{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:58:03Z","timestamp":1779101883498,"version":"3.51.4"},"reference-count":82,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"The National Institutes of Health, USA","doi-asserted-by":"publisher","award":["DK64111"],"award-info":[{"award-number":["DK64111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health, USA","doi-asserted-by":"publisher","award":["CA102537"],"award-info":[{"award-number":["CA102537"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health, USA","doi-asserted-by":"publisher","award":["HL139473"],"award-info":[{"award-number":["HL139473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Tensins are focal adhesion proteins that regulate various biological processes, such as mechanical sensing, cell adhesion, migration, invasion, and proliferation, through their multiple binding activities that transduce critical signals across the plasma membrane. When these molecular interactions and\/or mediated signaling are disrupted, cellular activities and tissue functions are compromised, leading to disease development. Here, we focus on the significance of the tensin family in renal function and diseases. The expression pattern of each tensin in the kidney, their roles in chronic kidney diseases, renal cell carcinoma, and their potentials as prognostic markers and\/or therapeutic targets are discussed in this review.<\/jats:p>","DOI":"10.3390\/life13061244","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T01:36:28Z","timestamp":1684978588000},"page":"1244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tensins in Kidney Function and Diseases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-9654","authenticated-orcid":false,"given":"Chien-Wei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, School of Medicine, University of California-Davis, Sacramento, CA 95817, USA"},{"name":"Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Hao","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, School of Medicine, University of California-Davis, Sacramento, CA 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrm3769","article-title":"The integrin adhesome: From genes and proteins to human disease","volume":"15","author":"Geiger","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/ncb1622","article-title":"A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration","volume":"9","author":"Katz","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1083\/jcb.125.5.1067","article-title":"Interactions of tensin with actin and identification of its three distinct actin-binding domains","volume":"125","author":"Lo","year":"1994","journal-title":"J. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/boc.201600053","article-title":"Tensins are versatile regulators of Rho GTPase signalling and cell adhesion","volume":"109","author":"Blangy","year":"2017","journal-title":"Biol. Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.tcb.2017.06.004","article-title":"Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation","volume":"27","author":"Georgiadou","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12346","DOI":"10.1038\/s41598-017-12382-8","article-title":"C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cellsig.2018.07.009","article-title":"Cellular phosphatase activity of C1-Ten\/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten\/Tensin2 SH2 domain","volume":"51","author":"Kim","year":"2018","journal-title":"Cell Signal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41419-019-2119-7","article-title":"Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"jcs254029","DOI":"10.1242\/jcs.254029","article-title":"Tensins\u2014Emerging insights into their domain functions, biological roles and disease relevance","volume":"134","author":"Liao","year":"2021","journal-title":"J. Cell Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/bj3510403","article-title":"Molecular characterization of human tensin","volume":"351","author":"Chen","year":"2000","journal-title":"Biochem. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1073\/pnas.022518699","article-title":"Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1158\/1541-7786.225.2.4","article-title":"Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3","volume":"2","author":"Cui","year":"2004","journal-title":"Mol. Cancer Res."},{"key":"ref_13","first-page":"4217","article-title":"Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer","volume":"62","author":"Lo","year":"2002","journal-title":"Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbamcr.2018.10.008","article-title":"Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation","volume":"1866","author":"Hong","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ng.3383","article-title":"Genetic association analyses highlight biological pathways underlying mitral valve prolapse","volume":"47","author":"Dina","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1164\/rccm.201102-0192OC","article-title":"Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function","volume":"184","author":"Wain","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/resp.12212","article-title":"Association of five genetic variants with chronic obstructive pulmonary disease susceptibility and spirometric phenotypes in a Chinese Han population","volume":"19","author":"Yang","year":"2014","journal-title":"Respirology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.jaci.2013.10.030","article-title":"Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype","volume":"133","author":"Ferreira","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"153950","DOI":"10.1016\/j.prp.2022.153950","article-title":"Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance","volume":"235","author":"Geramoutsou","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fleming, J.C., Woo, J., Moutasim, K., Hanley, C.J., Frampton, S.J., Wood, O., Ward, M., Woelk, C.H., Ottensmeier, C.H., and Hafizi, S. (2020). CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer. Cancers, 12.","DOI":"10.3390\/cancers12102963"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41467-018-02942-5","article-title":"Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer","volume":"9","author":"Klein","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1038\/onc.2011.26","article-title":"Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer","volume":"30","author":"Albasri","year":"2011","journal-title":"Oncogene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1002\/cam4.1834","article-title":"Aberrant CpG-methylation affects genes expression predicting survival in lung adenocarcinoma","volume":"7","author":"He","year":"2018","journal-title":"Cancer Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Misono, S., Seki, N., Mizuno, K., Yamada, Y., Uchida, A., Sanada, H., Moriya, S., Kikkawa, N., Kumamoto, T., and Suetsugu, T. (2019). Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex: miR-150-3p Regulates TNS4 in Lung Adenocarcinoma. Cancers, 11.","DOI":"10.3390\/cancers11050601"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10549-010-0890-3","article-title":"CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis","volume":"126","author":"Albasri","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1245\/s10434-008-9989-8","article-title":"Prognostic relevance of Tensin4 expression in human gastric cancer","volume":"15","author":"Sakashita","year":"2008","journal-title":"Ann. Surg. Oncol."},{"key":"ref_27","first-page":"1065","article-title":"Clinical Significance of Tensin 4 Gene Expression in Patients with Gastric Cancer","volume":"31","author":"Sawazaki","year":"2017","journal-title":"In Vivo"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"84112","DOI":"10.18632\/oncotarget.21109","article-title":"Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction","volume":"8","author":"Aratani","year":"2017","journal-title":"Oncotarget"},{"key":"ref_29","first-page":"1233","article-title":"Correlation between the expression of C-terminal tensin-like protein and the prognosis of hepatocellular carcin.noma","volume":"39","author":"Chen","year":"2014","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sjoestroem, C., Khosravi, S., Zhang, G., Martinka, M., and Li, G. (2013). C-terminal tensin-like protein is a novel prognostic marker for primary melanoma patients. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0080492"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"38143","DOI":"10.18632\/oncotarget.9411","article-title":"Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers","volume":"7","author":"Hong","year":"2016","journal-title":"Oncotarget"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbrc.2020.12.009","article-title":"Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells","volume":"534","author":"Chang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biocel.2014.04.003","article-title":"C-terminal tensin-like (CTEN): A promising biomarker and target for cancer","volume":"51","author":"Lo","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Burghel, G.J., Lin, W.Y., Whitehouse, H., Brock, I., Hammond, D., Bury, J., Stephenson, Y., George, R., and Cox, A. (2013). Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083859"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhou, H.M., Fang, Y.Y., Weinberger, P.M., Ding, L.L., Cowell, J.K., Hudson, F.Z., Ren, M., Lee, J.R., Chen, Q.K., and Su, H. (2016). Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2105-8"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.18632\/oncotarget.23275","article-title":"Elevated transgelin\/TNS1 expression is a potential biomarker in human colorectal cancer","volume":"9","author":"Zhou","year":"2018","journal-title":"Oncotarget"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1083\/jcb.136.6.1349","article-title":"Progressive kidney degeneration in mice lacking tensin","volume":"136","author":"Lo","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00335-005-0167-z","article-title":"Deficiency of the tensin2 gene in the ICGN mouse: An animal model for congenital nephrotic syndrome","volume":"17","author":"Cho","year":"2006","journal-title":"Mamm. Genome"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1292\/jvms.10-0144","article-title":"Genetic background strongly influences the severity of glomerulosclerosis in mice","volume":"72","author":"Nishino","year":"2010","journal-title":"J. Vet. Med. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"jcs249557","DOI":"10.1242\/jcs.249557","article-title":"GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD","volume":"133","author":"Dixon","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1038\/s41467-018-04193-w","article-title":"Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment","volume":"9","author":"Ashraf","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1538\/expanim.61.525","article-title":"Distinct distribution of the tensin family in the mouse kidney and small intestine","volume":"61","author":"Nishino","year":"2012","journal-title":"Exp. Anim."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1177\/002215540405200512","article-title":"Tensin is expressed in glomerular mesangial cells and is related to their attachment to surrounding extracellular matrix","volume":"52","author":"Takahara","year":"2004","journal-title":"J. Histochem. Cytochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000020592","article-title":"Cystic diseases of the kidney: Role of adhesion molecules in normal and abnormal tubulogenesis","volume":"7","author":"Wilson","year":"1999","journal-title":"Exp. Nephrol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.bbadis.2011.08.004","article-title":"Molecular mechanisms of polycystic kidney disease","volume":"1812","author":"Wilson","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrm3871","article-title":"Molecular mechanisms of de novo lumen formation","volume":"15","author":"Sigurbjornsdottir","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrm2523","article-title":"From cells to organs: Building polarized tissue","volume":"9","author":"Bryant","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1016\/j.cub.2010.12.003","article-title":"Molecular regulation of lumen morphogenesis","volume":"21","author":"Datta","year":"2011","journal-title":"Curr. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e2303037120","DOI":"10.1073\/pnas.2303037120","article-title":"Phase transition of tensin-1 during the focal adhesion disassembly and cell division","volume":"120","author":"Lee","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng.501","article-title":"Genome-wide association study identifies five loci associated with lung function","volume":"42","author":"Repapi","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1258\/002367789780863628","article-title":"Characteristics of mutant mice (ICGN) with spontaneous renal lesions: A new model for human nephrotic syndrome","volume":"23","author":"Ogura","year":"1989","journal-title":"Lab. Anim."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000188264","article-title":"Hereditary nephrotic syndrome with progression to renal failure in a mouse model (ICGN strain): Clinical study","volume":"68","author":"Ogura","year":"1994","journal-title":"Nephron"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1292\/jvms.61.769","article-title":"Abnormalities of extracellular matrices and transforming growth factor beta1 localization in the kidney of the hereditary nephrotic mice (ICGN strain)","volume":"61","author":"Uchio","year":"1999","journal-title":"J. Vet. Med. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000045733","article-title":"Decreased matrix metalloproteinase activity in the kidneys of hereditary nephrotic mice (ICGN strain)","volume":"86","author":"Uchio","year":"2000","journal-title":"Nephron"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1292\/jvms.63.1171","article-title":"Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome","volume":"63","author":"Manabe","year":"2001","journal-title":"J. Vet. Med. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2220\/biomedres.33.53","article-title":"The 129 genetic background affects susceptibility to glomerulosclerosis in tensin2-deficient mice","volume":"33","author":"Nishino","year":"2012","journal-title":"Biomed. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2220\/biomedres.36.323","article-title":"Genetic background-dependent diversity in renal failure caused by the tensin2 gene deficiency in the mouse","volume":"36","author":"Sasaki","year":"2015","journal-title":"Biomed. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1292\/jvms.16-0205","article-title":"Functional validation of tensin2 SH2-PTB domain by CRISPR\/Cas9-mediated genome editing","volume":"78","author":"Marusugi","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1292\/jvms.15-0442","article-title":"Tensin2-deficient mice on FVB\/N background develop severe glomerular disease","volume":"78","author":"Monobe","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"F124","DOI":"10.1152\/ajprenal.00192.2022","article-title":"Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis","volume":"324","author":"Yasuda","year":"2023","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sasaki, H., Kimura, J., Nagasaki, K., Marusugi, K., Agui, T., and Sasaki, N. (2016). Mouse chromosome 2 harbors genetic determinants of resistance to podocyte injury and renal tubulointerstitial fibrosis. BMC Genet., 17.","DOI":"10.1186\/s12863-016-0378-1"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Takahashi, Y., Sasaki, H., Okawara, S., and Sasaki, N. (2018). Genetic loci for resistance to podocyte injury caused by the tensin2 gene deficiency in mice. BMC Genet., 19.","DOI":"10.1186\/s12863-018-0611-1"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1538\/expanim.22-0031","article-title":"Tensin 2-deficient nephropathy: Mechanosensitive nephropathy, genetic susceptibility","volume":"71","author":"Sasaki","year":"2022","journal-title":"Exp. Anim."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1538\/expanim.19-0101","article-title":"Deletion of the Tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB\/N mouse strain","volume":"69","author":"Sasaki","year":"2020","journal-title":"Exp. Anim."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1172\/JCI44771","article-title":"mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice","volume":"121","author":"Inoki","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ejmg.2008.02.006","article-title":"Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype","volume":"51","author":"Borsani","year":"2008","journal-title":"Eur. J. Med. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1002\/ajmg.a.36770","article-title":"Mosaic deletion of EXOC6B: Further evidence for an important role of the exocyst complex in the pathogenesis of intellectual disability","volume":"164","author":"Evers","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cub.2010.12.037","article-title":"Transcriptional profiling identifies TNS4 function in epithelial tubulogenesis","volume":"21","author":"Kwon","year":"2011","journal-title":"Curr. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Chiu, C.L., Hong, S.Y., Tan, Y., Lee, Y.R., Shih, Y.P., Tepper, C.G., and Lo, S.H. (2022). C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice. Genes Dis., in press.","DOI":"10.1016\/j.gendis.2022.05.035"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"19799","DOI":"10.1073\/pnas.1911865116","article-title":"Force-induced recruitment of cten along keratin network in epithelial cells","volume":"116","author":"Cheah","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic Kidney Disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Lamas","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41392-022-01036-5","article-title":"Signaling pathways of chronic kidney diseases, implications for therapeutics","volume":"7","author":"Yuan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Wang, Z., Ye, J., Dong, F., Cao, L., Wang, M., and Sun, G. (2022). TNS1: Emerging Insights into Its Domain Function, Biological Roles, and Tumors. Biology, 11.","DOI":"10.3390\/biology11111571"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lousa, I., Reis, F., Beir\u00e3o, I., Alves, R., Belo, L., and Santos-Silva, A. (2020). New Potential Biomarkers for Chronic Kidney Disease Management-A Review of the Literature. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010043"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/s41388-017-0074-2","article-title":"Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1","volume":"37","author":"Goreczny","year":"2018","journal-title":"Oncogene"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"11765","DOI":"10.1038\/s41598-021-91154-x","article-title":"Transcriptomic landscape of early age onset of colorectal cancer identifies novel genes and pathways in Indian CRC patients","volume":"11","author":"Singh","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00066-021-01895-x","article-title":"miR-31-5p modulates cell progression in lung adenocarcinoma through TNS1\/p53 axis","volume":"198","author":"Zhu","year":"2022","journal-title":"Strahlenther. Onkol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Martuszewska, D., Ljungberg, B., Johansson, M., Landberg, G., Oslakovic, C., Dahlback, B., and Hafizi, S. (2009). Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004350"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4161\/epi.25075","article-title":"CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma","volume":"8","author":"Carter","year":"2013","journal-title":"Epigenetics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrurol.2013.24","article-title":"Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers","volume":"10","author":"Wood","year":"2013","journal-title":"Nat. Rev. Urol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12253","DOI":"10.1096\/fj.201900217R","article-title":"Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function","volume":"33","author":"Nagasu","year":"2019","journal-title":"FASEB J."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1244\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:41:20Z","timestamp":1760125280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":82,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["life13061244"],"URL":"https:\/\/doi.org\/10.3390\/life13061244","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]}}}