{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:25:12Z","timestamp":1767651912966,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background. The aim of the study was to assess the effect of baricitinib on 28-day all-cause mortality and the progression of respiratory failure in patients needing transfer to the intensive care unit (ICU) with COVID-19 pneumonia treated with high-flow oxygen therapy. Methods. This retrospective study included hospitalized patients with COVID-19 pneumonia treated with high-flow oxygen non-invasive ventilation receiving standard of care (SOC) or SOC in addition to baricitinib. Data on patients\u2019 characteristics, pro-inflammatory markers, D dimer, and National Early Warning Score 2 (NEWS2) values were collected and compared between groups. The primary endpoint was 28-day all-cause in-hospital mortality and the secondary outcome was transfer to the ICU. Results. The study included 125 patients. The primary outcome was observed in 44.8% of them: 27% in the baricitinib group vs. 62% in the SOC group, p &lt; 0.001. Transfer to the ICU ward was significantly lower in the baricitinib group: 29% vs. 81%, p &lt; 0.001. A significant improvement was observed when the baricitinib group was compared to SOC in procalcitonin, CRP, D-dimer, neutrophil-to-lymphocyte ratio values, and NEWS2. Conclusion. Treatment with baricitinib in addition to SOC was associated with reduced mortality and a lower prevalence of transfer to the ICU in hospitalized patients with COVID-19 pneumonia treated with high-flow oxygen non-invasive therapy.<\/jats:p>","DOI":"10.3390\/life13030755","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:09:56Z","timestamp":1678687796000},"page":"755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes in COVID-19 Patients with Pneumonia Treated with High-Flow Oxygen Therapy and Baricitinib\u2014Retrospective Single-Center Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3758-6757","authenticated-orcid":false,"given":"Du\u0161anka","family":"Obradovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute for Pulmonary Diseases of Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0124-9444","authenticated-orcid":false,"given":"Milica","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Clinic of Nephrology and Clinical Immunology, University Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Banjac","sequence":"additional","affiliation":[{"name":"Institute for Pulmonary Diseases of Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Bulaji\u0107","sequence":"additional","affiliation":[{"name":"Urgent Care Center, University Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0437-1200","authenticated-orcid":false,"given":"Vladimir","family":"\u0110urovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology and Clinical Immunology, University Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Uro\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Clinic of Hematology, University Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-8093","authenticated-orcid":false,"given":"Aleksandra","family":"Milovan\u010dev","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute for Cardiovascular Diseases of Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"635560","DOI":"10.3389\/fmed.2021.635560","article-title":"Mortality and Clinical Interventions in Critically Ill Patient With Coronavirus Disease 2019: A Systematic Review and Meta-Analysis","volume":"8","author":"Qian","year":"2021","journal-title":"Front. 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