{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:32:05Z","timestamp":1775032325593,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n of the Spanish Government","doi-asserted-by":"publisher","award":["PID2021-122486OA-I00"],"award-info":[{"award-number":["PID2021-122486OA-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The aim of this study is to evaluate the results obtained on the optical bench and clinically with an isofocal lens (ISOPure, BVI medical, Belgium) to compare them to a standard monofocal one (MicroPure, BVI medical, Belgium). To do so, we have combined laboratory investigation and a prospective, comparative, and randomized clinical study. First, we have measured the wavefront of the two models studied using a NIMO TR1504 (Lambda-X, Belgium) deflectometer for three nominal powers: +10.00, +20.00 and +30.00 D. In the randomized study with 48 patients, half of them implanted with ISOPure and the other with MicroPure, we have measured visual acuities and contrast sensitivity under photopic and mesopic conditions. The optical bench results show that the isofocal lens presented higher power than the monofocal one, at the lens center, due to the spherical aberration (coefficients Z(4,0), Z(6,0) and Z(8,0)) induced by the greater asphericity of its design. The addition obtained depended on the nominal power, from +1.00 to +1.50 D. The results of the clinical study showed that the ISOPure lens presented better visual outcomes, which were statistically significant, at intermediate distance compared to the MicroPure lens (p-values of 0.014 and 0.022 for 80 and 60 cm, respectively) without decreasing the contrast sensitivity. Clinical outcomes were not affected by pupillary size. In conclusion, due to the increase in power at the lens center due to its highly aspherical design, the isofocal lens evaluated showed better intermediate vision than the monofocal one.<\/jats:p>","DOI":"10.3390\/life13102001","type":"journal-article","created":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:58:09Z","timestamp":1696179489000},"page":"2001","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Optical and Clinical Outcomes of an Isofocal Intraocular Lens vs. a Monofocal Standard Lens"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9164-9627","authenticated-orcid":false,"given":"Lidia","family":"P\u00e9rez-Sanz","sequence":"first","affiliation":[{"name":"Optometry and Vision Department, Facultad de \u00d3ptica y Optometr\u00eda, Universidad Complutense de Madrid, C\/Arcos de Jal\u00f3n, 118, 28037 Madrid, Spain"},{"name":"Miranza IOA, C\/Galileo, 104, 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-2903","authenticated-orcid":false,"given":"Veronica","family":"Gonzalez-Fernandez","sequence":"additional","affiliation":[{"name":"Optics Department, Facultad de \u00d3ptica y Optometr\u00eda, Universidad Complutense de Madrid, C\/Arcos de Jal\u00f3n, 118, 28037 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-3256","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"G\u00f3mez-Pedrero","sequence":"additional","affiliation":[{"name":"Optics Department, Facultad de \u00d3ptica y Optometr\u00eda, Universidad Complutense de Madrid, C\/Arcos de Jal\u00f3n, 118, 28037 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8972-1784","authenticated-orcid":false,"given":"C\u00e9sar","family":"Albarr\u00e1n-Diego","sequence":"additional","affiliation":[{"name":"Departament d\u2019\u00d2ptica i Optometria i Ci\u00e8ncies de la Visi\u00f3, Facultat de F\u00edsica, Universitat de Val\u00e8ncia, C\/Doctor Moliner, 46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda-Montero","sequence":"additional","affiliation":[{"name":"Optometry and Vision Department, Facultad de \u00d3ptica y Optometr\u00eda, Universidad Complutense de Madrid, C\/Arcos de Jal\u00f3n, 118, 28037 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Optometry and Vision Department, Facultad de \u00d3ptica y Optometr\u00eda, Universidad Complutense de Madrid, C\/Arcos de Jal\u00f3n, 118, 28037 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fernandez, J., Rocha-de-Lossada, C., Zamorano-Martin, F., Rodriguez-Calvo-de-Mora, M., and Rodriguez-Vallejo, M. (2023). Positioning of enhanced monofocal intraocular lenses between conventional monofocal and extended depth of focus lenses: A scoping review. BMC Ophthalmol., 23.","DOI":"10.1186\/s12886-023-02844-1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1016\/j.ophtha.2020.09.026","article-title":"Multifocal and Extended Depth-of-Focus Intraocular Lenses in 2020","volume":"128","author":"Rampat","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/APO.0000000000000590","article-title":"Latest Development in Extended Depth-of-Focus Intraocular Lenses: An Update","volume":"12","author":"Alio","year":"2023","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_4","unstructured":"Fern\u00e1ndez Guti\u00e9rrez, D., Barbero Briones, S., Dorronso D\u00edaz, C., and Marcos Celestino, S. (2013). 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