{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:04:39Z","timestamp":1788379479842,"version":"build-2803163510"},"reference-count":74,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Sweet syndrome (SS) is a rare disease described as a febrile neutrophilic dermatosis with acute onset, the pathogenesis of which has not yet been elucidated. The syndrome is characterized by the sudden onset of erythematous infiltrated papules or plaques located on the upper body and is associated with fever, leukocytosis and neutrophilia. The lesions show a dense dermal infiltration with mature neutrophils. The condition is responsive to systemic steroids. The central nervous system, bones, muscles, eyes, ears, mouth, heart, lung, liver, kidneys, intestines, and spleen may be affected by SS as extracutaneous manifestations. More and more cases have been found to be associated with malignancies, particularly myelodysplastic syndrome, and, less frequently, other hematologic malignancies or solid tumors. Approximately 21% of patients with SS have an associated malignancy and up to 80% of MASS cases are associated with hematological diseases, predominantly myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Myelodysplastic syndrome is a clonal disease of the bone marrow characterized by inefficient hematopoiesis, dysplasia of the bone marrow and peripheral cytopenias. Affected patients have a high risk of leukemic transformation. After analyzing later studies and current practical aspects regarding MDS-related SS, we suggest an algorithm for evaluating these patients.<\/jats:p>","DOI":"10.3390\/life13030809","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T04:10:48Z","timestamp":1679026248000},"page":"809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sweet Syndrome Associated with Myelodysplastic Syndrome\u2014A Review of a Multidisciplinary Approach"],"prefix":"10.3390","volume":"13","author":[{"given":"C\u0103t\u0103lina Roxana","family":"Ferea","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Farmacy, 020021 Bucharest, Romania"},{"name":"Hematology Department, University Emergency Hospital, 050098 Bucharest, Romania"},{"name":"Faculty of Medicine and Pharmacy, \u201dDun\u0103rea de Jos\u201d University of Gala\u021bi, 800008 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stejara Nicoleta","family":"Mihai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Farmacy, 020021 Bucharest, Romania"},{"name":"Hematology Department, University Emergency Hospital, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-4872","authenticated-orcid":false,"given":"Gabriela","family":"Balan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201dDun\u0103rea de Jos\u201d University of Gala\u021bi, 800008 Gala\u021bi, Romania"},{"name":"Gastroenterology Department, \u201cSf. Apostol Andrei\u201d County Emergency Clinical Hospital Gala\u021bi, 800578 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minerva Codruta","family":"Badescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Farmacy, 700115 Ia\u0219i, Romania"},{"name":"III Internal Medicine Clinic, \u201cSf. Spiridon\u201d County Emergency Clinical Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Tutunaru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201dDun\u0103rea de Jos\u201d University of Gala\u021bi, 800008 Gala\u021bi, Romania"},{"name":"Laboratory Department, \u201cSf. Apostol Andrei\u201d County Emergency Clinical Hospital Gala\u021bi, 800578 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Lauren\u021biu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201dDun\u0103rea de Jos\u201d University of Gala\u021bi, 800008 Gala\u021bi, Romania"},{"name":"Dermatology Department, Clinical Hospital of Infectious Diseases \u201cSf. Cuvioasa Parascheva\u201d Gala\u021bi, 800179 Gala\u021bi, Romania"},{"name":"Multidisciplinary Integrated Center of Dermatological Interface Research MIC DIR, Dun\u0103rea de Jos\u201d University, 800008 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1590\/S0365-05962011000700045","article-title":"S\u00edndrome de Sweet e policondrite recidivante reveladores de s\u00edndrome mielodispl\u00e1sica","volume":"86","author":"Diamantino","year":"2011","journal-title":"An. Bras. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bjh.13485","article-title":"Chronic relapsing remitting Sweet syndrome\u2014A harbinger of myelodysplastic syndrome","volume":"170","author":"Kulasekararaj","year":"2015","journal-title":"Br. J. 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