{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:17:45Z","timestamp":1793427465574,"version":"4.5.0"},"reference-count":153,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This article is intended to deepen our knowledge to date regarding the functions of the resident microbiota\/microbiome in the urinary system for human health and disease. First, we sought to report the general characteristics (composition and stability) of the normal urinary system microbiota in the different anatomical sites in relation to some factors such as the effect of age, gender and diet, analyzing in detail the functions and the composition of the microbiota in the light of current knowledge. Several pieces of evidence suggest the importance of preserving the micro-ecosystem of the urinary system, and in some cases their relationship with diseases is important for maintaining human health is well understood. The female and male reproductive microbiota have mainly been studied over the past decade. In the past, the arrest was thought to have taken place in a sterile environment. Microorganisms of the microbiota form biofilms, three-dimensional structures, that differ in the reproductive organs and interact with both gametes and the embryo as well as with maternal tissues. These biofilms from the reproductive system also interact with others, such as that of the gastrointestinal tract. Reduction in its diversity intestinal microbiota can disrupt estrogen metabolism and affect the reproductive microbiota. It is therefore understood that its quantitative and qualitative identification is important for microbiota, but also the study of the structures formed by the microorganisms. A dysbiosis with local or systemic causes can lead to serious diseases. The role of probiotics in maintaining microbial population harmony (eubiosis) and preventing certain pathologies of the urinary and reproductive system was also investigated. A negative variation in the qualitative and quantitative composition of certain strains of microorganisms (dysbiosis) due to local or systemic causes can even lead to serious diseases. The role of probiotics in maintaining the healthy balance of microorganism populations (eubiosis), and thus in the prevention of certain pathologies of the urinary and reproductive system, has also been studied.<\/jats:p>","DOI":"10.3390\/life13071486","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T16:08:32Z","timestamp":1688141312000},"page":"1486","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives"],"prefix":"10.3390","volume":"13","author":[{"given":"Marica","family":"Colella","sequence":"first","affiliation":[{"name":"Microbiology and Virology Unit, Interdisciplinary Department of Medicine, University of Bari \u201cAldo Moro\u201d, Piazza G. Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skender","family":"Topi","sequence":"additional","affiliation":[{"name":"Department of Clinical Disciplines, School of Technical Medical Sciences, University of Elbasan \u201cA. Xhuvani\u201d, 3001 Elbasan, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9401-7377","authenticated-orcid":false,"given":"Raffaele","family":"Palmirotta","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Unit, Interdisciplinary Department of Medicine, University of Bari \u201cAldo Moro\u201d, Piazza G. Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Department of Clinical Disciplines, School of Technical Medical Sciences, University of Elbasan \u201cA. 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Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11884-016-0345-8","article-title":"The bladder is not sterile: History and current discoveries on the urinary microbiome","volume":"11","author":"Brady","year":"2016","journal-title":"Curr. Bladder Dysfunct. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1128\/JCM.05852-11","article-title":"Evidence of uncultivated bacteria in the adult female bladder","volume":"50","author":"Wolfe","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"23129","DOI":"10.1038\/srep23129","article-title":"Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid","volume":"6","author":"Collado","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.fertnstert.2015.10.021","article-title":"Introduction: Microbiome in human reproduction","volume":"104","author":"Franasiak","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/MOU.0000000000000396","article-title":"Female urinary microbiota","volume":"27","author":"Mueller","year":"2017","journal-title":"Curr. Opin. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrurol.2014.361","article-title":"The microbiome of the urinary tract\u2014A role beyond infection","volume":"12","author":"Whiteside","year":"2015","journal-title":"Nat. Rev. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.2014.303","article-title":"Urinary tract infections in older women: A clinical review","volume":"26","author":"Mody","year":"2014","journal-title":"JAMA"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Siddiqui, H., Nederbragt, A.J., Lagesen, K., Jeansson, S.L., and Jakobsen, K.S. (2011). Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons. BMC Microbiol., 11.","DOI":"10.1186\/1471-2180-11-244"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Nelson, D.E., Dong, Q., Van der Pol, B., Toh, E., Fan, B., Katz, B.P., Mi, D., Rong, R., Weinstock, G.M., and Sodergren, E. (2012). Bacterial communities of the coronal sulcus and distal urethra of adolescent males. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036298"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fcimb.2013.00041","article-title":"The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults","volume":"3","author":"Lewis","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Roth, R.S., Liden, M., and Huttner, A. (2022). The urobiome in men and women: A clinical review. Clin. Microbiol. Infect., 24, in press.","DOI":"10.1016\/j.cmi.2022.08.010"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: Epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Walker","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Santacroce, L., Imbimbo, C., Ballini, A., Crocetto, F., Scacco, S., Cantore, S., Di Zazzo, E., Colella, M., and Jirillo, E. (2022). Testicular Immunity and Its Connection with the Microbiota. Physiological and Clinical Implications in the Light of Personalized Medicine. J. Pers. Med., 12.","DOI":"10.3390\/jpm12081335"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/GCO.0000000000000298","article-title":"The urinary microbiota: A paradigm shift for bladder disorders?","volume":"28","author":"Brubaker","year":"2016","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_17","first-page":"S3","article-title":"Pathophysiology of lower urinary tract symptoms in the aging male population","volume":"7","author":"Lepor","year":"2005","journal-title":"Rev. Urol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4111\/icu.2020.61.4.338","article-title":"The microbiome in urological diseases","volume":"61","author":"Lee","year":"2020","journal-title":"Investig. Clin. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"620102","DOI":"10.3389\/fmed.2020.620102","article-title":"Focus on the Gut-Kidney Axis in Health and Disease","volume":"7","author":"Stavropoulou","year":"2021","journal-title":"Front. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3389\/fmicb.2018.01459","article-title":"The Gut Microbiome as a Major Regulator of the Gut-Skin Axis","volume":"9","author":"Salem","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Di Domenico, M., Ballini, A., Boccellino, M., Scacco, S., Lovero, R., Charitos, I.A., and Santacroce, L. (2022). The Intestinal Microbiota May Be a Potential Theranostic Tool for Personalized Medicine. J. Pers. Med., 12.","DOI":"10.3390\/jpm12040523"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.52586\/4930","article-title":"Current knowledge about the connection between health status and gut microbiota from birth to elderly. A narrative review","volume":"26","author":"Santacroce","year":"2021","journal-title":"Front. Biosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/hdi.12486","article-title":"The gut-kidney axis in chronic renal failure: A new potential target for therapy","volume":"21","author":"Khoury","year":"2017","journal-title":"Hemodial. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1007\/s00467-016-3527-x","article-title":"The gut-kidney axis","volume":"32","author":"Evenepoel","year":"2017","journal-title":"Pediatr. Nephrol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrurol.2016.227","article-title":"Functional urological disorders: A sensitized defence response in the bladder-gut-brain axis","volume":"14","author":"Leue","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cataldi, S., Poli, L., \u015eahin, F.N., Patti, A., Santacroce, L., Bianco, A., Greco, G., Ghinassi, B., Di Baldassarre, A., and Fischetti, F. (2022). The Effects of Physical Activity on the Gut Microbiota and the Gut-Brain Axis in Preclinical and Human Models: A Narrative Review. Nutrients, 14.","DOI":"10.3390\/nu14163293"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s40279-022-01696-x","article-title":"The Connection between Physical Exercise and Gut Microbiota: Implications for Competitive Sports Athletes","volume":"52","author":"Wegierska","year":"2022","journal-title":"Sports Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.4065\/79.8.1048","article-title":"Treatment of uncomplicated urinary tract infections in an era of increasing antimicrobial resistance","volume":"79","author":"Miller","year":"2004","journal-title":"Mayo. Clin. Proc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ajog.2015.05.032","article-title":"The new world of the urinary microbiota in women","volume":"213","author":"Brubaker","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1128\/JCM.03314-12","article-title":"Spectrum of bacterial colonization associated with urothelial cells from patients with chronic lower urinary tract symptoms","volume":"51","author":"Khasriya","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3934\/microbiol.2017.2.143","article-title":"Microbiome in the urinary system\u2014A review","volume":"3","author":"Tan","year":"2017","journal-title":"AIMS Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Prete, R.D., Ronga, L., Addati, G., Magrone, R., Abbasciano, A., Carlo, D.D., and Santacroce, L. (2019). A Retrospective Study about the Impact of Switching from Nested PCR to Multiplex Real-Time PCR on the Distribution of the Human Papillomavirus (HPV) Genotypes. Medicina, 55.","DOI":"10.3390\/medicina55080418"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1365-2036.2006.03174.x","article-title":"Bacterial translocation in the critically ill\u2014Evidence and methods of prevention","volume":"25","author":"Gatt","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000479918","article-title":"Bacterial Translocation from the Gut to the Distant Organs: An Overview","volume":"71","author":"Nagpal","year":"2017","journal-title":"Ann. Nutr. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jsap.12626","article-title":"Bacterial translocation in critical illness","volume":"58","author":"Krentz","year":"2017","journal-title":"J. Small Anim. Pract."},{"key":"ref_37","first-page":"30","article-title":"The role of the intestinal immune system in health and disease","volume":"20","author":"Gogos","year":"2003","journal-title":"Arch. Hell. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1053\/j.gastro.2016.04.024","article-title":"Beyond Intestinal Barrier: The Blood Endothelium as a Second Wall of Defense against Bacterial Invasion","volume":"150","author":"Ungaro","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/gut.46.4.515","article-title":"Surface hydrophobicity of the rat colonic mucosa is a defensive barrier against macromolecules and toxins","volume":"46","author":"Lugea","year":"2000","journal-title":"Gut"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"912","DOI":"10.2174\/1871530320666200807121050","article-title":"Determination of the Upper Reference Limit of Human Epididymis Secretory Protein 4 (HE4) in Healthy Male Individuals and Correlation with Renal and Fertility Markers","volume":"21","author":"Schirinzi","year":"2021","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1046\/j.1365-2036.2002.01310.x","article-title":"The role of the gut flora in health and disease, and its modification as therapy","volume":"16","author":"Hart","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4103\/0255-0857.118870","article-title":"Translocation of gut flora and its role in sepsis","volume":"31","author":"Vaishnavi","year":"2013","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.juro.2015.08.070","article-title":"The Presence of Oxalobacter formigenes in the Microbiome of Healthy Young Adults","volume":"195","author":"Barnett","year":"2016","journal-title":"J. Urol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1681\/ASN.2007101058","article-title":"Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones","volume":"19","author":"Kaufman","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2174\/1871530319666191009144217","article-title":"The \u201cScourge of the Renaissance\u201d. A Short Review about Treponema pallidum infection","volume":"20","author":"Santacroce","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dong, Q., Nelson, D.E., Toh, E., Diao, L., Gao, X., Fortenberry, J.D., and Van der Pol, B. (2011). The microbial communities in male first catch urine are highly similar to those in paired urethral swab specimens. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019709"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.eururo.2010.03.014","article-title":"Urinary incontinence, overactive bladder, and other lower urinary tract symptoms: A longitudinal population-based survey in men aged 45\u2013103 years","volume":"58","author":"Malmsten","year":"2010","journal-title":"Eur. Urol."},{"key":"ref_48","first-page":"618","article-title":"An\u00e1lisis del s\u00edndrome de vejiga hiperactiva y de la incontinencia urinaria en mujeres laboralmente activas entre 25\u201364 a\u00f1os. Estudio EPICC [Analysis of overactive bladder and urinary incontinence in working women aged between 25 and 64 years. EPICC study]","volume":"34","author":"Arlandis","year":"2010","journal-title":"Actas Urol\u00f3gicas Espa\u00f1olas"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e01283-14","DOI":"10.1128\/mBio.01283-14","article-title":"The female urinary microbiome: A comparison of women with and without urgency urinary incontinence","volume":"5","author":"Pearce","year":"2014","journal-title":"mBio"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.semcancer.2023.03.002","article-title":"Obesity and main urologic cancers: Current systematic evidence, novel biological mechanisms, perspectives and challenges","volume":"91","author":"Papavasileiou","year":"2023","journal-title":"Semin. Cancer Biol."},{"key":"ref_51","first-page":"285","article-title":"Bladder cancer: A review of diagnosis and management","volume":"92","author":"Metts","year":"2000","journal-title":"J. Natl. Med. Assoc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3390\/pathophysiology29030041","article-title":"Biomolecular Mechanisms of Autoimmune Diseases and Their Relationship with the Resident Microbiota: Friend or Foe?","volume":"29","author":"Topi","year":"2022","journal-title":"Pathophysiology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nwh.2016.12.004","article-title":"Pelvic Floor Muscle Training to Manage Overactive Bladder and Urinary Incontinence","volume":"21","author":"Angelini","year":"2017","journal-title":"Nurs. Womens Health"},{"key":"ref_54","first-page":"431","article-title":"The pathogenesis of bladder cancer","volume":"89","author":"Friedell","year":"1977","journal-title":"Am. J. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.urology.2018.12.034","article-title":"The Urinary Microbiome: Implications in Bladder Cancer Pathogenesis and Therapeutics","volume":"126","author":"Bajic","year":"2019","journal-title":"Urology"},{"key":"ref_56","first-page":"7","article-title":"Urine microbiota differ in bladder cancer","volume":"20","author":"Stone","year":"2023","journal-title":"Nat. Rev. Urol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"12157","DOI":"10.1038\/s41598-018-29054-w","article-title":"The urinary microbiome associated with bladder cancer","volume":"8","author":"Chow","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Hourigan, S.K., Zhu, W., SW Wong, W., Clemency, N.C., Provenzano, M., Vilboux, T., Niederhuber, J.E., Deeken, J., Chung, S., and McDaniel-Wiley, K. (2020). Studying the urine microbiome in superficial bladder cancer: Samples obtained by midstream voiding versus cystoscopy. BMC Urol., 20.","DOI":"10.1186\/s12894-020-0576-z"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Polimeno, L., Barone, M., Mosca, A., Viggiani, M.T., Joukar, F., Mansour-Ghanaei, F., Mavaddati, S., Daniele, A., Debellis, L., and Bilancia, M. (2020). Soy Metabolism by Gut Microbiota from Patients with Precancerous Intestinal Lesions. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040469"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fimmu.2020.00378","article-title":"The Interplay between Reproductive Tract Microbiota and Immunological System in Human Reproduction","volume":"11","author":"Ambrosino","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.maturitas.2017.06.025","article-title":"Estrogen-gut microbiome axis: Physiological and clinical implications","volume":"103","author":"Baker","year":"2017","journal-title":"Maturitas"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Human Microbiome Project Consortium (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207\u2013214.","DOI":"10.1038\/nature11234"},{"key":"ref_63","first-page":"485","article-title":"R\u00f4le protecteur de la flore de Doderle\u00efn [Protective role of the Doderle\u00efn flora]","volume":"31","author":"Lepargneur","year":"2002","journal-title":"J. Gynecol. Obstet. Biol. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.rbmo.2020.06.014","article-title":"The reproductive microbiome\u2014Clinical practice recommendations for fertility specialists","volume":"41","author":"Budding","year":"2020","journal-title":"Reprod. Biomed. Online"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/1471-0528.14390","article-title":"Why do lactobacilli dominate the human vaginal microbiota?","volume":"124","author":"Witkin","year":"2017","journal-title":"BJOG"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"631972","DOI":"10.3389\/fcimb.2021.631972","article-title":"The Female Vaginal Microbiome in Health and Bacterial Vaginosis","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.fertnstert.2015.10.010","article-title":"Gynecologic health and disease in relation to the microbiome of the female reproductive tract","volume":"104","author":"Green","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e3366","DOI":"10.7717\/peerj.3366","article-title":"Quantifying the human vaginal community state types (CSTs) with the species specificity index","volume":"5","author":"Ma","year":"2017","journal-title":"PeerJ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/clinids\/12.5.856","article-title":"Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora","volume":"12","author":"Cook","year":"1990","journal-title":"Rev. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Nakama, C., Thompson, B., Szybala, C., McBeth, A., Dobner, P., and Zwickey, H. (2022). The Continuum of Microbial Ecosystems along the Female Reproductive Tract: Implications for Health and Fertility. Pathogens, 11.","DOI":"10.3390\/pathogens11111244"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1057022","DOI":"10.3389\/fendo.2022.1057022","article-title":"Probiotic treatment with specific lactobacilli does not improve an unfavorable vaginal microbiota prior to fertility treatment-A randomized, double-blinded, placebo-controlled trial","volume":"13","author":"Jepsen","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1099\/mic.0.26905-0","article-title":"Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods","volume":"150","author":"Zhou","year":"2004","journal-title":"Microbiology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-0711-7-14","article-title":"Changes in the predominant human Lactobacillus flora during in vitro fertilisation","volume":"7","author":"Jakobsson","year":"2008","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1073\/pnas.1002611107","article-title":"Vaginal microbiome of reproductive-age women","volume":"108","author":"Ravel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"132ra52","DOI":"10.1126\/scitranslmed.3003605","article-title":"Temporal dynamics of the human vaginal microbiota","volume":"4","author":"Gajer","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/187153010790827975","article-title":"Does it make sense that diabetes is reciprocally associated with periodontal disease?","volume":"10","author":"Santacroce","year":"2010","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10815-007-9146-5","article-title":"Examination of bacterial contamination at the time of embryo transfer, and its impact on the IVF\/pregnancy outcome","volume":"24","author":"Selman","year":"2007","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102036","DOI":"10.1016\/j.jogoh.2020.102036","article-title":"Microbiome affecting reproductive outcome in ARTs","volume":"50","author":"Tsonis","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3389\/fmicb.2020.00551","article-title":"Crosstalk between Female Gonadal Hormones and Vaginal Microbiota Across Various Phases of Women\u2019s Gynecological Lifecycle","volume":"11","author":"Kaur","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.3389\/fimmu.2019.02823","article-title":"Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota","volume":"10","author":"Bardos","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/humrep\/det096","article-title":"Risks associated with bacterial vaginosis in infertility patients: A systematic review and meta-analysis","volume":"28","author":"Meys","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/humrep\/dew026","article-title":"Abnormal vaginal microbiota may be associated with poor reproductive outcomes: A prospective study in IVF patients","volume":"31","author":"Haahr","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s10096-020-04068-3","article-title":"Multi-year prevalence and macrolide resistance of Mycoplasma genitalium in clinical samples from a southern Italian hospital","volume":"40","author":"Angela","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.fertnstert.2017.05.034","article-title":"Endometrial microbiota-new player in town","volume":"108","author":"Moreno","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_85","first-page":"872","article-title":"Endometrial bacteria in asymptomatic, nonpregnant women","volume":"34","author":"Hemsell","year":"1989","journal-title":"J. Reprod. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.siny.2011.08.006","article-title":"Microbiota of the upper and lower genital tract","volume":"17","author":"Rampersaud","year":"2012","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2014.11.043","article-title":"Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women","volume":"212","author":"Mitchell","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ajog.2016.09.075","article-title":"Evidence that the endometrial microbiota has an effect on implantation success or failure","volume":"215","author":"Moreno","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_89","first-page":"237ra65","article-title":"The placenta harbors a unique microbiome","volume":"6","author":"Aagaard","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1080\/14767058.2021.1936487","article-title":"Investigating the origin of the fetal gut and placenta microbiome in twins","volume":"35","author":"Williams","year":"2021","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_91","first-page":"e1","article-title":"Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy","volume":"128","author":"Penders","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1203\/01.PDR.0000153869.96337.90","article-title":"Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor","volume":"57","author":"Steel","year":"2005","journal-title":"Pediatr. Res."},{"key":"ref_93","first-page":"331","article-title":"\u00c9tablissement du microbiote\u2014Une colonisation in utero d\u00e9terminante pour la sant\u00e9 future? [Microbiota establishment: An in utero colonization decisive for future health?]","volume":"34","author":"Gschwind","year":"2018","journal-title":"Med. Sci."},{"key":"ref_94","first-page":"CD008995","article-title":"Antibiotics prior to embryo transfer in ART","volume":"3","author":"Kroon","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/humrep\/17.2.337","article-title":"Bacterial colonization of the uterine cervix and success rate in assisted reproduction: Results of a prospective survey","volume":"17","author":"Salim","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/oxfordjournals.humrep.a019470","article-title":"Incidence of microbial growth from the tip of the embryo transfer catheter after embryo transfer in relation to clinical pregnancy rate following in-vitro fertilization and embryo transfer","volume":"11","author":"Egbase","year":"1996","journal-title":"Hum. Reprod."},{"key":"ref_97","first-page":"267","article-title":"Endometrial and vaginal microbiomes influence assisted reproductive technology outcomes","volume":"27","author":"Miyagi","year":"2023","journal-title":"JBRA Assist. Reprod."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Peric, A., Weiss, J., Vulliemoz, N., Baud, D., and Stojanov, M. (2019). Bacterial Colonization of the Female Upper Genital Tract. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143405"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Heeren, A.M., van Iperen, L., Klootwijk, D.B., de Melo Bernardo, A., Roost, M.S., Gomes Fernandes, M.M., Louwe, L.A., Hilders, C.G., Helmerhorst, F.M., and van der Westerlaken, L.A. (2015). Development of the follicular basement membrane during human gametogenesis and early folliculogenesis. BMC Dev. Biol., 15.","DOI":"10.1186\/s12861-015-0054-0"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Usman, S.F., Shuaibu, I.R., Durojaiye, K., Medugu, N., and Iregbu, K.C. (2021). The presence of microorganisms in follicular fluid and its effect on the outcome of in vitro fertilization-embryo transfer (IVF-ET) treatment cycles. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246644"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10815-018-1143-3","article-title":"Influence of follicular fluid and cumulus cells on oocyte quality: Clinical implications","volume":"35","author":"Giorgi","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/humrep\/der108","article-title":"Microbial colonization of follicular fluid: Alterations in cytokine expression and adverse assisted reproduction technology outcomes","volume":"26","author":"Pelzer","year":"2011","journal-title":"Hum. Reprod."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"431","DOI":"10.33073\/pjm-2021-043","article-title":"Can Lactobacillus spp. be a Factor Reducing the Risk of Miscarriage?","volume":"70","author":"Kiecka","year":"2021","journal-title":"Pol. J. Microbiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","article-title":"The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.resmic.2015.03.009","article-title":"Complementary seminovaginal microbiome in couples","volume":"166","author":"Punab","year":"2015","journal-title":"Res. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.fertnstert.2007.08.083","article-title":"Detection and identification of bacterial DNA in semen","volume":"90","author":"Kiessling","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Weng, S.L., Chiu, C.M., Lin, F.M., Huang, W.C., Liang, C., Yang, T., Yang, T.L., Liu, C.Y., Wu, W.Y., and Chang, Y.A. (2014). Bacterial communities in semen from men of infertile couples: Metagenomic sequencing reveals relationships of seminal microbiota to semen quality. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110152"},{"key":"ref_108","first-page":"1007366","article-title":"Microbiota, Prostatitis, and Fertility: Bacterial Diversity as a Possible Health Ally","volume":"2021","year":"2021","journal-title":"Adv. Urol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3389\/fmicb.2019.00234","article-title":"Sperm Microbiota and Its Impact on Semen Parameters","volume":"10","author":"Baud","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/venereology1010002","article-title":"The Persistence and Increase in Sexually Transmitted Diseases (STDs) to Pandemic Levels","volume":"1","author":"Santacroce","year":"2022","journal-title":"Venereology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40168-016-0161-6","article-title":"Bacterial communities in penile skin, male urethra, and vaginas of heterosexual couples with and without bacterial vaginosis","volume":"4","author":"Zozaya","year":"2016","journal-title":"Microbiome"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.fertnstert.2011.03.066","article-title":"Effect of vaginal probiotic lactobacilli on in vitro-induced sperm lipid peroxidation and its impact on sperm motility and viability","volume":"95","author":"Barbonetti","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Barbonetti, A., Vassallo, M.R., Cinque, B., Filipponi, S., Mastromarino, P., Cifone, M.G., Francavilla, S., and Francavilla, F. (2013). Soluble products of Escherichia coli induce mitochondrial dysfunction-related sperm membrane lipid peroxidation which is prevented by lactobacilli. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083136"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.fertnstert.2013.07.1991","article-title":"Microbiota of the seminal fluid from healthy and infertile men","volume":"100","author":"Hou","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MOU.0000000000000742","article-title":"The microbiome of the infertile male","volume":"30","author":"Lundy","year":"2020","journal-title":"Curr. Opin. Urol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.3389\/fimmu.2020.02184","article-title":"Female Gut and Genital Tract Microbiota-Induced Crosstalk and Differential Effects of Short-Chain Fatty Acids on Immune Sequelae","volume":"11","author":"Amabebe","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Aagaard, K., Riehle, K., Ma, J., Segata, N., Mistretta, T.A., Coarfa, C., Raza, S., Rosenbaum, S., Van den Veyver, I., and Milosavljevic, A. (2012). A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036466"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2049-2618-2-4","article-title":"The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women","volume":"2","author":"Romero","year":"2014","journal-title":"Microbiome"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0897.2011.01039.x","article-title":"Peri-conceptual cytokines--setting the trajectory for embryo implantation, pregnancy and beyond","volume":"66","author":"Robertson","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2010.01.008","article-title":"Immune regulation of conception and embryo implantation-all about quality control?","volume":"85","author":"Robertson","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jri.2014.02.005","article-title":"Foetal immune programming: Hormones, cytokines, microbes and regulatory T cells","volume":"104\u2013105","author":"Hsu","year":"2014","journal-title":"J. Reprod. Immunol."},{"key":"ref_123","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dhatariya, K., Dungan, K., Hershman, J.M., Hofland, J., and Kalra, S. (2000). Endotext, MDText.com, Inc."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3389\/fimmu.2020.02025","article-title":"T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh Cells","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1038\/s41598-019-45860-2","article-title":"IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responses","volume":"9","author":"Busse","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Pantos, K., Grigoriadis, S., Maziotis, E., Pistola, K., Xystra, P., Pantou, A., Kokkali, G., Pappas, A., Lambropoulou, M., and Sfakianoudis, K. (2022). The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042198"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.21873\/invivo.11664","article-title":"Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis","volume":"33","author":"Simopoulou","year":"2019","journal-title":"Vivo"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12978-021-01320-7","article-title":"Individualized luteal phase support after fresh embryo transfer: Unanswered questions, a review","volume":"19","author":"Zhao","year":"2022","journal-title":"Reprod. Health"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00248-007-9317-z","article-title":"Hormone therapy alters the composition of the vaginal microflora in ovariectomized rats","volume":"55","author":"Bezirtzoglou","year":"2008","journal-title":"Microb. Ecol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10815-011-9694-6","article-title":"The dynamics of the vaginal microbiome during infertility therapy with in vitro fertilization-embryo transfer","volume":"29","author":"Hyman","year":"2012","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s10815-020-01878-4","article-title":"Controlled ovarian stimulation and progesterone supplementation affect vaginal and endometrial microbiota in IVF cycles: A pilot study","volume":"37","author":"Carosso","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejogrb.2016.01.040","article-title":"Molecular detection of intrauterine microbial colonization in women with endometriosis","volume":"199","author":"Khan","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.12659\/MSM.900581","article-title":"Pregnancy, Delivery, and Neonatal Outcomes of In Vitro Fertilization-Embryo Transfer in Patient with Previous Cesarean Scar","volume":"22","author":"Zhang","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1080\/14767058.2018.1449826","article-title":"Maternal and neonatal outcomes associated with infertility","volume":"32","author":"Wang","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2174\/1871530322666220325114045","article-title":"The Toxic Effects of Endocrine Disrupting Chemicals (EDCs) on Gut Microbiota: Bisphenol A (BPA) A Review","volume":"22","author":"Charitos","year":"2022","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jpag.2008.01.073","article-title":"Bacterial populations in the vaginas of healthy adolescent women","volume":"22","author":"Yamamoto","year":"2009","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1128\/jcm.27.2.251-256.1989","article-title":"Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis","volume":"27","author":"Eschenbach","year":"1989","journal-title":"J. Clin. Microbiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/infdis\/174.5.1058","article-title":"Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections","volume":"174","author":"Hawes","year":"1996","journal-title":"J. Infect. Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00005176-199901000-00007","article-title":"Fecal microflora in healthy infants born by different methods of delivery: Permanent changes in intestinal flora after cesarean delivery","volume":"28","author":"Lehtonen","year":"1999","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/JCM.44.1.51-55.2006","article-title":"Association between preterm birth and vaginal colonization by mycoplasmas in early pregnancy","volume":"44","author":"Kataoka","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2174\/1871530320666200508115041","article-title":"Pre-Chemistry Concepts and Medical Therapy among Ancient Physicians through the Pre-Socratic Philosophers","volume":"20","author":"Santacroce","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Ballini, A., Charitos, I.A., Cantore, S., Topi, S., Bottalico, L., and Santacroce, L. (2023). About Functional Foods: The Probiotics and Prebiotics State of Art. Antibiotics, 12.","DOI":"10.3390\/antibiotics12040635"},{"key":"ref_143","first-page":"733","article-title":"The pivotal role of oral microbiota in health and disease","volume":"34","author":"Santacroce","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejogrb.2008.06.003","article-title":"Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women","volume":"141","author":"Petricevic","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/MCO.0b013e328331b611","article-title":"Targeting the vaginal microbiota with probiotics as a means to counteract infections","volume":"12","author":"Reid","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_146","first-page":"G941","article-title":"Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression","volume":"276","author":"Mack","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.micinf.2006.01.003","article-title":"Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: Randomized, double-blind, placebo-controlled trial","volume":"8","author":"Anukam","year":"2006","journal-title":"Microbes Infect."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Gargiulo Isacco, C., Balzanelli, M.G., Garzone, S., Lorusso, M., Inchingolo, F., Nguyen, K.C.D., Santacroce, L., Mosca, A., and Del Prete, R. (2023). Alterations of Vaginal Microbiota and Chlamydia trachomatis as Crucial Co-Causative Factors in Cervical Cancer Genesis Procured by HPV. Microorganisms, 11.","DOI":"10.3390\/microorganisms11030662"},{"key":"ref_149","first-page":"229","article-title":"Bacterial vaginosis: A review on clinical trials with probiotics","volume":"36","author":"Mastromarino","year":"2013","journal-title":"New Microbiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.rbmo.2017.04.005","article-title":"What fertility specialists should know about the vaginal microbiome: A review","volume":"35","author":"Menabrito","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/0971-5916.162127","article-title":"Evaluation of profertility effect of probiotic Lactobacillus plantarum 2621 in a murine model","volume":"142","author":"Bhandari","year":"2015","journal-title":"Indian J. Med. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"9061","DOI":"10.1038\/s41598-023-36126-z","article-title":"Microbial diversity in the vaginal microbiota and its link to pregnancy outcomes","volume":"13","author":"Baud","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_153","first-page":"DC18","article-title":"Comparative Study on the Vaginal Flora and Incidence of Asymptomatic Vaginosis among Healthy Women and in Women with Infertility Problems of Reproductive Age","volume":"11","author":"Babu","year":"2017","journal-title":"J. Clin. Diagn. 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