{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:25:26Z","timestamp":1790947526987,"version":"4.1.0"},"reference-count":253,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["2020-21201280"],"award-info":[{"award-number":["2020-21201280"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["DIRGI-CP2022-005"],"award-info":[{"award-number":["DIRGI-CP2022-005"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["12249"],"award-info":[{"award-number":["12249"]}]},{"name":"Programa de Becas\/Doctorado Nacional\/Government of Chile","award":["2020-21201280"],"award-info":[{"award-number":["2020-21201280"]}]},{"name":"Programa de Becas\/Doctorado Nacional\/Government of Chile","award":["DIRGI-CP2022-005"],"award-info":[{"award-number":["DIRGI-CP2022-005"]}]},{"name":"Programa de Becas\/Doctorado Nacional\/Government of Chile","award":["12249"],"award-info":[{"award-number":["12249"]}]},{"name":"National Institute for Agricultural and Veterinary Research (INIAV, Portugal)\/Ministerio de Economia y Finanzas\/Universidad T\u00e9cnica de Cotopaxi (UTC)\/Proyectos Generativos\/Government of Ecuador","award":["2020-21201280"],"award-info":[{"award-number":["2020-21201280"]}]},{"name":"National Institute for Agricultural and Veterinary Research (INIAV, Portugal)\/Ministerio de Economia y Finanzas\/Universidad T\u00e9cnica de Cotopaxi (UTC)\/Proyectos Generativos\/Government of Ecuador","award":["DIRGI-CP2022-005"],"award-info":[{"award-number":["DIRGI-CP2022-005"]}]},{"name":"National Institute for Agricultural and Veterinary Research (INIAV, Portugal)\/Ministerio de Economia y Finanzas\/Universidad T\u00e9cnica de Cotopaxi (UTC)\/Proyectos Generativos\/Government of Ecuador","award":["12249"],"award-info":[{"award-number":["12249"]}]},{"name":"COCIBA Funds","award":["2020-21201280"],"award-info":[{"award-number":["2020-21201280"]}]},{"name":"COCIBA Funds","award":["DIRGI-CP2022-005"],"award-info":[{"award-number":["DIRGI-CP2022-005"]}]},{"name":"COCIBA Funds","award":["12249"],"award-info":[{"award-number":["12249"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This review aims to explore advanced reproductive technologies for male fertility preservation, underscoring the essential role that animal models have played in shaping these techniques through historical contexts and into modern applications. Rising infertility concerns have become more prevalent in human populations recently. The surge in male fertility issues has prompted advanced reproductive technologies, with animal models playing a pivotal role in their evolution. Historically, animal models have aided our understanding in the field, from early reproductive basic research to developing techniques like artificial insemination, multiple ovulation, and in vitro fertilization. The contemporary landscape of male fertility preservation encompasses techniques such as sperm cryopreservation, testicular sperm extraction, and intracytoplasmic sperm injection, among others. The relevance of animal models will undoubtedly bridge the gap between traditional methods and revolutionary next-generation reproductive techniques, fortifying our collective efforts in enhancing male fertility preservation strategies. While we possess extensive knowledge about spermatogenesis and its regulation, largely thanks to insights from animal models that paved the way for human infertility treatments, a pressing need remains to further understand specific infertility issues unique to humans. The primary aim of this review is to provide a comprehensive analysis of how animal models have influenced the development and refinement of advanced reproductive technologies for male fertility preservation, and to assess their future potential in bridging the gap between current practices and cutting-edge fertility techniques, particularly in addressing unique human male factor infertility.<\/jats:p>","DOI":"10.3390\/life14010017","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T05:36:12Z","timestamp":1703136972000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bridging the Gap: Animal Models in Next-Generation Reproductive Technologies for Male Fertility Preservation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-1672","authenticated-orcid":false,"given":"Pedro M.","family":"Aponte","sequence":"first","affiliation":[{"name":"Colegio de Ciencias Biol\u00f3gicas y Ambientales (COCIBA), Universidad San Francisco de Quito (USFQ), Quito 170901, Ecuador"},{"name":"Instituto de Investigaciones en Biomedicina \u201cOne-Health\u201d, Universidad San Francisco de Quito (USFQ), Campus Cumbay\u00e1, Quito 170901, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Gutierrez-Reinoso","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Agropecuarias y Recursos Naturales, Carrera de Medicina Veterinaria, Universidad T\u00e9cnica de Cotopaxi (UTC), Latacunga 050150, Ecuador"},{"name":"Laboratorio de Biotecnolog\u00eda Animal, Departamento de Ciencia Animal, Facultad de Ciencias Veterinarias, Universidad de Concepci\u00f3n (UdeC), Chill\u00e1n 3780000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-6689","authenticated-orcid":false,"given":"Manuel","family":"Garcia-Herreros","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria (INIAV), 2005-048 Santar\u00e9m, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/pathophysiology28040030","article-title":"Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation","volume":"28","author":"Chereshnev","year":"2021","journal-title":"Pathophysiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.6061\/clinics\/2013(Sup01)09","article-title":"Hypogonadotropic Hypogonadism Revisited","volume":"68","author":"Fraietta","year":"2013","journal-title":"Clinics"},{"key":"ref_3","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. 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