{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:16:01Z","timestamp":1780640161208,"version":"3.54.1"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>According to the available ethnobotanical data, the Bouvardia ternifolia plant has long been used in Mexican traditional medicine to relieve the symptoms of inflammation. In the present study, the cytotoxic effect of extracts obtained from the flowers, leaves and stems of B. ternifolia using hexane, ethyl acetate (AcOEt) and methanol (MeOH) was evaluated by applying them to the SiHa and MDA-MB-231 cancer cell lines. An MTT reduction assay was carried out along with = biological activity assessments, and the content of total phenols, tannins, anthocyanins, betalains and saponins was quantified. According to the obtained results, nine extracts exhibited a cytotoxic effect against both the SiHa and MDA lines. The highest cytotoxicity was measured for leaves treated with the AcOEt (ID50 of 75 \u00b5g\/mL was obtained for MDA and 58.75 \u00b5g\/mL for SiHa) as well as inhibition on ABTS\u2022+ against DPPH\u2022 radical, while MeOH treatment of stems and AcOEt of flowers yielded the most significant antioxidant capacity (90.29% and 90.11% ABTS\u2022+ radical trapping). Moreover, the highest phenolic compound content was measured in the stems (134.971 \u00b1 0.294 mg EAG\/g), while tannins were more abundant in the leaves (257.646 mg eq cat\/g) and saponins were most prevalent in the flowers (20 \u00b1 0 HU\/mg). Screening tests indicated the presence of flavonoids, steroids, terpenes and coumarins, as well as ursolic acid, in all the studied extracts. These results demonstrate the biological potential of B. ternifolia.<\/jats:p>","DOI":"10.3390\/life13122319","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T06:56:00Z","timestamp":1702277760000},"page":"2319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antioxidant Activity and Anticarcinogenic Effect of Extracts from Bouvardia ternifolia (Cav.) Schltdl."],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-4113","authenticated-orcid":false,"given":"Carmen","family":"Valadez-Vega","sequence":"first","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Ex-Hacienda de la Concepci\u00f3n, Tilcuautla, San Agust\u00edn Tlaxiaca 42080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9545-6104","authenticated-orcid":false,"given":"Olivia","family":"Lugo-Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Preparatoria N\u00famero 1, Universidad Aut\u00f3noma del Estado de Hidalgo, Av. Benito Ju\u00e1rez S\/N, Constituci\u00f3n, Pachuca de Soto 42060, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Mendoza-Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Ex-Hacienda de la Concepci\u00f3n, Tilcuautla, San Agust\u00edn Tlaxiaca 42080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Villag\u00f3mez-Ibarra","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Qu\u00edmica, Instituto de Ciencias B\u00e1sicas e Ingenier\u00eda, Universidad Aut\u00f3noma del Estado del Hidalgo, Ciudad del Conocimiento, Mineral de la Reforma 42184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Velasco-Azorsa","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Biolog\u00eda, Instituto de Ciencias B\u00e1sicas e Ingenier\u00eda, Universidad Aut\u00f3noma del Estado del Hidalgo, Ciudad del Conocimiento, Mineral de la Reforma 42184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-270X","authenticated-orcid":false,"given":"Mirandeli","family":"Bautista","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Farmacia, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Ex-Hacienda de la Concepci\u00f3n, Tilcuautla, San Agust\u00edn Tlaxiaca 42080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-6904","authenticated-orcid":false,"given":"Gabriel","family":"Betanzos-Cabrera","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Nutrici\u00f3n, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Ex-Hacienda de la Concepci\u00f3n, Tilcuautla, San Agust\u00edn Tlaxiaca 42080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-0980","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Morales-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, M\u00e9xico, Plan de San Luis y D\u00edaz Mir\u00f3n, Col. Casco de Santo Tom\u00e1s, Del. Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-4598","authenticated-orcid":false,"given":"Eduardo Osiris","family":"Madrigal-Santill\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, M\u00e9xico, Plan de San Luis y D\u00edaz Mir\u00f3n, Col. Casco de Santo Tom\u00e1s, Del. Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.phytochem.2012.06.012","article-title":"Sterols with Antileishmanial Activity Isolated from the Roots of Pentalinon Andrieuxii","volume":"82","author":"Pan","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_2","unstructured":"Guzm\u00e1n Maldonado, S.H., Diaz Huacuz, R.S., and Gonz\u00e1lez Chavira, M.M. (2023, November 20). Plantas Medicinales La Realidad de Una Tradicion Ancestral. 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