{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:55:24Z","timestamp":1784674524217,"version":"3.55.0"},"reference-count":85,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Osteoarthritis (OA) is a progressive degenerative disease with an inflammatory background. Chronic myeloproliferative neoplasms (MPN) are clonal hematopoietic disorders characterized by chronic inflammation and a tendency for connective tissue remodeling. Aim: This study aimed to investigate the prevalence and associated risk factors of symptomatic OA (sOA) in MPN patients. Patients and methods: A total of 100 consecutive MPN (39 essential-thrombocythemia, 34 polycythemia-vera, 27 myelofibrosis) patients treated in two community hematologic centers were cross-sectionally evaluated. Patients were required to have both symptoms attributable to hip and\/or knee OA and radiographic confirmation to be considered as having sOA. Results: The prevalence of hip and\/or knee sOA was significantly higher among MPN patients than the previously reported prevalence in the general population of similar age (61% vs. 22%, p &lt; 0.001). Hip sOA was present in 50%, knee sOA in 51% and sOA of both localizations in 41% of patients. A high proportion of MPN patients had radiographic signs of hip OA (94%) and knee OA (98%) in the presence of attributable symptoms. Among the other factors, sOA was univariately associated with the presence of JAK2 mutation, myelofibrosis phenotype, older age, higher body weight, and higher MPN-SAF score (p &lt; 0.050 for all analyses). In the multivariate analysis, older age (odds ratio = 1.19, 95% confidence interval-CI 1.06\u20131.33) and higher body weight (OR = 1.15, 95% CI 1.06\u20131.25) were recognized as independent risk factors for sOA. On the other hand, cytoreductive treatment was a protective factor for sOA (OR = 0.07, 95% CI 0.006\u20130.86). Conclusions: The prevalence of sOA in MPN patients was higher than that in the general population and seems to correlate with older age, increased myeloproliferation and a higher inflammatory state. Whether cytoreductive treatment may postpone OA development in MPN patients warrants additional confirmation.<\/jats:p>","DOI":"10.3390\/life13061388","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T01:32:57Z","timestamp":1686792777000},"page":"1388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Hrvoje","family":"Holik","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Dr. Josip Ben\u010devi\u0107 General Hospital, 35000 Slavonski Brod, Croatia"},{"name":"Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Kre\u010dak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, General Hospital of \u0160ibenik-Knin County, 22000 \u0160ibenik, Croatia"},{"name":"Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-2040","authenticated-orcid":false,"given":"Marko","family":"Lucijani\u0107","sequence":"additional","affiliation":[{"name":"University Hospital Dubrava, 10000 Zagreb, Croatia"},{"name":"Faculty of Medicine, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Samard\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Dr. Josip Ben\u010devi\u0107 General Hospital, 35000 Slavonski Brod, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijel","family":"Pilipac","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, General Hospital of \u0160ibenik-Knin County, 22000 \u0160ibenik, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Vu\u010dini\u0107 Ljubi\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dr. Josip Ben\u010devi\u0107 General Hospital, 35000 Slavonski Brod, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017eena","family":"Coha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dr. Josip Ben\u010devi\u0107 General Hospital, 35000 Slavonski Brod, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Kitter Pipi\u0107","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, General Hospital \u2018Dr Josip Ben\u010devi\u0107\u2019, 35000 Slavonski Brod, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bla\u017eenka","family":"Mi\u0161ki\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dr. Josip Ben\u010devi\u0107 General Hospital, 35000 Slavonski Brod, Croatia"},{"name":"Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Zupan\u010di\u0107-\u0160alek","sequence":"additional","affiliation":[{"name":"Department of Hematology and Coagulation, University Hospital Holy Spirit, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Coras","year":"2022","journal-title":"Nat. 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