{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:57:00Z","timestamp":1793120220375,"version":"4.5.0"},"reference-count":150,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JSPS KAKENHI 20K06857"],"award-info":[{"award-number":["JSPS KAKENHI 20K06857"]}]},{"name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["JSPS KAKENHI 18K15369"],"award-info":[{"award-number":["JSPS KAKENHI 18K15369"]}]},{"name":"Takeda Science Foundation","award":["JSPS KAKENHI 20K06857"],"award-info":[{"award-number":["JSPS KAKENHI 20K06857"]}]},{"name":"Takeda Science Foundation","award":["JSPS KAKENHI 18K15369"],"award-info":[{"award-number":["JSPS KAKENHI 18K15369"]}]},{"name":"Young Scientists","award":["JSPS KAKENHI 20K06857"],"award-info":[{"award-number":["JSPS KAKENHI 20K06857"]}]},{"name":"Young Scientists","award":["JSPS KAKENHI 18K15369"],"award-info":[{"award-number":["JSPS KAKENHI 18K15369"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The involvement of the changed expression\/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer\u2019s disease (AD), has been suggested. AD is one of the age-related dementias, and is characterized by cognitive impairment with decreased memory function. Developing evidence demonstrates that decreased cell survival, synaptic dysfunction, and reduced neurogenesis are involved in the pathogenesis of AD. On the other hand, it is well known that neurotrophic factors, especially brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB, have multiple roles in the central nervous system (CNS), including neuronal maintenance, synaptic plasticity, and neurogenesis, which are closely linked to learning and memory function. Thus, many investigations regarding therapeutic approaches to AD, and\/or the screening of novel drug candidates for its treatment, focus on upregulation of the BDNF\/TrkB system. Furthermore, current studies also demonstrate that GDNF, IGF1, and bFGF, which play roles in neuroprotection, are associated with AD. In this review, we introduce data demonstrating close relationships between the pathogenesis of AD, neurotrophic factors, and drug candidates, including natural compounds that upregulate the BDNF-mediated neurotrophic system.<\/jats:p>","DOI":"10.3390\/life13030647","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T04:05:40Z","timestamp":1677470740000},"page":"647","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Tadahiro","family":"Numakawa","sequence":"first","affiliation":[{"name":"Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0908-2543","authenticated-orcid":false,"given":"Ryutaro","family":"Kajihara","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Sciences, Faculty of Life Science, Kumamoto University, Kumamoto 862-0976, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103318","DOI":"10.1016\/j.drudis.2022.07.003","article-title":"Neurotrophin-targeted therapeutics: A gateway to cognition and more?","volume":"27","author":"Nordvall","year":"2022","journal-title":"Drug Discov. 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