{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:05:41Z","timestamp":1791443141233,"version":"4.3.3"},"reference-count":171,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["R01MH124351"],"award-info":[{"award-number":["R01MH124351"]}]},{"name":"National Institutes of Health","award":["R01ES031823"],"award-info":[{"award-number":["R01ES031823"]}]},{"name":"National Institutes of Health","award":["R01 MH132226"],"award-info":[{"award-number":["R01 MH132226"]}]},{"name":"National Institutes of Health","award":["R01ES031823-03S1"],"award-info":[{"award-number":["R01ES031823-03S1"]}]},{"name":"National Institutes of Health","award":["T32AG067952-01"],"award-info":[{"award-number":["T32AG067952-01"]}]},{"name":"National Institutes of Health","award":["T32 GM008280"],"award-info":[{"award-number":["T32 GM008280"]}]},{"name":"National Institute of Aging","award":["R01MH124351"],"award-info":[{"award-number":["R01MH124351"]}]},{"name":"National Institute of Aging","award":["R01ES031823"],"award-info":[{"award-number":["R01ES031823"]}]},{"name":"National Institute of Aging","award":["R01 MH132226"],"award-info":[{"award-number":["R01 MH132226"]}]},{"name":"National Institute of Aging","award":["R01ES031823-03S1"],"award-info":[{"award-number":["R01ES031823-03S1"]}]},{"name":"National Institute of Aging","award":["T32AG067952-01"],"award-info":[{"award-number":["T32AG067952-01"]}]},{"name":"National Institute of Aging","award":["T32 GM008280"],"award-info":[{"award-number":["T32 GM008280"]}]},{"name":"Houston Area Molecular Biophysics Program","award":["R01MH124351"],"award-info":[{"award-number":["R01MH124351"]}]},{"name":"Houston Area Molecular Biophysics Program","award":["R01ES031823"],"award-info":[{"award-number":["R01ES031823"]}]},{"name":"Houston Area Molecular Biophysics Program","award":["R01 MH132226"],"award-info":[{"award-number":["R01 MH132226"]}]},{"name":"Houston Area Molecular Biophysics Program","award":["R01ES031823-03S1"],"award-info":[{"award-number":["R01ES031823-03S1"]}]},{"name":"Houston Area Molecular Biophysics Program","award":["T32AG067952-01"],"award-info":[{"award-number":["T32AG067952-01"]}]},{"name":"Houston Area Molecular Biophysics Program","award":["T32 GM008280"],"award-info":[{"award-number":["T32 GM008280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common cause of dementia and is classically characterized by two major histopathological abnormalities: extracellular plaques composed of amyloid beta (A\u03b2) and intracellular hyperphosphorylated tau. Due to the progressive nature of the disease, it is of the utmost importance to develop disease-modifying therapeutics that tackle AD pathology in its early stages. Attenuation of hippocampal hyperactivity, one of the earliest neuronal abnormalities observed in AD brains, has emerged as a promising strategy to ameliorate cognitive deficits and abate the spread of neurotoxic species. This aberrant hyperactivity has been attributed in part to the dysfunction of voltage-gated Na+ (Nav) channels, which are central mediators of neuronal excitability. Therefore, targeting Nav channels is a promising strategy for developing disease-modifying therapeutics that can correct aberrant neuronal phenotypes in early-stage AD. This review will explore the role of Nav channels in neuronal function, their connections to AD pathology, and their potential as therapeutic targets.<\/jats:p>","DOI":"10.3390\/life13081655","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:28:46Z","timestamp":1690766926000},"page":"1655","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Voltage-Gated Na+ Channels in Alzheimer\u2019s Disease: Physiological Roles and Therapeutic Potential"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-577X","authenticated-orcid":false,"given":"Timothy J.","family":"Baumgartner","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-1028","authenticated-orcid":false,"given":"Zahra","family":"Haghighijoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana A.","family":"Goode","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1280-9918","authenticated-orcid":false,"given":"Nolan M.","family":"Dvorak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3787-5474","authenticated-orcid":false,"given":"Parsa","family":"Arman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1141-1852","authenticated-orcid":false,"given":"Fernanda","family":"Laezza","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S517","DOI":"10.3233\/JAD-179907","article-title":"Amyloid-\u03b2 and Tau in Alzheimer\u2019s Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies","volume":"64","author":"Nisbet","year":"2018","journal-title":"J. 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