{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:03:03Z","timestamp":1777294983438,"version":"3.51.4"},"reference-count":109,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Acute lung injury (ALI) has been challenging health care systems since before the COVID-19 pandemic due to its morbidity, mortality, and length of hospital stay. In view of the complex pathogenesis of ALI, effective strategies for its prevention and treatment are still lacking. A growing body of evidence suggests that iron dysregulation is a common characteristic in many subtypes of ALI. On the one hand, iron is needed to produce reactive oxygen species (ROS) as part of the immune response to an infection; on the other hand, iron can accelerate the occurrence of ferroptosis and extend host cell damage. Iron chelation represents a novel therapeutic strategy for alleviating lung injury and improving the survival of patients with ALI. This article reviews the current knowledge of iron homeostasis, the role of iron in ALI development, and potential therapeutic targets.<\/jats:p>","DOI":"10.3390\/life13081659","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:28:46Z","timestamp":1690766926000},"page":"1659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Iron Chelation as a Potential Therapeutic Approach in Acute Lung Injury"],"prefix":"10.3390","volume":"13","author":[{"given":"Xiyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 1X5, Canada"},{"name":"Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-0238","authenticated-orcid":false,"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 1X5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce E.","family":"Holbein","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-9168","authenticated-orcid":false,"given":"Christian","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 1X5, Canada"},{"name":"Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada"},{"name":"Department of Physiology & Biophysics, Dalhousie University, Halifax, NS B3H 1X5, Canada"},{"name":"Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41419-022-04971-x","article-title":"STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53\/SLC7A11 pathway","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/jamp.2009.0775","article-title":"Acute lung injury: Epidemiology, pathogenesis, and treatment","volume":"23","author":"Johnson","year":"2010","journal-title":"J. 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