{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:40:03Z","timestamp":1789494003451,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The novel use of the omental flap in breast reconstruction has been increasing in research popularity within the last few decades. This technique has its roots in the early 20th century as surgeons explored the use of the omentum for a variety of reconstructive purposes across various surgical subspecialties. The current literature shows evidence of the benefits of using the omentum in autologous breast reconstruction compared to the more traditional abdominal, flank, thigh, and gluteal donor flap reconstruction. This method introduces a viable option for patients that do not meet the criteria for the traditional autologous reconstruction techniques allowing for the restoration of more natural appearing breasts without the added complication of donor-site mortality. Additionally, the omentum, with its rich source of vascularized lymph nodes, has been studied as a potential source for lymph node transfer in the treatment of mastectomy-associated lymphedema. In this review, we highlight the most recent research on the current practices of omental-based breast reconstruction techniques and their use in postmastectomy lymphedema. We discuss the history and natural progression of the development of omental-based reconstruction as an autologous breast reconstruction technique, highlight the latest advances and challenges for the utility of the omental flap in current surgical procedures, and present future directions for the potential role of omental-based breast reconstruction in postmastectomy breast surgery.<\/jats:p>","DOI":"10.3390\/life13061380","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T01:32:15Z","timestamp":1686706335000},"page":"1380","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Current Research on the Use of the Omental Flap in Breast Reconstruction and Post-Mastectomy Lymphedema: A Focus on Omental-Vascularized Lymph Node Transfer"],"prefix":"10.3390","volume":"13","author":[{"given":"Farrah","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Stanford University, Stanford, CA 94304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2971-8879","authenticated-orcid":false,"given":"Kometh","family":"Thawanyarat","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelissa","family":"Navarro","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Augusta University, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-7523","authenticated-orcid":false,"given":"Dung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Stanford University, Stanford, CA 94304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2505","DOI":"10.1097\/GOX.0000000000002505","article-title":"Robotically Assisted Omentum Flap Harvest: A Novel, Minimally Invasive Approach for Vascularized Lymph Node Transfer","volume":"8","author":"Frey","year":"2020","journal-title":"Plast. Reconstr. Surg. Glob. Open."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13019-020-01146-7","article-title":"Laparoscopic omental flap for the treatment of thoracic aortic graft infection: Report of two cases and review of the literature","volume":"15","author":"Zhou","year":"2020","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"313.e5","DOI":"10.1016\/j.avsg.2018.03.006","article-title":"Negative Pressure Wound Therapy to Promote Fixation and Remodeling of Omental Flap in Patients with Revascularized Limbs: A Case Series","volume":"52","author":"Settembre","year":"2018","journal-title":"Ann. Vasc. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1364e","DOI":"10.1097\/PRS.0000000000009716","article-title":"Omentum as a Vascular Carrier for Salvage Thoracic Spine Osseous Reconstruction","volume":"150","author":"Shahzad","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e4298","DOI":"10.1097\/GOX.0000000000004298","article-title":"Transretroperitoneal Pedicled Omental Flap for Coverage of Traumatic Sacral Defect: A Case Report","volume":"10","author":"Bruce","year":"2022","journal-title":"Plast. Reconstr. Surg. Glob. Open."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.reth.2019.07.008","article-title":"Omentum a powerful biological source in regenerative surgery","volume":"11","year":"2019","journal-title":"Regen. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0039-6109(05)70406-0","article-title":"The greater omentum: Anatomy, embryology, and surgical applications","volume":"80","year":"2000","journal-title":"Surg. Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.21037\/abs-20-109","article-title":"Evolution in breast reconstruction using the omentum","volume":"5","author":"Ma","year":"2021","journal-title":"Ann. Breast Surg."},{"key":"ref_9","first-page":"15","article-title":"The use of the great omentum in the surgery of breast cancer","volume":"71","author":"Kiricuta","year":"1963","journal-title":"Presse Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.7150\/jca.25556","article-title":"Oncoplastic breast reconstruction with omental flap: A retrospective study and systematic review","volume":"9","author":"Ni","year":"2018","journal-title":"J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e2988","DOI":"10.1097\/GOX.0000000000002988","article-title":"Use of the Omental Free Flap for Treatment of Chronic Anterior Skull Base Infections","volume":"8","author":"Kokosis","year":"2020","journal-title":"Plast. Reconstr. Surg. Glob. Open."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jso.24208","article-title":"Autologous flap breast reconstruction: Surgical algorithm and patient selection","volume":"113","author":"Nahabedian","year":"2016","journal-title":"J. Surg. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.cps.2020.07.001","article-title":"Autologous breast reconstruction in low body mass index patients","volume":"47","author":"Mohan","year":"2020","journal-title":"Clin. Plast. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cps.2017.08.003","article-title":"Indications and Controversies for Implant-Only Based Breast Reconstruction","volume":"45","author":"Brown","year":"2018","journal-title":"Clin. Plast. Surg."},{"key":"ref_15","unstructured":"American Society of Plastic Surgery (2023, May 01). Plastic Surgery Statistics Report: ASPS National Clearinghouse of Plastic Surgery Procedural Statistics. ASPS, 2020. Available online: https:\/\/www.plasticsurgery.org\/news\/plastic-surgery-statistics."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/PRS.0b013e318267efc5","article-title":"The advantages of free abdominal based flaps over implants for breast reconstruction in obese patients","volume":"130","author":"Garvey","year":"2012","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bjps.2019.09.040","article-title":"Autologous versus implant-based breast reconstruction: A systematic review and meta-analysis of Breast-Q patient-reported outcomes","volume":"73","author":"Toyserkani","year":"2020","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"903734","DOI":"10.3389\/fsurg.2022.903734","article-title":"Autologous vs. implant-based breast reconstruction after skin- and nipple-sparing mastectomy-A deeper insight considering surgical and patient-reported outcomes","volume":"9","author":"Holler","year":"2022","journal-title":"Front. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/jamasurg.2018.1687","article-title":"Comparison of 2-Year Complication Rates Among Common Techniques for Postmastectomy Breast Reconstruction","volume":"153","author":"Bennett","year":"2018","journal-title":"JAMA Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bjps.2022.11.044","article-title":"Implant vs. autologous tissue-based breast reconstruction: A systematic review and meta-analysis of the studies comparing surgical approaches in 55,455 patients","volume":"77","author":"Stefura","year":"2022","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/tbj.14025","article-title":"The evolution of autologous breast reconstruction","volume":"26","author":"Costanzo","year":"2020","journal-title":"Breast J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1245\/s10434-014-4328-8","article-title":"Omentum for Mammary Disorders: A 30-Year Systematic Review","volume":"22","author":"Claro","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/PRS.0000000000008963","article-title":"Creating a Biological Breast Implant with an Omental Fat-Augmented Free Flap","volume":"149","author":"Nguyen","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/00006534-200104150-00009","article-title":"Immediate Breast Reconstruction Using a Laparoscopically Harvested Omental Flap. Plastic and Reconstructive Surgery","volume":"107","author":"Tamtawi","year":"2001","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/micr.30126","article-title":"The laparoscopically harvested omentum as a free flap for autologous breast reconstruction","volume":"37","author":"Fechner","year":"2017","journal-title":"Microsurgery"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.amjsurg.2006.06.030","article-title":"Laparoscopically harvested omental flap for immediate breast reconstruction","volume":"192","author":"Zaha","year":"2006","journal-title":"Am. J. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kahter, A., Ghazy, H., Setit, A., Shams, N., Gohar, O., Abdelwahab, K., Eldamshety, O., and Fathi, A. (2022). Laparoscopically Harvested Omental Flap for Immediate Total Breast Reconstruction; Lessons Learnt Through Ten-Year Experience in a Tertiary Oncology Center. Surg. Innov., 15533506221120149.","DOI":"10.1177\/15533506221120149"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10549-020-05848-3","article-title":"Single-port laparoscopically harvested omental flap for immediate breast reconstruction","volume":"184","author":"Kim","year":"2020","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.bjps.2021.11.058","article-title":"Indications for Limitations Of The Omental Pedicle Flap In Immediate Breast Reconstruction-Surgical Results Evaluation And Breast-Q\u00a9 2.0 Survey","volume":"75","author":"Fabrizio","year":"2022","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10549-017-4124-9","article-title":"Oncoplastic surgery with omental flap reconstruction: A study of 200 cases","volume":"162","author":"Zaha","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1245\/s10434-022-12975-2","article-title":"A Novel Fat-Augmented Omentum-Based Construct for Unilateral and Bilateral Free-Flap Breast Reconstruction in Underweight and Normal Weight Women Receiving Nipple or Skin-Sparing Mastectomies","volume":"30","author":"Nguyen","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Crowley, J.S., Liu, F.C., Rizk, N.M., and Nguyen, D. (2023). Concurrent management of lymphedema and breast reconstruction with single-stage omental vascularized lymph node transfer and autologous breast reconstruction: A case series. Microsurgery.","DOI":"10.1002\/micr.31017"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1097\/00006534-199812000-00030","article-title":"Endoscopic omental harvest","volume":"102","author":"Kamei","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_34","first-page":"303","article-title":"Omental transposition for the treatment of chronic lymphedema","volume":"23","author":"Goldsmith","year":"1966","journal-title":"Rev. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/00000658-197412000-00009","article-title":"Long term evaluation of omental transposition for chronic lymphedema","volume":"180","author":"Goldsmith","year":"1974","journal-title":"Ann. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/00006534-197963060-00007","article-title":"Successful lymph node transplantation in rats, with restoration of lymphatic function","volume":"63","author":"Shesol","year":"1979","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_37","first-page":"137","article-title":"Autotransplantation of the greater omentum in the treatment of chronic lymphedema","volume":"27","author":"Egorov","year":"1994","journal-title":"Lymphology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/PRS.0000000000001374","article-title":"Laparoscopic Free Omental Lymphatic Flap for the Treatment of Lymphedema","volume":"136","author":"Nguyen","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/2292550317731762","article-title":"Laparoscopic Harvesting of Omental Flaps for Breast Reconstruction-A Review of the Literature and Outcome Analysis","volume":"26","author":"Shash","year":"2018","journal-title":"Plast. Surg. Oakv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.21037\/gs.2020.04.06","article-title":"Breast reconstruction using a laparoscopically harvested pedicled omental flap after endoscopic mastectomy for patients with breast cancer: An observational study of a minimally invasive method","volume":"9","author":"Wang","year":"2020","journal-title":"Gland. Surg."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1380\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:54:01Z","timestamp":1760126041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["life13061380"],"URL":"https:\/\/doi.org\/10.3390\/life13061380","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,13]]}}}