{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:46:12Z","timestamp":1760150772842,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Atypical polypoid adenomyoma (APAM) is a rare polypoid benign tumor of the uterus that causes irregular vaginal bleeding in women of reproductive age. It has the potential for malignant transformation, but it does not metastasize. APAM may coexist with endometrial hyperplasia and adenocarcinoma, usually leading to misdiagnosis. Histopathologically, it is a biphasic tumor, represented by the endometrioid glands with a complex histoarchitecture, with sometimes squamous morular metaplasia or cytologic atypia, interspersed with a fibromyomatous stroma. This tumor has a high incidence of recurrence. We present a very rare case of a 21-year-old patient, a virgin, without a significant medical history, with a bleeding mass occupying the vagina. The mass was excised using forceps, scissors, and a suture of the visible pedicle. After a four-year follow-up and no additional medical treatment, no relapse was observed. Given the risk of recurrence and progression, APAM might be treated via a hysterectomy in patients with no desire for pregnancy. Due to a lower recurrence rate, the conservative treatment of atypical polypoid adenomyoma performed via an operative hysteroscopy represents the best choice. Previously diagnosed in hysterectomy specimens, with the introduction of better-performing indirect imaging techniques, adenomyosis is a clinical entity that has the possibility of being diagnosed in the presurgical stage.<\/jats:p>","DOI":"10.3390\/life13122352","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T05:41:35Z","timestamp":1702878095000},"page":"2352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prolapsed Atypical Polypoid Adenomyoma\u2014A Case Report and Literature Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6524-145X","authenticated-orcid":false,"given":"Tudor","family":"Butureanu","sequence":"first","affiliation":[{"name":"Department of Mother and Child, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cElena Doamna\u201d University Hospital of Obstetrics and Gynecology, 49, Elena Doamna St., 700398 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Maria","family":"Haliciu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cElena Doamna\u201d University Hospital of Obstetrics and Gynecology, 49, Elena Doamna St., 700398 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Maria","family":"Apetrei","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cElena Doamna\u201d University Hospital of Obstetrics and Gynecology, 49, Elena Doamna St., 700398 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-9483","authenticated-orcid":false,"given":"Ioana","family":"Pavaleanu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cElena Doamna\u201d University Hospital of Obstetrics and Gynecology, 49, Elena Doamna St., 700398 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razvan Vladimir","family":"Socolov","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cElena Doamna\u201d University Hospital of Obstetrics and Gynecology, 49, Elena Doamna St., 700398 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2875-8991","authenticated-orcid":false,"given":"Raluca Anca","family":"Balan","sequence":"additional","affiliation":[{"name":"\u201cElena Doamna\u201d University Hospital of Obstetrics and Gynecology, 49, Elena Doamna St., 700398 Iasi, Romania"},{"name":"Department of Morpho-Functional Sciences I, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1038\/modpathol.2015.137","article-title":"A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus","volume":"29","author":"McCluggage","year":"2016","journal-title":"Mod. Pathol."},{"key":"ref_2","unstructured":"Kim, K.-R., Lax, S.F., Lazar, A.J., Longacre, T.A., Malpica, A., Matias-Guiu, X., Nucci, M.R., and Oliva, E. (2020). WHO Classification of Tumours Editorial Board. WHO Classification of Tumours. Female Genital Tumours, IARC. [5th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/aogs.13553","article-title":"Management of women with atypical polypoid adenomyoma of the uterus: A quantitative systematic review","volume":"98","author":"Raffone","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.29271\/jcpsp.2021.06.719","article-title":"Atypical Polypoid Adenomyoma (APAM)","volume":"31","author":"Javed","year":"2021","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/ijgc-2020-001886","article-title":"Atypical polypoid adenomyoma 2","volume":"31","author":"Grindstaff","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e20491","DOI":"10.1097\/MD.0000000000020491","article-title":"Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis","volume":"99","author":"Biasioli","year":"2020","journal-title":"Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Qi, H., Zhou, C., Huang, Z., Yang, N., and Wu, Q. (2022). Value of Transabdominal Combined Transvaginal Color Doppler Ultrasonography in the Distinguish between Uterine Adenomyoma and Uterine Fibroids. BioMed Res. 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Oncol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/12\/2352\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:39:51Z","timestamp":1760132391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/13\/12\/2352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["life13122352"],"URL":"https:\/\/doi.org\/10.3390\/life13122352","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2023,12,15]]}}}