{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:14:52Z","timestamp":1790612092120,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ataturk University Scientific Research Projects Coordination Unit","award":["TSA-2019-6950"],"award-info":[{"award-number":["TSA-2019-6950"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Angiogenic T (Tang) cells and endothelial progenitor cells (EPCs) play a role in maintaining vascular integrity and repair. This study considers the association between them and Beh\u00e7et disease (BD) and disease activity. Fifty patients with BD and forty-five age- and gender-matched healthy controls were included in the study. The participants\u2019 demographic, clinical, and laboratory characteristics were recorded, and their blood Tang cell and EPC counts were determined. Fifty patients were diagnosed with BD, consisting of 24 females and 26 males. The blood Tang cell (3.5 \u00b1 1.2 cells\/\u03bcL in patients, 4 \u00b1 0.9 cells\/\u03bcL in controls, p = 0.046)) and EPC (2.9 \u00b1 0.9 cells\/\u03bcL in patients, 3.7 \u00b1 1 cells\/\u03bcL in controls, p = 0.001) counts were significantly lower for the patient group with BD than for the control group. The blood Tang cell (42.5 \u00b1 4.9% in active patients, 48.9 \u00b1 7.9% in inactive patients, p = 0.001) and EPC (35.5 \u00b1 6.4% in active patients, 41.2 \u00b1 6.3% in inactive patients, p = 0.004) levels were lower for the patient group with active BD than for the inactive patient group. A weak positive correlation was present between the blood Tang cell and EPC percentage values in BD (r: 0.318, p = 0.002). It was determined that Tang cell and EPC counts are lower in BD, and these reductions become more profound with increasing disease activity. This situation may prevent the development of a sufficient immune response against a disease with a course of chronic inflammation or may trigger the formation of autoreactive immunity. A reduction in Tang cells and EPCs may serve as a marker or predictor of vascular damage in BD patients and represents the progression of vascular injury.<\/jats:p>","DOI":"10.3390\/life13061259","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T01:52:43Z","timestamp":1685065963000},"page":"1259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detection of Angiogenic T Cells and Endothelial Progenitor Cells in Beh\u00e7et Disease and Determination of Their Relationship with Disease Activity"],"prefix":"10.3390","volume":"13","author":[{"given":"Ayhan","family":"Kul","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Physical Medicine and Rehabilitation, Ataturk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurinnisa","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical Biochemistry, Ataturk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli Koseoglu","family":"Kurt","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical Biochemistry, Ataturk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasar","family":"Arslan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Physical Medicine and Rehabilitation, Ataturk University, Erzurum 25240, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"ref_1","first-page":"808","article-title":"Update of the EULAR recommendations for the management of Beh\u00e7et\u2019s syndrome","volume":"77","author":"Hatemi","year":"2018","journal-title":"Ann. 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