{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:47:24Z","timestamp":1778266044833,"version":"3.51.4"},"reference-count":72,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centre of Excellence for Research, Value Innovation and Entrepreneurship (CERVIE), UCSI University","award":["REIG-FAS-2022-007"],"award-info":[{"award-number":["REIG-FAS-2022-007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) The complexity of diabetes and diabetic wound healing remains a therapeutic challenge because proper and systematic wound care and management are essential to prevent chronic microbial infection and mechanical damage to the skin. Marantodes pumilum, locally known as \u2018Kacip Fatimah\u2019, is an herb that has been previously reported to possess anti-inflammatory, analgesic, antinociceptive and antipyretic properties. The current study aims to assess the antioxidant and fibroblast cell migration activities of the fractions eluded from the dichloromethane extract of M. pumilum leaves. (2) The total antioxidant capacity of M. pumilum was assessed using the total proanthocyanidins and phosphomolybdenum assays, while DPPH, nitric oxide, hydrogen peroxide and superoxide free radical scavenging assays were tested to determine the antioxidant potential of M. pumilum. An in vitro scratch wound assay was performed to measure the fibroblast cell migration rate using normal and insulin-resistant human dermal fibroblast cells. (3) All M. pumilum fractions exhibited good antioxidant and fibroblast cell migration activity, among which fractions A and E displayed the greatest effect. (4) M. pumilum\u2019s fibroblast migration activity could be attributed to its strong antioxidant properties along with its previously reported properties.<\/jats:p>","DOI":"10.3390\/life13061409","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T01:31:14Z","timestamp":1687138274000},"page":"1409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["In Vitro Antioxidant and Fibroblast Migration Activities of Fractions Eluded from Dichloromethane Leaf Extract of Marantodes pumilum"],"prefix":"10.3390","volume":"13","author":[{"given":"Abbirami","family":"Balachandran","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur 56000, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stepfanie N.","family":"Siyumbwa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, School of Medicine, Lusaka P.O. Box 50110, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-1968","authenticated-orcid":false,"given":"Gabriele R. A.","family":"Froemming","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak (UNIMAS), Kota Samarahan 94300, Sarawak, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-1079","authenticated-orcid":false,"given":"Morak-M\u0142odawska","family":"Beata","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Department of Organic Chemistry, Medical University of S\u00edlesia, Jagiellonska, Str. 4, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4144-990X","authenticated-orcid":false,"given":"Jele\u0144","family":"Ma\u0142gorzata","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Department of Organic Chemistry, Medical University of S\u00edlesia, Jagiellonska, Str. 4, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Charlie A.","family":"Lavilla","sequence":"additional","affiliation":[{"name":"Chemistry Department, College of Science & Mathematics, Mindanao State University-Iligan Institute of Technology, Iligan City 9200, Lanao del Norte, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-8130","authenticated-orcid":false,"given":"Merell P.","family":"Billacura","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences & Mathematics, Mindanao State University-Main Campus, Marawi City 9700, Lanao del Sur, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-2666","authenticated-orcid":false,"given":"Patrick N.","family":"Okechukwu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur 56000, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108615","DOI":"10.1016\/j.biopha.2019.108615","article-title":"Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing","volume":"112","author":"Patel","year":"2019","journal-title":"Biomed. Pharm."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Okonkwo, U.A., Chen, L., Ma, D., Haywood, V.A., Barakat, M., Urao, N., and DiPietro, L.A. (2020). Compromised angiogenesis and vascular integrity in impaired diabetic wound healing. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0231962"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.7150\/ijbs.11921","article-title":"bFGF Promotes the Migration of Human Dermal Fibroblasts under Diabetic Conditions through Reactive Oxygen Species Production via the PI3K\/Akt-Rac1- JNK Pathways","volume":"11","author":"Shi","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound Healing: A Cellular Perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing\u2014A literature review","volume":"91","author":"Costa","year":"2016","journal-title":"Bras. Derm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"781282","DOI":"10.3389\/fphar.2021.781282","article-title":"Dermal Fibroblast Migration and Proliferation Upon Wounding or Lipopolysaccharide Exposure is Mediated by Stathmin","volume":"12","author":"Cen","year":"2022","journal-title":"Front. Pharm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: The functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process: Reactive oxygen species and wound healing","volume":"14","author":"Dunnill","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3389\/fphys.2019.01587","article-title":"Neutrophil-Related Oxidants Drive Heart and Brain Remodeling After Ischemia\/Reperfusion Injury","volume":"10","author":"Carbone","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3389\/fphys.2020.00694","article-title":"Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases","volume":"11","author":"Kumar","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/0976-237X.142802","article-title":"Antioxidant mix: A novel pulpotomy medicament: A scanning electron microscopy evaluation","volume":"5","author":"Reddy","year":"2014","journal-title":"Contemp. Clin. Dent."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species","volume":"44","author":"He","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_12","unstructured":"Dogan, K.H. (2019). Wound Healing\u2014Current Perspectives, IntechOpen."},{"key":"ref_13","first-page":"742","article-title":"Anti-inflammatory, Analgesic, Antinociceptive and Antipyretic Investigation of Bioactive Constituents from Partial Purified Dichloromethane Crude Extracts from Leaves of Labisia pumila","volume":"3","author":"Okechukwu","year":"2014","journal-title":"IJPRS"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.22159\/ajpcr.2020.v13i4.36196","article-title":"Evaluation of anti-inflammatory, analgesic, antipyretic effect of Eicosane, Pentadecane, Octacosane, and Heneicosane","volume":"13","author":"Okechukwu","year":"2020","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_15","first-page":"44","article-title":"Partial Purification and Antinociceptive Investigation of Extracts of Leaves of Labisia pumila","volume":"4","author":"Samuagam","year":"2011","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4103\/2221-1691.244158","article-title":"Eicosane, pentadecane and palmitic acid: The effects in in vitro wound healing studies","volume":"8","author":"Chuah","year":"2018","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_17","first-page":"71","article-title":"Wound Healing and Anti-bacterial Activities of 2-Pentadecanone in STZ-Induced Type 2 Diabetic Rats","volume":"15","author":"Siyumbwa","year":"2019","journal-title":"Phcog. Mag."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1752-153X-6-43","article-title":"Assessment of flavonoids contents and in vitro antioxidant activity of Launaea procumbens","volume":"6","author":"Khan","year":"2012","journal-title":"Chem. Cent. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1248\/jhs.49.45","article-title":"Analysis of Proanthocyanidins in Grape Seed Extracts, Health Foods and Grape Seed Oils","volume":"49","author":"Nakamura","year":"2003","journal-title":"J. Health Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0378-8741(02)00338-0","article-title":"Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea","volume":"85","author":"Kim","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.foodchem.2008.08.008","article-title":"DPPH antioxidant assay revisited","volume":"113","author":"Sharma","year":"2009","journal-title":"Food Chem."},{"key":"ref_22","first-page":"183","article-title":"Phytochemical analysis and free-radical scavenging activity of Flemingia strobilifera (Linn) R. Br","volume":"1","author":"Madan","year":"2010","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s13197-013-1210-9","article-title":"Antioxidant activities of tamarind (Tamarindus indica) seed coat extracts using in vitro and in vivo models","volume":"51","author":"Sandesh","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"ref_24","first-page":"944","article-title":"Free radical scavenging activity of polyherbal formulation","volume":"3","author":"Aarti","year":"2009","journal-title":"Pharmacologyonline"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.mito.2021.10.001","article-title":"In vitro models of insulin resistance: Mitochondrial coupling is differently affected in liver and muscle cells","volume":"61","author":"Jakovljevic","year":"2021","journal-title":"Mitochondrion"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Feraco, A., Gorini, S., Armani, A., Camajani, E., Rizzo, M., and Caprio, M. (2021). Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons from Cultured Cells to Animal Models. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179327"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"609653","DOI":"10.3389\/fbioe.2020.609653","article-title":"Mechanical and Physical Regulation of Fibroblast-Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology","volume":"8","author":"Kurniawan","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.7150\/ijms.43986","article-title":"Fibroblast Proliferation and Migration in Wound Healing by Phytochemicals: Evidence for a Novel Synergic Outcome","volume":"17","author":"Addis","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbadis.2013.10.014","article-title":"Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study","volume":"1842","author":"Gimeno","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Burgess, J.L., Wyant, W.A., Abujamra, B.A., Kirsner, R.S., and Jozic, I. (2021). Diabetic Wound-Healing Science. Medicina, 57.","DOI":"10.3390\/medicina57101072"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100499","DOI":"10.1016\/j.scp.2021.100499","article-title":"Antioxidant and fibroblast-activating activities of the by-product of skate chondroitin extractive production","volume":"23","author":"Li","year":"2021","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1007\/s11033-020-05276-y","article-title":"Antioxidant molecular mechanism of adenosyl homocysteinase from cyanobacteria and its wound healing process in fibroblast cells","volume":"47","author":"Sarkar","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3389\/fphar.2018.00945","article-title":"Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellarianus","volume":"9","author":"Boakye","year":"2018","journal-title":"Front. Pharm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.msec.2018.05.020","article-title":"Effect of biogenic silver nanocubes on matrix metalloproteinases 2 and 9 expressions in hyperglycemic skin injury and its impact in early wound healing in streptozotocin-induced diabetic mice","volume":"91","author":"Krishnan","year":"2018","journal-title":"Mater. Sci. Eng."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fphys.2016.00341","article-title":"Engineered Biopolymeric Scaffolds for Chronic Wound Healing","volume":"7","author":"Dickinson","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/2347-9264.165438","article-title":"Role of angiogenesis and angiogenic factors in acute and chronic wound healing","volume":"2","author":"Honnegowda","year":"2015","journal-title":"Plast. Aesthetic Res."},{"key":"ref_37","first-page":"e17723","article-title":"Fibroblast Growth Factor 21 and Its Association With Oxidative Stress and Lipid Profile in Type 2 Diabetes Mellitus","volume":"13","author":"Aleem","year":"2021","journal-title":"Cureus"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.fct.2015.04.001","article-title":"In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effect and cytotoxicity\/gentoxicity profile","volume":"81","author":"Bagdas","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5530\/ax.2012.2.2.1","article-title":"Wound healing and antioxidant properties: Do they coexist in plants?","volume":"2","author":"Akkol","year":"2012","journal-title":"Free Rad. Antiox."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Balachandran, A., Choi, S.B., Beata, M.M., Ma\u0142gorzata, J., Froemming, G.R.A., Lavilla, C.A., Billacura, M.P., Siyumbwa, S.N., and Okechukwu, P.N. (2023). Antioxidant, Wound Healing Potential and In Silico Assessment of Naringin, Eicosane and Octacosane. Molecules, 28.","DOI":"10.3390\/molecules28031043"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Emran, T.B., Islam, F., Nath, N., Sutradhar, H., Das, R., Mitra, S., Alshahrani, M.M., Alhasaniah, A.H., and Sharma, R. (2022). Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint. Life, 13.","DOI":"10.3390\/life13010099"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3892\/mmr.2017.6133","article-title":"Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities (Review)","volume":"15","author":"Vijayaragahvan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Li, K., Diao, Y., Zhang, H., Wang, S., Zhang, Z., Yu, B., Huang, S., and Yang, H. (2011). Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats. BMC Complement. Altern. Med., 11.","DOI":"10.1186\/1472-6882-11-86"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/gerona\/glq161","article-title":"Protective Effects of Resveratrol Against Senescence-Associated Changes in Cultured Human Fibroblasts","volume":"66A","author":"Giovannelli","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1742-481X.2012.01119.x","article-title":"Evaluation of wound healing activity of ferulic acid in diabetic rats","volume":"11","author":"Ghaisas","year":"2014","journal-title":"Int. Wound J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e66118","DOI":"10.5812\/modernc.66118","article-title":"The Angiogenetic Effect of Resveratrol on Dermal Wound Healing in Balb\/C Mice","volume":"14","author":"Afshar","year":"2017","journal-title":"Mod. Care J."},{"key":"ref_47","first-page":"2450","article-title":"Ascorbic acid attenuates cell stress by activating the fibroblast growth factor 21\/fibroblast growth factor receptor 2\/adiponectin pathway in HepG2 cells","volume":"20","author":"Gu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10522-017-9685-9","article-title":"Sirtuins, a promising target in slowing down the ageing process","volume":"18","author":"Grabowska","year":"2017","journal-title":"Biogerontology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/biof.1032","article-title":"Sirtuin activators and inhibitors","volume":"38","author":"Villalba","year":"2012","journal-title":"Biofactors"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.freeradbiomed.2011.04.034","article-title":"The controversial links among calorie restriction, SIRT1, and resveratrol","volume":"51","author":"Hu","year":"2011","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.exger.2010.07.001","article-title":"Anti-ageing and rejuvenating effects of quercetin","volume":"45","author":"Chondrogianni","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s11033-019-05194-8","article-title":"Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells","volume":"47","author":"Okada","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.freeradbiomed.2007.11.023","article-title":"Effects of epigallocatechin-3-gallate on mitochondrial integrity and antioxidative enzyme activity in the aging process of human fibroblast","volume":"44","author":"Meng","year":"2008","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1248\/bpb.33.421","article-title":"Anti-aging effects of cyanidin under a stress-induced premature senescence cellular system","volume":"33","author":"Choi","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.15430\/JCP.2016.21.1.32","article-title":"Malvidin Protects WI-38 Human Fibroblast Cells Against Stress-induced Premature Senescence","volume":"21","author":"Seo","year":"2016","journal-title":"J. Cancer Prev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/rej.2018.2066","article-title":"Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts","volume":"22","author":"Liu","year":"2019","journal-title":"Rejuvenation Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Torres-Vega, J., G\u00f3mez-Alonso, S., P\u00e9rez-Navarro, J., Alarc\u00f3n-Enos, J., and Pastene-Navarrete, E. (2021). Polyphenolic Compounds Extracted and Purified from Buddleja globosa Hope (Buddlejaceae) Leaves Using Natural Deep Eutectic Solvents and Centrifugal Partition Chromatography. Molecules, 26.","DOI":"10.3390\/molecules26082192"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jep.2006.02.007","article-title":"Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. et Lind","volume":"107","author":"Singh","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jep.2010.09.011","article-title":"Antibacterial, antioxidant and fibroblast growth stimulation activity of crude extracts of Bridelia ferruginea leaf, a wound-healing plant of Nigeria","volume":"133","author":"Adetutu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_61","first-page":"41","article-title":"A Review on Biological Activities and Medicinal Properties Of Clerodendrum infortunatum Linn","volume":"6","author":"Das","year":"2014","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_62","first-page":"89","article-title":"Anti-inflammatory, analgesic and antipyretic activity of cassava leaf extract","volume":"6","author":"Sereme","year":"2013","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.11113\/jt.v81.13135","article-title":"Effect Of Manihot Esculenta Aqueous Extract and Therapeutic Ultrasound in Accelerating The Wound Healing Process In Vitro","volume":"81","author":"Anwar","year":"2019","journal-title":"J. Teknol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/0975-7406.171697","article-title":"Evaluation of antioxidant activity of Manihot esculenta Crantz in wistar rats","volume":"8","author":"Bahekar","year":"2016","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Noumedem, J.A.K., Mihasan, M., Lacmata, S.T., Stefan, M., Kuiate, J.R., and Kuete, V. (2013). Antibacterial activities of the methanol extracts of ten Cameroonian vegetables against Gram-negative multidrug-resistant bacteria. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-26"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"10157","DOI":"10.3390\/molecules161210157","article-title":"Antioxidant Phenolic Compounds of Cassava (Manihot esculenta) from Hainan","volume":"16","author":"Yi","year":"2010","journal-title":"Molecules"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12970-020-00389-y","article-title":"The effect of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation\u2014A study in healthy well-trained individuals after intensive resistance and endurance training","volume":"17","author":"Isenmann","year":"2020","journal-title":"J. Int. Soc. Sport. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/14756366.2012.759951","article-title":"Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF- \u03b1 and EGF production in chronic leg wound healing","volume":"29","author":"Nasole","year":"2014","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"120286","DOI":"10.1016\/j.biomaterials.2020.120286","article-title":"ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds","volume":"258","author":"Zhao","year":"2020","journal-title":"Biomaterials"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"12640","DOI":"10.1038\/s41598-019-49132-x","article-title":"Design and characterization of dual drug delivery based on in-situ assembled PVA\/PAN core-shell nanofibers for wound dressing application","volume":"9","author":"Kharaghani","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Lu, W.C., Chuang, F.S., Venkatesan, M., Cho, C.J., Chen, P.Y., Tzeng, Y.R., Yu, Y.Y., Rwei, S.P., and Kuo, C.C. (2020). Synthesis of Water Resistance and Moisture-Permeable Nanofiber Using Sodium Alginate-Functionalized Waterborne Polyurethane. Polymers, 12.","DOI":"10.3390\/polym12122882"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Lee, C.H., Huang, S.C., Hung, K.C., Cho, C.J., and Liu, S.J. (2022). Enhanced Diabetic Wound Healing Using Electrospun Biocompatible PLGA-Based Saxagliptin Fibrous Membranes. Nanomaterials, 12.","DOI":"10.3390\/nano12213740"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1409\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:55:38Z","timestamp":1760126138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/6\/1409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,17]]},"references-count":72,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["life13061409"],"URL":"https:\/\/doi.org\/10.3390\/life13061409","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,17]]}}}