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The reduced ligands were employed in the synthesis of zinc complexes of the general formula [ZnCl2(L)]. The structures of both the original and the reduced Schiff bases, as well as of the zinc complexes, were characterized by single-crystal X-ray analysis, along with NMR and IR spectroscopy. The antimicrobial activities of the reduced Schiff bases and their zinc complexes were evaluated in vitro against E. coli, S. aureus, and C. albicans. The compounds containing the 4-(trifluoromethylphenyl) moiety showed marked antibacterial activity. Interestingly, the antimicrobial effect of the zinc complex with this moiety was significantly higher than that of the corresponding free reduced ligand, comparable with ciprofloxacin used as standard. Thus, a synergic effect upon the complexation with zinc can be inferred.<\/jats:p>","DOI":"10.3390\/life13071516","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T01:41:36Z","timestamp":1688694096000},"page":"1516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antimicrobially Active Zn(II) Complexes of Reduced Schiff Bases Derived from Cyclohexane-1,2-diamine and Fluorinated Benzaldehydes\u2014Synthesis, Crystal Structure and Bioactivity"],"prefix":"10.3390","volume":"13","author":[{"given":"Bianka","family":"Obo\u0148ov\u00e1","sequence":"first","affiliation":[{"name":"Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odboj\u00e1rov 10, 832 32 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Habala","sequence":"additional","affiliation":[{"name":"Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odboj\u00e1rov 10, 832 32 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-9819","authenticated-orcid":false,"given":"Miroslava","family":"Liteck\u00e1","sequence":"additional","affiliation":[{"name":"Department of Materials Chemistry, Institute of Inorganic Chemistry of the CAS, Husinec-\u0158e\u017e \u010d.p. 1001, 250 68 \u0158e\u017e, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Herich","sequence":"additional","affiliation":[{"name":"Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odboj\u00e1rov 10, 832 32 Bratislava, Slovakia"},{"name":"Department of Physical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinsk\u00e9ho 9, 812 37 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bilkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odboj\u00e1rov 10, 832 32 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franti\u0161ek","family":"Bilka","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odboj\u00e1rov 10, 832 32 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branislav","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"NMR Laboratory, Faculty of Pharmacy, Comenius University in Bratislava, Odboj\u00e1rov 10, 832 32 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","unstructured":"Antimicrobial Resistance Collaborators (2022). 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