{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:56:26Z","timestamp":1782287786318,"version":"3.54.5"},"reference-count":54,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"State Plan for Scientific, Technical and Innovation Research 2021-2023","award":["PID2021-123091NB-C22"],"award-info":[{"award-number":["PID2021-123091NB-C22"]}]},{"name":"State Plan for Scientific, Technical and Innovation Research 2021-2023","award":["VIGROB-186"],"award-info":[{"award-number":["VIGROB-186"]}]},{"name":"Biotechnology Department of the University of Alicante","award":["PID2021-123091NB-C22"],"award-info":[{"award-number":["PID2021-123091NB-C22"]}]},{"name":"Biotechnology Department of the University of Alicante","award":["VIGROB-186"],"award-info":[{"award-number":["VIGROB-186"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The unique properties of spermatozoa are established through the spermatogenesis and maturation processes concurrently with its epigenome. It is known that damage to epigenetic mechanisms can lead to reproductive problems. However, scientific reviews addressing the role of the spermatozoa epigenome during the reproductive process are scarce. Therefore, the aim of this review was to offer a detailed overview of current knowledge in the field of spermatozoa epigenetics and its consequent implications. A full search was performed through three databases by combining five keywords. Inclusion criteria were implemented to grant accessibility, relevance, and concretion. Besides, some articles were manually removed or added to obtain an adequate and complete collection of 485 scientific publications. This compilation was used to conduct the bibliometric analysis and the data review separately. Bibliometric results displayed that spermatozoa epigenetics is an active and growing research area. The bibliographic overview showed that sperm epigenome correlates with the development of its function, explaining the environmental influence on reproductive pathologies or abnormal inheritance. The main conclusions were that the normal performance of sperm is heavily reliant on its epigenetics and that this study area is burgeoning, with the potential ability to provide society with clinical innovations in a short-term period.<\/jats:p>","DOI":"10.3390\/life13020364","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T07:34:41Z","timestamp":1675064081000},"page":"364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epigenetics Role in Spermatozoa Function: Implications in Health and Evolution\u2014An Overview"],"prefix":"10.3390","volume":"13","author":[{"given":"Julia","family":"Andreu-Noguera","sequence":"first","affiliation":[{"name":"Biotechnology Department, Science Faculty, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"L\u00f3pez-Botella","sequence":"additional","affiliation":[{"name":"Biotechnology Department, Science Faculty, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-8788","authenticated-orcid":false,"given":"Paula","family":"S\u00e1ez-Espinosa","sequence":"additional","affiliation":[{"name":"Biotechnology Department, Science Faculty, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-8154","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"G\u00f3mez-Torres","sequence":"additional","affiliation":[{"name":"Biotechnology Department, Science Faculty, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"ref_1","unstructured":"Allis, C.D., Caparros, M.-L., Jenuwein, T., and Reinberg, D. 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