{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:03:53Z","timestamp":1787954633528,"version":"build-2784847793"},"reference-count":112,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"VEGA","award":["1\/0398\/21"],"award-info":[{"award-number":["1\/0398\/21"]}]},{"name":"VEGA","award":["ITMS 313011V446"],"award-info":[{"award-number":["ITMS 313011V446"]}]},{"name":"the Ministry of Education, Science, Research, and Sport of the Slovak Republic","award":["1\/0398\/21"],"award-info":[{"award-number":["1\/0398\/21"]}]},{"name":"the Ministry of Education, Science, Research, and Sport of the Slovak Republic","award":["ITMS 313011V446"],"award-info":[{"award-number":["ITMS 313011V446"]}]},{"name":"Lisper","award":["1\/0398\/21"],"award-info":[{"award-number":["1\/0398\/21"]}]},{"name":"Lisper","award":["ITMS 313011V446"],"award-info":[{"award-number":["ITMS 313011V446"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Medicinal mushrooms have been used as a medicinal tool for many centuries and, nowadays, are used in the prevention and therapy of various diseases, including as an adjunct to cancer treatment. It is estimated that 14\u201316% of global cancer cases are caused by infectious events; one well-known infectious agent that leads to cancer is the human papillomavirus (HPV). HPV is responsible for more than 99.7% of cervical cancer cases and also may play a role in vaginal, vulvar, penile, anal, rectal, and oropharyngeal carcinogenesis. Coriolus versicolor, a basidiomycetes class mushroom, consists of glycoproteins called polysaccharide-K (PSK) and polysaccharopeptide (PSP), which are mainly responsible for its effectiveness in the fight against a variety of cancers. Its beneficial effect lies in its ability to arrest different phases of the cell cycle, immunomodulation or induction of apoptosis. Coriolus versicolor extractcan reduces BCL-2 expression or increases the expression of p53 tumour suppressor genes in breast tumour cell lines. Inhibition of proliferation was also demonstrated with HeLa cells, while cervical cytology abnormalities improved in patients who locally applied Coriolus versicolor-based vaginal gel. Coriolus versicolor extract itself, and also its combination with another medicinal mushroom, Ganoderma lucidum, leads to improved HPV clearance in HPV cervical or oral-positive patients. Medicinal mushrooms can also increase the effectiveness of vaccination. This review considers the use of medicinal mushrooms as a suitable adjunct to the treatment of many cancers or precanceroses, including those caused by the HPV virus.<\/jats:p>","DOI":"10.3390\/life13010244","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T03:10:34Z","timestamp":1673838634000},"page":"244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-9671","authenticated-orcid":false,"given":"Tomas","family":"Rokos","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4A, 036 01 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terezia","family":"Pribulova","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4A, 036 01 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Kozubik","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4A, 036 01 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-0508","authenticated-orcid":false,"given":"Kamil","family":"Biringer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4A, 036 01 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5979-8358","authenticated-orcid":false,"given":"Veronika","family":"Holubekova","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology and Diagnostics, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4C, 036 01 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Kudela","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4A, 036 01 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis","volume":"8","author":"Georges","year":"2020","journal-title":"Lancet Glob Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jhep.2019.08.025","article-title":"Epidemiology and surveillance for hepatocellular carcinoma: New trends","volume":"72","author":"Singal","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0140-6736(11)61177-X","article-title":"Burkitt\u2019s lymphoma","volume":"379","author":"Molyneux","year":"2012","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kamolratanakul, S., and Pitisuttithum, P. (2021). Human Papillomavirus Vaccine Efficacy and Effectiveness against Cancer. Vaccines, 9.","DOI":"10.3390\/vaccines9121413"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human papillomavirus and cervical cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_7","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2007). Human papillomaviruses. IARC Monogr. Eval. Carcinog Risks Hum., 90, 1\u2013636."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.biocel.2007.07.004","article-title":"Human papillomavirus: E6 and E7 oncogenes","volume":"39","author":"Boulet","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1086\/657321","article-title":"Cervical human papillomavirus prevalence in 5 continents: Meta-analysis of 1 million women with normal cytological findings","volume":"202","author":"Bruni","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.3389\/fmicb.2018.02896","article-title":"Involvement of Human Papillomaviruses in Cervical Cancer","volume":"28","author":"Wang","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/path.4424","article-title":"Are 20 human papillomavirus types causing cervical cancer?","volume":"234","author":"Arbyn","year":"2014","journal-title":"J. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/B978-0-323-04579-7.00156-8","article-title":"Papillomaviruses","volume":"Volume 2","author":"Viscidi","year":"2010","journal-title":"Infectious Diseases"},{"key":"ref_13","unstructured":"Luria, L., and Cardoza-Favarato, G. (2022, January 24). Human Papillomavirus, StatPearls. Treasure Island (FL), Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK448132\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"864","DOI":"10.20892\/j.issn.2095-3941.2020.0370","article-title":"Biological and clinical aspects of HPV-related cancers","volume":"17","author":"Szymonowicz","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"ref_15","first-page":"268","article-title":"Reference Centers for Disease Control and Prevention","volume":"36","year":"2004","journal-title":"Indian J. Pharmacol."},{"key":"ref_16","first-page":"46","article-title":"Medicinal Mushrooms: Ancient Remedies Meet Modern Science","volume":"13","author":"Stamets","year":"2014","journal-title":"Integr. Med."},{"key":"ref_17","unstructured":"PDQ Integrative, Alternative, and Complementary Therapies Editorial Board (2022, June 07). Medicinal Mushrooms (PDQ\u00ae): Health Professional Version, PDQ Cancer Information Summaries, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK401261\/?report=classic."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Venturella, G., Ferraro, V., Cirlincione, F., and Gargano, M.L. (2021). Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020634"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1615\/IntJMedMushr.v14.i2.10","article-title":"The role of culinary-medicinal mushrooms on human welfare with a pyramid model for human health","volume":"14","author":"Chang","year":"2012","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"806180","DOI":"10.1155\/2014\/806180","article-title":"Medicinal mushrooms","volume":"2014","author":"Lindequist","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/cbr.1994.9.63","article-title":"Suppression of cancer cell growth in vitro by the protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) with SOD mimicking activity","volume":"9","author":"Kobayashi","year":"1994","journal-title":"Cancer Biother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/IntJMedMushrooms.2018025250","article-title":"Antiproliferative Activity and Cytotoxicity of Some Medicinal Wood-Destroying Mushrooms from Russia","volume":"20","author":"Shnyreva","year":"2018","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Luk, S.U., Lee, T.K., Liu, J., Lee, D.T., Chiu, Y.T., Ma, S., Ng, I.O., Wong, Y.C., Chan, F.L., and Ling, M.T. (2011). Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population. PLoS ONE, 6.","DOI":"10.1371\/annotation\/0f6309be-936c-4974-97bf-ed3a98289cd9"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.7150\/ijms.28811","article-title":"In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells","volume":"16","author":"Prego","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1007\/s00253-020-10476-4","article-title":"Mushroom extracts and compounds with suppressive action on breast cancer: Evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials","volume":"104","author":"Wong","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5061639","DOI":"10.1155\/2017\/5061639","article-title":"Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite","volume":"2017","author":"Ricciardi","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1749-8546-5-16","article-title":"Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells","volume":"5","author":"Wan","year":"2010","journal-title":"Chin. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nrd2658","article-title":"BCL-2 family antagonists for cancer therapy","volume":"7","author":"Lessene","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"39436","DOI":"10.1021\/acsami.9b11877","article-title":"Enhanced Thermostability and Anticancer Activity in Breast Cancer Cells of Laccase Immobilized on Pluronic-Stabilized Nanoparticles","volume":"11","author":"Chauhan","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"638","DOI":"10.4161\/cbt.4.6.1721","article-title":"Differential anti-tumor activity of coriolus versicolor (Yunzhi) extract through p53- and\/or Bcl-2-dependent apoptotic pathway in human breast cancer cells","volume":"4","author":"Ho","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ptr.6513","article-title":"Coriolus versicolor-derived protein-bound polysaccharides trigger the caspase-independent cell death pathway in amelanotic but not melanotic melanoma cells","volume":"34","author":"Pawlikowska","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1021\/acschembio.9b00338","article-title":"Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential","volume":"14","author":"Boudreau","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1101\/gad.813200","article-title":"The Rb\/E2F pathway: Expanding roles and emerging paradigms","volume":"14","author":"Harbour","year":"2000","journal-title":"Genes Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/or.2013.2412","article-title":"Protein-bound polysaccharide-K induces apoptosis via mitochondria and p38 mitogen-activated protein kinase-dependent pathways in HL-60 promyelomonocytic leukemia cells","volume":"30","author":"Hirahara","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5607\/en.2011.20.2.100","article-title":"Protective Effect of Coriolus versicolor Cultivated in Citrus Extract Against Nitric Oxide-Induced Apoptosis in Human Neuroblastoma SK-N-MC Cells","volume":"20","author":"Kim","year":"2011","journal-title":"Exp. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.critrevonc.2017.11.001","article-title":"The role of Nuclear Factor-kappa B signaling in human cervical cancer","volume":"120","author":"Tilborghs","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","article-title":"The IRF family transcription factors in immunity and oncogenesis","volume":"26","author":"Tamura","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","article-title":"The JAK-STAT pathway at twenty","volume":"3","author":"Stark","year":"2012","journal-title":"Immunity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: A complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1128\/JVI.75.9.4283-4296.2001","article-title":"Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes","volume":"75","author":"Nees","year":"2001","journal-title":"J. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9486","DOI":"10.1128\/JVI.05007-11","article-title":"Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance","volume":"85","author":"Hong","year":"2011","journal-title":"J. Virol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1099\/vir.0.054486-0","article-title":"Human papillomavirus 16-encoded E7 protein inhibits IFN-\u03b3-mediated MHC class I antigen presentation and CTL-induced lysis by blocking IRF-1 expression in mouse keratinocytes","volume":"94","author":"Zhou","year":"2013","journal-title":"J. Gen. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e00828-19","DOI":"10.1128\/mSphere.00828-19","article-title":"Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription","volume":"5","author":"James","year":"2020","journal-title":"Msphere"},{"key":"ref_44","first-page":"81","article-title":"Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells","volume":"18","author":"Hsieh","year":"2001","journal-title":"Int. J. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/ptr.3378","article-title":"Coriolus versicolor suppresses inflammatory bowel disease by Inhibiting the expression of STAT1 and STAT6 associated with IFN-\u03b3 and IL-4 expression","volume":"25","author":"Lim","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1016\/j.lfs.2005.10.011","article-title":"Polysaccharide peptides from COV-1 strain of Coriolus versicolor induce hyperalgesia via inflammatory mediator release in the mouse","volume":"78","author":"Chan","year":"2006","journal-title":"Life Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.molimm.2014.11.007","article-title":"Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-\u03baB signaling pathways","volume":"64","author":"Yang","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3109\/02656736.2015.1046953","article-title":"Polysaccharide peptide from Coriolus versicolor induces interleukin 6-related extension of endotoxin fever in rats","volume":"31","author":"Jedrzejewski","year":"2015","journal-title":"Int. J. Hyperth."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hsieh, T.C., Wu, P., Park, S., and Wu, J.M. (2006). Induction of cell cycle changes and modulation of apoptogenic\/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I\u2019m-Yunity (PSP). BMC Complement. Altern. Med., 6.","DOI":"10.1186\/1472-6882-6-30"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10295-007-0252-2","article-title":"Disifin (sodium tosylchloramide) and Toll-like receptors (TLRs): Evolving importance in health and diseases","volume":"34","author":"Ofodile","year":"2007","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.fitote.2010.06.002","article-title":"Role for toll-like receptor 4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin, a Trametes versicolor mushroom extract","volume":"81","author":"Price","year":"2010","journal-title":"Fitoterapia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.2147\/JIR.S364945","article-title":"Dual Effect of the Extract from the Fungus Coriolus versicolor on Lipopolysaccharide-Induced Cytokine Production in RAW 264.7 Macrophages Depending on the Lipopolysaccharide Concentration","volume":"15","author":"Pawlikowska","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1016\/j.vaccine.2016.05.022","article-title":"The combination of Pleurotus ferulae water extract and CpG-ODN enhances the immune responses and antitumor efficacy of HPV peptides pulsed dendritic cell-based vaccine","volume":"34","author":"Li","year":"2016","journal-title":"Vaccine"},{"key":"ref_54","unstructured":"Nesuchlov\u00e1, M., Nov\u00e1kov\u00e1, E., and Kompan\u00edkov\u00e1, J. (2017). Imunol\u00f3gia\u2013ako Pracuje Imunitn\u00fd Syst\u00e9m, Martin, K-print."},{"key":"ref_55","unstructured":"Buc, M. (2012). Z\u00e1kladn\u00e1 a Klinick\u00e1 Imunol\u00f3gia, Veda."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1007\/s12325-020-01594-6","article-title":"Therapeutic Efficacy of a Coriolus versicolor-Based Vaginal Gel in Women with Cervical Uterine High-Risk HPV Infection: A Retrospective Observational Study","volume":"38","author":"Criscuolo","year":"2021","journal-title":"Adv. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/LGT.0000000000000596","article-title":"Efficacy of a Coriolus versicolor-Based Vaginal Gel in Women With Human Papillomavirus-Dependent Cervical Lesions: The PALOMA Study","volume":"25","author":"Serrano","year":"2021","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1615\/IntJMedMushrooms.v16.i5.80","article-title":"Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: A preliminary clinical trial","volume":"16","author":"Donatini","year":"2014","journal-title":"Int. J. Med. Mushrooms."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jaci.2005.05.036","article-title":"Innate immune responses to infection","volume":"116","author":"Tosi","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.imbio.2014.10.012","article-title":"TLR9 is expressed in human papillomavirus-positive cervical cells and is overexpressed in persistent infections","volume":"220","author":"Cannella","year":"2015","journal-title":"Immunobiology"},{"key":"ref_61","first-page":"363","article-title":"Humanpapillomavirus (HPV) deregulation of Toll-like receptor 9","volume":"3","author":"Hasan","year":"2014","journal-title":"Immunobiology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0306-3623(95)02058-6","article-title":"Immunomodulation and antitumor activity of polysaccharide-protein complex from the culture filtrates of a local edible mushroom, Tricholoma lobayense","volume":"27","author":"Liu","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/jphp.13104","article-title":"Crude polysaccharide from a wild mushroom enhances immune response in murine macrophage cells by TLR\/NF-\u03baB pathway","volume":"71","author":"Ghosh","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/ijc.25400","article-title":"Association between toll-like receptor expression and human papillomavirus type 16 persistence","volume":"128","author":"Daud","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.critrevonc.2018.05.011","article-title":"Therapeutic vaccines and immune checkpoints inhibition options for gynecological cancers","volume":"128","author":"Schiavi","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Fu, C., Zhou, L., Mi, Q.S., and Jiang, A. (2020). DC-Based Vaccines for Cancer Immunotherapy. Vaccines, 8.","DOI":"10.3390\/vaccines8040706"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/21645515.2018.1547604","article-title":"Pleurotus ferulae polysaccharides improve the antitumor efficacy of therapeutic human papillomavirus dendritic cell-based vaccine","volume":"15","author":"Li","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_68","first-page":"246","article-title":"Increased Response of Human T-Lymphocytes by Dendritic Cells Pulsed with HPV16E7 and Pleurotus sajor-caju-\u03b2-glucan (PBG)","volume":"15","author":"Roopngam","year":"2018","journal-title":"Iran. J. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e881","DOI":"10.1111\/j.1365-2567.2009.03099.x","article-title":"Coadministration of the fungal immunomodulatory protein FIP-Fve and a tumour-associated antigen enhanced antitumour immunity","volume":"128","author":"Ding","year":"2009","journal-title":"Immunology"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Medina, E., Berruguilla, E., Romero, I., Algarra, I., Collado, A., Garrido, F., and Garcia-Lora, A. (2008). The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer, 8.","DOI":"10.1186\/1471-2407-8-78"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Kne\u017eevi\u0107, A., Staji\u0107, M., Sofreni\u0107, I., Stanojkovi\u0107, T., Milovanovi\u0107, I., Te\u0161evi\u0107, V., and Vukojevi\u0107, J. (2018). Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203064"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/1871520617666171113121246","article-title":"Ganoderma lucidum Polysaccharides as An Anti-cancer Agent","volume":"18","author":"Sohretoglu","year":"2018","journal-title":"AntiCancer Agents Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.intimp.2005.08.026","article-title":"Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer","volume":"6","author":"Chen","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1142\/S0192415X11008610","article-title":"Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities","volume":"39","author":"Xu","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1016\/j.bmc.2004.08.003","article-title":"Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides","volume":"12","author":"Chen","year":"2004","journal-title":"Bioorganic Med. Chem."},{"key":"ref_76","first-page":"1387","article-title":"Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms","volume":"25","author":"Lin","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1081\/IMM-55813","article-title":"Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice","volume":"34","author":"Gao","year":"2005","journal-title":"Immunol. Invest."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1615\/IntJMedMushr.v16.i2.80","article-title":"Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes) on transformed cells by human papillomavirus","volume":"16","author":"Gariglio","year":"2014","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/ptr.5426","article-title":"Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells","volume":"29","author":"Ruan","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2058738419869489","DOI":"10.1177\/2058738419869489","article-title":"Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice","volume":"33","author":"Kong","year":"2019","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1159\/000505461","article-title":"Ganoderma Lucidum Polysaccharide, an Extract from Ganoderma Lucidum, Exerts Suppressive Effect on Cervical Cancer Cell Malignancy through Mitigating Epithelial-Mesenchymal and JAK\/STAT5 Signaling Pathway","volume":"105","author":"Jin","year":"2020","journal-title":"Pharmacology"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Morgan, E.L., and Macdonald, A. (2019). JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death. Cancers, 11.","DOI":"10.3390\/cancers11121934"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Morgan, E.L., Wasson, C.W., Hanson, L., Kealy, D., Pentland, I., McGuire, V., Scarpini, C., Coleman, N., Arthur, J.S.C., and Parish, J.L. (2018). STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006975"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"173180","DOI":"10.1155\/2014\/173180","article-title":"Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer","volume":"2014","author":"Ji","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tox.2003.10.012","article-title":"Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats","volume":"195","author":"Naziroglu","year":"2004","journal-title":"Toxicology"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Torres-Mart\u00ednez, B.D.M., Vargas-S\u00e1nchez, R.D., Torrescano-Urrutia, G.R., Esqueda, M., Rodr\u00edguez-Carpena, J.G., Fern\u00e1ndez-L\u00f3pez, J., Perez-Alvarez, J.A., and S\u00e1nchez-Escalante, A. (2022). Pleurotus Genus as a Potential Ingredient for Meat Products. Foods, 11.","DOI":"10.3390\/foods11060779"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1615\/IntJMedMushrooms.2020036673","article-title":"Ergosterol Peroxide Isolated from Oyster Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Potentially Induces Radiosensitivity in Cervical Cancer","volume":"22","author":"Zepeda","year":"2020","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1038\/s41598-021-83606-1","article-title":"Chemosensitizing activity of peptide from Lentinus squarrosulus (Mont.) on cisplatin-induced apoptosis in human lung cancer cells","volume":"11","author":"Khine","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/B978-0-444-59603-1.00013-8","article-title":"Pharmacological Effects of Cordyceps and Its Bioactive Compounds","volume":"40","author":"Prasain","year":"2013","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-3623(97)00076-1","article-title":"A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae)","volume":"30","author":"Ng","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Habtemariam, S. (2020). Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy. Biomedicines, 8.","DOI":"10.3390\/biomedicines8050135"},{"key":"ref_93","unstructured":"El-Ramady, H.R., Abdalla, N., Badgar, K., Hajd\u00fa, P., Eid, Y., and J\u00f3zsef, P. (2022, December 07). Edible Mushrooms. Encyclopedia. Available online: https:\/\/encyclopedia.pub\/entry\/22277."},{"key":"ref_94","first-page":"157","article-title":"Macrocybe lobayensis, an edible mushroom from Western Ghats of Kerala","volume":"15","author":"Vrinda","year":"2006","journal-title":"Mushroom Res."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Yoon, S.Y., Park, S.J., and Park, Y.J. (2018). The Anticancer Properties of Cordycepin and Their Underlying Mechanisms. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103027"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jff.2013.04.018","article-title":"Bioactive principles from Cordyceps sinensis: A potent food supplement\u2013A review","volume":"5","author":"Shashidhar","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_97","first-page":"5957","article-title":"Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model","volume":"9","author":"Omar","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/14756366.2016.1252759","article-title":"The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): A promising natural source of antiradical and AChE inhibitory agents","volume":"32","author":"Karaman","year":"2017","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.ijbiomac.2021.05.102","article-title":"Promising anticancer activity of polysaccharides and other macromolecules derived from oyster mushroom (Pleurotus sp.): An updated review","volume":"182","author":"Mishra","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.intimp.2006.04.002","article-title":"Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans","volume":"6","author":"Sarangi","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"ref_101","first-page":"143","article-title":"Effect of polysaccharide-peptide (PSP), an extract from yun-zhi, on chemotherapy-induced cytopenias","volume":"25","author":"Zhou","year":"1996","journal-title":"Ann. Acad. Med."},{"key":"ref_102","first-page":"207","article-title":"Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China","volume":"23","author":"Chang","year":"2017","journal-title":"Discov. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0305-7372(84)90005-7","article-title":"Krestin (PSK)","volume":"11","author":"Tsukagoshi","year":"1984","journal-title":"Cancer Treat. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3389\/fimmu.2017.01087","article-title":"Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide","volume":"8","author":"Saleh","year":"2017","journal-title":"Front Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1517\/13543784.2013.805202","article-title":"Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum\u2014A review","volume":"22","author":"Wu","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.2174\/092986710791698495","article-title":"Lentinus edodes: A macrofungus with pharmacological activities","volume":"17","author":"Bisen","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_107","first-page":"1595","article-title":"Apoptosis-inducing effects of lentinan on the proliferation of human bladder cancer T24 cells","volume":"28","author":"Bao","year":"2015","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/bs.pmbts.2019.02.013","article-title":"Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China","volume":"163","author":"Zhang","year":"2019","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.tiv.2011.02.001","article-title":"Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells","volume":"25","author":"Jeong","year":"2011","journal-title":"Toxicol. Vitr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/9780470559277.ch090203","article-title":"Nucleotide Analogues as Probes for DNA and RNA Polymerases","volume":"2","author":"Kuchta","year":"2010","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1261\/rna.1458909","article-title":"Cordycepin interferes with 3\u2032 end formation in yeast independently of its potential to terminate RNA chain elongation","volume":"15","author":"Holbein","year":"2009","journal-title":"RNA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5487\/TR.2019.35.2.181","article-title":"Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild Dried Lentinus squarrosulus (Mont.) Mushroom in Rats","volume":"35","author":"Ugbogu","year":"2019","journal-title":"Toxicol Res."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/1\/244\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:06:54Z","timestamp":1760119614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/1\/244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":112,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["life13010244"],"URL":"https:\/\/doi.org\/10.3390\/life13010244","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,16]]}}}