{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:58Z","timestamp":1787028778103,"version":"build-2736575974"},"reference-count":77,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Determining the antioxidant abilities and enzyme inhibition profiles of medicinally important plants and their oils is of great importance for a healthy life and the treatment of some common global diseases. Kiwifruit (Actinidia deliciosa) oil was examined and researched using several bioanalytical methods comprehensively for the first time in this research to determine its antioxidant, antiglaucoma, antidiabetic and anti-Alzheimer\u2019s capabilities. Additionally, the kiwifruit oil inhibitory effects on acetylcholinesterase (AChE), carbonic anhydrase II (CA II), and \u03b1-amylase, which are linked to a number of metabolic illnesses, were established. Furthermore, LC-HRMS analysis was used to assess the phenolic content of kiwifruit oil. It came to light that kiwifruit oil contained 26 different phenolic compounds. According to the LC-HRMS findings, kiwifruit oil is abundant in apigenin (74.24 mg\/L oil), epigallocatechin (12.89 mg\/L oil), caryophyllene oxide (12.89 mg\/L oil), and luteolin (5.49 mg\/L oil). In addition, GC-MS and GC-FID studies were used to ascertain the quantity and chemical composition of the essential oils contained in kiwifruit oil. Squalene (53.04%), linoleoyl chloride (20.28%), linoleic acid (2.67%), and palmitic acid (1.54%) were the most abundant compounds in kiwifruit oil. For radical scavenging activities of kiwifruit oil, 1,1-diphenyl-2-picryl-hydrazil (DPPH\u2022) and 2,2\u2032-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS\u2022+) radicals scavenging techniques were examined. These methods effectively demonstrated the potent radical scavenging properties of kiwifruit oil (IC50: 48.55 \u03bcg\/mL for DPPH\u2022, and IC50: 77.00 \u03bcg\/mL for ABTS\u2022+ scavenging). Also, for reducing capabilities, iron (Fe3+), copper (Cu2+), and Fe3+-2,4,6-tri(2-pyridyl)-S-triazine (TPTZ) reducing abilities were studied. Moreover, kiwifruit oil showed a considerable inhibition effect towards hCA II (IC50: 505.83 \u03bcg\/mL), AChE (IC50: 12.80 \u03bcg\/mL), and \u03b1-amylase (IC50: 421.02 \u03bcg\/mL). The results revealed that the use of kiwifruit oil in a pharmaceutical procedure has very important effects due to its antioxidant, anti-Alzheimer, antidiabetic, and antiglaucoma effects.<\/jats:p>","DOI":"10.3390\/life13091939","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T21:47:03Z","timestamp":1695246423000},"page":"1939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Antioxidant, Antiglaucoma, Anticholinergic, and Antidiabetic Effects of Kiwifruit (Actinidia deliciosa) Oil: Metabolite Profile Analysis Using LC-HR\/MS, GC\/MS and GC-FID"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-5704","authenticated-orcid":false,"given":"Eda Mehtap","family":"Ozden","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynebe","family":"Bingol","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques, Tokat Vocational School of Health Services, Gaziosmanpasa University, Tokat 60250, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzaffer","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Vocational School of Applied Sciences, Gelisim University, Istanbul 34315, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6912-3998","authenticated-orcid":false,"given":"Hasan","family":"Karagecili","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Health Sciences, Siirt University, Siirt 56100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekrem","family":"K\u00f6ksal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Arts, Erzincan Binali Yildirim University, Erzincan 24100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet C.","family":"Goren","sequence":"additional","affiliation":[{"name":"Department Chemistry, Faculty of Sciences, Gebze Technical University, Kocaeli 41400, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0626-2306","authenticated-orcid":false,"given":"Saleh H.","family":"Alwasel","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh 11362, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques, Tokat Vocational School of Health Services, Gaziosmanpasa University, Tokat 60250, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.indcrop.2015.03.030","article-title":"Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp. vulgare and subsp. hirtum) essential oils","volume":"70","author":"Sarikurkcu","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1111\/ijfs.13812","article-title":"Bioactive compounds and in vitro antioxidant activities of peel, flesh and seed powder of kiwi fruit","volume":"53","author":"Wang","year":"2018","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rana, A., Samtiya, M., Dhewa, T., Mishra, V., and Aluko, R.E. (2022). Health benefits of polyphenols: A concise review. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14264"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ozler, E., Topal, F., Topal, M., and Sar\u0131kaya, S.B.O. (2023). LC-HRMS profiling and phenolic content, cholinesterase, and antioxidant activities of Terminalia citrina. Chem. Biodivers., 20.","DOI":"10.1002\/cbdv.202201250"},{"key":"ref_5","first-page":"17","article-title":"Evaluation of the in vitro antioxidant properties of broccoli extracts (Brassica oleracea L.)","volume":"16","author":"Gulcin","year":"2004","journal-title":"Ital. J. Food Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1080\/10942912.2019.1656234","article-title":"The inhibition profile of sesamol against alpha-glycosidase and acetylcholinesterase enzyme","volume":"22","author":"Topal","year":"2019","journal-title":"Int. J. Food Proper."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.25135\/rnp.155.19.06.1326","article-title":"Secondary metabolites of ethanol extracts of Pinus sylvestris cones from eastern Anatolia and their antioxidant, cholinesterase and alpha-glucosidase activities","volume":"14","author":"Topal","year":"2020","journal-title":"Rec. Nat. Prod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1089\/jmf.2010.0197","article-title":"Antioxidant activity of eugenol: A structure-activity relationship study","volume":"14","author":"Gulcin","year":"2011","journal-title":"J. Med. Food."},{"key":"ref_9","first-page":"217","article-title":"Antioxidant activity of Melissa officinalis leaves","volume":"5","author":"Koksal","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e15588","DOI":"10.1111\/jfpp.15588","article-title":"Actinidia deliciosa (Kiwi fruit): A comprehensive review on the nutritional composition, health benefits, traditional utilization, and commercialization","volume":"45","author":"Satpal","year":"2021","journal-title":"J. Food Process. Preserv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"128469","DOI":"10.1016\/j.foodchem.2020.128469","article-title":"Kiwifruit (Actinidia spp.): A review of chemical diversity and biological activities","volume":"350","author":"Wang","year":"2021","journal-title":"Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.foodres.2011.03.003","article-title":"The multiple nutrition properties of some exotic fruits: Biological activity and active metabolites","volume":"44","author":"Dembitsky","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Karagecili, H., \u0130zol, E., Kirecci, E., and Gulcin, I. (2023). Determination of antioxidant, Anti-Alzheimer, antidiabetic, antiglaucoma and antimicrobial effects of zivzik pomegranate (Punica granatum)-A chemical profiling by LC-MS\/MS. Life, 13.","DOI":"10.3390\/life13030735"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"129499","DOI":"10.1016\/j.chemosphere.2020.129499","article-title":"A review of dietary phytochemicals and their relation to oxidative stress and human diseases","volume":"271","author":"Guan","year":"2021","journal-title":"Chemosphere"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e2100294","DOI":"10.1002\/ardp.202100294","article-title":"Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds","volume":"354","author":"Sever","year":"2021","journal-title":"Arch. Pharm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"132613","DOI":"10.1016\/j.molstruc.2022.132613","article-title":"Design, synthesis, biological evaluation and molecular docking studies of novel 1H-1,2,3-Triazole derivatives as potent inhibitors of carbonic anhydrase, acetylcholinesterase and aldose reductase","volume":"1257","author":"Demir","year":"2022","journal-title":"J. Mol. Struct."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"127802","DOI":"10.1016\/j.molstruc.2020.127802","article-title":"Novel amine-functionalized benzimidazolium salts: Synthesis, characterization, bioactivity, and molecular docking studies","volume":"1207","author":"Yigit","year":"2020","journal-title":"J. Mol. Struct."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e2000282","DOI":"10.1002\/ardp.202000282","article-title":"Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors","volume":"354","author":"Turkes","year":"2021","journal-title":"Arch. Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e2200132","DOI":"10.1002\/ardp.202200132","article-title":"Design, synthesis, and biological activity of novel dithiocarbamate-methylsulfonyl hybrids as carbonic anhydrase inhibitors","volume":"355","author":"Osmaniye","year":"2022","journal-title":"Arch. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wong, C.Y., Leong, K.H., He, X., Zheng, F., Sun, J., Wang, Z., Heh, C.H., and Kong, K.W. (2022). Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation. Food Biosci., 46.","DOI":"10.1016\/j.fbio.2022.101557"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Durmaz, L., Kiziltas, H., Guven, L., Karagecili, H., Alwasel, S., and Gulcin, I. (2022). Antioxidant, antidiabetic, anticholinergic, and antiglaucoma effects of magnofluorine. Molecules, 27.","DOI":"10.3390\/molecules27185902"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gulcin, I., Bingol, Z., Taslimi, P., Goren, A.C., Alwasel, S.H., and Tel, A.Z. (2022). Polyphenol contents, potential antioxidant, anticholinergic and antidiabetic properties of mountain mint (Cyclotrichium leucotrichum). Chem. Biodivers., 19.","DOI":"10.1002\/cbdv.202100775"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.foodchem.2009.03.095","article-title":"Chemical analysis, antioxidant, antiinflammatory and anticholinesterase activities of Origanum ehrenbergii Boiss and Origanum syriacum L. essential oils","volume":"117","author":"Loizzo","year":"2009","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e1900383","DOI":"10.1002\/ardp.201900383","article-title":"Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors","volume":"353","author":"Istrefi","year":"2017","journal-title":"Arch. Pharm."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.ijbiomac.2020.09.043","article-title":"Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors","volume":"163","author":"Sever","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.toxrep.2019.11.003","article-title":"Anticholinergic and antioxidant activities of usnic acid-an activity-structure insight","volume":"6","author":"Gulcin","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"340","DOI":"10.25135\/rnp.180.20.03.1582","article-title":"Lucilia sericata larval secretions stimulating wound healing effects on rat dermal fibroblast cells","volume":"14","author":"Akbas","year":"2020","journal-title":"Rec. Nat. Prod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-2999(99)00500-2","article-title":"Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models","volume":"379","author":"Sengoku","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"ref_29","first-page":"111","article-title":"Essential oils of three Hypericum species from colombia: Chemical composition, insecticidal and repellent activity against Sitophilus zeamais motsch. (coleoptera: Curculionidae)","volume":"15","author":"Plazas","year":"2021","journal-title":"Rec. Nat. Prod."},{"key":"ref_30","first-page":"10","article-title":"The leaf and the gall volatiles of Salvia fruticosa miller from turkey: Chemical composition and biological activities","volume":"15","author":"Ozek","year":"2021","journal-title":"Rec. Nat. Prod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.25135\/rnp.212.20.10.1842","article-title":"Composition and antimicrobial activity of essential oils from leaves and twigs of Magnolia hookeri var. Longirostrata, D.X.LI & R. Z. Zhou and Magnolia insignis wall. in Ha Giang province of Vietnam","volume":"15","author":"Ha","year":"2021","journal-title":"Rec. Nat. Prod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"276","DOI":"10.25135\/rnp.164.19.07.1342","article-title":"Chemical composition and anticholinesterase activity of the essential oil from the Ecuadorian plant Salvia pichinchensis benth","volume":"14","author":"Salinas","year":"2020","journal-title":"Rec. Nat. Prod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3109\/14756366.2015.1057723","article-title":"Antioxidant activity of taxifolin: An activity-structure relationship","volume":"31","author":"Topal","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/09637480600798132","article-title":"The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas","volume":"57","author":"Apak","year":"2006","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ardp.201100272","article-title":"Synthesis and antioxidant properties of (3,4-dihydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone and its derivatives","volume":"345","author":"Cetinkaya","year":"2012","journal-title":"Arch. Pharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"26","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gulcin, I., and Alwasel, S.H. (2023). DPPH radical scavenging assay. Processes, 11.","DOI":"10.3390\/pr11082248"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00204-011-0774-2","article-title":"Antioxidant activity of food constituents: An overview","volume":"86","author":"Gulcin","year":"2012","journal-title":"Arch. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ellman, G.L., Courtney, K.D., Andres, V., and Featherstone, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 7.","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.indcrop.2018.01.031","article-title":"Activity guided fractionation of pomegranate extract and its antioxidant, antidiabetic and antineurodegenerative properties","volume":"113","author":"Savikin","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ab.2006.01.036","article-title":"A quantitative starch-iodine method for measuring alpha-amylase and glucoamylase activities","volume":"351","author":"Xiao","year":"2006","journal-title":"Anal. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bioorg.2016.12.001","article-title":"Synthesis, characterization, anticancer, antimicrobial and carbonic anhydrase inhibition profiles of novel (3aR,4S,7R,7aS)-2-(4-((E)-3-(3-aryl)acryloyl) phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives","volume":"70","author":"Kocyigit","year":"2017","journal-title":"Bioorg. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"67","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1016\/S0021-9258(18)95800-X","article-title":"Esterase activities of human carbonic anhydrases B and C","volume":"242","author":"Verpoorte","year":"1967","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Gulcin, I., and Alwasel, S.H. (2022). Metal ions, metal chelators and metal chelating assay as antioxidant method. Processes, 10.","DOI":"10.3390\/pr10010132"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.procbio.2022.03.009","article-title":"Determination of LC-HRMS profiling, antioxidant activity, cytotoxic effect and enzyme inhibitory properties of Satureja avromanica using in vitro and in silico methods","volume":"116","author":"Kiziltas","year":"2022","journal-title":"Proceses. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.sajb.2020.11.023","article-title":"Bioactive constituents of Lathyrus czeczottianus and ethyl acetate and water extracts and their biological activities: An endemic plant to Turkey","volume":"143","author":"Ceylan","year":"2020","journal-title":"S. Afr. J. Bot."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cep.2012.01.003","article-title":"Intensification of extraction of natural products using ultrasonic irradiations-A review of current status","volume":"53","author":"Shirsath","year":"2012","journal-title":"Chem. Eng. Process. Process Intensif."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mollica, A., Scioli, G., Della Valle, A., Cichelli, A., Novellino, E., Bauer, M., Kamysz, W., Lorent-Martinez, E.J., Fernindez-de Cordova, M.L., and Castillo-Lopez, R. (2021). Phenolic analysis and in vitro biological activity of red wine, pomace and grape seeds oil derived from Vitis vinifera L. Cv. montepulciano d\u2019abruzzo. Antioxidants, 10.","DOI":"10.3390\/antiox10111704"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Dougnon, G., and Ito, M. (2021). Essential oil from the leaves of Chromolaena odorata, and sesquiterpene caryophyllene oxide induce sedative activity in mice. Pharmaceuticals, 14.","DOI":"10.3390\/ph14070651"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2174\/156800908786241050","article-title":"Luteolin, a flavonoid with potentials for cancer prevention and therapy","volume":"8","author":"Lin","year":"2009","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1515\/pac-2020-0902","article-title":"Methods to evaluate the scavenging activity of antioxidants toward reactive oxygen and nitrogen species","volume":"94","author":"Apak","year":"2022","journal-title":"Pure Appl. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jtcme.2023.01.001","article-title":"Modulators of diabetic neuropathy and inflammation from Saponaria officinalis: Isolation of active phytochemicals and potential mechanisms of action","volume":"13","author":"Raafat","year":"2023","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Mechchate, H., Es-safi, I., Haddad, H., Bekkari, H., Grafov, A., and Bousta, D. (2021). Combination of catechin, epicatechin, and rutin: Optimization of a novel complete antidiabetic formulation using a mixture design approach. J. Nutr. Biochem., 88.","DOI":"10.1016\/j.jnutbio.2020.108520"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejphar.2017.03.042","article-title":"Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights","volume":"803","author":"Nyane","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_56","first-page":"158","article-title":"Polyphenol contents and antioxidant properties of medlar (Mespilus germanica L.)","volume":"5","author":"Gulcin","year":"2011","journal-title":"Rec. Nat. Prod."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Huyut, Z., Beydemir, S., and Gulcin, I. (2017). Antioxidant and antiradical properties of selected flavonoids and phenolic compounds. Biochem. Res. Int., 2017.","DOI":"10.1155\/2017\/7616791"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ceylan, R., Zengin, G., Mahomoodally, M.F., Sinan, K.I., Ak, G., Jugreet, S., Cak\u0131r, O., Quelbani, R., Paksoy, M.Y., and Y\u0131lmaz, M.A. (2021). Enzyme inhibition and antioxidant functionality of eleven Inula species based on chemical components and chemometric insights. Biochem. Syst. Ecol., 95.","DOI":"10.1016\/j.bse.2021.104225"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100566","DOI":"10.1016\/j.jics.2022.100566","article-title":"GC\u2013MS analysis of phytoconstituents present in methanolic extract of Actinidia deliciosa L. fruits and its antioxidant activity","volume":"99","author":"Qadir","year":"2022","journal-title":"J. Indian Chem. Soc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1007\/s11694-019-00225-1","article-title":"Effect of packaging materials on the quality of kiwifruits (Actinidia deliciosa cv. Hayward)","volume":"13","author":"Sicari","year":"2019","journal-title":"J. Food Meas. Charact."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.foodchem.2008.08.025","article-title":"Antioxidant capacity and the relationship with polyphenol and vitamin C in Actinidia fruits","volume":"113","author":"Du","year":"2009","journal-title":"Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1080\/13102818.2018.1443400","article-title":"Evaluation of biochemical components and antioxidant capacity of different kiwifruit (Actinidia spp.) genotypes grown in China","volume":"32","author":"Wang","year":"2018","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zhu, C., Chou, O., Lee, F.Y., Wang, Z., Barrow, J.C., Dunshea, R.F., and Suleria, A.R.H. (2021). Characterization of phenolics in rejected kiwifruit and their antioxidant potential. Processes, 9.","DOI":"10.3390\/pr9050781"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.fshw.2023.03.019","article-title":"Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats","volume":"12","author":"Naoom","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.foodres.2011.03.031","article-title":"Polyphenol contents and in vitro antioxidant activities of lyophilised aqueous extract of kiwifruit (Actinidia deliciosa)","volume":"44","author":"Bursal","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.arabjc.2010.09.016","article-title":"Antioxidant activity of clove oil-A powerful antioxidant source","volume":"5","author":"Gulcin","year":"2012","journal-title":"Arab. J. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s10068-018-0321-5","article-title":"Kiwifruit of Actinidia eriantha cv. Bidan has in vitro antioxidative, anti-inflammatory and immunomodulatory effects on macrophages and splenocytes isolated from male BALB\/c mice","volume":"27","author":"Kim","year":"2018","journal-title":"Food Sci. Biotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s13580-015-1085-y","article-title":"Effect of maturity stage at harvest on antioxidant capacity and total phenolics in kiwifruits (Actinidia spp.) grown in Korea","volume":"56","author":"Lee","year":"2015","journal-title":"Hortic. Environ. Biotechnol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/carcin\/24.3.511","article-title":"Nutritional modulation of DNA repair in a human intervention study","volume":"24","author":"Collins","year":"2003","journal-title":"Carcinogenesis"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1475-2891-10-54","article-title":"Supplementation of a western diet with golden kiwifruits (Actinidia chinensis var.\u2019Hort 16A\u2019:) effects on biomarkers of oxidation damage and antioxidant protection","volume":"10","author":"Brevik","year":"2011","journal-title":"Nutr. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1080\/10942912.2019.1656232","article-title":"Anticholinergic, antidiabetic and antioxidant activities of cinnamon (Cinnamomum verum) bark extracts: Polyphenol contents analysis by LC-MS\/MS","volume":"22","author":"Gulcin","year":"2019","journal-title":"Int. J. Food Proper."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"121749","DOI":"10.1016\/j.talanta.2020.121749","article-title":"Electrochemical screening of genoprotective and antioxidative effectiveness of Origanum vulgare L. and its functionality in the prevention of neurodegenerative disorders","volume":"223","author":"Ligaj","year":"2021","journal-title":"Talanta"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10068-017-0030-5","article-title":"Effects of freeze-drying on antioxidant and anticholinesterase activities in various cultivars of kiwifruit (Actinidia spp.)","volume":"26","author":"Hwang","year":"2017","journal-title":"Food Sci. Biotechnol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5076029","DOI":"10.1155\/2017\/5076029","article-title":"Antiamylase, anticholinesterases, antiglycation, and glycation reversing potential of bark and leaf of ceylon cinnamon (Cinnamomum zeylanicum Blume) in vitro","volume":"2017","author":"Arachchige","year":"2017","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Wang, K., Li, M., Han, Q., Fu, R., and Ni, Y. (2021). Inhibition of \u03b1-amylase activity by insoluble and soluble dietary fibers from kiwifruit (Actinidia deliciosa). Food Biosci., 42.","DOI":"10.1016\/j.fbio.2021.101057"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Li, H.Y., Yuan, Q., Yang, Y.L., Han, Q.H., He, J.L., Zhao, L., Zhang, Q., Liu, S.X., Lin, D.-R., and Wu, D.T. (2018). Phenolic profiles, antioxidant capacities, and inhibitory effects on digestive enzymes of different kiwifruits. Molecules, 23.","DOI":"10.3390\/molecules23112957"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Turkes, C., Arslan, M., Demir, Y., Cocaj, L., Nixha, A.R., and Beydemir, S. (2019). Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors. Bioorg. Med., 89.","DOI":"10.1016\/j.bioorg.2019.103004"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/9\/1939\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:54:00Z","timestamp":1760129640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/9\/1939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":77,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["life13091939"],"URL":"https:\/\/doi.org\/10.3390\/life13091939","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]}}}