{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:36:10Z","timestamp":1789691770716,"version":"4.0.1"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI22\/00601"],"award-info":[{"award-number":["PI22\/00601"]}]},{"name":"European Union","award":["PI22\/00601"],"award-info":[{"award-number":["PI22\/00601"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the first two decades of life. One third of cases appear in the head and neck, with 60% of these being embryonal type. RMS is extremely rare in adults, comprising only 1% of adult malignancies, and of those, only 3.3% are rhabdomyosarcomas. (2) Case report: A 46 y.o. male presented with a 1 cm exophytic pediculated painless lesion on the dorsum of his tongue, with progressive growth for 3 months. An excisional biopsy revealed an \u201cembryonal rhabdomyosarcoma with fusocellular areas, with negative rearrangement for gen FOXO1A, negative MDM2 (only focal positivity), and positive INI-1\u201d. Subsequent contrast-enhanced MRI concluded the presence of a lesion with imprecise margins in the right half-tongue, 15 \u00d7 8 \u00d7 7 mm (longitudinal \u00d7 transverse \u00d7 craniocaudal), compatible with a sarcoma. The patient underwent a partial centrolingual glossectomy followed by reconstruction with a buccinator muscle local flap. After surgery, he received chemotherapy with eight cycles of VAC (vincristine, actinomycin, and cyclophosphamide) protocol. The patient is now disease free after 42 months, with good tongue function. (3) Discussion and conclusions: Embryonal RMS is an extremely rare sarcoma in adults, and the location in the tongue is even more exceptional (only two more similar cases are reported in the literature). The prognosis in adults is significantly poorer than in children. A complete margin-free resection with an adequate chemotherapy protocol is the treatment of choice in cases such as these.<\/jats:p>","DOI":"10.3390\/life13061255","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T01:52:43Z","timestamp":1685065963000},"page":"1255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Embryonal Rhabdomyosarcoma of the Tongue in Adults"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-9426","authenticated-orcid":false,"given":"Alberto","family":"D\u00edez-Montiel","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1on (liSGM), Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Ant\u00fanez-Conde","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1on (liSGM), Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-9240","authenticated-orcid":false,"given":"Carlos","family":"Navarro Cu\u00e9llar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1on (liSGM), Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3329-4896","authenticated-orcid":false,"given":"Manuel","family":"Tousidonis Rial","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1on (liSGM), Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ignacio","family":"Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1on (liSGM), Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Bonsfills","sequence":"additional","affiliation":[{"name":"ICIRE Institute for Reconstructive and Aesthetic Surgery, 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4843-5786","authenticated-orcid":false,"given":"Carolina Agra","family":"Pujol","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-3948","authenticated-orcid":false,"given":"Francisco Alijo","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-6498","authenticated-orcid":false,"given":"Santiago","family":"Ochandiano","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1on (liSGM), Gregorio Mara\u00f1on General University Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12105-016-0771-0","article-title":"Head and Neck Rhabdomyosarcoma: Clinical and Pathologic Characterization of Seven Cases","volume":"11","author":"Chen","year":"2017","journal-title":"Head Neck Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.14639\/0392-100X-1450","article-title":"Un Raro Caso Di Rabdiomiosarcoma Embrionario Dello Spazio Parafaringeo","volume":"37","author":"Iannella","year":"2017","journal-title":"Acta Otorhinolaryngol. 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