{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:06:45Z","timestamp":1788448005994,"version":"build-2803163510"},"reference-count":16,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Collision tumors, although rare, characterized by two distinctive (morphological, as well immunohistochemical) and spatially independent tumor components at the same location, are always puzzling for clinicians, pathologists, and patients because they do not fit into the usual approaches, being neither diagnostic nor therapeutic. Reviewing the specialized literature, to date, collision tumors have been reported in multiple locations such as the skin, esophagus, stomach, intestine, liver, kidney, bladder, adrenal gland, or thyroid. We report a case of coexistence at the same site of a malignant tumor of the ascending colon and a benign tumor emerging from the peritoneal lining, initially thought by the surgeon to be right-sided serosal carcinomatosis. But histopathological examination reveals that those multiple serosal nodules were benign granular cell tumors that have collided with highly aggressive transparietal signet-ring colon carcinoma. These results put the patient\u2019s prognosis and therapeutic strategy in a different light than the clinical and intraoperative evaluation.<\/jats:p>","DOI":"10.3390\/life13122263","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:33:56Z","timestamp":1701056036000},"page":"2263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Collision Tumors of the Colon and Peritoneum: Signet-Ring Cell Carcinoma and Granular Cell Tumor"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-4917","authenticated-orcid":false,"given":"Dorela-Codruta","family":"Lazureanu","sequence":"first","affiliation":[{"name":"Microscopic Morphology Department-Morphopathology, ANAPATMOL Research Centre, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Pathology Department, \u201cPius Brinzeu\u201d Emergency County Clinical Hospital Timisoara, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Anderco","sequence":"additional","affiliation":[{"name":"Pathology Department, \u201cPius Brinzeu\u201d Emergency County Clinical Hospital Timisoara, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Dema","sequence":"additional","affiliation":[{"name":"Radiotherapy Department, Emergency City Clinical Hospital Timisoara, 300079 Timi\u0219oara, Romania"},{"name":"Oncology Department, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-795X","authenticated-orcid":false,"given":"Aura","family":"Jurescu","sequence":"additional","affiliation":[{"name":"Microscopic Morphology Department-Morphopathology, ANAPATMOL Research Centre, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus","family":"Cornea","sequence":"additional","affiliation":[{"name":"Microscopic Morphology Department-Morphopathology, ANAPATMOL Research Centre, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Pathology Department, \u201cPius Brinzeu\u201d Emergency County Clinical Hospital Timisoara, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-9437","authenticated-orcid":false,"given":"Octavia","family":"Vita","sequence":"additional","affiliation":[{"name":"Microscopic Morphology Department-Morphopathology, ANAPATMOL Research Centre, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Tunescu","sequence":"additional","affiliation":[{"name":"Polytrauma Department, \u201cPius Brinzeu\u201d Emergency County Clinical Hospital Timisoara, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina","family":"Taban","sequence":"additional","affiliation":[{"name":"Microscopic Morphology Department-Morphopathology, ANAPATMOL Research Centre, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Pathology Department, \u201cPius Brinzeu\u201d Emergency County Clinical Hospital Timisoara, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"ref_1","first-page":"1206","article-title":"Collision tumor of the esophagus: Report of a case with mixed squamous cell carcinoma and gastrointestinal stromal tumor","volume":"7","author":"Qian","year":"2014","journal-title":"Int. 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Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.21037\/tcr.2018.07.14","article-title":"Prognosis and efficiency of adjuvant therapy in resected colon signet-ring cell carcinoma","volume":"7","author":"Sun","year":"2018","journal-title":"Transl. Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"14126","DOI":"10.1038\/s41598-020-70985-0","article-title":"The value of adjuvant chemotherapy in stage II\/III colorectal signet ring cell carcinoma","volume":"10","author":"Zhao","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ijc.28981","article-title":"Colorectal signet-ring cell carcinoma: Benefit from adjuvant chemotherapy but a poor prognostic factor","volume":"136","author":"Hugen","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.21873\/anticanres.14742","article-title":"Stage III and Metastatic Lymph Node Ratio Are the only Independent Prognostic Factors in Colorectal Signet-ring Cell Carcinoma Patients","volume":"40","author":"Alfredo","year":"2020","journal-title":"Anticancer Res. Dec."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/12\/2263\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:31:09Z","timestamp":1760131869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/12\/2263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":16,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["life13122263"],"URL":"https:\/\/doi.org\/10.3390\/life13122263","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]}}}