{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:57Z","timestamp":1787028777442,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: to test the association with overall survival (OS) of low attenuation areas (LAAs) quantified by staging computed tomography (CT) of patients who underwent radical surgery for nonsmall-cell lung cancer (NSCLC). Methods: patients who underwent radical surgery for NSCLC at our institution between 1 January 2017 and 30 November 2021 were retrospectively evaluated. Patients who performed staging or follow-up CTs in other institutions, who received lung radiotherapy or chemotherapy, and who underwent previous lung surgery were excluded. At staging and 12-months follow-up CT, LAAs defined as voxels &lt;\u2212950 Hounsfield units, were extracted by software. The percent of LAAs relative to whole-lung volume (%LAAs) and the ratio between LAAs in the lobe to resect and whole-lung LAAs (%LAAs lobe ratio) were calculated. Cox proportional hazards regression analysis was used to test the association between OS and LAAs. Results: the final sample included 75 patients (median age 70 years, IQR 63\u201375 years; females 29\/75, 39%). It identified a significant association with OS for pathological stage III (HR, 6.50; 95%CI, 1.11\u201337.92; p = 0.038), staging CT %LAAs \u2265 5% (HR, 7.27; 95%CI, 1.60\u201332.96; p = 0.010), and staging CT %LAA lobe ratio &gt; 10% (HR, 0.24; 95%CI 0.05\u20130.94; p = 0.046). Conclusions: in patients with NSCLC who underwent radical surgery, a %LAAs \u2265 5% and a %LAA lobe ratio &gt; 10% at staging CT are predictors, respectively, of shorter and longer OS. The LAA ratio to the whole lung at staging CT could be a critical factor to predict the overall survival of the NSCLC patients treated by surgery.<\/jats:p>","DOI":"10.3390\/life13061377","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T01:35:30Z","timestamp":1686620130000},"page":"1377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between Mortality and Lung Low Attenuation Areas in NSCLC Treated by Surgery"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2794-5237","authenticated-orcid":false,"given":"Davide","family":"Colombi","sequence":"first","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-3072","authenticated-orcid":false,"given":"Ganiyat Adenike Ralitsa","family":"Adebanjo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery (DiMeC), Scienze Radiologiche, University of Parma, Via Gramsci 14, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Delfanti","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Surgery Unit, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Emergency Department, Pulmonology Unit, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-2243","authenticated-orcid":false,"given":"Nicola","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Capelli","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Surgery Unit, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Franco","sequence":"additional","affiliation":[{"name":"Emergency Department, Pulmonology Unit, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Michieletti","sequence":"additional","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/annonc\/mdx222","article-title":"Early and Locally Advanced Non-Small-Cell Lung Cancer (NSCLC): ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up","volume":"28","author":"Postmus","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_2","first-page":"447","article-title":"Non-Small Cell Lung Cancer after Surgery and Chemoradiotherapy: Follow-up and Response Assessment","volume":"19","author":"Colombi","year":"2013","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jia, B., Zheng, Q., Wang, J., Sun, H., Zhao, J., Wu, M., An, T., Wang, Y., Zhuo, M., and Li, J. (2020). A Nomogram Model to Predict Death Rate among Non-Small Cell Lung Cancer (NSCLC) Patients with Surgery in Surveillance, Epidemiology, and End Results (SEER) Database. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07147-y"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5152\/dir.2015.14457","article-title":"Longitudinal Evolution of Incidentally Detected Solitary Pure Ground-Glass Nodules on Ct: Relation to Clinical Metrics","volume":"21","author":"Silva","year":"2015","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.21037\/jtd.2016.06.70","article-title":"Prognostic Significance of CT-Emphysema Score in Patients with Advanced Squamous Cell Lung Cancer","volume":"8","author":"Kim","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1378\/chest.110.4.885","article-title":"Combined Operations for Lung Volume Reduction Surgery and Lung Cancer","volume":"110","author":"McKenna","year":"1996","journal-title":"Chest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/thorax.56.10.791","article-title":"Lobar Volume Reduction Surgery: A Method of Increasing the Lung Cancer Resection Rate in Patients with Emphysema","volume":"56","author":"Edwards","year":"2001","journal-title":"Thorax"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.jtcvs.2005.06.049","article-title":"Does Lobectomy for Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease Affect Lung Function? A Multicenter National Study","volume":"130","author":"Baldi","year":"2005","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1378\/chest.11-0101","article-title":"Emphysema Scores Predict Death from COPD and Lung Cancer","volume":"141","author":"Zulueta","year":"2012","journal-title":"Chest"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sato, S., Nakamura, M., Shimizu, Y., Goto, T., Koike, T., Ishikawa, H., and Tsuchida, M. (2019). The Impact of Emphysema on Surgical Outcomes of Early-Stage Lung Cancer: A Retrospective Study. BMC Pulm. Med., 19.","DOI":"10.1186\/s12890-019-0839-1"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Sverzellati, N., Colombi, D., Randi, G., Pavarani, A., Silva, M., Walsh, S.L., Pistolesi, M., Alfieri, V., Chetta, A., and Vaccarezza, M. (2013). Computed Tomography Measurement of Rib Cage Morphometry in Emphysema. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068546"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.201209-1722OC","article-title":"Mortality by Level of Emphysema and Airway Wall Thickness","volume":"187","author":"Johannessen","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1148\/radiol.2018172294","article-title":"CT-Based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study","volume":"288","author":"Lynch","year":"2018","journal-title":"Radiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.chest.2020.12.007","article-title":"Endobronchial Valves for the Treatment of Advanced Emphysema","volume":"159","author":"Klooster","year":"2021","journal-title":"Chest"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.21037\/jtd-20-1280","article-title":"Comparison between Quantitative Computed Tomography, Scintigraphy, and Anatomical Methods for Prediction of Postoperative FEV1 and DLCO: Effects of Chronic Obstructive Pulmonary Disease Status and Resected Lobes","volume":"12","author":"Yokoba","year":"2020","journal-title":"J. Thorac. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Colombi, D., Risoli, C., Delfanti, R., Chiesa, S., Morelli, N., Petrini, M., Capelli, P., Franco, C., and Michieletti, E. (2023). Software-Based Assessment of Well-Aerated Lung at CT for Quantification of Predicted Pulmonary Function in Resected NSCLC. Life, 13.","DOI":"10.3390\/life13010198"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jtho.2015.12.114","article-title":"The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer","volume":"11","author":"Detterbeck","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jtho.2016.01.025","article-title":"The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer","volume":"11","author":"Detterbeck","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e211S","DOI":"10.1378\/chest.12-2355","article-title":"Methods for Staging Non-Small Cell Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd Ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"143","author":"Silvestri","year":"2013","journal-title":"Chest"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1183\/09031936.00184308","article-title":"ERS\/ESTS Clinical Guidelines on Fitness for Radical Therapy in Lung Cancer Patients (Surgery and Chemo-Radiotherapy)","volume":"34","author":"Brunelli","year":"2009","journal-title":"Eur. Respir. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1148\/radiol.2015141579","article-title":"CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society1","volume":"277","author":"Lynch","year":"2015","journal-title":"Radiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e278S","DOI":"10.1378\/chest.12-2359","article-title":"Treatment of Stage I and II Non-Small Cell Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd Ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"143","author":"Howington","year":"2013","journal-title":"Chest"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1213\/ANE.0000000000005773","article-title":"Statistics from a (agreement) to Z (z score): A guide to interpreting common measures of association, agreement, diagnostic accuracy, effect size, heterogeneity, and reliability in medical research","volume":"133","author":"Schober","year":"2021","journal-title":"Anesth. Analg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1053\/j.semtcvs.2010.04.005","article-title":"Surgical Resection in Combination with Lung Volume Reduction Surgery for Stage I Non-Small Cell Lung Cancer","volume":"22","author":"Yacoub","year":"2010","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"920457","DOI":"10.3389\/fsurg.2022.920457","article-title":"Computer-Assisted Image-Based Risk Analysis and Planning in Lung Surgery\u2014A Review","volume":"9","author":"Krass","year":"2022","journal-title":"Front. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.2147\/COPD.S321541","article-title":"Predicting Respiratory Complications Following Lobectomy Using Quantitative CT Measures of Emphysema","volume":"16","author":"Kitazawa","year":"2021","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1148\/radiol.2020191429","article-title":"Five-Year Progression of Emphysema and Air Trapping at Ct in Smokers with and Those without Chronic Obstructive Pulmonary Disease: Results from the COPDGene Study","volume":"295","author":"Pompe","year":"2020","journal-title":"Radiology"},{"key":"ref_29","first-page":"4","article-title":"Optimization of Pulmonary Emphysema Quantification on CT Scans of COPD Patients Using Hybrid Iterative and Post Processing Techniques: Correlation with Pulmonary Function Tests","volume":"10","author":"Nijholt","year":"2019","journal-title":"Insights Imaging"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1377\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:53:36Z","timestamp":1760126016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["life13061377"],"URL":"https:\/\/doi.org\/10.3390\/life13061377","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]}}}