{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:22:26Z","timestamp":1774311746278,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075-15-2022-301"],"award-info":[{"award-number":["075-15-2022-301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Heart transplantation is a treatment of choice for patients with severe heart failure. Infection transmission from a donor to a recipient remains a prominent problem in organ transplantation. However, the risk of SARS-CoV-2 transmission in nonlung organ transplantation is still unclear. In this article we presented a case of a 28-year-old pregnant woman who developed heart failure soon after recovery from a SARS-CoV-2 infection in the third trimester of gestation. In the postpartum period, the heart disease worsened and the patient required cardiac transplantation. We examined the recipient\u2019s heart and made a diagnosis of left ventricular noncompaction cardiomyopathy. Immunohistochemical analysis showed SARS-CoV-2 antigen expression in the donor\u2019s heart before transplantation, and after the transplantation, an endomyocardial biopsy was taken. Moreover, an ultrastructural assessment of the endomyocardial specimen revealed endothelial and pericyte injury and a single particle on the surface of the endothelium consistent with SARS-CoV-2 viral particles. Recent findings in the literature associated these damages with SARS-CoV-2 infection. The present study describes the rare case of SARS-CoV-2 transmission from donor to postpartum recipient through a heart transplant and demonstrates the importance of endomyocardial biopsy before and after heart transplantation.<\/jats:p>","DOI":"10.3390\/life13071551","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T01:43:22Z","timestamp":1689212602000},"page":"1551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Scenarios in Heart Transplantation and Persistency of SARS-CoV-2 (Case Report)"],"prefix":"10.3390","volume":"13","author":[{"given":"Lubov","family":"Mitrofanova","sequence":"first","affiliation":[{"name":"Almazov National Medical Research Centre, St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-8403","authenticated-orcid":false,"given":"Igor","family":"Makarov","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Gorshkov","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, St. Petersburg 197341, Russia"},{"name":"Smorodintsev Research Institute of Influenza, St. Petersburg 197376, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Vorobeva","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Simonenko","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Starshinova","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-4467","authenticated-orcid":false,"given":"Dmitry","family":"Kudlay","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, I.M. Sechenov First Moscow State Medical University, Moscow 119992, Russia"},{"name":"Institute of Immunology FMBA of Russia, Moscow 115478, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Karonova","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, St. Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.24171\/j.phrp.2021.0186","article-title":"Associations of pre-existing cardiovascular morbidity with severity and the fatality rate in COVID-19 patients: A systematic review and meta-analysis","volume":"13","author":"Alzoughool","year":"2022","journal-title":"Osong Public Health Res. 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