{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:08:59Z","timestamp":1790345339877,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: While gender differences of several diseases have been already described in the literature, studies in the area of hyperacusis are still scant. Despite the fact that hyperacusis is a condition that severely affects the patient\u2019s quality of life, it is not well investigated; a comprehensive understanding of its features, eventually including gender differences, could be a valuable asset in developing clinical intervention strategies. Aim: To evaluate gender differences among subjects affected by hyperacusis. Methods: A literature search was conducted focused on adult patients presenting hyperacusis, using the MedLine bibliographic database. Relevant peer-reviewed studies, published in the last 20 years, were sought. A total of 259 papers have been identified, but only 4 met the inclusion criteria. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results: The four selected papers included data from 604 patients; of these, 282 subjects resulted as affected by hyperacusis (125 females and 157 males). Questionnaires for analyzing factors affecting the attentional, social and emotional variance of hyperacusis (such as VAS, THI, TSCH, MASH) were administered to all included subjects. The data suggest that there are no hyperacusis gender-specific differences in the assessed population samples. Conclusions: The literature data suggest that males and females exhibit a similar level of hyperacusis. However, in light of the subjective nature of this condition, the eventual set up of further tests to assess hyperacusis features could be very helpful in the near future.<\/jats:p>","DOI":"10.3390\/life13102092","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:59:01Z","timestamp":1697893141000},"page":"2092","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hyperacusis: Focus on Gender Differences: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Lucia Belen","family":"Musumano","sequence":"first","affiliation":[{"name":"ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9509-9722","authenticated-orcid":false,"given":"Stavros","family":"Hatzopoulos","sequence":"additional","affiliation":[{"name":"ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-8983","authenticated-orcid":false,"given":"Virginia","family":"Fancello","sequence":"additional","affiliation":[{"name":"ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bianchini","sequence":"additional","affiliation":[{"name":"ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Bellini","sequence":"additional","affiliation":[{"name":"Centre for Studies on Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pelucchi","sequence":"additional","affiliation":[{"name":"ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-1915","authenticated-orcid":false,"given":"Piotr Henryk","family":"Skar\u017cy\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Sensory Organs, 1 Mokra Street, 05-830 Kajetany, Poland"},{"name":"Department of Teleaudiology and Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, 10 Mochnackiego Street, 02-042 Warsaw, Poland"},{"name":"Heart Failure and Cardiac Rehabilitation Department, Faculty of Dental Medicine, Medical University of Warsaw, 8 Kondratowicza Street, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-1698","authenticated-orcid":false,"given":"Magdalena B.","family":"Skar\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Institute of Sensory Organs, 1 Mokra Street, 05-830 Kajetany, Poland"},{"name":"Center of Hearing and Speech Medincus, 05-830 Warsaw, Poland"},{"name":"Pharmacy Department, Department of Pharmacotherapy and Pharmaceutical Care, Medical University of Warsaw, 02-042 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-2295","authenticated-orcid":false,"given":"Andrea","family":"Ciorba","sequence":"additional","affiliation":[{"name":"ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0001-6519(06)78731-3","article-title":"Fisiopatolog\u00eda y tratamiento de la hiperacusia (hipersensibilidad al sonido)","volume":"57","author":"Plaza","year":"2006","journal-title":"Acta Otorrinolaringol. 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