{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:39:18Z","timestamp":1785199158231,"version":"3.55.0"},"reference-count":144,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["CF-51208"],"award-info":[{"award-number":["CF-51208"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Kr\u00fcppel-like factors (KLFs) are a set of DNA-binding proteins belonging to a family of zinc-finger transcription factors, which have been associated with many biological processes related to the activation or repression of genes, inducing cell growth, differentiation, and death, and the development and maintenance of tissues. In response to metabolic alterations caused by disease and stress, the heart will undergo cardiac remodeling, leading to cardiovascular diseases (CVDs). KLFs are among the transcriptional factors that take control of many physiological and, in this case, pathophysiological processes of CVD. KLFs seem to be associated with congenital heart disease-linked syndromes, malformations because of autosomal diseases, mutations that relate to protein instability, and\/or loss of functions such as atheroprotective activities. Ischemic damage also relates to KLF dysregulation because of the differentiation of cardiac myofibroblasts or a modified fatty acid oxidation related to the formation of a dilated cardiomyopathy, myocardial infarctions, left ventricular hypertrophy, and diabetic cardiomyopathies. In this review, we describe the importance of KLFs in cardiovascular diseases such as atherosclerosis, myocardial infarction, left ventricle hypertrophy, stroke, diabetic cardiomyopathy, and congenital heart diseases. We further discuss microRNAs that have been involved in certain regulatory loops of KLFs as they may act as critical in CVDs.<\/jats:p>","DOI":"10.3390\/life13020420","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T02:57:24Z","timestamp":1675306644000},"page":"420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Involvement of Kr\u00fcppel-like Factors in Cardiovascular Diseases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-6475","authenticated-orcid":false,"given":"Michelle G.","family":"Santoyo-Suarez","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena D.","family":"Mares-Montemayor","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo R.","family":"Padilla-Rivas","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Delgado-Gallegos","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana G.","family":"Quiroz-Reyes","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Roacho-Perez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego F.","family":"Benitez-Chao","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Garza-Oca\u00f1as","sequence":"additional","affiliation":[{"name":"Departamente de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Arevalo-Martinez","sequence":"additional","affiliation":[{"name":"Departamente de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-4603","authenticated-orcid":false,"given":"Elsa N.","family":"Garza-Trevi\u00f1o","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0337-9912","authenticated-orcid":false,"given":"Jose Francisco","family":"Islas","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Medicina Molecular, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.12965\/jer.130049","article-title":"Aging, Exercise, and Extracellular Matrix in the Heart","volume":"9","author":"Kwak","year":"2013","journal-title":"J. Exerc. Rehabil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.jacc.2013.02.071","article-title":"Cardiopoietic Stem Cell Therapy in Heart Failure: The C-CURE (Cardiopoietic Stem Cell Therapy in Heart FailURE) Multicenter Randomized Trial with Lineage-Specified Biologics","volume":"61","author":"Bartunek","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nm738","article-title":"Kr\u00fcppel-like Zinc-Finger Transcription Factor KLF5\/BTEB2 Is a Target for Angiotensin II Signaling and an Essential Regulator of Cardiovascular Remodeling","volume":"8","author":"Shindo","year":"2002","journal-title":"Nat. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"554597","DOI":"10.3389\/fcvm.2020.554597","article-title":"Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution","volume":"7","author":"Majid","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1093\/cvr\/cvab200","article-title":"Progress in Cardiac Research: From Rebooting Cardiac Regeneration to a Complete Cell Atlas of the Heart","volume":"117","author":"Davidson","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_6","unstructured":"Ritchie, H., Spooner, F., and Roser, M. (2018). Causes of Death, Our World in Data."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Xu, J., Murphy, S.L., Kochanek, K.D., and Arias, E. (2021). Mortality in the United States, 2021 Key Findings Data from the National Vital Statistics System, CDC.","DOI":"10.15620\/cdc:122516"},{"key":"ref_8","first-page":"2776","article-title":"A Novel, Erythroid Cell-Specific Murine Transcription Factor That Binds to the CACCC Element and Is Related to the Kriippel Family of Nuclear Proteinst","volume":"13","author":"Miller","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110308","DOI":"10.1016\/j.cellsig.2022.110308","article-title":"Kr\u00fcppel-like Factors in Bone Biology","volume":"93","author":"Zakeri","year":"2022","journal-title":"Cell. Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0092-8674(86)90817-2","article-title":"A Conserved Family of Nuclear Proteins Containing Structural Elements of the Finger Protein Encoded by Kr\u00fcppel, a Drosophila Segmentation Gene","volume":"47","author":"Schuh","year":"1986","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ebiom.2019.01.021","article-title":"Kr\u03cbppel-like Factors (KLFs) in Renal Physiology and Disease","volume":"40","author":"Rane","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrc3582","article-title":"Kr\u00fcppel-like Factors in Cancer","volume":"13","author":"Tetreault","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1084\/jem.20031132","article-title":"KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation","volume":"199","author":"SenBanerjee","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1089\/ars.2010.3647","article-title":"\u201cGo with the Flow\u201d: How Kr\u00fcppel-like Factor 2 Regulates the Vasoprotective Effects of Shear Stress","volume":"15","author":"Nayak","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.120.316738","article-title":"KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy","volume":"128","author":"Kyriazis","year":"2021","journal-title":"Circ. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e000622","DOI":"10.1161\/JAHA.113.000622","article-title":"Deletion of Kr\u00fcppel-like Factor 4 in Endothelial and Hematopoietic Cells Enhances Neointimal Formation Following Vascular Injury","volume":"3","author":"Yoshida","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yjmcc.2021.10.002","article-title":"Kr\u00fcppel-like Factor (KLF) 5: An Emerging Foe of Cardiovascular Health","volume":"163","author":"Palioura","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Pei, J., Grishin, N.V., and Xu, E.Y. (2013). A New Family of Predicted Kr\u00fcppel-Like Factor Genes and Pseudogenes in Placental Mammals. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081109"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12013-008-9008-5","article-title":"Keep Your Fingers off My DNA: Protein-Protein Interactions Mediated by C2H2 Zinc Finger Domains","volume":"50","author":"Brayer","year":"2008","journal-title":"Cell Biochem. Biophys."},{"key":"ref_20","first-page":"183","article-title":"DNA Recognition by Cys2HiS2 Zinc Finger Proteins","volume":"3","author":"Wolfe","year":"1999","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S1357-2725(00)00059-5","article-title":"The Biology of the Mammalian Kr\u00fcppel-like Family of Transcription Factors","volume":"32","author":"Dang","year":"2000","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fcvm.2018.00069","article-title":"Kr\u00fcppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease","volume":"5","author":"Oishi","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/gb-2003-4-2-206","article-title":"Protein Family Review Sp1- and Kr\u00fcppel-like Transcription Factors","volume":"4","author":"Kaczynski","year":"2003","journal-title":"Genome Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1097-2765(02)00443-4","article-title":"CtBP, an Unconventional Transcriptional Torepressor in Development and Oncogenesis","volume":"9","author":"Chinnadurai","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.biocel.2007.01.025","article-title":"Transcriptional Regulation by C-Terminal Binding Proteins","volume":"39","author":"Chinnadurai","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1093\/emboj\/17.17.5129","article-title":"Cloning and Characterization of MCtBP2, a Co-Repressor That Associates with Basic Kruppel-like Factor and Other Mammalian Transcriptional Regulators","volume":"17","author":"Turner","year":"1998","journal-title":"EMBO J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16325","DOI":"10.18632\/oncotarget.13883","article-title":"Characterization and Phylogenetic Analysis of Kr\u00fcppel-like Transcription Factor (KLF) Gene Family in Tree Shrews (Tupaia Belangeri Chinensis)","volume":"8","author":"Shao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian Kr\u00fcppel-Like Factors in Health and Diseases","volume":"90","author":"McConnell","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1136\/annrheumdis-2021-221867","article-title":"Kr\u00fcppel-like Factor-4 and Kr\u00fcppel-like Factor-2 Are Important Regulators of Joint Tissue Cells and Protect against Tissue Destruction and Inflammation in Osteoarthritis","volume":"81","author":"Kawata","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Memon, A., and Lee, W.K. (2018). KLF10 as a Tumor Suppressor Gene and Its TGF-\u03b2 Signaling. Cancers, 10.","DOI":"10.3390\/cancers10060161"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ebiom.2017.03.036","article-title":"Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts","volume":"18","author":"Patel","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/MOH.0000000000000337","article-title":"Kr\u00fcppel-like Factors in Endothelial Cell Biology","volume":"24","author":"Chang","year":"2017","journal-title":"Curr. Opin. Hematol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.3324\/haematol.2014.104943","article-title":"Kr\u00fcppel-like Transcription Factors KLF1 and KLF2 Have Unique and Coordinate Roles in Regulating Embryonic Erythroid Precursor Maturation","volume":"99","author":"Vinjamur","year":"2014","journal-title":"Haematologica"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1073\/pnas.0701981104","article-title":"Kruppel-like Factor 15 Is a Regulator of Cardiomyocyte Hypertrophy","volume":"104","author":"Fisch","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"27449","DOI":"10.1074\/jbc.M110.107292","article-title":"Regulation of Cardiac Gene Expression by KLF15, a Repressor of Myocardin Activity","volume":"285","author":"Leenders","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1038\/sj.emboj.7601379","article-title":"The Kruppel-like Transcription Factor KLF13 Is a Novel Regulator of Heart Development","volume":"25","author":"Andelfinger","year":"2006","journal-title":"EMBO J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1038\/cddis.2011.130","article-title":"Cardiomyocyte Death: Mechanisms and Translational Implications","volume":"2","author":"Chiong","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Roacho-P\u00e9rez, J.A., Garza-Trevi\u00f1o, E.N., Moncada-Saucedo, N.K., Carriquiry-Chequer, P.A., Valencia-G\u00f3mez, L.E., Matthews, E.R., G\u00f3mez-Flores, V., Simental-Mend\u00eda, M., Delgado-Gonzalez, P., and Delgado-Gallegos, J.L. (2022). Artificial Scaffolds in Cardiac Tissue Engineering. Life, 12.","DOI":"10.20944\/preprints202203.0305.v1"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41569-019-0155-8","article-title":"Mechanical Regulation of Gene Expression in Cardiac Myocytes and Fibroblasts","volume":"16","author":"Saucerman","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_40","first-page":"980","article-title":"MiRNA Regulation during Cardiac Development and Remodeling in Cardiomyopathy","volume":"12","author":"Chaitra","year":"2013","journal-title":"EXCLI J."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Islas, J., and Moreno-Cuevas, J. (2018). A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update. Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201805.0154.v1"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7477","DOI":"10.1021\/bi030045n","article-title":"Novel Phosphorylation Target in the Serum Response Factor MADS Box Regulates","volume":"42","author":"Iyer","year":"2003","journal-title":"Biochemistry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1002\/stem.1464","article-title":"Brief Report: Srf-Dependent MiR-210 Silences the Sonic Hedgehog Signaling during Cardiopoesis","volume":"31","author":"Zheng","year":"2013","journal-title":"Stem Cells"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4161\/trns.24588","article-title":"Transient Mesp1 Expression: A Driver of Cardiac Cell Fate Determination","volume":"4","author":"Liu","year":"2013","journal-title":"Transcription"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/CIRCULATIONAHA.118.036748","article-title":"Cardiovascular Disease-Related Morbidity and Mortality in Women with a History of Pregnancy Complications: Systematic Review and Meta-Analysis","volume":"139","author":"Grandi","year":"2019","journal-title":"Circulation"},{"key":"ref_46","first-page":"e38","article-title":"Heart Disease and Stroke Statistics-2016 Update a Report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/CIRCRESAHA.115.306383","article-title":"Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function","volume":"118","author":"Drosatos","year":"2016","journal-title":"Circ. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3389\/fphys.2018.01514","article-title":"Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control","volume":"9","author":"Borghetti","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/1573403X14666180222102312","article-title":"Management of Measurable Variable Cardiovascular Disease\u2019 Risk Factors","volume":"14","author":"Nola","year":"2018","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_50","first-page":"910","article-title":"Enfermedad Cardiovascular Ateroscler\u00f3tica. Revisi\u00f3n de Las Escalas de Riesgo y Edad Cardiovascular","volume":"6","year":"2018","journal-title":"Med. Interna M\u00e9xico"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1016\/j.jacc.2019.09.052","article-title":"Long-Term Cardiovascular Risk in Women with Hypertension during Pregnancy","volume":"74","author":"Honigberg","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pcad.2013.10.016","article-title":"Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease","volume":"56","author":"Bastien","year":"2014","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1873-3468.12964","article-title":"Role of Mitochondrial ROS in the Brain: From Physiology to Neurodegeneration","volume":"592","author":"Angelova","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tan, B.L., and Norhaizan, M.E. (2019). Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. Nutrients, 11.","DOI":"10.3390\/nu11112579"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1161\/ATVBAHA.117.310478","article-title":"Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis","volume":"38","author":"Starke","year":"2018","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e038761","DOI":"10.1136\/bmjopen-2020-038761","article-title":"Comparison of Cardiovascular Disease Risk Factors, Assessment and Management in Men and Women, Including Consideration of Absolute Risk: A Nationally Representative Cross-Sectional Study","volume":"10","author":"Banks","year":"2020","journal-title":"BMJ Open"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/jmcb\/mjx037","article-title":"Kr\u00fcppel-like Factors and Vascular Wall Homeostasis","volume":"9","author":"Fan","year":"2017","journal-title":"J. Mol. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Dabravolski, S.A., Sukhorukov, V.N., Kalmykov, V.A., Grechko, A.V., Shakhpazyan, N.K., and Orekhov, A.N. (2022). The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020254"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10861","DOI":"10.1074\/jbc.M411586200","article-title":"Mechanisms Responsible for the Promoter-Specific Effects of Myocardin","volume":"280","author":"Zhou","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biochi.2019.06.007","article-title":"Induction of Endothelial Dysfunction by Oxidized Low-Density Lipoproteins via Downregulation of Erk-5\/Mef2c\/KLF2 Signaling: Amelioration by Fisetin","volume":"163","author":"Patel","year":"2019","journal-title":"Biochimie"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e007134","DOI":"10.1161\/JAHA.117.007134","article-title":"Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis","volume":"6","author":"Xu","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/jmcb\/mjaa080","article-title":"Current Knowledge of Kr\u00fcppel-like Factor 5 and Vascular Remodeling: Providing Insights for Therapeutic Strategies","volume":"13","author":"Xie","year":"2021","journal-title":"J. Mol. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.gene.2017.02.025","article-title":"Kr\u00fcppel-like Factor 4 (KLF4): What We Currently Know","volume":"611","author":"Ghaleb","year":"2017","journal-title":"Gene"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/j.ymthe.2018.08.012","article-title":"Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Soluble Factors from Human Mesenchymal Stem Cells","volume":"26","author":"Yoshida","year":"2018","journal-title":"Mol. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"37798","DOI":"10.1074\/jbc.M006323200","article-title":"Positive- and Negative-Acting Kruppel-like Transcription Factors Bind a Transforming Growth Factor \u03b2 Control Element Required for Expression of the Smooth Muscle Cell Differentiation Marker SM22\u03b1 in vivo","volume":"275","author":"Adam","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nm.3866","article-title":"KLF4-Dependent Phenotypic Modulation of Smooth Muscle Cells Has a Key Role in Atherosclerotic Plaque Pathogenesis","volume":"21","author":"Shankman","year":"2015","journal-title":"Nat. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/CIRCRESAHA.108.176974","article-title":"Conditional Deletion of Kr\u00fcppel-like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury","volume":"102","author":"Yoshida","year":"2008","journal-title":"Circ. Res."},{"key":"ref_68","first-page":"256","article-title":"Atherosclerosis and Inflammation. New Therapeutic Approaches","volume":"155","author":"Climent","year":"2020","journal-title":"Med. Clin."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","article-title":"Cardiac Fibrosis in Myocardial Infarction\u2014From Repair and Remodeling to Regeneration","volume":"365","author":"Talman","year":"2016","journal-title":"Cell Tissue Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.bbadis.2013.07.023","article-title":"Regulation of Fetal Gene Expression in Heart Failure","volume":"1832","author":"Dirkx","year":"2013","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Belian, E., Noseda, M., Abreu Paiva, M.S., Leja, T., Sampson, R., and Schneider, M.D. (2015). Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125384"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1089\/scd.2013.0375","article-title":"Monophasic and Biphasic Electrical Stimulation Induces a Precardiac Differentiation in Progenitor Cells Isolated from Human Heart","volume":"23","author":"Pietronave","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2021.05.019","article-title":"Direct Reprogramming as a Route to Cardiac Repair","volume":"122","author":"Garry","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.stem.2007.05.012","article-title":"Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells","volume":"1","author":"Yamanaka","year":"2007","journal-title":"Cell Stem Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ncb1827","article-title":"Reprogramming of Fibroblasts into Induced Pluripotent Stem Cells with Orphan Nuclear Receptor Esrrb","volume":"11","author":"Feng","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1073\/pnas.0811426106","article-title":"Reprogramming of Murine and Human Somatic Cells Using a Single Polycistronic Vector","volume":"106","author":"Carey","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wang, Y., Liu, Y., Wang, N., Qi, Y., and Du, J. (2013). Kr\u00fcppel-Like Factor 4 Transcriptionally Regulates TGF-\u03921 and Contributes to Cardiac Myofibroblast Differentiation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063424"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCULATIONAHA.120.047420","article-title":"Cardiomyocyte Kr\u00fcppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy","volume":"143","author":"Hoffman","year":"2021","journal-title":"Circulation"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/physrev.00006.2004","article-title":"Myocardial Substrate Metabolism in the Normal and Failing Heart","volume":"85","author":"Stanley","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12551-017-0265-7","article-title":"Genetic Epidemiology of Titin-Truncating Variants in the Etiology of Dilated Cardiomyopathy","volume":"9","author":"Tabish","year":"2017","journal-title":"Biophys. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"103827","DOI":"10.1016\/j.ejmg.2019.103827","article-title":"Identification and Functional Characterization of KLF5 as a Novel Disease Gene Responsible for Familial Dilated Cardiomyopathy","volume":"63","author":"Di","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1573403X12666160606120254","article-title":"Type 2 Diabetes and Heart Failure: Challenges and Solutions","volume":"12","author":"Thomas","year":"2016","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s12035-017-0556-9","article-title":"Genetic Deletion of Kr\u00fcppel-Like Factor 11 Aggravates Ischemic Brain Injury","volume":"55","author":"Tang","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1016\/j.bbrc.2017.11.205","article-title":"KLF4 Protects Brain Microvascular Endothelial Cells from Ischemic Stroke Induced Apoptosis by Transcriptionally Activating MALAT1","volume":"495","author":"Yang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12974-020-01780-x","article-title":"KLF4 Alleviates Cerebral Vascular Injury by Ameliorating Vascular Endothelial Inflammation and Regulating Tight Junction Protein Expression Following Ischemic Stroke","volume":"17","author":"Zhang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1093\/hmg\/ddi256","article-title":"CCM1 and CCM2 Protein Interactions in Cell Signaling: Implications for Cerebral Cavernous Malformations Pathogenesis","volume":"14","author":"Zawistowski","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1172\/JCI39679","article-title":"CCM3 Signaling through Sterile 20\u2013like Kinases Plays an Essential Role during Zebrafish Cardiovascular Development and Cerebral Cavernous Malformations","volume":"120","author":"Zheng","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/STROKEAHA.120.031523","article-title":"CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation through Map3k3-KLF Signaling Pathway","volume":"52","author":"Choi","year":"2021","journal-title":"Stroke"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"eaau0731","DOI":"10.1126\/sciadv.aau0731","article-title":"Ponatinib (AP24534) Inhibits MEKK3-KLF Signaling and Prevents Formation and Progression of Cerebral Cavernous Malformations","volume":"4","author":"Choi","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2174\/15701611113119990014","article-title":"Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease","volume":"13","author":"Hamburg","year":"2015","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/embor.2010.172","article-title":"MiR-146a and Kr\u00fcppel-like Factor 4 Form a Feedback Loop to Participate in Vascular Smooth Muscle Cell Proliferation","volume":"12","author":"Sun","year":"2011","journal-title":"EMBO Rep."},{"key":"ref_92","first-page":"9935671","article-title":"Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment","volume":"2021","author":"Wang","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"McCoy, M.G., Jamaiyar, A., Sausen, G., Cheng, H.S., P\u00e9rez-Cremades, D., Zhuang, R., Chen, J., Goodney, P.P., Creager, M.A., and Sabatine, M.S. (2022). MicroRNA-375 Repression of Kruppel-like Factor 5 Improves Angiogenesis in Diabetic Critical Limb Ischemia. Angiogenesis.","DOI":"10.1007\/s10456-022-09856-3"},{"key":"ref_94","unstructured":"Chen, S., and Wang, T. (2022). Kruppel-like Factor 4 Promotes Autophagy in Human Monocytes Leukemia Cells under High Glucose Conditions by Inhibiting AKT\/MTOR Signaling Pathway. Res. Sq."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.21037\/atm-20-5828","article-title":"Expressions and Relationship of Kr\u00fcppel-like Factor 15 and Endothelial Nitric Oxide Synthase in Experimental Deep Venous Thrombosis","volume":"8","author":"Yang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_96","first-page":"1735","article-title":"Transcriptome Analysis of Klf15 mediated Inhibitory Functions in a Mouse Deep Venous Thrombosis Model","volume":"45","author":"Zhou","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"E119","DOI":"10.1161\/ATVBAHA.120.312674","article-title":"Recent Insights into the Regulation of Coagulation and Thrombosis","volume":"40","author":"Li","year":"2020","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_98","first-page":"777","article-title":"KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression","volume":"122","author":"Wenying","year":"2021","journal-title":"Thromb. Haemost."},{"key":"ref_99","unstructured":"McDermott, D.A., Fong, J.C., and Basson, C.T. (2022, December 08). Holt-Oram Syndrome, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1111\/."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/hmg\/ddx009","article-title":"KLF13 Is a Genetic Modifier of the Holt-Oram Syndrome Gene TBX5","volume":"26","author":"Darwich","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Li, W., Li, B., Li, T., Zhang, E., Wang, Q., Chen, S., and Sun, K. (2020). Identification and Analysis of KLF13 Variants in Patients with Congenital Heart Disease. BMC Med. Genet., 21.","DOI":"10.1186\/s12881-020-01009-x"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/humu.9410","article-title":"A Novel Mutation in TheGATA4 Gene in Patients with Tetralogy of Fallot","volume":"27","author":"Nemer","year":"2006","journal-title":"Hum. Mutat."},{"key":"ref_103","first-page":"11273","article-title":"KLF13 Loss-of-Function Variation Contributes to Familial Congenital Heart Defects","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3892\/etm.2022.11240","article-title":"A Novel KLF13 Mutation Underlying Congenital Patent Ductus Arteriosus and Ventricular Septal Defect, as well as Bicuspid Aortic Valve","volume":"23","author":"Abhinav","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2106\/00004623-199506000-00007","article-title":"The Thoracolumbar Spine in Marfan Syndrome","volume":"77","author":"Sponseller","year":"1995","journal-title":"J. Bone Jt. Surg."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/01.CIR.52.4.651","article-title":"Aortic Root Dilatation and Mitral Valve Prolapse in Marfan\u2019s Syndrome: An ECHOCARDIOgraphic Study","volume":"52","author":"Brown","year":"1975","journal-title":"Circulation"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1161\/ATVBAHA.120.314670","article-title":"Single-Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm","volume":"40","author":"Pedroza","year":"2020","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/jcmm.12825","article-title":"Phenotypic Switching of Vascular Smooth Muscle Cells in the \u201cnormal Region\u201d of Aorta from Atherosclerosis Patients Is Regulated by MiR-145","volume":"20","author":"Zhang","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"9719","DOI":"10.1074\/jbc.M412862200","article-title":"Kruppel-like Factor 4 Abrogates Myocardin-Induced Activation of Smooth Muscle Gene Expression","volume":"280","author":"Liu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"G490","DOI":"10.1152\/ajpgi.90393.2008","article-title":"KLF4 Gene Expression Is Inhibited by the Notch Signaling Pathway That Controls Goblet Cell Differentiation in Mouse Gastrointestinal Tract","volume":"296","author":"Zheng","year":"2009","journal-title":"AJP Gastrointest. Liver Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"120810","DOI":"10.1016\/j.biomaterials.2021.120810","article-title":"MiR-145 Micelles Mitigate Atherosclerosis by Modulating Vascular Smooth Muscle Cell Phenotype","volume":"273","author":"Chin","year":"2021","journal-title":"Biomaterials"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/ATVBAHA.119.312787","article-title":"Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation","volume":"39","author":"Petsophonsakul","year":"2019","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1111\/jcmm.13269","article-title":"MicroRNA Let-7g Suppresses PDGF-Induced Conversion of Vascular Smooth Muscle Cell into the Synthetic Phenotype","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2119\/molmed.2015.00041","article-title":"Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions","volume":"21","author":"Shyu","year":"2015","journal-title":"Mol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/iub.298","article-title":"Role of Kr\u00fcppel-like Factor 4 in Phenotypic Switching and Proliferation of Vascular Smooth Muscle Cells","volume":"62","author":"Zheng","year":"2010","journal-title":"IUBMB Life"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nature08195","article-title":"MiR-145 and MiR-143 Regulate Smooth Muscle Cell Fate and Plasticity","volume":"460","author":"Cordes","year":"2009","journal-title":"Nature"},{"key":"ref_117","first-page":"95","article-title":"Differential Expression of Serum MiR-126, MiR-141 and MiR-21 as Novel Biomarkers for Early Detection of Liver Metastasis in Colorectal Cancer","volume":"26","author":"Yin","year":"2014","journal-title":"Chin. J. Cancer Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1161\/ATVBAHA.114.303572","article-title":"MicroRNA-126 in Atherosclerosis","volume":"34","author":"Boon","year":"2014","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/labinvest.2010.104","article-title":"Role of Serum Response Factor in the Pathogenesis of Disease","volume":"90","author":"Miano","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0092-8674(01)00404-4","article-title":"Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor","volume":"105","author":"Wang","year":"2001","journal-title":"Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/cvr\/cvw174","article-title":"Identifying Circulating MicroRNAs as Biomarkers of Cardiovascular Disease: A Systematic Review","volume":"111","author":"Navickas","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/CIRCRESAHA.111.240150","article-title":"MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch in vitro and Vascular Remodeling in vivo","volume":"109","author":"Torella","year":"2011","journal-title":"Circ. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2009.08.136","article-title":"MicroRNA-133 Regulates the Expression of GLUT4 by Targeting KLF15 and Is Involved in Metabolic Control in Cardiac Myocytes","volume":"389","author":"Horie","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4331\/wjbc.v6.i3.162","article-title":"Roles of the Canonical MyomiRs MiR-1, -133 and -206 in Cell Development and Disease","volume":"6","author":"Mitchelson","year":"2015","journal-title":"World J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1161\/ATVBAHA.111.244053","article-title":"Site-Specific MicroRNA-92a Regulation of Kr\u00fcppel-Like Factors 4 and 2 in Atherosusceptible Endothelium","volume":"32","author":"Fang","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/CIRCRESAHA.114.302213","article-title":"Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice","volume":"114","author":"Loyer","year":"2014","journal-title":"Circ. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13000-020-00942-y","article-title":"Silence of MiR-32-5p Promotes Endothelial Cell Viability by Targeting KLF2 and Serves as a Diagnostic Biomarker of Acute Myocardial Infarction","volume":"15","author":"Dai","year":"2020","journal-title":"Diagn. Pathol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"421","DOI":"10.21037\/cdt-19-700","article-title":"MicroRNA-363-3p Serves as a Diagnostic Biomarker of Acute Myocardial Infarction and Regulates Vascular Endothelial Injury by Targeting KLF2","volume":"10","author":"Gao","year":"2020","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yjmcc.2017.11.003","article-title":"A Carvedilol-Responsive MicroRNA, MiR-125b-5p Protects the Heart from Acute Myocardial Infarction by Repressing pro-Apoptotic Bak1 and Klf13 in Cardiomyocytes","volume":"114","author":"Bayoumi","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Uray, K., Major, E., and Lontay, B. (2020). MicroRNA Regulatory Pathways in the Control of the Actin\u2013Myosin Cytoskeleton. Cells, 9.","DOI":"10.3390\/cells9071649"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/cdd.2016.28","article-title":"The Long Noncoding RNA NRF Regulates Programmed Necrosis and Myocardial Injury during Ischemia and Reperfusion by Targeting MiR-873","volume":"23","author":"Wang","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"30119","DOI":"10.1074\/jbc.M111.258814","article-title":"Transforming Growth Factor-\u03921 (TGF-\u03921) Utilizes Distinct Pathways for the Transcriptional Activation of MicroRNA 143\/145 in Human Coronary Artery Smooth Muscle Cells","volume":"286","author":"Long","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/scd.2010.0283","article-title":"MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4","volume":"20","author":"Xie","year":"2011","journal-title":"Stem Cells Dev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00210-019-01728-w","article-title":"MiR-137-3p Exacerbates the Ischemia-Reperfusion Injured Cardiomyocyte Apoptosis by Targeting KLF15","volume":"393","author":"Zhao","year":"2020","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/nature08889","article-title":"MicroRNA-Mediated Integration of Haemodynamics and Vegf Signalling during Angiogenesis","volume":"464","author":"Nicoli","year":"2010","journal-title":"Nature"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbadis.2017.10.021","article-title":"Regulatory Crosstalk between KLF5, MiR-29a and Fbw7\/CDC4 Cooperatively Promotes Atherosclerotic Development","volume":"1864","author":"Zheng","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.omtn.2021.03.009","article-title":"Interfering MicroRNA-410 Attenuates Atherosclerosis via the HDAC1\/KLF5\/IKB\u03b1\/NF-\u039aB Axis","volume":"24","author":"Nan","year":"2021","journal-title":"Mol. Ther.-Nucleic Acids"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s41065-019-0112-x","article-title":"Identification of Key MicroRNAs in the Carotid Arteries of ApoE\u2212\/\u2212 Mice Exposed to Disturbed Flow","volume":"156","author":"Wang","year":"2019","journal-title":"Hereditas"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13287-018-0895-0","article-title":"MiR-10a Rejuvenates Aged Human Mesenchymal Stem Cells and Improves Heart Function after Myocardial Infarction through KLF4","volume":"9","author":"Dong","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1080\/15384101.2021.1907512","article-title":"Promoting Roles of KLF5 in Myocardial Infarction in Mice Involving MicroRNA-27a Suppression and the Following GFPT2\/TGF-\u03b2\/Smad2\/3 Axis Activation","volume":"20","author":"Tian","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1515\/biol-2020-0100","article-title":"Long Noncoding RNA FTX Ameliorates Hydrogen Peroxide-Induced Cardiomyocyte Injury by Regulating the MiR-150\/KLF13 Axis","volume":"15","author":"Zhang","year":"2020","journal-title":"Open Life Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.12659\/MSM.897266","article-title":"Inhibition of MiR-92a May Protect Endothelial Cells after Acute Myocardial Infarction in Rats: Role of KLF2\/4","volume":"22","author":"Liu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.neuroscience.2013.10.055","article-title":"MicroRNA-124 Is down Regulated in Nerve-Injured Motor Neurons and It Potentially Targets MRNAs for KLF6 and STAT3","volume":"256","author":"Nagata","year":"2014","journal-title":"Neuroscience"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"H641","DOI":"10.1152\/ajpheart.00660.2016","article-title":"MicroRNA-124 Controls Human Vascular Smooth Muscle Cell Phenotypic Switch via Sp1","volume":"313","author":"Tang","year":"2017","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/2\/420\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:21:56Z","timestamp":1760120516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/2\/420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":144,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["life13020420"],"URL":"https:\/\/doi.org\/10.3390\/life13020420","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202212.0212.v1","asserted-by":"object"}]},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,2]]}}}