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Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1080\/02713683.2022.2093381","article-title":"Short- and Long-Term Effects of a Multi-Component, Artificial Tear on Preocular Tear Film Stability, Tear Evaporation and Tear Film Optical Dynamic: A Prospective Randomized Double-Phase Study","volume":"47","author":"Montani","year":"2022","journal-title":"Curr. Eye Res."},{"key":"ref_41","first-page":"e396","article-title":"Autologous versus allogeneic versus umbilical cord sera for the treatment of severe dry eye disease: A double-blind randomized clinical trial","volume":"100","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1177\/11206721221141481","article-title":"Management of inflammation in dry eye disease: Recommendations from a European panel of experts","volume":"33","author":"Messmer","year":"2022","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Borroni, D., Paytuv\u00ed-Gallart, A., Sanseverino, W., G\u00f3mez-Huertas, C., Bonci, P., Romano, V., Giannaccare, G., Rechichi, M., Meduri, A., and Oliverio, G.W. (2022). Exploring the Healthy Eye Microbiota Niche in a Multicenter Study. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810229"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e00355","DOI":"10.1016\/j.btre.2019.e00355","article-title":"Metagenomics in ophthalmology: Hypothesis or real prospective?","volume":"23","author":"Gallon","year":"2019","journal-title":"Biotechnol. 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Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e000956","DOI":"10.1136\/bmjophth-2021-000956","article-title":"Microbiome and immune-mediated dry eye: A review","volume":"7","author":"Watane","year":"2022","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"An, Q., and Zou, H. (2022). Ocular surface microbiota dysbiosis contributes to the high prevalence of dry eye disease in diabetic patients. Crit. Rev. Microbiol., 1\u201310.","DOI":"10.1080\/1040841X.2022.2142090"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1045990","DOI":"10.3389\/fmed.2022.1045990","article-title":"Metagenomic nanopore sequencing of ocular microbiome in patients with meibomian gland dysfunction","volume":"9","author":"Jing","year":"2022","journal-title":"Front. 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