{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:31:20Z","timestamp":1791865880946,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>To ensure patient care in an oncological fertility preservation (FP) programme, specialists must provide technology that best suits the patients\u2019 clinical conditions. In vitro oocyte maturation (IVM) and ovarian tissue cryopreservation (OTC) are possible fertility preservation treatments for women in need of urgent oncological treatment. IVM consists of the retrieval of immature oocytes from small antral follicles, with no or minimal ovarian stimulation by gonadotropins. Therefore, IVM has become a pertinent option for fertility preservation, especially for cases whereby ovarian stimulation is unfeasible or contra-indicated. Existing data on immature oocytes, retrieved transvaginally (OPU-IVM) or extracted from ovarian tissue \u2018ex vivo\u2019 (OTO-IVM), are still limited on technical consistency, efficacy, and safety. The present retrospective cohort study includes 89 women undergoing fertility preservation using IVM methodologies and 26 women undergoing ovarian stimulation (OS) in concomitant period. In total, 533 immature oocytes were collected from IVM patients, achieving a maturation rate of 57% and 70% in OTO-IVM and 73% and 82% in OPU-IVM at 24 h and 48 h in culture, respectively. The observed high maturation rates might be due to the use of patients\u2019 serum in its innate status, i.e., without heat-inactivation. This permitted 7.6 \u00b1 5.7 and 4.6 \u00b1 4.9 oocytes to be vitrified in OTO-IVM and OPU-IVM, respectively, compared to 6.8 \u00b1 4.6 from OS patients. Regarding OS patients, two of them underwent embryo transfer following the insemination of warmed oocytes after complete remission, resulting in a single live birth from one patient. Upon follow-up of two OTO-IVM patients after the termination of their oncological treatment, a total of 11 warmed oocytes lead to a transfer of a single embryo, but pregnancy was not achieved. From OPU-IVM, six embryos were transferred in three patients 4.25 years after oocyte vitrification, leading to the live birth of a healthy boy. The present case of live birth is among the first cases reported so far and supports the notion that IVM might be a relevant and safe FP option for cancer patients when oocyte preservation is required but ovarian stimulation is contra-indicated.<\/jats:p>","DOI":"10.3390\/life13061355","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T01:32:34Z","timestamp":1686274354000},"page":"1355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of Different In Vitro Maturation Procedures for Oocyte Cryopreservation for Fertility Preservation and yet Another Live Birth in a Cancer Patient"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-9180","authenticated-orcid":false,"given":"Daniela","family":"Nogueira","sequence":"first","affiliation":[{"name":"Fertility Institute La Croix du Sud\u2014INOVIE Fertilit\u00e9, Clinique La Croix du Sud, 52 Chemin de Ribaute, 31130 Toulouse, France"},{"name":"ART Fertility Clinics, Abu Dhabi P.O. Box 60202, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Fajau-Prevot","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinique La Croix du Sud, 54 Chemin de Ribaute, 31130 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Clouet","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinique La Croix du Sud, 54 Chemin de Ribaute, 31130 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Assouline","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinique La Croix du Sud, 52 Chemin de Ribaute, 31130 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Deslandres","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Institut Universitaire du Cancer de Toulouse, 1 Av. Ir\u00e8ne Joliot-Curie, 31100 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Montagut","sequence":"additional","affiliation":[{"name":"Fertility Institute La Croix du Sud\u2014INOVIE Fertilit\u00e9, Clinique La Croix du Sud, 52 Chemin de Ribaute, 31130 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/humrep\/dey216","article-title":"The Impact of Cancer on Subsequent Chance of Pregnancy: A Population-Based Analysis","volume":"33","author":"Anderson","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"ESHRE Guideline Group on Female Fertility Preservation, Anderson, R.A., Amant, F., Braat, D., D\u2019Angelo, A., Chuva de Sousa Lopes, S.M., Demeestere, I., Dwek, S., Frith, L., and Lambertini, M. (2020). 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