{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T20:53:36Z","timestamp":1778014416159,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH","doi-asserted-by":"publisher","award":["1P20GM121299-01A1"],"award-info":[{"award-number":["1P20GM121299-01A1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH","doi-asserted-by":"publisher","award":["3P20GM121299-04S1"],"award-info":[{"award-number":["3P20GM121299-04S1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"Women\u2019s Health Initiative Supplement to ACCORD","doi-asserted-by":"publisher","award":["1P20GM121299-01A1"],"award-info":[{"award-number":["1P20GM121299-01A1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"Women\u2019s Health Initiative Supplement to ACCORD","doi-asserted-by":"publisher","award":["3P20GM121299-04S1"],"award-info":[{"award-number":["3P20GM121299-04S1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: Metabolic syndrome amplifies the risk of gestational diabetes, preeclampsia, and preterm labor in pregnant women. Similarly, women with substance use disorder have worsened obstetric and birth outcomes. Despite these two conditions being major healthcare disparities in Appalachia, the health outcomes of this cohort have not been studied thus far. This study looks at the health outcomes of this cohort. Method and Results: In this retrospective cohort study, we analyzed 27,955 mothers who delivered at Cabell Huntington Hospital between January 2010 and November 2021. We implemented Chi-square tests to determine the associations and multiple logistic regression methods for comparison after controlling for other factors, and found that MetS, together with SUD, significantly increases the risk as well as the number of pregnancy complications such as gestational diabetes (p-value &lt; 0.001), preeclampsia (p-value &lt; 0.001), premature rupture (p-value &lt; 0.001), preterm labor (p-value &lt; 0.001), and newborn disorder (p-value &lt; 0.001) compared to the women who had none or had either MetS or SUD alone. Conclusion: Women with both metabolic syndrome and substance abuse had worsened pregnancy and neonatal outcomes compared to women with metabolic syndrome or SUD alone. In conclusion, analysis of all the variables is crucial to strategically planning and implementing health interventions that will positively influence the health outcome of the pregnant woman as well as the child.<\/jats:p>","DOI":"10.3390\/life13091933","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T02:47:52Z","timestamp":1695091672000},"page":"1933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal and Neonatal Outcomes in Women with Metabolic Syndrome and Substance Use Disorder"],"prefix":"10.3390","volume":"13","author":[{"given":"Vijaya Lakshmi","family":"Sundaram","sequence":"first","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Lamichhane","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subha","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3304-2920","authenticated-orcid":false,"given":"Usha","family":"Murughiyan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA"},{"name":"Department of Internal Medicine, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"ref_1","unstructured":"(2023, August 24). 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