{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:23:06Z","timestamp":1760149386896,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado del Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["20200181"],"award-info":[{"award-number":["20200181"]}],"id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Antiepileptic drugs affect embryonic development when administered during pregnancy, generating severe alterations, such as as cleft lip, spina bifida, heart abnormalities, or neuronal alterations. The compound DL-4-hydroxy-4-phenylhexanamide (DL-HEPB), a phenyl alcohol amide structurally different from known anticonvulsants, has shown good anticonvulsant effects in previous studies. However, its effects on intrauterine development are unknown. So, the purpose of this study was to determine the potential of DL-HEPB to produce alterations in conceptus. Pregnant Wistar rats were orally exposed to 0, 50, 100, and 200 mg\/kg of DL-HEPB during organogenesis, and their food consumption and weight gain were measured. On gestation day 21, pregnant females were euthanized to analyze the fetuses for external, visceral, and skeletal malformations. A significant decrease in food consumption and body weight was observed in mothers, without any other manifestation of toxicity. In fetuses, no external malformations, visceral, or skeletal abnormalities, were observed under the dose of 100 mg\/kg, while the dose of 200 mg\/kg caused malformations in low frequency in brain and kidneys. In view of the results obtained, DL-HEPB could be a good starting point for the design of new highly effective anticonvulsant agents, with much lower developmental toxicity than that shown by commercial anticonvulsants.<\/jats:p>","DOI":"10.3390\/life13081714","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:11:22Z","timestamp":1691662282000},"page":"1714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developmental Toxicity Study of DL-4-Hydroxy-4-Phenylhexanamide (DL-HEPB) in Rats"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4765-5568","authenticated-orcid":false,"given":"Jos\u00e9 Melesio","family":"Crist\u00f3bal-Luna","sequence":"first","affiliation":[{"name":"Laboratorio de Toxicolog\u00eda Precl\u00ednica, Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu 399, Col. Nueva Industrial Vallejo, Del. Gustavo A. Madero, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Ang\u00e9lica","family":"Mojica-Villegas","sequence":"additional","affiliation":[{"name":"Laboratorio de Toxicolog\u00eda Precl\u00ednica, Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu 399, Col. Nueva Industrial Vallejo, Del. Gustavo A. Madero, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Enrique","family":"Meza-Toledo","sequence":"additional","affiliation":[{"name":"Laboratorio de Quimioterapia Experimental, Departamento de Bioqu\u00edmica, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Unidad Profesional L\u00e1zaro C\u00e1rdenas, Prolongaci\u00f3n de Carpio y Plan de Ayala s\/n, Col. Santo T\u00f3mas, Alcald\u00eda Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-0154","authenticated-orcid":false,"given":"Yuliana","family":"Garc\u00eda-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Toxicolog\u00eda Precl\u00ednica, Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu 399, Col. Nueva Industrial Vallejo, Del. Gustavo A. Madero, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"P\u00e9rez-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Col. Casco de Santo Tom\u00e1s, Del. Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-9831","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Chamorro-Cevallos","sequence":"additional","affiliation":[{"name":"Laboratorio de Toxicolog\u00eda Precl\u00ednica, Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu 399, Col. Nueva Industrial Vallejo, Del. Gustavo A. Madero, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21646821.2018.1428455","article-title":"The Revised Definition and Classification of Epilepsy for Neurodiagnostic Technologists","volume":"58","author":"Fisher","year":"2018","journal-title":"Neurodiagn. 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