{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:23:12Z","timestamp":1774045392393,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research University Higher School of Economics (HSE University)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Transspinal direct current stimulation (tsDCS) is a non-invasive technique used to modulate spinal cord activity. However, the effects and mechanisms of this stimulation are currently not comprehensively known. This study aimed to estimate the effect of different intensities of tsDCS applied at the level of cervical enlargement of the spinal cord (C7-Th1 segments) on the excitability of the corticospinal system (CSS) and the correction of motor skills in healthy subjects. The effect of tsDCS was estimated by the motor-evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) in the primary motor cortex (M1). The study involved 54 healthy adults aged 22 \u00b1 4 years. The application of 11 min anodal tsDCS at the level of the cervical spine C7-Th1 with a current intensity of 2.5 mA did not change the MEP amplitude of the upper limb muscles, in contrast to the data that we previously obtained with a current intensity of 1.5 mA. We also found no difference in the effect of 2.5 mA stimulation on motor skill correction in healthy subjects in the nine-hole peg test (9-HPT) and the serial reaction time task (SRT) as with 1.5 mA stimulation. Our data show that an increase in the intensity of stimulation does not lead to an increase in the effects but rather reduces the effects of stimulation. These results provide information about the optimally appropriate stimulation current intensities to induce CSS excitability and the ability of tsDCS to influence motor skills in healthy adults.<\/jats:p>","DOI":"10.3390\/life13122353","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T05:41:35Z","timestamp":1702878095000},"page":"2353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transspinal Direct Current Electrical Stimulation Selectively Affects the Excitability of the Corticospinal System, Depending on the Intensity but Not Motor Skills"],"prefix":"10.3390","volume":"13","author":[{"given":"Alena","family":"Popyvanova","sequence":"first","affiliation":[{"name":"Centre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, 101000 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-0221","authenticated-orcid":false,"given":"Ekaterina","family":"Pomelova","sequence":"additional","affiliation":[{"name":"Centre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, 101000 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Bredikhin","sequence":"additional","affiliation":[{"name":"Centre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, 101000 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Koriakina","sequence":"additional","affiliation":[{"name":"Centre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, 101000 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Shestakova","sequence":"additional","affiliation":[{"name":"Centre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, 101000 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-6633","authenticated-orcid":false,"given":"Evgeny","family":"Blagovechtchenski","sequence":"additional","affiliation":[{"name":"Centre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, 101000 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/1073858404270843","article-title":"The Corticospinal System: From Development to Motor Control","volume":"11","author":"Martin","year":"2005","journal-title":"Neuroscientist"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.clinph.2008.07.249","article-title":"Effect of Spinal Transcutaneous Direct Current Stimulation on Somatosensory Evoked Potentials in Humans","volume":"119","author":"Cogiamanian","year":"2008","journal-title":"Clin. 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