{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:51:06Z","timestamp":1782175866255,"version":"3.54.5"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The progressive reappearance of Zika virus (ZIKV) infections since October 2013 and its circulation in &gt;70 countries and territories (from French Polynesia to Brazil and other countries in the Americas, with sporadic spread in Europe and the East) has long been reported as a global public health emergency. ZIKV is a virus transmitted by arthropods (arboviruses), mainly by Aedes mosquitoes. ZIKV can also be transmitted to humans through mechanisms other than vector infection such as sexual intercourse, blood transfusions, and mother-to-child transmission. The latter mode of transmission can give rise to a severe clinical form called congenital Zika syndrome (CZS), which can result in spontaneous abortion or serious pathological alterations in the fetus such as microcephaly or neurological and orofacial anomalies. In this study, beside a succinct overview of the etiological, microbiological, and epidemiological aspects and modes of transmission of Zika virus infections, we have focused our attention on the pathogenetic and histopathological aspects in pregnancy and the pathogenetic and molecular mechanisms that can determine microcephaly, and consequently the clinical alterations, typical of the fetus and newborns, in a subject affected by CZS.<\/jats:p>","DOI":"10.3390\/life14010055","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T09:56:27Z","timestamp":1703757387000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Congenital Zika Virus Syndrome: Microcephaly and Orofacial Anomalies"],"prefix":"10.3390","volume":"14","author":[{"given":"Gaetano","family":"Scotto","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, University Hospital \u201cOORR\u201d Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2186-9621","authenticated-orcid":false,"given":"Salvatore","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food, Natural Resource and Engineering, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-2425","authenticated-orcid":false,"given":"Francesca","family":"Spirito","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzina","family":"Fazio","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, Virology Unit, University Hospital \u201cOORR\u201d Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1016\/S1473-3099(18)30269-X","article-title":"Unexpected outbreaks of arbovirus infections: Lessons learned from the Pacific and tropical America","volume":"18","author":"Musso","year":"2018","journal-title":"Lancet Infect. 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