{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:24:30Z","timestamp":1789759470008,"version":"4.0.1"},"reference-count":343,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitalization in Romania","award":["PCE43\/2021"],"award-info":[{"award-number":["PCE43\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The skin\u2019s recognised functions may undergo physiological alterations due to ageing, manifesting as varying degrees of facial wrinkles, diminished tautness, density, and volume. Additionally, these functions can be disrupted (patho)physiologically through various physical and chemical injuries, including surgical trauma, accidents, or chronic conditions like ulcers associated with diabetes mellitus, venous insufficiency, or obesity. Advancements in therapeutic interventions that boost the skin\u2019s innate regenerative abilities could significantly enhance patient care protocols. The application of Platelet-Rich Plasma (PRP) is widely recognized for its aesthetic and functional benefits to the skin. Yet, the endorsement of PRP\u2019s advantages often borders on the dogmatic, with its efficacy commonly ascribed solely to the activation of fibroblasts by the factors contained within platelet granules. PRP therapy is a cornerstone of regenerative medicine which involves the autologous delivery of conditioned plasma enriched by platelets. This is achieved by centrifugation, removing erythrocytes while retaining platelets and their granules. Despite its widespread use, the precise sequences of cellular activation, the specific cellular players, and the molecular machinery that drive PRP-facilitated healing are still enigmatic. There is still a paucity of definitive and robust studies elucidating these mechanisms. In recent years, telocytes (TCs)\u2014a unique dermal cell population\u2014have shown promising potential for tissue regeneration in various organs, including the dermis. TCs\u2019 participation in neo-angiogenesis, akin to that attributed to PRP, and their role in tissue remodelling and repair processes within the interstitia of several organs (including the dermis), offer intriguing insights. Their potential to contribute to, or possibly orchestrate, the skin regeneration process following PRP treatment has elicited considerable interest. Therefore, pursuing a comprehensive understanding of the cellular and molecular mechanisms at work, particularly those involving TCs, their temporal involvement in structural recovery following injury, and the interconnected biological events in skin wound healing and regeneration represents a compelling field of study.<\/jats:p>","DOI":"10.3390\/life14010040","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T23:00:12Z","timestamp":1703545212000},"page":"40","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4580-104X","authenticated-orcid":false,"given":"Catalin G.","family":"Manole","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Biology and Histology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Ultrastructural Pathology Laboratory, \u201cVictor Babe\u0219\u201d National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-7204","authenticated-orcid":false,"given":"Cristina","family":"Soare","sequence":"additional","affiliation":[{"name":"Department of Oncological Dermatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Cristina","family":"Ceafalan","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology and Histology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Cell Biology, Neurosciences and Experimental Myology Laboratory, \u201cVictor Babe\u0219\u201d National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad M.","family":"Voiculescu","sequence":"additional","affiliation":[{"name":"Department of Oncological Dermatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41587-019-0079-1","article-title":"Toward a New Generation of Smart Skins","volume":"37","author":"Someya","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref_2","first-page":"4183","article-title":"Synthesis and Physiological Implications of Melanic Pigments (Review)","volume":"17","author":"Maranduca","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000454919","article-title":"Skin Wound Healing: An Update on the Current Knowledge and Concepts","volume":"58","author":"Sorg","year":"2017","journal-title":"Eur. Surg. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"xxi","DOI":"10.1046\/j.1523-1747.2003.12575.x","article-title":"Fibrin Is a Many Splendored Thing","volume":"121","author":"Clark","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound Healing: A Cellular Perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/wound.2012.0383","article-title":"Neutrophils and Wound Repair: Positive Actions and Negative Reactions","volume":"2","author":"Wilgus","year":"2013","journal-title":"Adv. Wound Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0002-9610(03)00296-4","article-title":"Understanding the Role of Immune Regulation in Wound Healing","volume":"187","author":"Park","year":"2004","journal-title":"Am. J. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1017\/S1462399411001943","article-title":"Inflammation and Wound Healing: The Role of the Macrophage","volume":"13","author":"Koh","year":"2011","journal-title":"Expert. Rev. Mol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ni.2705","article-title":"Tissue-Resident Macrophages","volume":"14","author":"Davies","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2011.07.001","article-title":"Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises","volume":"21","author":"Armulik","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/exd.12782","article-title":"Pericytes in Wound Healing: Friend or Foe?","volume":"24","author":"Ansell","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of Putative Progenitor Endothelial Cells for Angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nm1075","article-title":"Progenitor Cell Trafficking Is Regulated by Hypoxic Gradients through HIF-1 Induction of SDF-1","volume":"10","author":"Ceradini","year":"2004","journal-title":"Nat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/ten.tea.2015.0277","article-title":"Adipose-Derived Stem Cell-Seeded Hydrogels Increase Endogenous Progenitor Cell Recruitment and Neovascularization in Wounds","volume":"22","author":"Kosaraju","year":"2016","journal-title":"Tissue Eng. Part. A"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.jid.5700786","article-title":"Keratinocyte\u2013Fibroblast Interactions in Wound Healing","volume":"127","author":"Werner","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ncb3532","article-title":"Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties","volume":"19","author":"Donati","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cell.2007.01.014","article-title":"Epithelial Stem Cells: Turning over New Leaves","volume":"128","author":"Blanpain","year":"2007","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound Healing--Aiming for Perfect Skin Regeneration","volume":"276","author":"Martin","year":"1997","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"eade7007","DOI":"10.1126\/sciadv.ade7007","article-title":"Breakthrough Treatments for Accelerated Wound Healing","volume":"9","author":"Freedman","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gushiken, L.F.S., Beserra, F.P., Bastos, J.K., Jackson, C.J., and Pellizzon, C.H. (2021). Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies. Life, 11.","DOI":"10.3390\/life11070665"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/wrr.12384","article-title":"Rapid Identification of Slow Healing Wounds","volume":"24","author":"Jung","year":"2016","journal-title":"Wound Repair Regen."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s12026-011-8261-7","article-title":"Immunomodulation at Epithelial Sites by Obesity and Metabolic Disease","volume":"52","author":"Cheung","year":"2012","journal-title":"Immunol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1233800","DOI":"10.3389\/fimmu.2023.1233800","article-title":"Fibroblasts\u2014The Cellular Choreographers of Wound Healing","volume":"14","author":"Knoedler","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"C1545","DOI":"10.1152\/ajpcell.00254.2023","article-title":"Fibrosis in Burns: An Overview of Mechanisms and Therapies","volume":"325","author":"Faour","year":"2023","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.jbiomech.2014.03.031","article-title":"Mechanotransduction and Fibrosis","volume":"47","author":"Duscher","year":"2014","journal-title":"J. Biomech."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal Adhesion Kinase Links Mechanical Force to Skin Fibrosis via Inflammatory Signaling","volume":"18","author":"Wong","year":"2012","journal-title":"Nat. Med."},{"key":"ref_28","first-page":"3024","article-title":"Effects of Autologous Platelet-rich Plasma Injections on Facial Skin Rejuvenation","volume":"19","author":"Du","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_29","first-page":"e156344","article-title":"UVB-Mediated DNA Damage Induces Matrix Metalloproteinases to Promote Photoaging in an AhR- and SP1-Dependent Manner","volume":"7","author":"Kim","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Everts, P., Onishi, K., Jayaram, P., Lana, J.F., and Mautner, K. (2020). Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int. J. Mol. Sci., 21.","DOI":"10.20944\/preprints202010.0069.v1"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1234263","DOI":"10.1155\/2019\/1234263","article-title":"Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations","volume":"2019","author":"Hersant","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_32","first-page":"125","article-title":"Comparative Study on the Effect of Injectable Platelet Rich Plasma versus Its Topical Application in the Treatment of Thermal Burn in Adult Male Albino Rat: Histological and Immunohistochemical Study","volume":"45","author":"Morgan","year":"2021","journal-title":"Egypt. J. Histol."},{"key":"ref_33","first-page":"453","article-title":"Platelet Rich Plasma\u2014A New Biotechnology for Treatment of Sports Injuries","volume":"150","author":"Laver","year":"2011","journal-title":"Harefuah"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1160\/THS10-11-0720","article-title":"Platelets, Inflammation and Tissue Regeneration","volume":"105","author":"Nurden","year":"2011","journal-title":"Thromb. Haemost."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S1079-2104(98)90029-4","article-title":"Platelet-Rich Plasma","volume":"85","author":"Marx","year":"1998","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1941738110366385","article-title":"Platelet-Rich Plasma: Where Are We Now and Where Are We Going?","volume":"2","author":"Cole","year":"2010","journal-title":"Sports Health A Multidiscip. Approach"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1182\/asheducation-2010.1.387","article-title":"Understanding and Evaluating Platelet Function","volume":"2010","author":"Brass","year":"2010","journal-title":"Hematology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00008505-200110000-00002","article-title":"Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP?","volume":"10","author":"Marx","year":"2001","journal-title":"Implant. Dent."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1097\/01.PRS.0000138251.07040.51","article-title":"Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing","volume":"114","author":"Eppley","year":"2004","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1524-475X.2002.10510.x","article-title":"Fibroblast Proliferation Due to Exposure to a Platelet Concentrate in Vitro Is PH Dependent","volume":"10","author":"Liu","year":"2002","journal-title":"Wound Repair Regen."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0014-4800(03)00017-0","article-title":"Platelet-Rich Plasma Gel Promotes Differentiation and Regeneration during Equine Wound Healing","volume":"74","author":"Carter","year":"2003","journal-title":"Exp. Mol. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"147e","DOI":"10.1097\/01.prs.0000239606.92676.cf","article-title":"Platelet-Rich Plasma: A Review of Biology and Applications in Plastic Surgery","volume":"118","author":"Eppley","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_43","first-page":"45","article-title":"Effect of Platelet-Rich Plasma on Bone Growth and Osseointegration in Human Maxillary Sinus Grafts: Three Bilateral Case Reports","volume":"22","author":"Froum","year":"2002","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1515\/med-2016-0048","article-title":"Platelet Rich Plasma: A Short Overview of Certain Bioactive Components","volume":"11","author":"Pavlovic","year":"2016","journal-title":"Open Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/ijd.14172","article-title":"Combining Microneedling with Other Minimally Invasive Procedures for Facial Rejuvenation: A Split-face Comparative Study","volume":"57","author":"Hossam","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3324\/haematol.2019.220988","article-title":"Glycoprotein Ib clustering in platelets can be inhibited by \u03b1-linolenic acid as revealed by cryo-electron tomography","volume":"105","author":"Stivala","year":"2020","journal-title":"Haematologica"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5045\/br.2016.51.1.3","article-title":"Platelet-Rich Plasma: A Healing Virtuoso","volume":"51","author":"Jain","year":"2016","journal-title":"Blood Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.joms.2003.12.003","article-title":"Platelet-Rich Plasma: Evidence to Support Its Use","volume":"62","author":"Marx","year":"2004","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid","volume":"219","author":"Senger","year":"1983","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.ijrobp.2003.11.041","article-title":"Review of Epidermal Growth Factor Receptor Biology","volume":"59","author":"Herbst","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Josefsson, E.C., Vainchenker, W., and James, C. (2020). Regulation of Platelet Production and Life Span: Role of Bcl-XL and Potential Implications for Human Platelet Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207591"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41597-022-01852-y","article-title":"A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations","volume":"9","author":"Sturm","year":"2022","journal-title":"Sci. Data"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","article-title":"What Old Means to Bone","volume":"21","author":"Manolagas","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"155560","DOI":"10.1016\/j.cyto.2021.155560","article-title":"The Regenerative Mechanisms of Platelet-Rich Plasma: A Review","volume":"144","author":"Santos","year":"2021","journal-title":"Cytokine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2217932","DOI":"10.1080\/09537104.2023.2217932","article-title":"How Can We Use Proteomics to Learn More about Platelets?","volume":"34","author":"Aslan","year":"2023","journal-title":"Platelets"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2186707","DOI":"10.1080\/09537104.2023.2186707","article-title":"What Can the Plasma Proteome Tell Us about Platelets (and Vice Versa)?","volume":"34","author":"Bruzek","year":"2023","journal-title":"Platelets"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1182\/blood.2020005230","article-title":"MiR-125a-5p Regulates Megakaryocyte Proplatelet Formation via the Actin-Bundling Protein L-Plastin","volume":"136","author":"Bhatlekar","year":"2020","journal-title":"Blood"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/ATVBAHA.122.317559","article-title":"PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte\/Platelet Granule Integrity and Platelet Functions","volume":"42","author":"Caux","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jca.1015","article-title":"CD41+ and CD42+ Hematopoietic Progenitor Cells May Predict Platelet Engraftment after Allogeneic Peripheral Blood Stem Cell Transplantation","volume":"16","author":"Demirer","year":"2001","journal-title":"J. Clin. Apher."},{"key":"ref_60","unstructured":"Machlus, K.R., and Italiano, J.E. (2019). Platelets, Elsevier."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e78662","DOI":"10.7554\/eLife.78662","article-title":"CXCR4high Megakaryocytes Regulate Host-Defense Immunity against Bacterial Pathogens","volume":"11","author":"Wang","year":"2022","journal-title":"Elife"},{"key":"ref_62","unstructured":"Thon, J.N., and Italiano, J.E. (2012). Antiplatelet Agents, Springer."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1182\/blood.V89.7.2336","article-title":"Ultrastructure of Platelet Formation by Human Megakaryocytes Cultured With the Mpl Ligand","volume":"89","author":"Cramer","year":"1997","journal-title":"Blood"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1182\/bloodadvances.2020002843","article-title":"Lung Megakaryocytes Display Distinct Transcriptional and Phenotypic Properties","volume":"4","author":"Yeung","year":"2020","journal-title":"Blood Adv."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"100053","DOI":"10.1016\/j.rpth.2023.100053","article-title":"Megakaryocytes in the Lung: History and Future Perspectives","volume":"7","author":"Livada","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1038\/s41467-023-39598-9","article-title":"Highly Efficient Platelet Generation in Lung Vasculature Reproduced by Microfluidics","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/ATVBAHA.119.312129","article-title":"New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors","volume":"39","author":"Noetzli","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The Incredible Journey: From Megakaryocyte Development to Platelet Formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/09537104.2019.1667497","article-title":"Megakaryocyte Polyploidization: Role in Platelet Production","volume":"31","author":"Vainchenker","year":"2020","journal-title":"Platelets"},{"key":"ref_70","first-page":"3","article-title":"Megakaryopoiesis and Platelet Production: Insight into Hematopoietic Stem Cell Proliferation and Differentiation","volume":"2","author":"Guo","year":"2015","journal-title":"Stem Cell Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2017.10.001","article-title":"Megakaryocyte and Polyploidization","volume":"57","author":"Mazzi","year":"2018","journal-title":"Exp. Hematol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature21706","article-title":"The Lung Is a Site of Platelet Biogenesis and a Reservoir for Haematopoietic Progenitors","volume":"544","author":"Caudrillier","year":"2017","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1182\/blood-2005-07-2755","article-title":"Characterization of the Megakaryocyte Demarcation Membrane System and Its Role in Thrombopoiesis","volume":"107","author":"Schulze","year":"2006","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1182\/blood.V120.21.2300.2300","article-title":"Novel Concept of Platelet Production from Megakaryocyte in Intact Bone Marrow: Proplatelet and Thick Protrusion","volume":"120","author":"Kowata","year":"2012","journal-title":"Blood"},{"key":"ref_75","unstructured":"Heijnen, H.F.G., and Korporaal, S.J.A. (2017). Platelets in Thrombotic and Non-Thrombotic Disorders, Springer International Publishing."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1182\/blood-2014-09-600858","article-title":"Microtubule Sliding Drives Proplatelet Elongation and Is Dependent on Cytoplasmic Dynein","volume":"125","author":"Bender","year":"2015","journal-title":"Blood"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1182\/bloodadvances.2019001303","article-title":"Actin\/Microtubule Crosstalk during Platelet Biogenesis in Mice Is Critically Regulated by Twinfilin1 and Cofilin1","volume":"4","author":"Becker","year":"2020","journal-title":"Blood Adv."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Boscher, J., Guinard, I., Eckly, A., Lanza, F., and L\u00e9on, C. (2020). Blood Platelet Formation at a Glance. J. Cell Sci., 133.","DOI":"10.1242\/jcs.244731"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1083\/jcb.201006102","article-title":"Cytoskeletal Mechanics of Proplatelet Maturation and Platelet Release","volume":"191","author":"Thon","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.str.2021.06.001","article-title":"Super-Resolution Imaging Reveals Cytoskeleton-Dependent Organelle Rearrangement within Platelets at Intermediate Stages of Maturation","volume":"29","author":"Go","year":"2021","journal-title":"Structure"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1182\/bloodadvances.2021006073","article-title":"Analysis of Preplatelets and Their Barbell Platelet Derivatives by Imaging Flow Cytometry","volume":"6","author":"Kemble","year":"2022","journal-title":"Blood Adv."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/09537104.2016.1257786","article-title":"The Cellular Basis of Platelet Secretion: Emerging Structure\/Function Relationships","volume":"28","author":"Yadav","year":"2017","journal-title":"Platelets"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/09537104.2016.1235685","article-title":"Golgi Proteins in Circulating Human Platelets Are Distributed across Non-Stacked, Scattered Structures","volume":"28","author":"Yadav","year":"2017","journal-title":"Platelets"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fcvm.2019.00153","article-title":"Role of Platelet Mitochondria: Life in a Nucleus-Free Zone","volume":"6","author":"Melchinger","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Chaudhary, P.K., Kim, S., and Kim, S. (2023). Shedding Light on the Cell Biology of Platelet-Derived Extracellular Vesicles and Their Biomedical Applications. Life, 13.","DOI":"10.3390\/life13061403"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Soslau, G. (2023). Platelet Protein Synthesis, Regulation, and Post-Translational Modifications: Mechanics and Function. Crit. Rev. Biochem. Mol. Biol., 1\u201319.","DOI":"10.1080\/10409238.2023.2224532"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1538-7836.2008.03211.x","article-title":"Protein Synthesis by Platelets: Historical and New Perspectives","volume":"7","author":"Weyrich","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1021\/acs.biochem.0c00450","article-title":"Post-Translational Modifications of Platelet-Derived Amyloid Precursor Protein by Coagulation Factor XIII-A*","volume":"59","author":"Hur","year":"2020","journal-title":"Biochemistry"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Huang, J., Zhang, P., Solari, F.A., Sickmann, A., Garcia, A., Jurk, K., and Heemskerk, J.W.M. (2021). Molecular Proteomics and Signalling of Human Platelets in Health and Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189860"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1074\/mcp.M114.038513","article-title":"Copy Number Analysis of the Murine Platelet Proteome Spanning the Complete Abundance Range","volume":"13","author":"Zeiler","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.114.301598","article-title":"What Can Proteomics Tell Us About Platelets?","volume":"114","author":"Burkhart","year":"2014","journal-title":"Circ. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2220046","DOI":"10.1080\/09537104.2023.2220046","article-title":"How Can Platelet Proteomics Best Be Used to Interrogate Disease?","volume":"34","author":"Zellner","year":"2023","journal-title":"Platelets"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Potts, K.S., Farley, A., Dawson, C.A., Rimes, J., Biben, C., de Graaf, C., Potts, M.A., Stonehouse, O.J., Carmagnac, A., and Gangatirkar, P. (2020). Membrane Budding Is a Major Mechanism of in Vivo Platelet Biogenesis. J. Exp. Med., 217.","DOI":"10.1084\/jem.20191206"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/rth2.12112","article-title":"Imaging Platelet Biogenesis in Vivo","volume":"2","author":"Schulze","year":"2018","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1182\/blood-2015-08-607929","article-title":"Understanding Platelet Generation from Megakaryocytes: Implications for in Vitro\u2013Derived Platelets","volume":"127","author":"Sim","year":"2016","journal-title":"Blood"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1007\/s00018-020-03749-8","article-title":"Generation and Manipulation of Human IPSC-Derived Platelets","volume":"78","author":"Sugimoto","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Eguren, A., G\u00f3mez-\u00c1lvarez, M., Franc\u00e9s-Herrero, E., Romeu, M., Ferrero, H., Seli, E., and Cervell\u00f3, I. (2022). Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415942"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/cts.12788","article-title":"Good Manufacturing Practice-Grade of Megakaryocytes Produced by a Novel Ex Vivo Culturing Platform","volume":"13","author":"Guan","year":"2020","journal-title":"Clin. Transl. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1186\/s40064-016-2384-1","article-title":"Platelet Generation in Vivo and in Vitro","volume":"5","author":"Wang","year":"2016","journal-title":"Springerplus"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Cuenca-Zamora, E.J., Ferrer-Mar\u00edn, F., Rivera, J., and Teruel-Montoya, R. (2019). Tubulin in Platelets: When the Shape Matters. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143484"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1083\/jcb.147.6.1299","article-title":"Blood Platelets Are Assembled Principally at the Ends of Proplatelet Processes Produced by Differentiated Megakaryocytes","volume":"147","author":"Italiano","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.jtha.2023.01.006","article-title":"Repeated Platelet Activation and the Potential of Previously Activated Platelets to Contribute to Thrombus Formation","volume":"21","author":"Baaten","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1206906","DOI":"10.3389\/fimmu.2023.1206906","article-title":"Platelet Formation and Activation Are Influenced by Neuronal Guidance Proteins","volume":"14","author":"Tang","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2139365","DOI":"10.1080\/09537104.2022.2139365","article-title":"Effects of Platelets Activated by Different Agonists on Fibrin Formation and Thrombin Generation","volume":"34","author":"Muravlev","year":"2023","journal-title":"Platelets"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.3324\/haematol.2019.239111","article-title":"Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation","volume":"106","author":"Bornert","year":"2020","journal-title":"Haematologica"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Van Dijk, J., Bompard, G., Cau, J., Kunishima, S., Rabeharivelo, G., Mateos-Langerak, J., Cazevieille, C., Cavelier, P., Boizet-Bonhoure, B., and Delsert, C. (2018). Microtubule Polyglutamylation and Acetylation Drive Microtubule Dynamics Critical for Platelet Formation. BMC Biol., 16.","DOI":"10.1186\/s12915-018-0584-6"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1016\/j.bpj.2023.07.010","article-title":"Force Generation in Human Blood Platelets by Filamentous Actomyosin Structures","volume":"122","author":"Blumberg","year":"2023","journal-title":"Biophys. J."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Dur\u00e1n-Saenz, N.Z., Serrano-Puente, A., Gallegos-Flores, P.I., Mendoza-Almanza, B.D., Esparza-Ibarra, E.L., Godina-Gonz\u00e1lez, S., Gonz\u00e1lez-Curiel, I.E., Ayala-Luj\u00e1n, J.L., Hern\u00e1ndez-Barrales, M., and Cueto-Villalobos, C.F. (2022). Platelet Membrane: An Outstanding Factor in Cancer Metastasis. Membranes, 12.","DOI":"10.3390\/membranes12020182"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Protty, M.B., Jenkins, P.V., Collins, P.W., and O\u2019Donnell, V.B. (2022). The Role of Procoagulant Phospholipids on the Surface of Circulating Blood Cells in Thrombosis and Haemostasis. Open Biol., 12.","DOI":"10.1098\/rsob.210318"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41580-023-00604-z","article-title":"Regulation of Phospholipid Distribution in the Lipid Bilayer by Flippases and Scramblases","volume":"24","author":"Sakuragi","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Pollet, H., Conrard, L., Cloos, A.-S., and Tyteca, D. (2018). Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?. Biomolecules, 8.","DOI":"10.3390\/biom8030094"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41589-020-0564-3","article-title":"Author Correction: Plasma Membranes Are Asymmetric in Lipid Unsaturation, Packing and Protein Shape","volume":"16","author":"Lorent","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lagoutte-Renosi, J., Allemand, F., Ramseyer, C., Rabani, V., and Davani, S. (2021). Influence of Antiplatelet Agents on the Lipid Composition of Platelet Plasma Membrane: A Lipidomics Approach with Ticagrelor and Its Active Metabolite. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031432"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Nenna, A., Nappi, F., Lusini, M., Satriano, U.M., Schilir\u00f2, D., Spadaccio, C., and Chello, M. (2021). Effect of Statins on Platelet Activation and Function: From Molecular Pathways to Clinical Effects. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/6661847"},{"key":"ref_115","unstructured":"Thomas, S.G. (2019). Platelets, Elsevier."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1161\/01.RES.0000251742.71301.16","article-title":"Activation of Platelet Function Through G Protein\u2013Coupled Receptors","volume":"99","author":"Offermanns","year":"2006","journal-title":"Circ. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1182\/blood-2011-01-330688","article-title":"The Spectrin-Based Membrane Skeleton Stabilizes Mouse Megakaryocyte Membrane Systems and Is Essential for Proplatelet and Platelet Formation","volume":"118","author":"Wang","year":"2011","journal-title":"Blood"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1039\/C8SM02136H","article-title":"Human Blood Platelets Contract in Perpendicular Direction to Shear Flow","volume":"15","author":"Hanke","year":"2019","journal-title":"Soft Matter"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3109\/09537109309013226","article-title":"The Formation of Fusiform Proplatelets and Their Transformation to Discoid Platelets","volume":"4","author":"Behnke","year":"1993","journal-title":"Platelets"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1182\/blood-2014-11-607614","article-title":"Platelet Geometry Sensing Spatially Regulates \u03b1-Granule Secretion to Enable Matrix Self-Deposition","volume":"126","author":"Sakurai","year":"2015","journal-title":"Blood"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/MOH.0000000000000070","article-title":"Shaping the Platelet Response to Vascular Injury","volume":"21","author":"Stalker","year":"2014","journal-title":"Curr. Opin. Hematol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"O\u2019Sullivan, L.R., Cahill, M.R., and Young, P.W. (2021). The Importance of Alpha-Actinin Proteins in Platelet Formation and Function, and Their Causative Role in Congenital Macrothrombocytopenia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179363"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1021\/bi100541t","article-title":"The Platelet Actin Cytoskeleton Associates with SNAREs and Participates in \u03b1-Granule Secretion","volume":"49","author":"Woronowicz","year":"2010","journal-title":"Biochemistry"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/bjh.12682","article-title":"Secrets of Platelet Exocytosis\u2014What Do We Really Know about Platelet Secretion Mechanisms?","volume":"165","author":"Golebiewska","year":"2014","journal-title":"Br. J. Haematol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"M\u00e9nasch\u00e9, G., Long\u00e9, C., Bratti, M., and Blank, U. (2021). Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.652077"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1038\/s41467-022-33230-y","article-title":"Differential Dysregulation of Granule Subsets in WASH-Deficient Neutrophil Leukocytes Resulting in Inflammation","volume":"13","author":"Johnson","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Ebstrup, M.L., Dias, C., Heitmann, A.S.B., S\u00f8nder, S.L., and Nylandsted, J. (2021). Actin Cytoskeletal Dynamics in Single-Cell Wound Repair. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910886"},{"key":"ref_128","first-page":"353","article-title":"The Surface-Connected Canalicular System of Blood Platelets--a Fenestrated Membrane System","volume":"101","author":"White","year":"1980","journal-title":"Am. J. Pathol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/09537104.2020.1719993","article-title":"Canalicular System Reorganization during Mouse Platelet Activation as Revealed by 3D Ultrastructural Analysis","volume":"32","author":"Pokrovskaya","year":"2021","journal-title":"Platelets"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/jth.13225","article-title":"STEM Tomography Reveals That the Canalicular System and A-granules Remain Separate Compartments during Early Secretion Stages in Blood Platelets","volume":"14","author":"Pokrovskaya","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_131","unstructured":"Neum\u00fcller, J., Ellinger, A., and Wagner, T. (2015). The Transmission Electron Microscope\u2014Theory and Applications, InTech."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.bbamem.2015.04.006","article-title":"Platelet Membrane Variations and Their Effects on \u03b4-Granule Secretion Kinetics and Aggregation Spreading among Different Species","volume":"1848","author":"Gruba","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1182\/blood.V74.6.1983.1983","article-title":"The Fate of the Open Canalicular System in Surface and Suspension- Activated Platelets","volume":"74","author":"Escolar","year":"1989","journal-title":"Blood"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1182\/blood-2013-03-492330","article-title":"Biogenesis of the Demarcation Membrane System (DMS) in Megakaryocytes","volume":"123","author":"Eckly","year":"2014","journal-title":"Blood"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/09537104.2018.1431388","article-title":"Structure and Function of the Open Canalicular System\u2014The Platelet\u2019s Specialized Internal Membrane Network","volume":"29","author":"Selvadurai","year":"2018","journal-title":"Platelets"},{"key":"ref_136","unstructured":"Osman, S., Dalmay, D., and Mahaut-Smith, M. (2018). Platelets and Megakaryocytes, Springer."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/rth2.12260","article-title":"3D Ultrastructural Analysis of A-granule, Dense Granule, Mitochondria, and Canalicular System Arrangement in Resting Human Platelets","volume":"4","author":"Pokrovskaya","year":"2020","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1161\/ATVBAHA.118.311614","article-title":"Unlocking the Molecular Secrete(s) of \u03b1-Granule Biogenesis","volume":"38","author":"Noetzli","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2018.01.012","article-title":"Comparison of 3D Cellular Imaging Techniques Based on Scanned Electron Probes: Serial Block Face SEM vs. Axial Bright-Field STEM Tomography","volume":"202","author":"McBride","year":"2018","journal-title":"J. Struct. Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1182\/blood-2012-07-445080","article-title":"Platelet Secretion Is Kinetically Heterogeneous in an Agonist-Responsive Manner","volume":"120","author":"Jonnalagadda","year":"2012","journal-title":"Blood"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/hep.28331","article-title":"The Profile of Platelet A-granule Released Molecules Affects Postoperative Liver Regeneration","volume":"63","author":"Starlinger","year":"2016","journal-title":"Hepatology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/09537104.2016.1240768","article-title":"The Nuts and Bolts of the Platelet Release Reaction","volume":"28","author":"Joshi","year":"2017","journal-title":"Platelets"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/j.1538-7836.2010.03932.x","article-title":"The A-granule Proteome: Novel Proteins in Normal and Ghost Granules in Gray Platelet Syndrome","volume":"8","author":"Maynard","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1111\/j.1538-7836.2007.02690.x","article-title":"Proteomic Analysis of Platelet A-granules Using Mass Spectrometry","volume":"5","author":"Maynard","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_145","unstructured":"Mosher, D.F., Pesciotta, D.M., Loftus, J.C., and Albrecht, R.M. (1985). Platelet Membrane Glycoproteins, Springer US."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.omtn.2021.12.038","article-title":"Targeting Transgenic Proteins to Alpha Granules for Platelet-Directed Gene Therapy","volume":"27","author":"Woods","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1182\/blood.V87.4.1385.bloodjournal8741385","article-title":"Alpha-Granule Membrane Mirrors the Platelet Plasma Membrane and Contains the Glycoproteins Ib, IX, and V","volume":"87","author":"Berger","year":"1996","journal-title":"Blood"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platelet \u03b1-Granules: Basic Biology and Clinical Correlates","volume":"23","author":"Blair","year":"2009","journal-title":"Blood Rev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1182\/blood-2007-11-122515","article-title":"The Yin-Yang of Platelet Granules","volume":"111","author":"Abrams","year":"2008","journal-title":"Blood"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1182\/blood-2007-09-113837","article-title":"Angiogenesis Is Regulated by a Novel Mechanism: Pro- and Antiangiogenic Proteins Are Organized into Separate Platelet \u03b1 Granules and Differentially Released","volume":"111","author":"Italiano","year":"2008","journal-title":"Blood"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Everts, P.A., Lana, J.F., Onishi, K., Buford, D., Peng, J., Mahmood, A., Fonseca, L.F., van Zundert, A., and Podesta, L. (2023). Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures: A Narrative Review. Biomedicines, 11.","DOI":"10.20944\/preprints202306.0745.v1"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Da Costa Marques, R., Simon, J., d\u2019Arros, C., Landfester, K., Jurk, K., and Mail\u00e4nder, V. (2022). Proteomics Reveals Differential Adsorption of Angiogenic Platelet Lysate Proteins on Calcium Phosphate Bone Substitute Materials. Regen. Biomater., 9.","DOI":"10.1093\/rb\/rbac044"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3390\/hematolrep15030041","article-title":"Platelet Delta (\u03b4)-Storage Pool Deficiency: A Case Series and Review of the Literature","volume":"15","author":"Beirat","year":"2023","journal-title":"Hematol. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Gunning, W.T., Raghavan, M., Calomeni, E.P., Turner, J.N., Roysam, B., Roysam, S., Smith, M.R., Kouides, P.A., and Lachant, N.A. (2020). A Morphometric Analysis of Platelet Dense Granules of Patients with Unexplained Bleeding: A New Entity of Delta-Microgranular Storage Pool Deficiency. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061734"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"BSR20180458","DOI":"10.1042\/BSR20180458","article-title":"Sorting Machineries: How Platelet-Dense Granules Differ from \u03b1-Granules","volume":"38","author":"Chen","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_156","unstructured":"Flaumenhaft, R., and Sharda, A. (2019). Platelets, Elsevier."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Bai, M.-J., Wang, J.-L., Elsheikha, H.M., Liang, Q.-L., Chen, K., Nie, L.-B., and Zhu, X.-Q. (2018). Functional Characterization of Dense Granule Proteins in Toxoplasma gondii RH Strain Using CRISPR-Cas9 System. Front. Cell Infect. Microbiol., 8.","DOI":"10.3389\/fcimb.2018.00300"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Griffith, M.B., Pearce, C.S., and Heaslip, A.T. (2022). Dense Granule Biogenesis, Secretion, and Function in Toxoplasma gondii. J. Eukaryot. Microbiol., 69.","DOI":"10.1111\/jeu.12904"},{"key":"ref_159","first-page":"319","article-title":"Identification of Novel Dense-Granule Proteins in Toxoplasma gondii by Two Proximity-Based Biotinylation Approaches","volume":"18","author":"Pan","year":"2018","journal-title":"J. Proteome Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1182\/blood.V128.22.3728.3728","article-title":"Bleeding Risks Associated with Confirmed Platelet Dense Granule Deficiency and\/or Impaired Aggregation Responses","volume":"128","author":"Iyer","year":"2016","journal-title":"Blood"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"23","DOI":"10.12659\/AJCR.881464","article-title":"A Case of Platelet Storage Pool Deficiency of Dense Granules (Delta SPD)","volume":"12","author":"Maatouk","year":"2011","journal-title":"Am. J. Case Rep."},{"key":"ref_162","first-page":"1","article-title":"Estrogen Modulates Serotonin Effects on Vasoconstriction through Src Inhibition","volume":"50","author":"Kim","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"24316","DOI":"10.1073\/pnas.2007642117","article-title":"Hemostasis vs. Homeostasis: Platelets Are Essential for Preserving Vascular Barrier Function in the Absence of Injury or Inflammation","volume":"117","author":"Gupta","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/jth.15240","article-title":"Platelets Maintain Vascular Barrier Function in the Absence of Injury or Inflammation","volume":"19","author":"Camerer","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.blre.2014.10.003","article-title":"Platelet Secretion: From Haemostasis to Wound Healing and Beyond","volume":"29","author":"Golebiewska","year":"2015","journal-title":"Blood Rev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circ. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/09537100500169926","article-title":"Platelet Secretory Granules or Secretory Lysosomes?","volume":"16","author":"Polasek","year":"2005","journal-title":"Platelets"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/BF00304319","article-title":"Histochemistry of Glycosidases of Megakaryocytes and Platelets","volume":"10","author":"Monis","year":"1967","journal-title":"Histochemie"},{"key":"ref_169","first-page":"1161","article-title":"Lipoproteins, Platelets, and Atherothrombosis","volume":"62","author":"Vilahur","year":"2009","journal-title":"Rev. Espa\u00f1ola Cardiol. Engl. Ed."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1182\/bloodadvances.2018019158","article-title":"SNARE-Dependent Membrane Fusion Initiates \u03b1-Granule Matrix Decondensation in Mouse Platelets","volume":"2","author":"Pokrovskaya","year":"2018","journal-title":"Blood Adv."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.ATV.0000075965.88456.48","article-title":"Molecular Basis of Platelet Granule Secretion","volume":"23","author":"Flaumenhaft","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Yang, F., Ma, J., Zhu, D., Wang, Z., Li, Y., He, X., Zhang, G., and Kang, X. (2023). The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential. Biomolecules, 13.","DOI":"10.3390\/biom13071139"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood-2016-01-693705","article-title":"Adult Human Megakaryocyte-Erythroid Progenitors Are in the CD34+CD38mid Fraction","volume":"128","author":"Sanada","year":"2016","journal-title":"Blood"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1203\/01.pdr.0000127020.00090.51","article-title":"Megakaryocyte Growth and Development Factor Is a Potent Growth Factor for Primitive Hematopoietic Progenitors in the Human Fetus","volume":"55","author":"Muench","year":"2004","journal-title":"Pediatr. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1182\/blood.V91.11.4065","article-title":"Thrombopoietin Enhances the Production of Myeloid Cells, but Not Megakaryocytes, in Juvenile Chronic Myelogenous Leukemia","volume":"91","author":"Sawai","year":"1998","journal-title":"Blood"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"100184","DOI":"10.1016\/j.rpth.2023.100184","article-title":"Regulation of Megakaryo\/Thrombopoiesis by Endosomal Toll-like Receptor 7 and 8 Activation of CD34+ Cells in a Viral Infection Model","volume":"7","author":"Tatti","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1083339","DOI":"10.3389\/fimmu.2023.1083339","article-title":"Megakaryocytes Respond during Sepsis and Display Innate Immune Cell Behaviors","volume":"14","author":"Frydman","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jcb.22184","article-title":"Common Features of Megakaryocytes and Hematopoietic Stem Cells: What\u2019s the Connection?","volume":"107","author":"Huang","year":"2009","journal-title":"J. Cell Biochem."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40164-022-00273-2","article-title":"The GPIb-IX Complex on Platelets: Insight into Its Novel Physiological Functions Affecting Immune Surveillance, Hepatic Thrombopoietin Generation, Platelet Clearance and Its Relevance for Cancer Development and Metastasis","volume":"11","author":"Bendas","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/09537104.2020.1856360","article-title":"Platelet Surface GPIb\u03b1, Activated GPIIb-IIIa, and P-Selectin Levels in Adult Veno-Arterial Extracorporeal Membrane Oxygenation Patients","volume":"33","author":"Mazzeffi","year":"2022","journal-title":"Platelets"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0300-8932(09)71035-8","article-title":"Molecular Basis of Leukocyte\u2013Endothelium Interactions during the Inflammatory Response","volume":"62","author":"Barreiro","year":"2009","journal-title":"Rev. Espa\u00f1ola Cardiol. Engl. Ed."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"568","DOI":"10.21037\/cdt.2018.07.01","article-title":"Interaction between Platelets and Endothelium: From Pathophysiology to New Therapeutic Options","volume":"8","author":"Hamilos","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1167\/iovs.03-0526","article-title":"Platelets Adhering to the Vascular Wall Mediate Postischemic Leukocyte\u2013Endothelial Cell Interactions in Retinal Microcirculation","volume":"45","author":"Nishijima","year":"2004","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000091107","article-title":"Interaction of Platelets, Leukocytes and the Endothelium*","volume":"33","author":"Sachs","year":"2006","journal-title":"Transfus. Med. Hemotherapy"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00441-021-03471-2","article-title":"Endothelial Cells and Coagulation","volume":"387","author":"Neubauer","year":"2022","journal-title":"Cell Tissue Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"29","DOI":"10.21037\/aob.2019.12.04","article-title":"Platelet Physiology and Immunology: Pathogenesis and Treatment of Classical and Non-Classical Fetal and Neonatal Alloimmune Thrombocytopenia","volume":"4","author":"Chen","year":"2019","journal-title":"Ann. Blood"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2147\/JBM.S356028","article-title":"The Role of Platelet-Selectin as a Marker of Thrombocyte Aggregation on Cerebral Sinus Venous Thrombosis","volume":"13","author":"Amalia","year":"2022","journal-title":"J. Blood Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"642761","DOI":"10.3389\/fonc.2021.642761","article-title":"The Role of Platelet Cell Surface P-Selectin for the Direct Platelet-Tumor Cell Contact During Metastasis Formation in Human Tumors","volume":"11","author":"Fabricius","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Conley, H.E., and Sheats, M.K. (2023). Targeting Neutrophil \u03922-Integrins: A Review of Relevant Resources, Tools, and Methods. Biomolecules, 13.","DOI":"10.3390\/biom13060892"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/09537104.2018.1430358","article-title":"Measuring and Interpreting Platelet-Leukocyte Aggregates","volume":"29","author":"Finsterbusch","year":"2018","journal-title":"Platelets"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3389\/fimmu.2018.02712","article-title":"Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation","volume":"9","author":"Rossaint","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Wang, L., and Tang, C. (2020). Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249760"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Burnouf, T., Chou, M.-L., Lundy, D.J., Chuang, E.-Y., Tseng, C.-L., and Goubran, H. (2023). Expanding Applications of Allogeneic Platelets, Platelet Lysates, and Platelet Extracellular Vesicles in Cell Therapy, Regenerative Medicine, and Targeted Drug Delivery. J. Biomed. Sci., 30.","DOI":"10.1186\/s12929-023-00972-w"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1026386","DOI":"10.3389\/fphar.2022.1026386","article-title":"Platelets and Platelet Extracellular Vesicles in Drug Delivery Therapy: A Review of the Current Status and Future Prospects","volume":"13","author":"Dai","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/09537104.2021.1882668","article-title":"Targeting Platelet Inhibition Receptors for Novel Therapies: PECAM-1 and G6b-B","volume":"32","author":"Gibbins","year":"2021","journal-title":"Platelets"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/jth.14721","article-title":"Platelet Lipidome: Dismantling the \u201cTrojan Horse\u201d in the Bloodstream","volume":"18","author":"Chatterjee","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Marcinczyk, N., Misztal, T., Gromotowicz-Poplawska, A., Zebrowska, A., Rusak, T., Radziwon, P., and Chabielska, E. (2021). Utility of Platelet Endothelial Cell Adhesion Molecule 1 in the Platelet Activity Assessment in Mouse and Human Blood. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179611"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Jansen, E.E., Braun, A., Jansen, P., and Hartmann, M. (2021). Platelet-Therapeutics to Improve Tissue Regeneration and Wound Healing\u2014Physiological Background and Methods of Preparation. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080869"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/imr.13119","article-title":"Platelet Extracellular Vesicles and the Secretory Interactome Join Forces in Health and Disease","volume":"312","author":"Boilard","year":"2022","journal-title":"Immunol. Rev."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Komatsuya, K., Kaneko, K., and Kasahara, K. (2020). Function of Platelet Glycosphingolipid Microdomains\/Lipid Rafts. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155539"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Chatterjee, M., Ehrenberg, A., Toska, L.M., Metz, L.M., Klier, M., Krueger, I., Reusswig, F., and Elvers, M. (2020). Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217906"},{"key":"ref_202","unstructured":"Akkaya F\u0131rat, A. (2023). Chemokines Updates, IntechOpen."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1537-2995.2008.02033.x","article-title":"Identification of an Optimal Concentration of Platelet Gel for Promoting Angiogenesis in Human Endothelial Cells","volume":"49","author":"Giusti","year":"2009","journal-title":"Transfusion"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"a041174","DOI":"10.1101\/cshperspect.a041174","article-title":"Platelets and (Lymph) Angiogenesis","volume":"13","author":"Roweth","year":"2023","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12967-021-02922-2","article-title":"Cellular and Molecular Mediators of Lymphangiogenesis in Inflammatory Bowel Disease","volume":"19","author":"Ocansey","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/mt.2014.61","article-title":"Human Podoplanin-Positive Monocytes and Platelets Enhance Lymphangiogenesis Through the Activation of the Podoplanin\/CLEC-2 Axis","volume":"22","author":"Hur","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.2147\/JIR.S366620","article-title":"The Role of Podoplanin in the Immune System and Inflammation","volume":"15","author":"Zhang","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/jth.14726","article-title":"Crosstalk between Hemostasis and Lymphangiogenesis","volume":"18","author":"Tsukiji","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/rth2.12338","article-title":"Platelet CLEC-2 and Lung Development","volume":"4","author":"Tsukiji","year":"2020","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Bautch, V.L., and Caron, K.M. (2015). Blood and Lymphatic Vessel Formation. Cold Spring Harb. Perspect. Biol., 7.","DOI":"10.1101\/cshperspect.a008268"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Puricelli, C., Boggio, E., Gigliotti, C.L., Stoppa, I., Sutti, S., Giordano, M., Dianzani, U., and Rolla, R. (2023). Platelets, Protean Cells with All-Around Functions and Multifaceted Pharmacological Applications. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054565"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Bao, H., Li, Z.-T., Xu, L.-H., Su, T.-Y., Han, Y., Bao, M., Liu, Z., Fan, Y.-J., Lou, Y., and Chen, Y. (2021). Platelet-Derived Extracellular Vesicles Increase Col8a1 Secretion and Vascular Stiffness in Intimal Injury. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.641763"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"21420","DOI":"10.1038\/s41598-020-77934-x","article-title":"The Antiplatelet Agent Revacept Prevents the Increase of Systemic Thromboxane A2 Biosynthesis and Neointima Hyperplasia","volume":"10","author":"Alberti","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Subbotin, V.M. (2007). Analysis of Arterial Intimal Hyperplasia: Review and Hypothesis. Theor. Biol. Med. Model., 4.","DOI":"10.1186\/1742-4682-4-41"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1002\/mco2.350","article-title":"The Role of Platelets in the Regulation of Tumor Growth and Metastasis: The Mechanisms and Targeted Therapy","volume":"4","author":"Liao","year":"2023","journal-title":"MedComm"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"e12072","DOI":"10.1016\/j.heliyon.2022.e12072","article-title":"Roles of Platelets in Tumor Invasion and Metastasis: A Review","volume":"8","author":"Bian","year":"2022","journal-title":"Heliyon"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13045-018-0669-2","article-title":"Role of Platelets and Platelet Receptors in Cancer Metastasis","volume":"11","author":"Schlesinger","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"15477","DOI":"10.1038\/s41598-021-94735-y","article-title":"Interactions of Platelets with Circulating Tumor Cells Contribute to Cancer Metastasis","volume":"11","author":"Anvari","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.4252\/wjsc.v12.i11.1237","article-title":"Role of Platelets and Breast Cancer Stem Cells in Metastasis","volume":"12","author":"Maldonado","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fmed.2018.00317","article-title":"The Platelet Response to Tissue Injury","volume":"5","author":"Eisinger","year":"2018","journal-title":"Front Med."},{"key":"ref_221","first-page":"237","article-title":"A Note from History: The Discovery of Blood Cells","volume":"33","author":"Hajdu","year":"2003","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00000637-199709000-00017","article-title":"A Historical Review of Hemostasis, Thrombosis, and Antithrombotic Therapy","volume":"39","author":"Stassen","year":"1997","journal-title":"Ann. Plast. Surg."},{"key":"ref_223","first-page":"349","article-title":"Historical Overview of the Role of Platelets in Hemostasis and Thrombosis","volume":"86","year":"2001","journal-title":"Haematologica"},{"key":"ref_224","first-page":"1","article-title":"Platelet-Rich Plasma Peptides: Key for Regeneration","volume":"2012","year":"2012","journal-title":"Int. J. Pept."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2217\/rme.14.54","article-title":"Wound Healing: An Update","volume":"9","author":"Zielins","year":"2014","journal-title":"Regen. Med."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1001\/jama.1944.02850140022006","article-title":"Use of Thrombin and Fibrinogen in Skin Grafting","volume":"124","author":"Cronkite","year":"1944","journal-title":"J. Am. Med. Assoc."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"FSO231","DOI":"10.4155\/fsoa-2017-0045","article-title":"An Overview of Platelet Products (PRP, PRGF, PRF, Etc.) in the Iranian Studies","volume":"3","author":"Raeissadat","year":"2017","journal-title":"Future Sci. OA"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cytogfr.2004.03.007","article-title":"The PDGF Family: Four Gene Products Form Five Dimeric Isoforms","volume":"15","author":"Fredriksson","year":"2004","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ad.2013.12.021","article-title":"Plasma Rico En Plaquetas: Aplicaciones En Dermatolog\u00eda","volume":"106","year":"2015","journal-title":"Actas Dermosifiliogr."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"De Angelis, B., D\u2019Autilio, M.F.L.M., Orlandi, F., Pepe, G., Garcovich, S., Scioli, M.G., Orlandi, A., Cervelli, V., and Gentile, P. (2019). Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091486"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/jispcd.JISPCD_284_17","article-title":"Platelets and Their Pathways in Dentistry: Systematic Review","volume":"7","author":"Khan","year":"2017","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Cervelli, V., Bocchini, I., Di Pasquali, C., De Angelis, B., Cervelli, G., Curcio, C.B., Orlandi, A., Scioli, M.G., Tati, E., and Delogu, P. (2013). P.R.L. Platelet Rich Lipotransfert: Our Experience and Current State of Art in the Combined Use of Fat and PRP. Biomed. Res. Int., 2013.","DOI":"10.1155\/2013\/434191"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1563\/aaid-joi-D-17-00179","article-title":"Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High Is the Level of Scientific Evidence?","volume":"44","author":"Ghanaati","year":"2018","journal-title":"J. Oral Implantol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.2174\/138920112800624463","article-title":"L-PRP\/L-PRF in Esthetic Plastic Surgery, Regenerative Medicine of the Skin and Chronic Wounds","volume":"13","author":"Choukroun","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_235","first-page":"664","article-title":"Platelet-Rich Plasma: A Promising Innovation in Dentistry","volume":"69","author":"Demiralp","year":"2003","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_236","first-page":"529","article-title":"Plasma Rich in Growth Factors: Preliminary Results of Use in the Preparation of Future Sites for Implants","volume":"14","author":"Anitua","year":"1999","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Ra Hara, G., and Basu, T. (2014). Platelet-Rich Plasma in Regenerative Medicine. Biomed. Res. Ther., 1.","DOI":"10.7603\/s40730-014-0005-6"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1007\/s00784-017-2063-9","article-title":"Injectable Platelet Rich Fibrin (i-PRF): Opportunities in Regenerative Dentistry?","volume":"21","author":"Miron","year":"2017","journal-title":"Clin. Oral. Investig."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00403-019-01999-6","article-title":"A Systematic Review of the Safety and Effectiveness of Platelet-Rich Plasma (PRP) for Skin Aging","volume":"312","author":"Ismail","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.5966\/sctm.2015-0107","article-title":"The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial","volume":"4","author":"Gentile","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Gentile, P., Calabrese, C., De Angelis, B., Dionisi, L., Pizzicannella, J., Kothari, A., De Fazio, D., and Garcovich, S. (2020). Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020431"},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Cervelli, V., Garcovich, S., Bielli, A., Cervelli, G., Curcio, B.C., Scioli, M.G., Orlandi, A., and Gentile, P. (2014). The Effect of Autologous Activated Platelet Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/760709"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1097\/01.prs.0000239560.29172.33","article-title":"The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery","volume":"118","author":"Uebel","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/jocd.12561","article-title":"Comparative Study of the Efficacy of Platelet-rich Plasma Combined with Carboxytherapy vs Its Use with Fractional Carbon Dioxide Laser in Atrophic Acne Scars","volume":"18","author":"Hamed","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/jocd.12459","article-title":"Microneedling Combined with Platelet-rich Plasma or Trichloroacetic Acid Peeling for Management of Acne Scarring: A Split-face Clinical and Histologic Comparison","volume":"17","author":"Hossam","year":"2018","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s10815-018-1159-8","article-title":"Platelet-Rich Plasma Therapy and Reproductive Medicine","volume":"35","author":"Frantz","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4111\/icu.2018.59.1.61","article-title":"Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions","volume":"59","author":"Matz","year":"2018","journal-title":"Investig. Clin. Urol."},{"key":"ref_248","first-page":"E170","article-title":"Efficacy and Safety of Treatment of Hyposecretory Dry Eye with Platelet-rich Plasma","volume":"97","author":"Molina","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/0378-6323.125467","article-title":"Platelet-Rich Plasma in Dermatology: Boon or a Bane?","volume":"80","author":"Arshdeep","year":"2014","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_250","first-page":"3","article-title":"Classification of Platelet Concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for Topical and Infiltrative Use in Orthopedic and Sports Medicine: Current Consensus, Clinical Implications and Perspectives","volume":"4","author":"Andia","year":"2014","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1080\/14712598.2020.1798925","article-title":"Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: An Expert Opinion and Proposal for a Novel Classification and Coding System","volume":"20","author":"Kon","year":"2020","journal-title":"Expert. Opin. Biol. Ther."},{"key":"ref_252","first-page":"56","article-title":"Assessing Clinical Implications and Perspectives of the Pathophysiological Effects of Erythrocytes and Plasma Free Hemoglobin in Autologous Biologics for Use in Musculoskeletal Regenerative Medicine Therapies","volume":"11","author":"Everts","year":"2019","journal-title":"A Review. Regen. Ther."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Oneto, P., Zubiry, P.R., Schattner, M., and Etulain, J. (2020). Anticoagulants Interfere With the Angiogenic and Regenerative Responses Mediated by Platelets. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00223"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(16)31406-4","article-title":"Hypertrophic Scarring: The Greatest Unmet Challenge after Burn Injury","volume":"388","author":"Finnerty","year":"2016","journal-title":"Lancet"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/lsm.20905","article-title":"Photodynamic Photorejuvenation of the Face with a Combination of Microneedling, Red Light, and Broadband Pulsed Light","volume":"42","author":"Clementoni","year":"2010","journal-title":"Lasers Surg. Med."},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Elsayed, M. (2017). Evaluation of the Effect of Platelet-Rich Plasma on Post-Burn Scars. Open Access J. Surg., 5.","DOI":"10.19080\/OAJS.2017.05.555660"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4103\/1673-5374.346461","article-title":"Platelet-Rich Plasma Promotes Peripheral Nerve Regeneration after Sciatic Nerve Injury","volume":"18","author":"Wang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_258","first-page":"281","article-title":"Platelet-Rich Plasma in Regenerative Medicine: Possible Applications in Management of Burns and Post-Burn Scars: A Review","volume":"25","author":"Hosseini","year":"2023","journal-title":"Cell J."},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"Horgos, M.S., Pop, O.L., Sandor, M., Borza, I.L., Negrean, R.A., Cote, A., Neamtu, A.-A., Grierosu, C., Sachelarie, L., and Huniadi, A. (2023). Platelets Rich Plasma (PRP) Procedure in the Healing of Atonic Wounds. J. Clin. Med., 12.","DOI":"10.3390\/jcm12123890"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"tkaa028","DOI":"10.1093\/burnst\/tkaa028","article-title":"Platelet-Rich Plasma Accelerates Skin Wound Healing by Promoting Re-Epithelialization","volume":"8","author":"Xu","year":"2020","journal-title":"Burns Trauma."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00238-023-02050-8","article-title":"Role for Platelet Rich Plasma as an Adjuvant Therapy in Wound Healing and Burns","volume":"46","author":"Knightly","year":"2023","journal-title":"Eur. J. Plast. Surg."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Imam, M.S., Alotaibi, A.A.S., Alotaibi, N.O.M., Alosaimi, N.S., Alotaibi, S.G.M., and Abdelrahim, M.E.A. (2023). Efficiency of Platelet-rich Plasma in the Management of Burn Wounds: A Meta-analysis. Int. Wound J.","DOI":"10.1111\/iwj.14419"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"e19452","DOI":"10.1016\/j.heliyon.2023.e19452","article-title":"Therapeutic Role of Mesenchymal Stem Cells and Platelet-Rich Plasma on Skin Burn Healing and Rejuvenation: A Focus on Scar Regulation, Oxido-Inflammatory Stress and Apoptotic Mechanisms","volume":"9","author":"Tammam","year":"2023","journal-title":"Heliyon"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4103\/0378-6323.116726","article-title":"What\u2032s New in Cicatricial Alopecia?","volume":"79","author":"Dogra","year":"2013","journal-title":"Indian. J. Dermatol. Venereol. Leprol."},{"key":"ref_265","first-page":"35881","article-title":"Comprehensive Overview and Treatment Update on Hair Loss","volume":"3","author":"Rodrigues","year":"2013","journal-title":"J. Cosmet. Dermatol. Sci. Appl."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Sadgrove, N., Batra, S., Barreto, D., and Rapaport, J. (2023). An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing \u2018the Big Eight Strikes\u2019. Cosmetics, 10.","DOI":"10.3390\/cosmetics10040106"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/12034754231168839","article-title":"Alopecia Areata: An Updated Review for 2023","volume":"27","author":"Sibbald","year":"2023","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4103\/0378-6323.116730","article-title":"Androgenetic Alopecia: An Update","volume":"79","author":"Kaliyadan","year":"2013","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s40257-023-00760-0","article-title":"Chronic Telogen Effluvium: Is It a Distinct Condition? A Systematic Review","volume":"24","author":"Daunton","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Cindy Gasnier, R.B. (2015). Autologous Platelet Rich Plasma as a Treatment of Male Androgenetic Alopecia: Study of 14 Cases. J. Clin. Exp. Dermatol. Res., 6.","DOI":"10.4172\/2155-9554.10000292"},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Gentile, P., Cole, J., Cole, M., Garcovich, S., Bielli, A., Scioli, M., Orlandi, A., Insalaco, C., and Cervelli, V. (2017). Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020408"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4103\/0973-6247.162713","article-title":"Efficacy of Platelet-Rich Plasma in Treatment of Androgenic Alopecia","volume":"9","author":"Singhal","year":"2015","journal-title":"Asian J. Transfus. Sci."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0974-2077.138352","article-title":"Platelet-Rich Plasma in Androgenic Alopecia: Myth or an Effective Tool","volume":"7","author":"Khatu","year":"2014","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"49","DOI":"10.33589\/19.2.0049","article-title":"The Effects of Autologus Platelet Rich Plasma and Various Growth Factors on Non-Transplanted Miniaturized Hair","volume":"19","author":"Greco","year":"2009","journal-title":"Int. Soc. Hair Restor. Surg."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijwd.2018.08.004","article-title":"Platelet-rich plasma for androgenetic alopecia: A review of the literature and proposed treatment protocol","volume":"5","author":"Stevens","year":"2019","journal-title":"Int. J. Women Dermatol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/0974-2077.191657","article-title":"Outcome of Intra-Operative Injected Platelet-Rich Plasma Therapy during Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients","volume":"9","author":"Garg","year":"2016","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_277","doi-asserted-by":"crossref","unstructured":"Natarelli, N., Gahoonia, N., and Sivamani, R.K. (2023). Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss. J. Clin. Med., 12.","DOI":"10.3390\/jcm12030893"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.reth.2022.10.005","article-title":"Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature","volume":"21","author":"Shimizu","year":"2022","journal-title":"Regen. Ther."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/jdv.12062","article-title":"The Effect of CD34+ Cell-containing Autologous Platelet-rich Plasma Injection on Pattern Hair Loss: A Preliminary Study","volume":"28","author":"Kang","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1524-4725.2012.02394.x","article-title":"Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth","volume":"38","author":"Li","year":"2012","journal-title":"Dermatol. Surg."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"524","DOI":"10.2174\/1574888X12666170504120244","article-title":"Up-to-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss","volume":"12","author":"Shin","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/jocd.12167","article-title":"Systematic Review of the Use of Platelet-rich Plasma in Aesthetic Dermatology","volume":"14","author":"Leo","year":"2015","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/bjd.12397","article-title":"A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata","volume":"169","author":"Trink","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaad.2009.10.031","article-title":"Alopecia Areata Update","volume":"62","author":"Alkhalifah","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Teng, H., and Chen, H. (2023). Platelet-rich Plasma in the Treatment of Alopecia Areata after COVID-19 Vaccination. Clin. Case Rep., 11.","DOI":"10.1002\/ccr3.7342"},{"key":"ref_286","first-page":"e38751","article-title":"Platelet-Rich Plasma in Alopecia Areata: A Case Report With a Mini Review of Literature","volume":"15","author":"Todorova","year":"2023","journal-title":"Cureus"},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"Pensato, R., Al-Amer, R., and La Padula, S. (2023). Platelet-Rich Plasma for Treating Androgenic Alopecia: A Systematic Review. Aesthetic Plast. Surg.","DOI":"10.1007\/s00266-023-03482-0"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"057","DOI":"10.4103\/0970-0358.155271","article-title":"Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience","volume":"48","author":"Singh","year":"2015","journal-title":"Indian J. Plast. Surg."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jdcr.2015.07.004","article-title":"Successful Treatment of Corticosteroid-Resistant Ophiasis-Type Alopecia Areata (AA) with Platelet-Rich Plasma (PRP)","volume":"1","author":"Donovan","year":"2015","journal-title":"JAAD Case Rep."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"e12437","DOI":"10.1111\/dth.12437","article-title":"Platelets Rich Plasma versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation","volume":"30","author":"Ibrahim","year":"2017","journal-title":"Dermatol. Ther."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s00266-022-03224-8","article-title":"Platelet-Rich Plasma for Treatment of Hair Loss Improves Patient-Reported Quality of Life","volume":"47","author":"Meyers","year":"2023","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_292","first-page":"195","article-title":"Evaluation of the Safety and Efficacy of Platelet-Rich Plasma in the Treatment of Female Patients with Chronic Telogen Effluvium: A Randomised, Controlled, Double-Blind, Pilot Clinical Trial","volume":"89","author":"Abdelhaleem","year":"2022","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s13287-021-02527-y","article-title":"A Systematic Summary of Survival and Death Signalling during the Life of Hair Follicle Stem Cells","volume":"12","author":"Hu","year":"2021","journal-title":"Stem. Cell Res. Ther."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000502919","article-title":"The Clinical Efficacy and Safety of Autologous Activated Platelet-Rich Plasma Injection in Androgenetic Alopecia","volume":"6","author":"Paththinige","year":"2020","journal-title":"Skin. Appendage Disord."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Gentile, P., and Garcovich, S. (2020). Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil\u00ae, Finasteride\u00ae, and Adult Stem Cell-Based Therapy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082702"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000477353","article-title":"A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification","volume":"4","author":"Alves","year":"2018","journal-title":"Skin. Appendage Disord."},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"El-Fakahany, H., Raouf, H.A., and Medhat, W. (2016). Using Automated Microneedling with Platelet Rich Plasma for Treating Cicatricial Alopecia, Recalcitrant Alopecia Areata and Traction Alopecia, Case Report. Proc. J. Am. Acad. Dermatol., AB140.","DOI":"10.1016\/j.jaad.2016.02.551"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10561-022-10039-z","article-title":"Platelet-Rich Plasma: A Comparative and Economical Therapy for Wound Healing and Tissue Regeneration","volume":"24","author":"Verma","year":"2023","journal-title":"Cell Tissue Bank."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0974-2077.178562","article-title":"Successful Hair Transplant Outcome in Cicatricial Lichen Planus of the Scalp by Combining Scalp and Beard Hair along with Platelet Rich Plasma","volume":"9","author":"Saxena","year":"2016","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1083\/jcb.109.1.429","article-title":"Platelet-Derived Growth Factor and Transforming Growth Factor-Beta Enhance Tissue Repair Activities by Unique Mechanisms","volume":"109","author":"Pierce","year":"1989","journal-title":"J. Cell Biol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nbt0398-247","article-title":"Role of Morphogenetic Proteins in Skeletal Tissue Engineering and Regeneration","volume":"16","author":"Reddi","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","article-title":"The Biology of Vascular Endothelial Growth Factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000445630","article-title":"Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt\/\u03b2-Catenin Signaling","volume":"39","author":"Zhang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.bi.58.070189.003043","article-title":"The Heparin-Binding (Fibroblast) Growth Factor Family of Proteins","volume":"58","author":"Burgess","year":"1989","journal-title":"Annu. Rev. Biochem."},{"key":"ref_305","first-page":"466","article-title":"Face and Neck Revitalization with Platelet-Rich Plasma (PRP): Clinical Outcome in a Series of 23 Consecutively Treated Patients","volume":"9","author":"Redaelli","year":"2010","journal-title":"J. Drugs Dermatol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/jocd.12258","article-title":"Assessment of the Efficacy and Safety of Single Platelet-rich Plasma Injection on Different Types and Grades of Facial Wrinkles","volume":"16","author":"Elnehrawy","year":"2017","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3109\/14764172.2014.949274","article-title":"Evaluation of Effects of Platelet-Rich Plasma on Human Facial Skin","volume":"16","author":"Yuksel","year":"2014","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/09546634.2018.1524821","article-title":"Platelet-Rich Plasma Is a Useful Therapeutic Option in Melasma","volume":"30","author":"Hofny","year":"2019","journal-title":"J. Dermatol. Treat."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/DSS.0000000000001083","article-title":"Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation: Clinical, Instrumental, and Flow Cytometry Assessment","volume":"43","author":"Cameli","year":"2017","journal-title":"Dermatol. Surg."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"e20220020","DOI":"10.1590\/1678-7757-2022-0020","article-title":"Autologous Platelet Concentrates for Facial Rejuvenation","volume":"30","author":"BUZALAF","year":"2022","journal-title":"J. Appl. Oral Sci."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1684\/ejd.2014.2267","article-title":"Effects of Platelet-Rich Plasma on Wrinkles and Skin Tone in Asian Lower Eyelid Skin: Preliminary Results from a Prospective, Randomised, Split-Face Trial","volume":"24","author":"Kang","year":"2014","journal-title":"Eur. J. Dermatol."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/jocd.12072","article-title":"Assessment of Efficacy of Platelet-rich Plasma (PRP) on Infraorbital Dark Circles and Crow\u2019s Feet Wrinkles","volume":"13","author":"Mehryan","year":"2014","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4103\/0019-5154.159628","article-title":"Safety and Efficacy of Growth Factor Concentrate in the Treatment of Nasolabial Fold Correction: Split Face Pilot Study","volume":"60","author":"Totey","year":"2015","journal-title":"Indian. J. Dermatol."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1473-2165.2010.00486.x","article-title":"Platelet-Rich Fibrin Matrix for Improvement of Deep Nasolabial Folds","volume":"9","author":"Sclafani","year":"2010","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/jocd.12802","article-title":"Autologous Pure Platelet-rich Plasma Injections for Facial Skin Rejuvenation: Biometric Instrumental Evaluations and Patient-reported Outcomes to Support Antiaging Effects","volume":"18","author":"Everts","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/dsu.12392","article-title":"Autologous Platelet Rich Plasma: Topical Versus Intradermal After Fractional Ablative Carbon Dioxide Laser Treatment of Atrophic Acne Scars","volume":"40","author":"Gawdat","year":"2014","journal-title":"Dermatol. Surg."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0974-2077.150742","article-title":"Split Face Comparative Study of Microneedling with PRP versus Microneedling with Vitamin C in Treating Atrophic Post Acne Scars","volume":"7","author":"Chawla","year":"2014","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/DSS.0000000000001248","article-title":"Microneedling: A Review and Practical Guide","volume":"44","author":"Alster","year":"2018","journal-title":"Dermatol. Surg."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/jocd.12207","article-title":"Combined Autologous Platelet-rich Plasma with Microneedling Verses Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-face Study","volume":"15","author":"Asif","year":"2016","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_320","first-page":"864","article-title":"Platelet-Rich Plasma versus CROSS Technique with 100% Trichloroacetic Acid versus Combined Skin Needling and Platelet Rich Plasma in the Treatment of Atrophic Acne Scars: A Comparative Study","volume":"40","author":"Nofal","year":"2014","journal-title":"Dermatol. Surg."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jocd.12356","article-title":"Therapeutic Effect of Microneedling and Autologous Platelet-rich Plasma in the Treatment of Atrophic Scars: A Randomized Study","volume":"16","author":"Ibrahim","year":"2017","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/09546634.2017.1365111","article-title":"Skin Microneedling plus Platelet-Rich Plasma versus Skin Microneedling Alone in the Treatment of Atrophic Post Acne Scars: A Split Face Comparative Study","volume":"29","author":"Ibrahim","year":"2018","journal-title":"J. Dermatol. Treat."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/0378-6323.174378","article-title":"Efficacy of Autologous Platelet-Rich Plasma Combined with Fractional Ablative Carbon Dioxide Resurfacing Laser in Treatment of Facial Atrophic Acne Scars: A Split-Face Randomized Clinical Trial","volume":"82","author":"Faghihi","year":"2016","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1524-4725.2011.01999.x","article-title":"The Efficacy of Autologous Platelet Rich Plasma Combined with Ablative Carbon Dioxide Fractional Resurfacing for Acne Scars: A Simultaneous Split-Face Trial","volume":"37","author":"Lee","year":"2011","journal-title":"Dermatol. Surg."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/JCAS.JCAS_99_17","article-title":"Fractional CO 2 Laser vs Fractional CO 2 with Topical Platelet-Rich Plasma in the Treatment of Acne Scars: A Split-Face Comparison Trial","volume":"10","author":"Kar","year":"2017","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/lsm.22776","article-title":"Combination of Platelet Rich Plasma in Fractional Carbon Dioxide Laser Treatment Increased Clinical Efficacy of for Acne Scar by Enhancement of Collagen Production and Modulation of Laser-induced Inflammation","volume":"50","author":"Min","year":"2018","journal-title":"Lasers Surg. Med."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3892\/mmr.2013.1455","article-title":"The Efficacy of Autologous Platelet-Rich Plasma Combined with Erbium Fractional Laser Therapy for Facial Acne Scars or Acne","volume":"8","author":"Zhu","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s13555-021-00575-z","article-title":"Efficacy and Safety of Platelet-Rich Plasma in Melasma: A Systematic Review and Meta-Analysis","volume":"11","author":"Zhao","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s13555-017-0194-1","article-title":"Melasma: An Up-to-Date Comprehensive Review","volume":"7","author":"Elbuluk","year":"2017","journal-title":"Dermatol. Ther."},{"key":"ref_330","doi-asserted-by":"crossref","unstructured":"Maddaleno, A.S., Camargo, J., Mitjans, M., and Vinardell, M.P. (2021). Melanogenesis and Melasma Treatment. Cosmetics, 8.","DOI":"10.3390\/cosmetics8030082"},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2147\/CCID.S396272","article-title":"New Mechanistic Insights of Melasma","volume":"16","author":"Liu","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/phpp.12783","article-title":"Melasma: The Need for Tailored Photoprotection to Improve Clinical Outcomes","volume":"38","author":"Granger","year":"2022","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_333","first-page":"e44035","article-title":"Combined Synergetic Effect of Lipoconcentrate Fat Grafting, Nanofat Transfer, Platelet-Rich Plasma, Microneedling, and CO2 Fractional Laser for Plastic Regenerative and Esthetic Surgery and Cosmetic Care","volume":"15","author":"Qari","year":"2023","journal-title":"Cureus"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/ar4493","article-title":"Biology of Platelet-Rich Plasma and Its Clinical Application in Cartilage Repair","volume":"16","author":"Xie","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/PRS.0000000000007509","article-title":"Platelet-Rich Plasma: Evolving Role in Plastic Surgery","volume":"147","author":"Chamata","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of Platelet Concentrates: From Pure Platelet-Rich Plasma (P-PRP) to Leucocyte- and Platelet-Rich Fibrin (L-PRF)","volume":"27","author":"Rasmusson","year":"2009","journal-title":"Trends Biotechnol."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"e000060","DOI":"10.1136\/bmjsem-2015-000060","article-title":"DEPA Classification: A Proposal for Standardising PRP Use and a Retrospective Application of Available Devices","volume":"2","author":"Magalon","year":"2016","journal-title":"BMJ Open Sport. Exerc. Med."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1111\/jcmm.12671","article-title":"Skin Telocytes versus Fibroblasts: Two Distinct Dermal Cell Populations","volume":"19","author":"Kang","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-981-10-1061-3_20","article-title":"The Cutaneous Telocytes","volume":"913","author":"Manole","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_340","doi-asserted-by":"crossref","unstructured":"Manole, C.G., Gherghiceanu, M., Ceafalan, L.C., and Hinescu, M.E. (2022). Dermal Telocytes: A Different Viewpoint of Skin Repairing and Regeneration. Cells, 11.","DOI":"10.3390\/cells11233903"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1111\/j.1582-4934.2011.01449.x","article-title":"Experimental Acute Myocardial Infarction: Telocytes Involvement in Neo-Angiogenesis","volume":"15","author":"Manole","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1582-4934.2011.01325.x","article-title":"MiR-193 Expression Differentiates Telocytes from Other Stromal Cells","volume":"15","author":"Cismasiu","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"752.4","DOI":"10.1096\/fasebj.27.1_supplement.752.4","article-title":"Telocytes and Stem Cells in Regenerative Medicine","volume":"27","author":"Nicolescu","year":"2013","journal-title":"FASEB J."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/1\/40\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:57Z","timestamp":1760132517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/1\/40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,25]]},"references-count":343,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["life14010040"],"URL":"https:\/\/doi.org\/10.3390\/life14010040","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,25]]}}}