{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:10:12Z","timestamp":1788207012863,"version":"build-2803163510"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Cancer therapies have revolutionized patient survival rates, yet they come with the risk of cardiotoxicity, necessitating effective monitoring and management. The existing guidelines offer a limited empirical basis for practical approaches in various clinical scenarios. This article explores the intricate relationship between cancer therapy and the cardiovascular system, highlighting the role of advanced multimodality imaging in monitoring patients before, during, and after cancer treatment. This review outlines the cardiovascular effects of different cancer therapy classes, offering a comprehensive understanding of their dose- and time-dependent impacts. This paper delves into diverse imaging modalities such as echocardiography, cardiac magnetic resonance imaging, cardiac computed tomography, and nuclear imaging, detailing their strengths and limitations in various conditions due to cancer treatment, such as cardiac dysfunction, myocarditis, coronary artery disease, Takotsubo cardiomyopathy, pulmonary hypertension, arterial hypertension, valvular heart diseases, and heart failure with preserved ejection fraction. Moreover, it underscores the significance of long-term follow-up for cancer survivors and discusses future directions.<\/jats:p>","DOI":"10.3390\/life13102103","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:54:35Z","timestamp":1698040475000},"page":"2103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multimodality Cardiovascular Imaging of Cardiotoxicity Due to Cancer Therapy"],"prefix":"10.3390","volume":"13","author":[{"given":"Carla","family":"Contaldi","sequence":"first","affiliation":[{"name":"Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Montesarchio","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Catapano","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5669-574X","authenticated-orcid":false,"given":"Luigi","family":"Falco","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Caputo","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"D\u2019Aniello","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-7424","authenticated-orcid":false,"given":"Daniele","family":"Masarone","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pacileo","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3322\/caac.21565","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14545","DOI":"10.1002\/cam4.5980","article-title":"Current perspectives of cardio-oncology: Epidemiology, adverse effects, pre-treatment screening and prevention strategies","volume":"12","author":"Bychowski","year":"2023","journal-title":"Cancer Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1056\/NEJMra1100265","article-title":"Cardiovascular toxic effects of targeted cancer therapies","volume":"375","author":"Moslehi","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1001\/jamacardio.2016.2132","article-title":"Oncocardiology\u2014Past, present, and future: A review","volume":"1","author":"Yeh","year":"2016","journal-title":"JAMA Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.echo.2014.07.012","article-title":"Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: A report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"27","author":"Plana","year":"2014","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/ejhf.2017","article-title":"Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: A position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC)","volume":"22","author":"Pudil","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/ejhf.1920","article-title":"Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: A position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society","volume":"22","author":"Lyon","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1093\/ehjci\/jeac106","article-title":"2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"23","author":"Lyon","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/eurheartj\/ehab674","article-title":"Defining cardiovascular toxicities of cancer therapies: An International Cardio-Oncology Society (IC-OS) consensus statement","volume":"43","author":"Herrmann","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.jacc.2022.08.743","article-title":"Advances in Multimodality Imaging in Cardio-Oncology: JACC State-of-the-Art Review","volume":"80","author":"Baldassarre","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jacc.2023.03.393","article-title":"2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure with Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee","volume":"81","author":"Kittleson","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107171","DOI":"10.1016\/j.vph.2023.107171","article-title":"SGLT2-i prevent left ventricular dysfunction induced by anthracycline in mouse model: A systematic-review and meta-analysis","volume":"150","author":"Faggiano","year":"2023","journal-title":"Vascul. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jaccao.2023.03.011","article-title":"The Association of Sodium-Glucose Cotransporter 2 Inhibitors with Cardiovascular Outcomes in Anthracycline-Treated Patients with Cancer","volume":"5","author":"Carrasco","year":"2023","journal-title":"JACC CardioOncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/CIRCRESAHA.115.303633","article-title":"Cardio-oncology: An update on cardiotoxicity of cancer-related treatment","volume":"118","author":"Lenneman","year":"2016","journal-title":"Circ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fcvm.2017.00066","article-title":"Radiation-induced cardiovascular disease: A clinical perspective","volume":"4","author":"Saiki","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1161\/CIRCULATIONAHA.116.025434","article-title":"Risk of Heart Failure with Preserved Ejection Fraction in Older Women After Contemporary Radiotherapy for Breast Cancer","volume":"135","author":"Saiki","year":"2017","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1200\/JCO.2016.70.5400","article-title":"Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline","volume":"35","author":"Armenian","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/ejhf.1631","article-title":"Troponins and brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients: A meta-analysis","volume":"22","author":"Michel","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jcmg.2018.06.003","article-title":"Multi-modality imaging in the assessment of cardiovascular toxicity in the cancer patient","volume":"11","author":"Plana","year":"2018","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.hfc.2021.01.001","article-title":"Role of Cardiac Magnetic Resonance Imaging in Heart Failure","volume":"17","author":"Contaldi","year":"2021","journal-title":"Heart Fail. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.hfc.2020.08.006","article-title":"Cardiovascular Magnetic Resonance in Right Heart and Pulmonary Circulation Disorders","volume":"17","author":"Contaldi","year":"2021","journal-title":"Heart Fail. Clin."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.hfc.2018.12.015","article-title":"Right Ventricular Size and Function in Chronic Heart Failure: Not to Be Forgotten","volume":"15","author":"Zhou","year":"2019","journal-title":"Heart Fail. Clin."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/ehjci\/jeaa345","article-title":"Role of cardiovascular magnetic resonance imaging in cardio-oncology","volume":"22","author":"Saunderson","year":"2021","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00330-011-2345-6","article-title":"Left and right ventricle assessment with Cardiac CT: Validation study vs. Cardiac MR","volume":"22","author":"Maffei","year":"2012","journal-title":"Eur. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.amjcard.2013.11.016","article-title":"Meta- analysis of global left ventricular function comparing multidetector computed tomography with cardiac magnetic resonance imaging","volume":"113","author":"Sharma","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_29","first-page":"635","article-title":"Cardiac computed tomography in cardio-oncology: JACC: CardioOncology primer","volume":"3","author":"Yang","year":"2021","journal-title":"Cardio Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.echo.2013.12.005","article-title":"Analysis of left ventricular volumes and function: A multicenter comparison of cardiac magnetic resonance imaging, cine ventriculography, and unenhanced and contrast-enhanced two-dimensional and three-dimensional echocardiography","volume":"27","author":"Hoffmann","year":"2014","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.echo.2017.11.013","article-title":"Clinical Applications of Ultrasonic Enhancing Agents in Echocardiography: 2018 American Society of Echocardiography Guidelines Update","volume":"31","author":"Porter","year":"2018","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_33","first-page":"677","article-title":"Strain imaging in cardio-oncology","volume":"2","author":"Liu","year":"2020","journal-title":"Cardio Oncol."},{"key":"ref_34","first-page":"977","article-title":"Echocardiographic parameters of left ventricular size and function as predictors of symptomatic heart failure in patients with a left ventricular ejection fraction of 50%\u201359% treated with anthracyclines","volume":"16","author":"Mousavi","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.echo.2016.02.018","article-title":"Myocardial strain is associated with adverse clinical cardiac events in patients treated with anthracyclines","volume":"29","author":"Ali","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1001\/jamacardio.2019.2952","article-title":"Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-analysis","volume":"4","author":"Oikonomou","year":"2019","journal-title":"JAMA Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jacc.2020.11.020","article-title":"Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy","volume":"77","author":"Thavendiranathan","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10741-015-9521-8","article-title":"Echocardiographic assessment of left ventricular systolic function: From ejection fraction to torsion","volume":"21","author":"Cameli","year":"2016","journal-title":"Heart Fail. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ehjci\/jey188","article-title":"Echocardiographic reference ranges for normal non-invasive myocardial work indices: Results from the EACVI NORRE study","volume":"20","author":"Manganaro","year":"2019","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijcard.2022.06.067","article-title":"Deterioration in myocardial work indices precedes changes in global longitudinal strain following anthracycline chemotherapy","volume":"363","author":"Zhan","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jcmg.2022.02.027","article-title":"Diagnostic and Prognostic Value of Myocardial Work Indices for Identification of Cancer Therapy-Related Cardiotoxicity","volume":"15","author":"Thampinathan","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Moya, A., Buytaert, D., Beles, M., Paolisso, P., Duchenne, J., Huygh, G., Langmans, C., Roelstraete, A., Verstreken, S., and Goethals, M. (2023). Serial Non-Invasive Myocardial Work Measurements for Patient Risk Stratification and Early Detection of Cancer Therapeutics-Related Cardiac Dysfunction in Breast Cancer Patients: A Single-Centre Observational Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041652"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.21037\/qims-22-817","article-title":"Evaluating the effect of PD-1 inhibitors on left ventricular function in lung cancer with noninvasive myocardial work","volume":"13","author":"Li","year":"2023","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"609194","DOI":"10.1155\/2015\/609194","article-title":"Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy","volume":"2015","author":"Calleja","year":"2015","journal-title":"J. Oncol."},{"key":"ref_45","first-page":"20","article-title":"Detection of right ventricular dysfunction by three-dimensional echocardiography and two-dimensional speckle tracking in breast cancer patients receiving anthracycline-based chemotherapy","volume":"9","author":"Sabry","year":"2023","journal-title":"Cardiooncology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.15190\/d.2019.7","article-title":"Longitudinal strain analysis allows the identification of subclinical deterioration of right ventricular function in patients with cancer therapy-related left ventricular dysfunction","volume":"7","author":"Cherata","year":"2019","journal-title":"Discoveries"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/ehjci\/jes139","article-title":"Altered left ventricular longitudinal diastolic function correlates with reduced systolic function immediately after anthracycline chemotherapy","volume":"14","author":"Stoodley","year":"2013","journal-title":"Eur. Heart J. Cardiovasc. Imaging."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijcard.2021.02.013","article-title":"Left Atrial Strain changes in patients with breast cancer during anthracycline therapy","volume":"330","author":"Arias","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.echo.2013.02.008","article-title":"Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity","volume":"26","author":"Negishi","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_50","first-page":"135","article-title":"New non-invasive index for combined sistoli and diastolic ventricular function","volume":"26","author":"Tei","year":"1995","journal-title":"J. Cardiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Puzzovivo, A., Fioretti, A.M., Minoia, C., Villoni, R., Carbonara, S., Graziano, G., Pavone, F., Guarini, A., and Oliva, S. (2022). Echocardiography Monitoring during Anthracycline Administration in Hodgkin and Non-Hodgkin\u2019s Lymphoma: The Tei Index Evaluation. J. Pers. Med., 12.","DOI":"10.3390\/jpm12020290"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ccl.2019.07.006","article-title":"Echocardiography Imaging of Cardiotoxicity","volume":"37","author":"Kang","year":"2019","journal-title":"Cardiol. Clin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijcard.2005.07.029","article-title":"Early reduction in left ventricular contractile reserve detected by dobutamine stress echo predicts high-dose chemotherapy-induced cardiac toxicity","volume":"111","author":"Civelli","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1442-200X.2006.02210.x","article-title":"Evaluation of cardiac reserved function by high-dose dobutamine stress echocardiography in asymptomatic anthracycline-treated survivors of childhood cancer","volume":"48","author":"Hamada","year":"2006","journal-title":"Pediatr. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S1525-2167(03)00017-9","article-title":"Repetitive dobutamine stress echocardiography for the prediction of anthracycline cardiotoxicity","volume":"4","author":"Bountioukos","year":"2003","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2020.10.002","article-title":"Usefulness of Stress Echocardiography in the Management of Patients Treated with Anticancer Drugs","volume":"34","author":"Novo","year":"2021","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_57","first-page":"775","article-title":"Impaired coronary flow reserve in metastatic cancer patients treated with sunitinib","volume":"18","author":"Sen","year":"2013","journal-title":"J. BUON"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1053\/euhj.2000.2011","article-title":"Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable?","volume":"21","author":"Bellenger","year":"2000","journal-title":"Eur. Heart J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11897-020-00455-1","article-title":"Traditional and novel imaging of right ventricular function in patients with heart failure and reduced ejection fraction","volume":"17","author":"Sciaccaluga","year":"2020","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/CIRCULATIONAHA.117.027740","article-title":"Association of Feature-Tracking Cardiac Magnetic Resonance Imaging Left Ventricular Global Longitudinal Strain with All-Cause Mortality in Patients with Reduced Left Ventricular Ejection Fraction","volume":"135","author":"Romano","year":"2017","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/COC.0b013e31829e19be","article-title":"Cardiac magnetic resonance imaging for the assessment of the myocardium after doxorubicin-based chemotherapy","volume":"38","author":"Lunning","year":"2015","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijcard.2018.03.041","article-title":"Myocardial strain imaging by cardiac magnetic resonance for detection of subclinical myocardial dysfunction in breast cancer patients receiving trastuzumab and chemotherapy","volume":"261","author":"Ong","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/heartjnl-2019-316297","article-title":"Variability in echocardiography and MRI for detection of cancer therapy cardiotoxicity","volume":"106","author":"Lambert","year":"2020","journal-title":"Heart"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e004560","DOI":"10.1161\/CIRCHEARTFAILURE.117.004560","article-title":"Left Ventricular Mass Change After Anthracycline Chemotherapy","volume":"11","author":"Jordan","year":"2018","journal-title":"Circ. Heart Fail."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jamacardio.2023.0494","article-title":"Comprehensive Cardiovascular Magnetic Resonance Tissue Characterization and Cardiotoxicity in Women with Breast Cancer","volume":"8","author":"Thavendiranathan","year":"2023","journal-title":"JAMA Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e003584","DOI":"10.1161\/CIRCIMAGING.115.003584","article-title":"Characterization of the Changes in Cardiac Structure and Function in Mice Treated with Anthracyclines Using Serial Cardiac Magnetic Resonance Imaging","volume":"9","author":"Farhad","year":"2016","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.amjcard.2012.11.022","article-title":"Myocardial extracellular volume by cardiac magnetic resonance imaging in patients treated with anthracycline-based chemotherapy","volume":"111","author":"Neilan","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijcard.2015.08.153","article-title":"Assessment of the relationships between left ventricular filling pressures and longitudinal dysfunction with myocardial fibrosis in uncomplicated hypertensive patients","volume":"202","author":"Contaldi","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1532-429X-15-48","article-title":"Diffuse myocardial fibrosis by T1-mapping in children with subclinical anthracycline cardiotoxicity: Relationship to exercise capacity, cumulative dose and remodeling","volume":"15","author":"Tham","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/ehf2.12277","article-title":"Native myocardial T1 time can predict development of subsequent anthracycline-induced cardiomyopathy","volume":"5","author":"Muehlberg","year":"2018","journal-title":"ESC Heart Fail."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jcmg.2016.06.006","article-title":"Progressive 3-Month Increase in LV MyocardialECV After Anthracycline-Based Chemotherapy","volume":"10","author":"Jordan","year":"2017","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jcmg.2018.05.012","article-title":"Anthracycline Therapy Is Associated with Cardiomyocyte Atrophy and Preclinical Manifestations of Heart Disease","volume":"11","author":"Shah","year":"2018","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1253\/circj.CJ-20-1288","article-title":"Usefulness of Cardiac Computed Tomography in the Diagnosis of Anti-Cancer Therapy-Related Cardiac Dysfunction-Consistency with Magnetic Resonance Imaging","volume":"85","author":"Sueta","year":"2021","journal-title":"Circ. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13244-022-01224-5","article-title":"Myocardial extracellular volume derived from contrast-enhanced chest computed tomography for longitudinal evaluation of cardiotoxicity in patients with breastcancer treated with anthracyclines","volume":"13","author":"Tu","year":"2022","journal-title":"Insights Imaging"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jacc.2019.11.049","article-title":"Global Longitudinal Strain and Cardiac Events in Patients with Immune Checkpoint Inhibitor-Related Myocarditis","volume":"75","author":"Awadalla","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jacc.2021.01.050","article-title":"Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients with Immune Checkpoint Inhibitor-Associated Myocarditis","volume":"77","author":"Thavendiranathan","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.acvd.2021.12.001","article-title":"18F-fluorodeoxyglucose positron emission tomography\/computed tomography imaging for the diagnosis of immune checkpoint inhibitor-associated myocarditis","volume":"15","author":"Ederhy","year":"2022","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1148\/rg.23si035504","article-title":"CT and MR imaging of pericardial disease","volume":"23","author":"Wang","year":"2003","journal-title":"Radiographics"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12968-017-0389-8","article-title":"Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)","volume":"19","author":"Messroghli","year":"2017","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMoa2107038","article-title":"Empagliflozin in Heart Failure with a Preserved Ejection Fraction","volume":"385","author":"Anker","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jchf.2021.11.006","article-title":"Baseline Characteristics of Patients with HF with Mildly Reduced and Preserved Ejection Fraction: DELIVER Trial","volume":"10","author":"Solomon","year":"2022","journal-title":"JACC Heart Fail."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s11912-023-01445-x","article-title":"Cardiac Arrhythmias in Oncological Patients-Epidemiology, Risk Factors, and Management within the Context of the New ESC 2022 Guidelines","volume":"25","author":"Gawlik","year":"2023","journal-title":"Curr. Oncol. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e005443","DOI":"10.1161\/CIRCEP.117.005443","article-title":"Cancer Treatment-Induced Arrhythmias: Focus on Chemotherapy and Targeted Therapies","volume":"10","author":"Buza","year":"2017","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_84","first-page":"17","article-title":"Anthracycline cardiotoxicity: Current methods of diagnosis and possible role of18F-FDG PET\/CT as a new biomarker","volume":"9","author":"Becker","year":"2023","journal-title":"Cardiooncology"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/10\/2103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:10:14Z","timestamp":1760130614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/10\/2103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":84,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["life13102103"],"URL":"https:\/\/doi.org\/10.3390\/life13102103","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]}}}