{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:19:42Z","timestamp":1787505582112,"version":"build-2736575974"},"reference-count":104,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-127566NB-I00"],"award-info":[{"award-number":["PID2021-127566NB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["ACIF-2021\/243"],"award-info":[{"award-number":["ACIF-2021\/243"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Social Fund","award":["PID2021-127566NB-I00"],"award-info":[{"award-number":["PID2021-127566NB-I00"]}]},{"name":"European Social Fund","award":["ACIF-2021\/243"],"award-info":[{"award-number":["ACIF-2021\/243"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Infertility is a growing concerning health problem affecting around 15% of couples worldwide. Conventional semen parameters have limited accuracy for male infertility potential determination. Current advances in the understanding of male infertility indicate that environmental and occupational exposure to chemical contaminants are important etiological factors leading to infertility problems. In this context, some heavy metals (HMs) can be considered as endocrine-disrupting compounds (EDCs), thus altering the seminal quality. This systematic review aims to summarize the key points to detect and quantify HMs in human seminal plasma (SP) and the involved analytical tools. Our results showed that that for HM quantification, atomic absorption spectroscopy (AAS) and inductively coupled plasma (ICP) were the most employed techniques while Zn, Cd, Pb, and Cr were the analytes most often detected. Fast, reliable, and sensitive quantification of EDCs in SP could be important for the development of accurate diagnostic and preventive strategies to address male infertility towards providing personalized therapy.<\/jats:p>","DOI":"10.3390\/life13040925","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T10:19:33Z","timestamp":1680257973000},"page":"925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analytical Determination of Heavy Metals in Human Seminal Plasma\u2014A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-826X","authenticated-orcid":false,"given":"Andrea","family":"L\u00f3pez-Botella","sequence":"first","affiliation":[{"name":"Biotechnology Department, Faculty of Sciences, University of Alicante, Carretera San Vicente del Raspeig s\/n, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-6103","authenticated-orcid":false,"given":"Raquel","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, Carretera San Vicente del Raspeig s\/n, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiza","family":"Paul","sequence":"additional","affiliation":[{"name":"iGLS, Av. de Ansaldo, 12, 03540 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Aizpurua","sequence":"additional","affiliation":[{"name":"IVF Spain, Reproductive Medicine, 03540 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-8154","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"G\u00f3mez-Torres","sequence":"additional","affiliation":[{"name":"Biotechnology Department, Faculty of Sciences, University of Alicante, Carretera San Vicente del Raspeig s\/n, 03690 Alicante, Spain"},{"name":"IVF Spain, Reproductive Medicine, 03540 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-7050","authenticated-orcid":false,"given":"Jos\u00e9-Luis","family":"Todol\u00ed-Torr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, Carretera San Vicente del Raspeig s\/n, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.rbmo.2017.12.005","article-title":"A search for molecular mechanisms underlying male idiopathic infertility","volume":"36","author":"Bracke","year":"2018","journal-title":"Reprod. 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