{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:32:16Z","timestamp":1782372736550,"version":"3.54.5"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: MatriDerm and Integra are both widely used collagenic acellular dermal matrices (ADMs) in the surgical setting, with similar characteristics in terms of healing time and clinical indication. The aim of the present study is to compare the two ADMs in terms of clinical and histological results in the setting of dermato-oncological surgery. Methods: Ten consecutive patients with medical indications to undergo surgical excision of skin cancers were treated with a 2-step procedure at our Dermatologic Surgery Unit. Immediately after tumor removal, both ADMs were positioned on the wound bed, one adjacent to the other. Closure through split-thickness skin grafting was performed after approximately 3 weeks. Conventional histology, immunostaining and ELISA assay were performed on cutaneous samples at different timepoints. Results: No significant differences were detected in terms of either final clinical outcomes or in extracellular matrix content of the neoformed dermis. However, Matriderm was observed to induce scar retraction more frequently. In contrast, Integra was shown to carry higher infectious risk and to be more slowly reabsorbed into the wound bed. Sometimes foreign body-like granulomatous reactions were also observed, especially in Integra samples. Conclusions: Even in the presence of subtle differences between the ADMs, comparable global outcomes were demonstrated after dermato-oncological surgery.<\/jats:p>","DOI":"10.3390\/life13020463","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T03:57:16Z","timestamp":1675828636000},"page":"463","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-7769","authenticated-orcid":false,"given":"Alessia","family":"Paganelli","sequence":"first","affiliation":[{"name":"Dermatologic Surgery Unit, Modena University Hospital, Via del Pozzo 71, 41124 Modena, Italy"},{"name":"PhD Course in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Giovanni","family":"Naselli","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Unit, Modena University Hospital, Via del Pozzo 71, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-8791","authenticated-orcid":false,"given":"Laura","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Azzoni","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-0003","authenticated-orcid":false,"given":"Alessandra","family":"Pisciotta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-8152","authenticated-orcid":false,"given":"Anna Maria","family":"Cesinaro","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Modena University Hospital, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Benassi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-2961","authenticated-orcid":false,"given":"Shaniko","family":"Kaleci","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-5718","authenticated-orcid":false,"given":"Federico","family":"Garbarino","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Unit, Modena University Hospital, Via del Pozzo 71, 41124 Modena, Italy"},{"name":"PhD Course in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Unit, Modena University Hospital, Via del Pozzo 71, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fiorentini","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Unit, Modena University Hospital, Via del Pozzo 71, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Reggiani","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Unit, Modena University Hospital, Via del Pozzo 71, 41124 Modena, Italy"},{"name":"PhD Course in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Magnoni","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Unit, Modena University Hospital, Via del Pozzo 71, 41124 Modena, Italy"},{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.fsc.2011.06.009","article-title":"Skin: Histology and Physiology of Wound Healing","volume":"19","author":"Gantwerker","year":"2011","journal-title":"Facial Plast. Surg. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound Repair and Regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur. Surg. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cpm.2020.07.007","article-title":"Skin Graft Techniques","volume":"37","author":"Khan","year":"2020","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/exd.13460","article-title":"The Tension Biology of Wound Healing","volume":"28","author":"Harn","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s13770-021-00419-z","article-title":"Engineering of Immune Microenvironment for Enhanced Tissue Remodeling","volume":"19","author":"Ko","year":"2022","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/bjd.13954","article-title":"Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing","volume":"173","author":"Martin","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Guillamat-Prats, R. (2021). The Role of MSC in Wound Healing, Scarring and Regeneration. Cells, 10.","DOI":"10.3390\/cells10071729"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s40257-020-00536-w","article-title":"Skin Microbiota and Its Interplay with Wound Healing","volume":"21","author":"Burgess","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0094-1298(02)00066-4","article-title":"Wound Healing and Diabetes Mellitus","volume":"30","author":"Greenhalgh","year":"2003","journal-title":"Clin. Plast. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/iwj.12623","article-title":"Wound Management for the 21st Century: Combining Effectiveness and Efficiency","volume":"13","author":"Lindholm","year":"2016","journal-title":"Int. Wound. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000501071","article-title":"In Vitro Engineering of a Skin Substitute Based on Adipose-Derived Stem Cells","volume":"207","author":"Paganelli","year":"2019","journal-title":"Cells Tissues Organs"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1097\/GOX.0b013e31828ff9f4","article-title":"The Role of Wound Healing and Its Everyday Application in Plastic Surgery: A Practical Perspective and Systematic Review","volume":"1","author":"Ireton","year":"2013","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_13","unstructured":"Azmat, C.E., and Council, M. (2021). StatPearls, StatPearls Publishing."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/sj.jid.5700715","article-title":"Tissue Engineering for Cutaneous Wounds","volume":"127","author":"Clark","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jtv.2022.05.005","article-title":"Clinical Research on the Use of Bordered Foam Dressings in the Treatment of Complex Wounds: A Systematic Review of Reported Outcomes and Applied Measurement Instruments","volume":"31","author":"Raepsaet","year":"2022","journal-title":"J. Tissue. Viability"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1021\/acsnano.1c00204","article-title":"Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diff.2015.05.002","article-title":"In Vitro Keratinocyte Expansion for Cell Transplantation Therapy Is Associated with Differentiation and Loss of Basal Layer Derived Progenitor Population","volume":"89","author":"Young","year":"2015","journal-title":"Differentiation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"983","DOI":"10.36849\/JDD.6132","article-title":"Reconstructing the Glabella and Nasal Root","volume":"21","author":"Neill","year":"2022","journal-title":"J. Drugs. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/DSS.0000000000002810","article-title":"Reconstruction of Perioral Defects After Mohs Micrographic Surgery or Excision: A Systematic Review of the Literature","volume":"47","author":"Shahwan","year":"2021","journal-title":"Dermatol. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1021\/acscentsci.6b00371","article-title":"Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications","volume":"3","author":"Hamdan","year":"2017","journal-title":"ACS Cent. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1089\/ten.teb.2016.0455","article-title":"A Review of Cell-Based Strategies for Soft Tissue Reconstruction","volume":"23","author":"Brett","year":"2017","journal-title":"Tissue. Eng. Part. B Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S487","DOI":"10.1097\/SAP.0000000000002873","article-title":"Adipose Grafting for Volume and Scar Release","volume":"86","author":"Le","year":"2021","journal-title":"Ann. Plast. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/j.1524-4725.2011.02156.x","article-title":"Five Years of Experience Using a Dermal Substitute: Indications, Histologic Studies, and First Results Using a New Single-Layer Tool","volume":"37","author":"Papa","year":"2011","journal-title":"Dermatol. Surg."},{"key":"ref_24","first-page":"183","article-title":"Advances in Wound Healing and Wound Care Technologies\u2013A review","volume":"61","author":"Latha","year":"2020","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/ijd.16157","article-title":"Surgical Management and Oncological Follow-up of Cutaneous Squamous Cell Carcinomas Arising in Epidermolysis Bullosa Patients","volume":"61","author":"Paganelli","year":"2022","journal-title":"Int. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1097\/SCS.0000000000005717","article-title":"Integra in Scalp Reconstruction After Tumor Excision: Recommendations from a Multidisciplinary Advisory Board","volume":"30","author":"Magnoni","year":"2019","journal-title":"J. Craniofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.bjps.2010.03.017","article-title":"The Use of Dermal Regeneration Template (Integra\u00ae) for Reconstruction of a Large Full-Thickness Scalp and Calvarial Defect with Exposed Dura","volume":"63","author":"Chipp","year":"2010","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5999\/aps.2014.41.4.330","article-title":"The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects","volume":"41","author":"Min","year":"2014","journal-title":"Arch. Plast. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/dsu.12044","article-title":"Dermal Equivalents in Oncology: Benefit of One-Stage Procedure","volume":"39","author":"Pauchot","year":"2013","journal-title":"Dermatol. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1111\/jocd.13342","article-title":"Use of a Multilayered Acellular Dermal Substitute with Simultaneous Full-Thickness Skin Graft for the One-Stage Coverage of Nasal Skin Defects","volume":"19","author":"You","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1016\/j.bjps.2021.08.018","article-title":"Treatment of Burn Contractures with Allogeneic Human Dermal Fibroblasts Improves Vancouver Scar Scale: A Phase I\/II Trial","volume":"74","author":"Bourne","year":"2021","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s12263-012-0291-9","article-title":"Conjugated Linoleic Acid Isomers Modulate Protein Expression Profile in Rat Hepatocytes","volume":"7","author":"Rossi","year":"2012","journal-title":"Genes Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e34861","DOI":"10.7554\/eLife.34861","article-title":"Capillary Pericytes Express \u03b1-Smooth Muscle Actin, Which Requires Prevention of Filamentous-Actin Depolymerization for Detection","volume":"7","author":"Yemisci","year":"2018","journal-title":"Elife"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2174\/1570161117666190408170144","article-title":"Advances in Dermoepidermal Skin Substitutes for Diabetic Foot Ulcers","volume":"18","author":"Kakagia","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/iwj.13306","article-title":"Surgical Management of Squamous Cell Carcinoma Arising in Patients Affected by Epidermolysis Bullosa: A Comparative Study","volume":"17","author":"Paganelli","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_36","first-page":"9805980","article-title":"Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience","volume":"2017","author":"Campagnari","year":"2017","journal-title":"Int. J. Surg. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/iwj.12924","article-title":"Skin Cancers and Dermal Substitutes: Is It Safe? Review of the Literature and Presentation of a 2-Stage Surgical Protocol for the Treatment of Non-Melanoma Skin Cancers of the Head in Fragile Patients","volume":"15","author":"Marcasciano","year":"2018","journal-title":"Int. Wound J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/01.prs.0000270298.68331.8a","article-title":"The Use of Artificial Dermis in the Reconstruction of Oncologic Surgical Defects","volume":"120","author":"Tufaro","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bjps.2019.11.004","article-title":"ADM-Assisted Prepectoral Breast Reconstruction and Skin Reduction Mastectomy: Expanding the Indications for Subcutaneous Reconstruction","volume":"73","author":"Onesti","year":"2020","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1159\/000512201","article-title":"Human Acellular Dermal Matrix (Epiflex\u00ae) in Immediate Implant-Based Breast Reconstruction after Skin- and Nipple-Sparing Mastectomy and Treatment of Capsular Fibrosis: Results of a Multicenter, Prospective, Observational NOGGO-AWOGyn Study","volume":"16","author":"Beier","year":"2021","journal-title":"Breast Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/SAP.0000000000001997","article-title":"Acellular Dermal Matrix-Sparing Direct-to-Implant Prepectoral Breast Reconstruction: A Comparative Study Including Cost Analysis","volume":"84","author":"Alnaif","year":"2020","journal-title":"Ann. Plast. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e2127806","DOI":"10.1001\/jamanetworkopen.2021.27806","article-title":"Effect of Immediate Implant-Based Breast Reconstruction After Mastectomy with and Without Acellular Dermal Matrix Among Women with Breast Cancer: A Randomized Clinical Trial","volume":"4","author":"Lohmander","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/bjs5.50324","article-title":"Quality of Life and Patient Satisfaction after Implant-Based Breast Reconstruction with or without Acellular Dermal Matrix: Randomized Clinical Trial","volume":"4","author":"Lohmander","year":"2020","journal-title":"BJS Open"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2066","DOI":"10.6061\/clinics\/2021\/e2066","article-title":"Acellular Dermal Matrix in Skin Wound Healing in Rabbits\u2014Histological and Histomorphometric Analyses","volume":"76","author":"Zanata","year":"2021","journal-title":"Clinics"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.burns.2008.07.018","article-title":"Matriderm versus Integra: A Comparative Experimental Study","volume":"35","author":"Schneider","year":"2009","journal-title":"Burns"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/5584_2018_226","article-title":"Tissue Engineered Skin Substitutes","volume":"1107","author":"Goodarzi","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.bjps.2013.07.002","article-title":"Dermal Autografts as a Substitute for Acellular Dermal Matrices (ADM) in Tissue Expander Breast Reconstruction: A Prospective Comparative Study","volume":"66","author":"Lynch","year":"2013","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"938798","DOI":"10.3389\/fbioe.2022.938798","article-title":"A Comparative Study on Two Types of Porcine Acellular Dermal Matrix Sponges Prepared by Thermal Crosslinking and Thermal-Glutaraldehyde Crosslinking Matrix Microparticles","volume":"10","author":"Huang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00383-011-2990-5","article-title":"Matriderm\u00ae 1 Mm versus Integra\u00ae Single Layer 1.3 Mm for One-Step Closure of Full Thickness Skin Defects: A Comparative Experimental Study in Rats","volume":"28","author":"Biedermann","year":"2012","journal-title":"Pediatr. Surg. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.burns.2019.09.005","article-title":"Comparative Long-Term Study between Two Dermal Regeneration Templates for the Reconstruction of Burn Scar Contractures in Humans: Clinical and Histological Results","volume":"46","author":"Vana","year":"2020","journal-title":"Burns"},{"key":"ref_51","first-page":"245","article-title":"The Use of Dermal Regeneration Templates for Primary Burns Surgery in A UK Regional Burns Centre","volume":"33","author":"Phillips","year":"2020","journal-title":"Ann. Burns Fire Disasters"},{"key":"ref_52","first-page":"1189","article-title":"The Effects of Cross-linking a Collagen-elastin Dermal Template on Scaffold Bio-stability and Degradation","volume":"14","author":"Maitz","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/wrr.13002","article-title":"Evaluation of Contraction of the Split-Thickness Skin Graft Using Three Dermal Matrices in the Treatment of Burn Contractures: A Randomised Clinical Trial","volume":"30","author":"Castro","year":"2022","journal-title":"Wound. Repair Regen."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00238-018-1419-y","article-title":"Reconstruction with Artificial Dermis of Oncological Surgical Defects in the Craniofacial District\u2014Matriderm\u00ae versus Integra\u00ae: A Non-Randomized, Unblinded Single-Operator Case Series","volume":"41","author":"Torresini","year":"2018","journal-title":"Eur. J. Plast. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1365-4632.2011.05189.x","article-title":"Risk Factors for Surgical Site Infection after Dermatological Surgery","volume":"51","author":"Heal","year":"2012","journal-title":"Int. J. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/1346-8138.15782","article-title":"Invasive and in Situ Lesions of Squamous Cell Carcinoma Are Independent Factors for Postoperative Surgical-Site Infection after Outpatient Skin Tumors Surgery: A Retrospective Study of 512 Patients","volume":"48","author":"Nakamura","year":"2021","journal-title":"J. Dermatol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/2\/463\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:26:29Z","timestamp":1760120789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/2\/463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,7]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["life13020463"],"URL":"https:\/\/doi.org\/10.3390\/life13020463","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,7]]}}}