"Implanted System for Orthostatic Hypotension in Multiple-System Atrophy","volume":"386","author":"Squair","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s12265-020-10014-7","article-title":"Acute Cardiovascular Effects of Non-Invasive Electrical Spinal Cord Stimulation: Results from a Pilot Study in Humans","volume":"13","author":"Mikhaylov","year":"2020","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1134\/S036211971606013X","article-title":"Mechanisms of spinal cord electrical stimulation action on autonomic functions","volume":"42","author":"Moshonkina","year":"2016","journal-title":"Hum. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41586-020-03180-w","article-title":"Neuroprosthetic Baroreflex Controls Haemodynamics after Spinal Cord Injury","volume":"590","author":"Squair","year":"2021","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnhum.2018.00083","article-title":"Normalization of Blood Pressure With Spinal Cord Epidural Stimulation After Severe Spinal Cord Injury","volume":"12","author":"Harkema","year":"2018","journal-title":"Front. Hum. 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