{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:07:43Z","timestamp":1790885263376,"version":"4.1.0"},"reference-count":97,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T00:00:00Z","timestamp":1673136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Melanoma is the most dangerous form of skin cancer that develops from the malignant transformation of the melanocytes located in the basal layer of the epidermis (cutaneous melanoma). Melanocytes may also be found in the meninges, eyes, ears, gastrointestinal tract, genito-urinary system, or other mucosal surfaces (mucosal melanoma). Melanoma is caused by an uncontrolled proliferation of melanocytes, that at first may form a benign lesion (nevogenesis), but in time, it may transition to melanoma, determining what it is named, melanomagenesis. Some tumors may appear spontaneously (de novo melanoma) or on preexisting lesions (nevus-associated melanoma). The exact cause of melanoma may not be fully understood yet, but there are some factors that initiate and promote this malignant process. This study aims to provide a summary of the latest articles regarding the key factors that may lead to melanomagenesis. The secondary objectives are to reveal the relationship between nevi and melanoma, to understand the cause of \u201cde novo\u201d and \u201cnevus-associated melanoma\u201d and highlight the differences between these subtypes.<\/jats:p>","DOI":"10.3390\/life13010181","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T02:31:30Z","timestamp":1673231490000},"page":"181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Review: The Key Factors to Melanomagenesis"],"prefix":"10.3390","volume":"13","author":[{"given":"Cristina-Raluca","family":"(Jitian) Mihulecea","sequence":"first","affiliation":[{"name":"Doctoral Studies, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, 300041 Timi\u0219oara, Romania"},{"name":"Dermatology Clinic, Emergency Clinical County Hospital of Sibiu, 550245 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rotaru","sequence":"additional","affiliation":[{"name":"Doctoral Studies, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, 300041 Timi\u0219oara, Romania"},{"name":"Dermatology Clinic, Emergency Clinical County Hospital of Sibiu, 550245 Sibiu, Romania"},{"name":"Dermatology Department, Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Strashilov, S., and Yordanov, A. 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