{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:53:01Z","timestamp":1792007581202,"version":"4.4.0"},"reference-count":55,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive optical imaging technique based on a combination of the principles of optical coherence tomography and reflectance confocal microscopy with line-field illumination, which can generate cell-resolved images of the skin in vivo. This article reports on the LC-OCT technique and its application in dermatology. The principle of the technique is described, and the latest technological innovations are presented. The technology has been miniaturized to fit within an ergonomic handheld probe, allowing for the easy access of any skin area on the body. The performance of the LC-OCT device in terms of resolution, field of view, and acquisition speed is reported. The use of LC-OCT in dermatology for the non-invasive detection, characterization, and therapeutic follow-up of various skin pathologies is discussed. Benign and malignant melanocytic lesions, non-melanocytic skin tumors, such as basal cell carcinoma, squamous cell carcinoma and actinic keratosis, and inflammatory and infectious skin conditions are considered. Dedicated deep learning algorithms have been developed for assisting in the analysis of LC-OCT images of skin lesions.<\/jats:p>","DOI":"10.3390\/life13122268","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T06:45:35Z","timestamp":1701153935000},"page":"2268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3451-4230","authenticated-orcid":false,"given":"Flora","family":"Latriglia","sequence":"first","affiliation":[{"name":"DAMAE Medical, 75013 Paris, France"},{"name":"Laboratoire Charles Fabry, Centre National de la Recherche Scientifique, Institut d\u2019Optique Graduate School, Universit\u00e9 Paris-Saclay, 91127 Palaiseau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-4531","authenticated-orcid":false,"given":"Jonas","family":"Ogien","sequence":"additional","affiliation":[{"name":"DAMAE Medical, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Tavernier","sequence":"additional","affiliation":[{"name":"DAMAE Medical, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Fischman","sequence":"additional","affiliation":[{"name":"DAMAE Medical, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), 1070 Anderlecht, Belgium"},{"name":"Department of Dermatology, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), 1070 Anderlecht, Belgium"},{"name":"Groupe d\u2019Imagerie Cutan\u00e9e Non Invasive (GICNI) of the Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie (SFD), 75008 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-9961","authenticated-orcid":false,"given":"Jean-Luc","family":"Perrot","sequence":"additional","affiliation":[{"name":"Groupe d\u2019Imagerie Cutan\u00e9e Non Invasive (GICNI) of the Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie (SFD), 75008 Paris, France"},{"name":"University Hospital of Saint-Etienne, 42100 Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Dubois","sequence":"additional","affiliation":[{"name":"DAMAE Medical, 75013 Paris, France"},{"name":"Laboratoire Charles Fabry, Centre National de la Recherche Scientifique, Institut d\u2019Optique Graduate School, Universit\u00e9 Paris-Saclay, 91127 Palaiseau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5826\/dpc.0702a01","article-title":"Epidemiological trends in skin cancer","volume":"7","author":"Apalla","year":"2017","journal-title":"Dermatol. 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