{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:52:47Z","timestamp":1787806367174,"version":"build-2784847793"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Immediate delivery is an established concept for preventing life-threatening complications in mothers with HELLP syndrome; however, it is associated with preterm births. Methods: Cases of HELLP syndrome diagnosed at the university hospitals of Halle and Magdeburg (Germany) were analyzed retrospectively. Each patient of the treatment group was administered 64 mg of methylprednisolone (MP) intravenously for 10 days, with the dosage being reduced by 50% every other day in patients from Halle (n = 65). Almost immediate delivery was performed in the control groups (n = 45, Halle; n = 28, Magdeburg). Results: Pregnancies in the treatment group were prolonged by 4 days (median 1\u201355 days). The platelet counts increased from 76,060 \u00b1 22,900\/\u03bcL to 117,430 \u00b1 39,065\/\u03bcL in the MP group compared with an increase from 66,500 \u00b1 25,852\/\u03bcL to 83,430 \u00b1 34,608\/\u03bcL in control group 1 and from 78,890 \u00b1 19,100\/\u03bcL to 131,080 \u00b1 50,900\/\u00b5L in control group 2 (p &lt; 0.001). Severe neonatal complications were significantly reduced in the treatment group (p &lt; 0.05): sepsis, 9.25% vs. 24%; ventilation, 44.6% vs. 46.5%; and infant death, 1.6% vs. 8.6%. Conclusions: In a selected collective of patients with HELLP syndrome, prolongation of pregnancy using MP treatment improved maternal and neonatal outcomes.<\/jats:p>","DOI":"10.3390\/life13041013","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:03:38Z","timestamp":1681437818000},"page":"1013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prolongation of Pregnancy in Patients with HELLP Syndrome Using Methylprednisolone: A Retrospective Multicentric Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-4160","authenticated-orcid":false,"given":"Anna Katharina","family":"Hosten","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bonitz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Heinrich-Braun-Klinikum Zwickau, 08060 Zwickau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Th\u00e4le","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Helios Hospital Sangerhausen, 06526 Sangerhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-0730","authenticated-orcid":false,"given":"Michael","family":"Tchirikov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"ref_1","unstructured":"Woudstra, D.M., Chandra, S., Hofmeyr, G.J., and Dowswell, T. (2010). Cochrane Database of Systematic Reviews, Cochrane Library."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/s-1999-15371","article-title":"Prolongation of Pregnancy in Patients Suffering from HELLP Syndrome [Schwangerschaftsverl\u00e4ngerung bei Patientinnen mit HELLP-Syndrom]","volume":"59","author":"Beinder","year":"1999","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.2174\/1389201019666180712115215","article-title":"HELLP Syndrome: Pathophysiology and Current Therapies","volume":"19","author":"Wallace","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/0002-9378(94)90054-X","article-title":"Antepartum corticosteroids: Disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP)","volume":"171","author":"Magann","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4274\/jcrpe.v3i3.31","article-title":"Fetal adrenal suppression due to maternal corticosteroid use: Case report","volume":"3","author":"Daar","year":"2011","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Brownfoot, F.C., Crowther, C.A., and Middleton, P. (2008). Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst. Rev., Cd006764. (In English).","DOI":"10.1002\/14651858.CD006764.pub2"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.yhbeh.2010.06.007","article-title":"Glucocorticoids, prenatal stress and the programming of disease","volume":"59","author":"Harris","year":"2011","journal-title":"Horm. Behav."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neubiorev.2018.05.024","article-title":"Cardiovascular effects of prenatal stress\u2014Are there implications for cerebrovascular, cognitive and mental health outcome?","volume":"117","author":"Kroegel","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_9","unstructured":"(2023, April 08). AWMF 015\/018: Hypertensive Schwangerschaftserkrankungen: Diagnostik und Therapie. S2k-Leitlinie. German Guidelines on Hypertension in Pregnancy From 2019 (Valid Until 2024). Available online: https:\/\/register.awmf.org\/de\/leitlinien\/detail\/015-018."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.ajog.2005.06.058","article-title":"It has been a great ride: The history of HELLP syndrome","volume":"193","author":"Weinstein","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.ajog.2005.08.044","article-title":"Understanding and managing HELLP syndrome: The integral role of aggressive glucocorticoids for mother and child","volume":"195","author":"Martin","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_12","unstructured":"NICE (2019). Hypertension in pregnancy: Diagnosis and management (NG 133), National Institute for Health and Care Excellence: Guidelines."},{"key":"ref_13","unstructured":"(2013). Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy. Obstet. Gynecol., 122, 1122\u20131131."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1515\/JPM.2000.033","article-title":"HELLP Syndrome","volume":"28","author":"Rath","year":"2000","journal-title":"J. Perinat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-2007-999615","article-title":"Maternal death from carotid artery thrombosis associated with the syndrome of hemolysis, elevated liver function, and low platelets","volume":"6","author":"Katz","year":"1989","journal-title":"Am. J. Perinatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1515\/jpme.1998.26.6.486","article-title":"Prognosis of children born to mothers with HELLP-syndrome","volume":"26","author":"Kevekordes","year":"1998","journal-title":"J. Perinat Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000078679","article-title":"Neonatal outcome in pregnancies after preterm delivery for HELLP syndrome","volume":"58","author":"Aslan","year":"2004","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0002-9378(99)70178-X","article-title":"Neonatal outcome in severe preeclampsia at 24 to 36 weeks\u2019 gestation: Does the HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome matter?","volume":"180","author":"Abramovici","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e220483","DOI":"10.1001\/jamapediatrics.2022.0483","article-title":"Evaluation of Long-term Outcomes Associated With Preterm Exposure to Antenatal Corticosteroids: A Systematic Review and Meta-analysis","volume":"176","author":"Ninan","year":"2022","journal-title":"JAMA Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.12659\/MSM.895220","article-title":"Corticosteroid Therapy for Management of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome: A Meta-Analysis","volume":"21","author":"Mao","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/CIRCULATIONAHA.111.034793","article-title":"Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia","volume":"124","author":"Thadhani","year":"2011","journal-title":"Circulation"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/4\/1013\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:15:37Z","timestamp":1760123737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/4\/1013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["life13041013"],"URL":"https:\/\/doi.org\/10.3390\/life13041013","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]}}}