{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:12:52Z","timestamp":1789517572517,"version":"build-2803163510"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The ability of Heteroctenus junceus scorpion venom to modulate the concentration of cytokines related to its antitumoral effect is unknown. F3II cells were treated with \u00bc IC50, \u00bd IC50 and the IC50 of H. junceus scorpion venom. Tumor growth kinetics in F3II-bearing mice were evaluated after 24 days of oral administration of venom doses. The effect of tumor lysates on F3II cell viability was evaluated by MTT assay, while cytokines present in each sample were determined by ELISA. In supernatant, H. junceus scorpion venom decreased the concentration of IL-6 (p &lt; 0.001), IFN-\u03b3 (p &lt; 0.001), IL-1\u03b2 (p &lt; 0.01); meanwhile IL-12 (p &lt; 0.001) and TNF-\u03b1 (p &lt; 0.001) levels increased significantly, according to the concentration and the time of incubation. Heteroctenus junceus scorpion venom effectively inhibits in vivo tumor progression. In the sera, a significant decrease was observed in TNF-\u03b1 levels (p &lt; 0.05). In tumor lysates, IL-6 decreased significantly in the groups treated with 12.5 mg\/kg (p &lt; 0.001) and 25 mg\/kg (p &lt; 0.05). Heteroctenus junceus scorpion venom is capable of modulating other proinflammatory and protumoral cytokines involved in the inflammation associated with cancer.<\/jats:p>","DOI":"10.3390\/life13122287","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:44:42Z","timestamp":1701330282000},"page":"2287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Heteroctenus junceus Scorpion Venom Modulates the Concentration of Pro-Inflammatory Cytokines in F3II Tumor Cells"],"prefix":"10.3390","volume":"13","author":[{"given":"Arianna","family":"Yglesias-Rivera","sequence":"first","affiliation":[{"name":"Research Department, Laboratories of Biopharmaceutical and Chemistry Productions (LABIOFAM), Ave. Independencia Km 16 1\/2, Santiago de las Vegas, Boyeros, La Habana 10800, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermis","family":"S\u00e1nchez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Microbiology Department, Institute of Tropical Medicine \u201cPedro Kouri\u201d, Autopista Novia del Mediod\u00eda Km 6 1\/2, La Lisa, La Habana 17100, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-8740","authenticated-orcid":false,"given":"Carmen","family":"Soto-Febles","sequence":"additional","affiliation":[{"name":"Center for Protein Studies, Biology Faculty, University of Havana, Calle 25 Entre J e I, # 455, Plaza de la Revoluci\u00f3n, La Habana 10400, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1958-809X","authenticated-orcid":false,"given":"Lianet","family":"Monzote","sequence":"additional","affiliation":[{"name":"Microbiology Department, Institute of Tropical Medicine \u201cPedro Kouri\u201d, Autopista Novia del Mediod\u00eda Km 6 1\/2, La Lisa, La Habana 17100, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. 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