{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:25:23Z","timestamp":1792697123945,"version":"4.5.0"},"reference-count":295,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, making it one of the most prevalent chronic liver disorders. MASLD encompasses a range of liver pathologies, from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) with inflammation, hepatocyte damage, and fibrosis. Interestingly, the liver exhibits close intercommunication with fatty tissue. In fact, adipose tissue could contribute to the etiology and advancement of MASLD, acting as an endocrine organ that releases several hormones and cytokines, with the adipokines assuming a pivotal role. The levels of adipokines in the blood are altered in people with MASLD, and recent research has shed light on the crucial role played by adipokines in regulating energy expenditure, inflammation, and fibrosis in MASLD. However, MASLD disease is a multifaceted condition that affects various aspects of health beyond liver function, including its impact on hemostasis. The alterations in coagulation mechanisms and endothelial and platelet functions may play a role in the increased vulnerability and severity of MASLD. Therefore, more attention is being given to imbalanced adipokines as causative agents in causing disturbances in hemostasis in MASLD. Metabolic inflammation and hepatic injury are fundamental components of MASLD, and the interrelation between these biological components and the hemostasis pathway is delineated by reciprocal influences, as well as the induction of alterations. Adipokines have the potential to serve as the shared elements within this complex interrelationship. The objective of this review is to thoroughly examine the existing scientific knowledge on the impairment of hemostasis in MASLD and its connection with adipokines, with the aim of enhancing our comprehension of the disease.<\/jats:p>","DOI":"10.3390\/life14010093","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T07:59:20Z","timestamp":1704700760000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Role of Perturbated Hemostasis in MASLD and Its Correlation with Adipokines"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5751-9263","authenticated-orcid":false,"given":"Salvatore","family":"Pezzino","sequence":"first","affiliation":[{"name":"Mediterranean Foundation \u201cGB Morgagni\u201d, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-5005","authenticated-orcid":false,"given":"Tonia","family":"Luca","sequence":"additional","affiliation":[{"name":"Mediterranean Foundation \u201cGB Morgagni\u201d, 95125 Catania, Italy"},{"name":"Department of Medical, Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacarla","family":"Castorina","sequence":"additional","affiliation":[{"name":"Mediterranean Foundation \u201cGB Morgagni\u201d, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Puleo","sequence":"additional","affiliation":[{"name":"Mediterranean Foundation \u201cGB Morgagni\u201d, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Latteri","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Castorina","sequence":"additional","affiliation":[{"name":"Mediterranean Foundation \u201cGB Morgagni\u201d, 95125 Catania, Italy"},{"name":"Department of Medical, Surgical Sciences and Advanced Technologies \u201cG.F. 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Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.cgh.2021.11.004","article-title":"Clinical and Patient-Reported Outcomes From Patients with Nonalcoholic Fatty Liver Disease across the World: Data From the Global Non-Alcoholic Steatohepatitis (NASH)\/Non-Alcoholic Fatty Liver Disease (NAFLD) Registry","volume":"20","author":"Younossi","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.3350\/cmh.2022.0424","article-title":"Non-Alcoholic Fatty Liver Disease: Definition and Subtypes","volume":"29","author":"Han","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-020-00570-y","article-title":"NAFLD as a Continuum: From Obesity to Metabolic Syndrome and Diabetes","volume":"12","author":"Valerio","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Pouwels, S., Sakran, N., Graham, Y., Leal, A., Pintar, T., Yang, W., Kassir, R., Singhal, R., Mahawar, K., and Ramnarain, D. (2022). Non-Alcoholic Fatty Liver Disease (NAFLD): A Review of Pathophysiology, Clinical Management and Effects of Weight Loss. BMC Endocr. Disord., 22.","DOI":"10.1186\/s12902-022-00980-1"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Pezzino, S., Sofia, M., Faletra, G., Mazzone, C., Litrico, G., La Greca, G., and Latteri, S. (2022). Gut-Liver Axis and Non-Alcoholic Fatty Liver Disease: A Vicious Circle of Dysfunctions Orchestrated by the Gut Microbiome. Biology, 11.","DOI":"10.3390\/biology11111622"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Pezzino, S., Sofia, M., Greco, L.P., Litrico, G., Filippello, G., Sarv\u00e0, I., Greca, G., and Latteri, S. (2023). Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021166"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: A Multisystem Disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_10","first-page":"404","article-title":"Epidemiology of Nonalcoholic Fatty Liver Disease in Europe: A Systematic Review and Meta-Analysis","volume":"34","author":"Cholongitas","year":"2021","journal-title":"Ann. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/liv.13299","article-title":"The Epidemiology of Non-Alcoholic Fatty Liver Disease","volume":"37","author":"Bellentani","year":"2017","journal-title":"Liver Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1210\/endrev\/bnz009","article-title":"Nonalcoholic Fatty Liver Disease in Adults: Current Concepts in Etiology, Outcomes, and Management","volume":"41","author":"Marjot","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7150\/ijbs.29599","article-title":"Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer","volume":"15","author":"Divella","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.14218\/JCTH.2021.00268","article-title":"Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications","volume":"10","author":"Ogresta","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1055\/s-0033-1334866","article-title":"Diagnosis and Management of Nonalcoholic Fatty Liver Disease and Its Hemostatic\/Thrombotic and Vascular Complications","volume":"39","author":"Targher","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tripodi, A., Lombardi, R., Primignani, M., La Mura, V., Peyvandi, F., and Fracanzani, A.L. (2022). Hypercoagulability in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD): Causes and Consequences. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020249"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-2002-23205","article-title":"Coagulation Disorders in Liver Disease","volume":"22","author":"Amitrano","year":"2002","journal-title":"Semin. Liver Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3325\/cmj.2021.62.25","article-title":"Non-Alcoholic Fatty Liver Disease\u2014A Procoagulant Condition?","volume":"62","author":"Kukla","year":"2021","journal-title":"Croat. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2019.01.029","article-title":"Does Nonalcoholic Fatty Liver Disease Cause Cardiovascular Disease? Current Knowledge and Gaps","volume":"282","author":"Santos","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejim.2010.01.005","article-title":"The Coagulopathy of Chronic Liver Disease: Is There a Causal Relationship with Bleeding? Yes","volume":"21","author":"Basili","year":"2010","journal-title":"Eur. J. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5009\/gnl19069","article-title":"Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease","volume":"14","author":"Li","year":"2020","journal-title":"Gut Liver"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1053\/j.gastro.2019.12.054","article-title":"Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease","volume":"158","author":"Azzu","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, X., Rao, H., Liu, F., Wei, L., Li, H., and Wu, C. (2021). Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease. Cells, 10.","DOI":"10.3390\/cells10123300"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD Development and Therapeutic Strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11154-022-09709-w","article-title":"The Endocrine Adipose Organ","volume":"23","author":"Cinti","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1079\/PNS200194","article-title":"Physiological Role of Adipose Tissue: White Adipose Tissue as an Endocrine and Secretory Organ","volume":"60","author":"Trayhurn","year":"2001","journal-title":"Proc. Nutr. Soc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/BF03344048","article-title":"Adipose Tissue Hormones","volume":"25","year":"2002","journal-title":"J. Endocrinol. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cld.2017.08.007","article-title":"Pathophysiology of Nonalcoholic Fatty Liver Disease\/Nonalcoholic Steatohepatitis","volume":"22","author":"Manne","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.3748\/wjg.v20.i28.9330","article-title":"Non-Alcoholic Fatty Liver Disease and Obesity: Biochemical, Metabolic and Clinical Presentations","volume":"20","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Clemente-Su\u00e1rez, V.J., Redondo-Fl\u00f3rez, L., Beltr\u00e1n-Velasco, A.I., Mart\u00edn-Rodr\u00edguez, A., Mart\u00ednez-Guardado, I., Navarro-Jim\u00e9nez, E., Laborde-C\u00e1rdenas, C.C., and Tornero-Aguilera, J.F. (2023). The Role of Adipokines in Health and Disease. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051290"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4093\/dmj.2012.36.5.317","article-title":"Clinical Relevance of Adipokines","volume":"36","year":"2012","journal-title":"Diabetes Metab. J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Francisco, V., Sanz, M.J., Real, J.T., Marques, P., Capuozzo, M., Ait Eldjoudi, D., and Gualillo, O. (2022). Adipokines in Non-Alcoholic Fatty Liver Disease: Are We on the Road toward New Biomarkers and Therapeutic Targets?. Biology, 11.","DOI":"10.3390\/biology11081237"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"842636","DOI":"10.3389\/fphar.2022.842636","article-title":"Platelets in Non-Alcoholic Fatty Liver Disease","volume":"13","author":"Dalbeni","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Adolph, T.E., Grander, C., Grabherr, F., and Tilg, H. (2017). Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081649"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1053\/j.gastro.2006.05.054","article-title":"Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance","volume":"131","author":"Tilg","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tem.2008.08.005","article-title":"Insulin Resistance, Inflammation, and Non-Alcoholic Fatty Liver Disease","volume":"19","author":"Tilg","year":"2008","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_37","first-page":"B4890","article-title":"Metabolism and Insulin Signaling in Common Metabolic Disorders and Inherited Insulin Resistance","volume":"61","year":"2014","journal-title":"Dan. Med. J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Fujii, H., Kawada, N., and Japan Study Group of NAFLD (JSG-NAFLD) (2020). The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113863"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Armandi, A., Rosso, C., Caviglia, G.P., and Bugianesi, E. (2021). Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease. Metabolites, 11.","DOI":"10.3390\/metabo11030155"},{"key":"ref_40","first-page":"259","article-title":"The Adipokines in the Pathogenesis and Treatment of Nonalcoholic Fatty Liver Disease","volume":"20","author":"Boutari","year":"2016","journal-title":"Hippokratia"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"H2031","DOI":"10.1152\/ajpheart.01058.2004","article-title":"Adipokines: Molecular Links between Obesity and Atheroslcerosis","volume":"288","author":"Lau","year":"2005","journal-title":"Am. J. Physiol.\u2014Heart Circ. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"578966","DOI":"10.3389\/fphys.2020.578966","article-title":"Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases","volume":"11","author":"Recinella","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/1076029611418962","article-title":"Significant Associations Among Hemostatic Parameters, Adipokines, and Components of the Metabolic Syndrome in Japanese Preschool Children","volume":"18","author":"Horigome","year":"2012","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1467-789X.2009.00593.x","article-title":"Role of Adipose Tissue in Haemostasis, Coagulation and Fibrinolysis","volume":"10","author":"Faber","year":"2009","journal-title":"Obes. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fendo.2013.00071","article-title":"Adipokines Mediate Inflammation and Insulin Resistance","volume":"4","author":"Kwon","year":"2013","journal-title":"Front. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.diabet.2007.09.004","article-title":"Adipokines: The Missing Link between Insulin Resistance and Obesity","volume":"34","author":"Feve","year":"2008","journal-title":"Diabetes Metab."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kr\u00fcger-Genge, A., Blocki, A., Franke, R.-P., and Jung, F. (2019). Vascular Endothelial Cell Biology: An Update. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184411"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nasiri-Ansari, N., Androutsakos, T., Flessa, C.-M., Kyrou, I., Siasos, G., Randeva, H.S., Kassi, E., and Papavassiliou, A.G. (2022). Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review. Cells, 11.","DOI":"10.3390\/cells11162511"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yau, J.W., Teoh, H., and Verma, S. (2015). Endothelial Cell Control of Thrombosis. BMC Cardiovasc. Disord., 15.","DOI":"10.1186\/s12872-015-0124-z"},{"key":"ref_50","unstructured":"LaPelusa, A., and Dave, H.D. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1055\/s-0035-1550433","article-title":"Vascular Disease in Patients with Nonalcoholic Fatty Liver Disease","volume":"41","author":"Potze","year":"2015","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2003-38328","article-title":"Basic Mechanisms of Hemostasis","volume":"3","author":"Hackeng","year":"2003","journal-title":"Semin. Vasc. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/MBC.0000000000001099","article-title":"The Physiology of Hemostasis","volume":"33","author":"Sierra","year":"2022","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sillen, M., and Declerck, P.J. (2021). A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052721"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1111\/j.1755-5922.2010.00171.x","article-title":"Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions","volume":"28","author":"Cesari","year":"2010","journal-title":"Cardiovasc. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1182\/blood.2020008951","article-title":"Plasminogen: An Enigmatic Zymogen","volume":"137","author":"Keragala","year":"2021","journal-title":"Blood"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41598-020-79948-x","article-title":"Role of PAI-1 in Hepatic Steatosis and Dyslipidemia","volume":"11","author":"Levine","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12944-023-01854-8","article-title":"Association between Fatty Liver Index and Blood Coagulation Markers: A Population-Based Study","volume":"22","author":"Freuer","year":"2023","journal-title":"Lipids Health Dis."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Robea, M.A., Balmus, I.-M., Girleanu, I., Huiban, L., Muzica, C., Ciobica, A., Stanciu, C., Cimpoesu, C.D., and Trifan, A. (2023). Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease\u2014Oxidative Stress and Inflammation Relevance. Medicina, 59.","DOI":"10.3390\/medicina59091614"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2036.2007.03509.x","article-title":"Review Article: Coagulation Disorders in Chronic Liver Disease","volume":"26","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.thromres.2020.12.002","article-title":"Translational Insight into Prothrombotic State and Hypercoagulation in Nonalcoholic Fatty Liver Disease","volume":"198","author":"Ciavarella","year":"2021","journal-title":"Thromb. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhep.2014.03.013","article-title":"Procoagulant Imbalance in Patients with Non-Alcoholic Fatty Liver Disease","volume":"61","author":"Tripodi","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"100598","DOI":"10.1016\/j.jhepr.2022.100598","article-title":"Clinical and Genetic Determinants of the Fatty Liver-Coagulation Balance Interplay in Individuals with Metabolic Dysfunction","volume":"4","author":"Valenti","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.3892\/etm.2021.10790","article-title":"Non-Alcoholic Fatty Liver Disease and Hematologic Manifestations (Review)","volume":"22","author":"Dop","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00281-021-00876-7","article-title":"The Contact System in Liver Injury","volume":"43","author":"Rangaswamy","year":"2021","journal-title":"Semin. Immunopathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/jth.13327","article-title":"Role of Hemostatic Factors in Hepatic Injury and Disease: Animal Models de-Liver","volume":"14","author":"Kopec","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/jth.15312","article-title":"Targeting von Willebrand Factor in Liver Diseases: A Novel Therapeutic Strategy?","volume":"19","author":"Groeneveld","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/cld.935","article-title":"Coagulation Homeostasis in Liver Disease","volume":"16","author":"Caldwell","year":"2020","journal-title":"Clin. Liver Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5560560","DOI":"10.1155\/2023\/5560560","article-title":"Coagulation Dysfunction in Patients with Liver Cirrhosis and Splenomegaly and Its Countermeasures: A Retrospective Study of 1522 Patients","volume":"2023","author":"Lv","year":"2023","journal-title":"Dis. Markers"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"20420188221145549","DOI":"10.1177\/20420188221145549","article-title":"MAFLD: A Multisystem Disease","volume":"14","author":"Pipitone","year":"2023","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"329","DOI":"10.14218\/JCTH.2021.00178","article-title":"Metabolic-Associated Fatty Liver Disease (MAFLD): A Multi-Systemic Disease Beyond the Liver","volume":"10","author":"Kaya","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Gidaro, A., Manetti, R., Delitala, A.P., Salvi, E., Bergamaschini, L., Vidili, G., and Castelli, R. (2021). Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study. J. Clin. Med., 10.","DOI":"10.3390\/jcm10214906"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1016\/j.jtha.2023.06.017","article-title":"The Prothrombotic Tendency of Metabolic-Associated Fatty Liver Disease","volume":"21","author":"Swan","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"622473","DOI":"10.3389\/fcvm.2020.622473","article-title":"Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition","volume":"7","author":"Sillen","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/jn\/138.8.1452","article-title":"Nonalcoholic Fatty Liver Disease in Humans Is Associated with Increased Plasma Endotoxin and Plasminogen Activator Inhibitor 1 Concentrations and with Fructose Intake1","volume":"138","author":"Thuy","year":"2008","journal-title":"J. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"100064","DOI":"10.1016\/j.cytox.2022.100064","article-title":"Plasminogen Activator Inhibitor-1 Mediate Downregulation of Adiponectin in Type 2 Diabetes Patients with Metabolic Syndrome","volume":"4","author":"Nawaz","year":"2022","journal-title":"Cytokine X"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"206","DOI":"10.15403\/jgld-4091","article-title":"Plasminogen Activator Inhibitor-1 Levels in Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis","volume":"31","author":"Alsharoh","year":"2022","journal-title":"J. Gastrointestin Liver Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e000683","DOI":"10.1136\/bmjgast-2021-000683","article-title":"Plasminogen Activator Inhibitor Is Significantly Elevated in Liver Transplant Recipients with Decompensated NASH Cirrhosis","volume":"8","author":"Rivas","year":"2021","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_79","first-page":"1238","article-title":"Hepatic and Portal Vein Thrombosis in Cirrhosis: Possible Role in Development of Parenchymal Extinction and Portal Hypertension","volume":"21","author":"Wanless","year":"1995","journal-title":"Hepatology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1152\/physiol.00013.2023","article-title":"NAFLD: An Emerging Causal Factor for Cardiovascular Disease","volume":"38","author":"Li","year":"2023","journal-title":"Physiology"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Niederseer, D., Wernly, B., Aigner, E., Stickel, F., and Datz, C. (2021). NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030467"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/MEG.0000000000001689","article-title":"Association between Nonalcoholic Fatty Liver Disease and Portal Vein Thrombosis: A Systematic Review and Meta-Analysis","volume":"32","author":"Lin","year":"2020","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1177\/00033197221091317","article-title":"Atherosclerosis and Non-Alcoholic Fatty Liver Disease","volume":"73","author":"Balta","year":"2022","journal-title":"Angiology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1116861","DOI":"10.3389\/fcvm.2023.1116861","article-title":"The Interplay between Nonalcoholic Fatty Liver Disease and Atherosclerotic Cardiovascular Disease","volume":"10","author":"Finney","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3109\/09537104.2010.540049","article-title":"The Association between Non-Alcoholic Hepatic Steatosis and Mean Platelet Volume in an Obese Korean Population","volume":"22","author":"Shin","year":"2011","journal-title":"Platelets"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/MCG.0000000000000340","article-title":"Nonalcoholic Fatty Liver Disease and Mean Platelet Volume: A Systemic Review and Meta-Analysis","volume":"50","author":"Madan","year":"2016","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/jrms.JRMS_711_16","article-title":"Comparison of Platelet Number and Function between Nonalcoholic Fatty Liver Disease and Normal Individuals","volume":"22","author":"Saremi","year":"2017","journal-title":"J. Res. Med. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.2147\/DMSO.S367483","article-title":"Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease","volume":"15","author":"Yin","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1007\/s00535-011-0436-4","article-title":"Platelet Count for Predicting Fibrosis in Nonalcoholic Fatty Liver Disease","volume":"46","author":"Yoneda","year":"2011","journal-title":"J. Gastroenterol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/hepr.13884","article-title":"Multicenter, Retrospective, Cohort Study Shows Platelet Counts Predict Hepatocellular Carcinoma Development in Patients with Nonalcoholic Fatty Liver Disease","volume":"53","author":"Fujii","year":"2023","journal-title":"Hepatol. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.jtha.2023.08.014","article-title":"Fibrinogen and Fibrin: Synthesis, Structure, and Function in Health and Disease","volume":"21","author":"Wolberg","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1378\/chest.124.3_suppl.18S","article-title":"Thrombin and Platelet Activation","volume":"124","author":"Brass","year":"2003","journal-title":"Chest"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.2741\/1715","article-title":"Platelet Aggregation: Involvement of Thrombin and Fibrin(Ogen)","volume":"10","author":"Lisman","year":"2005","journal-title":"Front. Biosci."},{"key":"ref_95","first-page":"39","article-title":"The Pathophysiology of Thrombocytopenia in Chronic Liver Disease","volume":"8","author":"Mitchell","year":"2016","journal-title":"Hepat. Med."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Mussbacher, M., Brunnthaler, L., Panhuber, A., Starlinger, P., and Assinger, A. (2021). Till Death Do Us Part\u2014The Multifaceted Role of Platelets in Liver Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063113"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.molmed.2023.03.001","article-title":"Recent Insights into Lysosomal Acid Lipase Deficiency","volume":"29","author":"Korbelius","year":"2023","journal-title":"Trends Mol. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e00116","DOI":"10.14309\/ctg.0000000000000116","article-title":"Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated with Nonalcoholic Fatty Liver Disease","volume":"11","author":"Ferri","year":"2020","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41591-019-0379-5","article-title":"Platelet GPIb\u03b1 Is a Mediator and Potential Interventional Target for NASH and Subsequent Liver Cancer","volume":"25","author":"Malehmir","year":"2019","journal-title":"Nat. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12964-019-0428-1","article-title":"cAMP- and cGMP-Elevating Agents Inhibit GPIb\u03b1-Mediated Aggregation but Not GPIb\u03b1-Stimulated Syk Activation in Human Platelets","volume":"17","author":"Makhoul","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.2174\/1381612826666200131101553","article-title":"Nonalcoholic Fatty Liver Disease-Evidence for a Thrombophilic State?","volume":"26","author":"Spinosa","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e222","DOI":"10.1016\/j.dld.2015.07.018","article-title":"Cardiovascular Risk and Inflammation in Nonalcoholic Fatty Liver Disease: The Upregulation of Inflammatory Platelet Transcripts Suggest a Role for Platelets in the \u201cInflammatory Network\u201d of NAFLD","volume":"47","author":"Alberelli","year":"2015","journal-title":"Dig. Liver Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"708959","DOI":"10.3389\/fimmu.2021.708959","article-title":"Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression","volume":"12","author":"Mattos","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fendo.2020.00294","article-title":"Obesity-Induced Changes in Bone Marrow Homeostasis","volume":"11","author":"Benova","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/MEG.0000000000000429","article-title":"Nonalcoholic Fatty Liver Disease and Carotid Artery Atherosclerosis in Children and Adults: A Meta-Analysis","volume":"27","author":"Madan","year":"2015","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e1554","DOI":"10.1002\/hsr2.1554","article-title":"Association of Nonalcoholic Fatty Liver Disease and Carotid Media-intima Thickness: A Systematic Review and a Meta-analysis","volume":"6","author":"Khoshbaten","year":"2023","journal-title":"Health Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"655557","DOI":"10.3389\/fphar.2021.655557","article-title":"Targeting Liver Sinusoidal Endothelial Cells: An Attractive Therapeutic Strategy to Control Inflammation in Nonalcoholic Fatty Liver Disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"105739","DOI":"10.1016\/j.phrs.2021.105739","article-title":"Hepatic Stellate Cells Role in the Course of Metabolic Disorders Development\u2014A Molecular Overview","volume":"170","author":"Bourebaba","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4254\/wjh.v11.i5.412","article-title":"Roles of Hepatic Stellate Cells in Acute Liver Failure: From the Perspective of Inflammation and Fibrosis","volume":"11","author":"Li","year":"2019","journal-title":"World J. Hepatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3892\/mmr.2021.12003","article-title":"Interaction of Non-Parenchymal Hepatocytes in the Process of Hepatic Fibrosis","volume":"23","author":"Cheng","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"13306","DOI":"10.3748\/wjg.v20.i37.13306","article-title":"Nonalcoholic Fatty Liver Disease and Vascular Disease: State-of-the-Art","volume":"20","author":"Fargion","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00392-020-01709-7","article-title":"NAFLD and Cardiovascular Diseases: A Clinical Review","volume":"110","author":"Kasper","year":"2021","journal-title":"Clin. Res. Cardiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"568","DOI":"10.21037\/cdt.2018.07.01","article-title":"Interaction between Platelets and Endothelium: From Pathophysiology to New Therapeutic Options","volume":"8","author":"Hamilos","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00281-011-0285-5","article-title":"van Endothelium\u2014Role in Regulation of Coagulation and Inflammation","volume":"34","author":"Hinsbergh","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1038\/s41467-023-39752-3","article-title":"Endothelial Cell CD36 Regulates Membrane Ceramide Formation, Exosome Fatty Acid Transfer and Circulating Fatty Acid Levels","volume":"14","author":"Peche","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s11901-020-00543-9","article-title":"Exercise as Medicine: The Impact of Exercise Training on Nonalcoholic Fatty Liver Disease","volume":"19","author":"Thorp","year":"2020","journal-title":"Curr. Hepatol. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"H1298","DOI":"10.1152\/ajpheart.00306.2014","article-title":"Exercise Training Reverses Endothelial Dysfunction in Nonalcoholic Fatty Liver Disease","volume":"307","author":"Pugh","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e54271","DOI":"10.15252\/embr.202154271","article-title":"Endothelial-immune Crosstalk Contributes to Vasculopathy in Nonalcoholic Fatty Liver Disease","volume":"23","author":"Ng","year":"2022","journal-title":"EMBO Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"812030","DOI":"10.3389\/fcvm.2022.812030","article-title":"Association Between Non-Alcoholic Fatty Liver Disease and Risk of Stroke: A Systematic Review and Meta-Analysis","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Kj\u00e6rgaard, K., Mikkelsen, A.C.D., Wernberg, C.W., Gr\u00f8nkj\u00e6r, L.L., Eriksen, P.L., Damholdt, M.F., Mookerjee, R.P., Vilstrup, H., Lauridsen, M.M., and Thomsen, K.L. (2021). Cognitive Dysfunction in Non-Alcoholic Fatty Liver Disease\u2014Current Knowledge, Mechanisms and Perspectives. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040673"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-0043-1762585","article-title":"Emerging Links between Nonalcoholic Fatty Liver Disease and Neurodegeneration","volume":"43","author":"Kelty","year":"2023","journal-title":"Semin. Liver Dis."},{"key":"ref_122","first-page":"153","article-title":"Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: In Physiology and in Disease States","volume":"15","author":"Tran","year":"2022","journal-title":"Am. J. Biomed. Sci. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/MCO.0b013e32819f8ecd","article-title":"Insulin Action and Insulin Resistance in Vascular Endothelium","volume":"10","author":"Muniyappa","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Takeda, Y., Matoba, K., Sekiguchi, K., Nagai, Y., Yokota, T., Utsunomiya, K., and Nishimura, R. (2020). Endothelial Dysfunction in Diabetes. Biomedicines, 8.","DOI":"10.3390\/biomedicines8070182"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"ofac073","DOI":"10.1093\/ofid\/ofac073","article-title":"Association of Nonalcoholic Fatty Liver Disease with COVID-19 Severity and Pulmonary Thrombosis: CovidFAT, a Prospective, Observational Cohort Study","volume":"9","author":"Vrsaljko","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e13338","DOI":"10.1111\/eci.13338","article-title":"COVID-19 and Non-Alcoholic Fatty Liver Disease: Two Intersecting Pandemics","volume":"50","author":"Portincasa","year":"2020","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.dsx.2021.03.019","article-title":"Non-Alcoholic Fatty Liver Disease and Clinical Outcomes in Patients with COVID-19: A Comprehensive Systematic Review and Meta-Analysis","volume":"15","author":"Singh","year":"2021","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ijid.2020.10.015","article-title":"Susceptibility of the Obese Population to COVID-19","volume":"101","author":"Kimura","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5114\/amsad\/160950","article-title":"Liver Injury in COVID-19 Patients with Non-Alcoholic Fatty Liver Disease: An Update","volume":"8","author":"Miranda","year":"2023","journal-title":"Arch. Med. Sci. Atheroscler. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1007\/s42399-020-00631-3","article-title":"NAFLD and COVID-19: A Pooled Analysis","volume":"2","author":"Sachdeva","year":"2020","journal-title":"SN Compr. Clin. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jhep.2020.09.006","article-title":"NAFLD Is a Predictor of Liver Injury in COVID-19 Hospitalized Patients but Not of Mortality, Disease Severity on the Presentation or Progression\u2014The Debate Continues","volume":"74","author":"Mushtaq","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s40001-022-00865-y","article-title":"Systems Biology Approach Reveals a Common Molecular Basis for COVID-19 and Non-Alcoholic Fatty Liver Disease (NAFLD)","volume":"27","author":"Jiang","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/09537104.2021.1962519","article-title":"Alterations in Platelets during SARS-CoV-2 Infection","volume":"33","author":"Brambilla","year":"2021","journal-title":"Platelets"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41419-020-03333-9","article-title":"SARS-CoV-2 Infection Is Associated with a pro-Thrombotic Platelet Phenotype","volume":"12","author":"Bongiovanni","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Schrick, D., T\u0151k\u00e9s-F\u00fczesi, M., R\u00e9ger, B., and Moln\u00e1r, T. (2021). Plasma Fibrinogen Independently Predicts Hypofibrinolysis in Severe COVID-19. Metabolites, 11.","DOI":"10.3390\/metabo11120826"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/hepr.13577","article-title":"Association of Coagulopathy with Liver Dysfunction in Patients with COVID-19","volume":"51","author":"Tsutsumi","year":"2021","journal-title":"Hepatol. Res."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Abenavoli, L., Aquila, I., Sacco, M.A., Scarlata, G.G.M., Procopio, A.C., Boccuto, L., Scarpellini, E., Greco, M., Foti, D.P., and Ricci, P. (2023). Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series. Diseases, 11.","DOI":"10.3390\/diseases11040141"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.metabol.2015.11.006","article-title":"Adipokines in Nonalcoholic Fatty Liver Disease","volume":"65","author":"Polyzos","year":"2016","journal-title":"Metabolism"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S1665-2681(19)31822-8","article-title":"Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease","volume":"8","year":"2009","journal-title":"Ann. Hepatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41392-022-01073-0","article-title":"Trends in Insulin Resistance: Insights into Mechanisms and Therapeutic Strategy","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Chao, H.-W., Chao, S.-W., Lin, H., Ku, H.-C., and Cheng, C.-F. (2019). Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020298"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1228072","DOI":"10.3389\/fendo.2023.1228072","article-title":"Association between Dietary Glycemic Index and Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus","volume":"14","author":"Salavatizadeh","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"866751","DOI":"10.3389\/fcvm.2022.866751","article-title":"Thrombosis and Inflammation\u2014A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C","volume":"9","author":"Kohli","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1053\/j.gastro.2020.02.020","article-title":"Metabolic Inflammation\u2014A Role for Hepatic Inflammatory Pathways as Drivers of Comorbidities in Nonalcoholic Fatty Liver Disease?","volume":"158","author":"Gehrke","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_145","first-page":"329","article-title":"Non-Alcoholic Fatty Liver Disease: Cause or Effect of Metabolic Syndrome","volume":"32","author":"Grander","year":"2016","journal-title":"Viszeralmedizin"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2141.1988.tb02490.x","article-title":"Plasminogen Activator Inhibitor (PAI-1) in Plasma and Platelets","volume":"70","author":"Booth","year":"1988","journal-title":"Br. J. Haematol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"923","DOI":"10.2174\/092986708783955455","article-title":"Fibrinolysis: The Key to New Pathogenetic Mechanisms","volume":"15","author":"Zorio","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s001250050868","article-title":"Adipose Tissue Secretion of Plasminogen Activator Inhibitor-1 in Non-Obese and Obese Individuals","volume":"41","author":"Eriksson","year":"1998","journal-title":"Diabetologia"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/cphy.c160004","article-title":"Adipose Tissue-Derived Plasminogen Activator Inhibitor-1 Function and Regulation","volume":"6","author":"Kaji","year":"2016","journal-title":"Compr. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.blre.2016.05.002","article-title":"The Contribution of Different Adipose Tissue Depots to Plasma Plasminogen Activator Inhibitor-1 (PAI-1) Levels","volume":"30","author":"Barnard","year":"2016","journal-title":"Blood Rev."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2141.2012.09074.x","article-title":"PAI-1, Progress in Understanding the Clinical Problem and Its Aetiology","volume":"157","author":"Iwaki","year":"2012","journal-title":"Br. J. Haematol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3389\/fphar.2018.01087","article-title":"PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1111\/bph.15476","article-title":"Complement, Inflammation and Thrombosis","volume":"178","author":"Rawish","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Kuijpers, M.J.E., Heemskerk, J.W.M., and Jurk, K. (2022). Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105825"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1182\/blood.2023020535","article-title":"Hemostasis without Clot Formation: How Platelets Guard the Vasculature in Inflammation, Infection, and Malignancy","volume":"142","author":"Kaiser","year":"2023","journal-title":"Blood"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00109-014-1170-1","article-title":"NLRP3 Inflammasome Activation Is Required for Fibrosis Development in NAFLD","volume":"92","author":"Wree","year":"2014","journal-title":"J. Mol. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm.3260","article-title":"How Cytokine Networks Fuel Inflammation: Toward a Cytokine-Based Disease Taxonomy","volume":"19","author":"Schett","year":"2013","journal-title":"Nat. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1165\/rcmb.2012-0404OC","article-title":"Plasminogen-Stimulated Inflammatory Cytokine Production by Airway Smooth Muscle Cells Is Regulated by Annexin A2","volume":"49","author":"Schuliga","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"109761","DOI":"10.1016\/j.cellsig.2020.109761","article-title":"The Multifaceted Role of Plasminogen in Inflammation","volume":"75","author":"Heissig","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"22351","DOI":"10.1073\/pnas.2010229117","article-title":"IL-6 Trans-Signaling Induces Plasminogen Activator Inhibitor-1 from Vascular Endothelial Cells in Cytokine Release Syndrome","volume":"117","author":"Kang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"880298","DOI":"10.3389\/fimmu.2022.880298","article-title":"Association of Inflammatory Cytokines with Non-Alcoholic Fatty Liver Disease","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.ATV.18.1.1","article-title":"The Adipocyte and Hemostatic Balance in Obesity","volume":"18","author":"Loskutoff","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_163","first-page":"15919","article-title":"PAI-1 and TNF-\u03b1 Profiles of Adipose Tissue in Obese Cardiovascular Disease Patients","volume":"8","author":"Akan","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/BF03402048","article-title":"Insulin Continues to Induce Plasminogen Activator Inhibitor 1 Gene Expression in Insulin-Resistant Mice and Adipocytes","volume":"6","author":"Samad","year":"2000","journal-title":"Mol. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/1520-7560(200005\/06)16:3<192::AID-DMRR114>3.0.CO;2-G","article-title":"Relationship between Plasma Plasminogen Activator Inhibitor 1 and Insulin Resistance","volume":"16","author":"Bastard","year":"2000","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/j.1538-7836.2005.01420.x","article-title":"PAI-1 and Atherothrombosis","volume":"3","author":"Vaughan","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12959-018-0166-4","article-title":"Association between Plasminogen Activator Inhibitor-1 and Cardiovascular Events: A Systematic Review and Meta-Analysis","volume":"16","author":"Jung","year":"2018","journal-title":"Thromb. J."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/jth.15701","article-title":"Elevated Plasma Levels of Plasminogen Activator Inhibitor-1 Are Associated with Risk of Future Incident Venous Thromboembolism","volume":"20","author":"Frischmuth","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s42255-019-0041-z","article-title":"Metabolic Messengers: Adiponectin","volume":"1","author":"Straub","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/npjamd.2015.13","article-title":"Adiponectin\/Adiponectin Receptor in Disease and Aging","volume":"1","author":"Iwabu","year":"2015","journal-title":"npj Aging Mech. Dis."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.ejhg.5201120","article-title":"Association of the Human Adiponectin Gene and Insulin Resistance","volume":"12","author":"Filippi","year":"2004","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/ijo.2016.104","article-title":"Adiponectin Mediates the Additive Effects of Combining Daily Exercise with Caloric Restriction for Treatment of Non-Alcoholic Fatty Liver","volume":"40","author":"Cho","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"154026","DOI":"10.1016\/j.metabol.2019.154026","article-title":"Low Levels of Total and High-Molecular-Weight Adiponectin May Predict Non-Alcoholic Fatty Liver in Korean Adults","volume":"103","author":"Kim","year":"2020","journal-title":"Metabolism"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1038\/s41467-020-19668-y","article-title":"AdipoR1\/AdipoR2 Dual Agonist Recovers Nonalcoholic Steatohepatitis and Related Fibrosis via Endoplasmic Reticulum-Mitochondria Axis","volume":"11","author":"Xu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1507\/endocrj.52.519","article-title":"Serum Adiponectin, Resistin Levels and Non-Alcoholic Fatty Liver Disease in Obese Children","volume":"52","author":"Zou","year":"2005","journal-title":"Endocr. J."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2478\/v10039-009-0047-y","article-title":"Serum Concentration of Adiponectin, Leptin and Resistin in Obese Children with Non-Alcoholic Fatty Liver Disease","volume":"54","author":"Lebensztejn","year":"2009","journal-title":"Adv. Med. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Ramanathan, R., Ali, A.H., and Ibdah, J.A. (2022). Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137280"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3389\/fphys.2020.00767","article-title":"The Emerging Role of Hepatocellular eNOS in Non-Alcoholic Fatty Liver Disease Development","volume":"11","author":"Cunningham","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4254\/wjh.v10.i10.708","article-title":"Adiponectin as a Novel Biomarker for Liver Fibrosis","volume":"10","author":"Udomsinprasert","year":"2018","journal-title":"World J. Hepatol."},{"key":"ref_180","first-page":"917","article-title":"Adiponectin inhibits the activation of hepatic stellate cells induced by TGFb1 via up-regulating the expression of eNOS","volume":"19","author":"Wang","year":"2011","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.21991","article-title":"High Molecular Weight Adiponectin Inhibits Proliferation of Hepatic Stellate Cells via Activation of Adenosine Monophosphate-Activated Protein Kinase","volume":"47","author":"Adachi","year":"2008","journal-title":"Hepatology"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/01.ATV.0000194076.84568.81","article-title":"Adiponectin Acts as an Endogenous Antithrombotic Factor","volume":"26","author":"Kato","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Kim, J.-E., Kim, J.-S., Jo, M.-J., Cho, E., Ahn, S.-Y., Kwon, Y.-J., and Ko, G.-J. (2022). The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome. Molecules, 27.","DOI":"10.3390\/molecules27020334"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1160\/th14-03-0199","article-title":"The Relevance of Coagulation in Cardiovascular Disease: What Do the Biomarkers Tell Us?","volume":"112","author":"Lowe","year":"2014","journal-title":"Thromb. Haemost."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Willich, S.N., and Muller, J.E. (1996). Triggering of Acute Coronary Syndromes: Implications for Prevention, Springer. Developments in Cardiovascular Medicine.","DOI":"10.1007\/978-94-009-1577-0"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e22709","DOI":"10.1002\/jcla.22709","article-title":"Low Serum Adiponectin Is a Predictor of Progressing to Nonalcoholic Fatty Liver Disease","volume":"33","author":"Zhang","year":"2018","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1210\/jc.2017-00933","article-title":"Adiponectin Predicts High-Density Lipoprotein Cholesterol Efflux Capacity in Adults Irrespective of Body Mass Index and Fat Distribution","volume":"102","author":"Marsche","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"54","DOI":"10.12965\/jer.140100","article-title":"Role of Adiponectin in Metabolic and Cardiovascular Disease","volume":"10","author":"Lee","year":"2014","journal-title":"J. Exerc. Rehabil."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1476-5381.2011.01395.x","article-title":"Adiponectin and Cardiovascular Health: An Update","volume":"165","author":"Hui","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"E527","DOI":"10.1152\/ajpendo.00110.2003","article-title":"Regulation of Adiponectin by Adipose Tissue-Derived Cytokines: In Vivo and in Vitro Investigations in Humans","volume":"285","author":"Bruun","year":"2003","journal-title":"Am. J. Physiol.\u2014Endocrinol. Metab."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1677\/JOE-06-0047","article-title":"Pro-Inflammatory Delipidizing Cytokines Reduce Adiponectin Secretion from Human Adipocytes without Affecting Adiponectin Oligomerization","volume":"192","author":"Simons","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/rth2.12080","article-title":"The Coagulation System in Atherothrombosis: Implications for New Therapeutic Strategies","volume":"2","author":"Olie","year":"2018","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1161\/01.CIR.0000089190.95415.9F","article-title":"New Markers of Inflammation and Endothelial Cell Activation","volume":"108","author":"Szmitko","year":"2003","journal-title":"Circulation"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"718432","DOI":"10.3389\/fimmu.2021.718432","article-title":"Trafficking of Mononuclear Phagocytes in Healthy Arteries and Atherosclerosis","volume":"12","author":"Tomas","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12944-015-0141-z","article-title":"Research Advances in the Relationship between Nonalcoholic Fatty Liver Disease and Atherosclerosis","volume":"14","author":"Xu","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"H656","DOI":"10.1152\/ajpheart.00115.2010","article-title":"Adiponectin Primes Human Monocytes into Alternative Anti-Inflammatory M2 Macrophages","volume":"299","author":"Lovren","year":"2010","journal-title":"Am. J. Physiol.\u2014Heart Circ. Physiol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s42255-019-0095-y","article-title":"Leptin and the Endocrine Control of Energy Balance","volume":"1","author":"Friedman","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Izquierdo, A.G., Crujeiras, A.B., Casanueva, F.F., and Carreira, M.C. (2019). Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?. Nutrients, 11.","DOI":"10.3390\/nu11112704"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3389\/fphys.2018.00640","article-title":"Obesity, Fat Mass and Immune System: Role for Leptin","volume":"9","author":"Francisco","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00125-015-3769-3","article-title":"Circulating Leptin in Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis","volume":"59","author":"Polyzos","year":"2016","journal-title":"Diabetologia"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.thromres.2020.01.021","article-title":"The Association between Leptin Concentration and Blood Coagulation: Results from the NEO Study","volume":"188","author":"Buis","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1046\/j.1538-7836.2003.00445.x","article-title":"Leptin Increase Is Associated with Markers of the Hemostatic System in Obese Healthy Women","volume":"1","author":"Guagnano","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/j.1538-7836.2007.02578.x","article-title":"Leptin Induces Tissue Factor Expression in Human Peripheral Blood Mononuclear Cells: A Possible Link between Obesity and Cardiovascular Risk?","volume":"5","author":"Napoleone","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbrc.2009.12.158","article-title":"Leptin Upregulates the Expression of Plasminogen Activator Inhibitor-1 in Human Vascular Endothelial Cells","volume":"392","author":"Singh","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/01.hjh.0000222743.06584.66","article-title":"Role of Leptin in Blood Pressure Regulation and Arterial Hypertension","volume":"24","year":"2006","journal-title":"J. Hypertens."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1172\/JCI13143","article-title":"Leptin-Dependent Platelet Aggregation and Arterial Thrombosis Suggests a Mechanism for Atherothrombotic Disease in Obesity","volume":"108","author":"Konstantinides","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"E695","DOI":"10.1152\/ajpendo.00125.2005","article-title":"Leptin-Mediated Activation of Human Platelets: Involvement of a Leptin Receptor and Phosphodiesterase 3A-Containing Cellular Signaling Complex","volume":"289","author":"Elbatarny","year":"2005","journal-title":"Am. J. Physiol.\u2014Endocrinol. Metab."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/13816128113199990017","article-title":"Leptin-Induced Endothelial Dysfunction: A Target for Therapeutic Interventions","volume":"20","author":"Payne","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2174\/13816128113199990021","article-title":"Mechanisms Linking Leptin to Arterial and Venous Thrombosis: Potential Pharmacological Targets","volume":"20","author":"Konstantinides","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnins.2013.00051","article-title":"The Role of Leptin in the Control of Insulin-Glucose Axis","volume":"7","author":"Amitani","year":"2013","journal-title":"Front. Neurosci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/157339508784325046","article-title":"Leptin and Inflammation","volume":"4","author":"Iikuni","year":"2008","journal-title":"Curr. Immunol. Rev."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Cortegana, C., Garc\u00eda-Galey, A., Tami, M., del Pino, P., Carmona, I., L\u00f3pez, S., Alba, G., and S\u00e1nchez-Margalet, V. (2021). Role of Leptin in Non-Alcoholic Fatty Liver Disease. Biomedicines, 9.","DOI":"10.3390\/biomedicines9070762"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbrc.2016.10.079","article-title":"Leptin Promotes Endothelial Dysfunction in Chronic Kidney Disease through AKT\/GSK3\u03b2 and \u03b2-Catenin Signals","volume":"480","author":"Ding","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s11906-008-0082-2","article-title":"Leptin and Mechanisms of Endothelial Dysfunction and Cardiovascular Disease","volume":"10","author":"Knudson","year":"2008","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"H48","DOI":"10.1152\/ajpheart.01159.2004","article-title":"Leptin Receptors Are Expressed in Coronary Arteries, and Hyperleptinemia Causes Significant Coronary Endothelial Dysfunction","volume":"289","author":"Knudson","year":"2005","journal-title":"Am. J. Physiol.\u2014Heart Circ. Physiol."},{"key":"ref_216","first-page":"192","article-title":"Leptin Mediated ObRb Receptor Increases Expression of Adhesion Intercellular Molecules and Cyclooxygenase 2 on Murine Aorta Tissue Inducing Endothelial Dysfunction","volume":"6","author":"Zarate","year":"2013","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_217","first-page":"156","article-title":"The Association of Serum Leptin Level and Anthropometric Measures with the Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus","volume":"7","author":"Afarid","year":"2018","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/sj.eye.6702011","article-title":"Vitreous Leptin Levels in Retinal Disease","volume":"20","author":"Maberley","year":"2006","journal-title":"Eye"},{"key":"ref_219","unstructured":"Shukla, U.V., and Tripathy, K. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1271027","DOI":"10.3389\/fendo.2023.1271027","article-title":"Association between Adipocytokines and Diabetic Retinopathy: A Systematic Review and Meta-Analysis","volume":"14","author":"Jiang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.2337\/diabetes.53.9.2443","article-title":"Leptin Stimulates Ischemia-Induced Retinal Neovascularization: Possible Role of Vascular Endothelial Growth Factor Expressed in Retinal Endothelial Cells","volume":"53","author":"Suganami","year":"2004","journal-title":"Diabetes"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1477-9560-7-15","article-title":"Hemostasis and Inflammation: Two of a Kind?","volume":"7","author":"Verhamme","year":"2009","journal-title":"Thromb. J."},{"key":"ref_223","unstructured":"van der Poll, T., de Jonge, E., and ten Cate An, H. (2013). Madame Curie Bioscience Database [Internet], Landes Bioscience."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s10875-010-9507-1","article-title":"Leptin Activates Human B Cells to Secrete TNF-\u03b1, IL-6, and IL-10 via JAK2\/STAT3 and p38MAPK\/ERK1\/2 Signaling Pathway","volume":"31","author":"Agrawal","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Tazawa, R., Uchida, K., Fujimaki, H., Miyagi, M., Inoue, G., Sekiguchi, H., Murata, K., Takata, K., Kawakubo, A., and Takaso, M. (2019). Elevated Leptin Levels Induce Inflammation through IL-6 in Skeletal Muscle of Aged Female Rats. BMC Musculoskelet. Disord., 20.","DOI":"10.1186\/s12891-019-2581-5"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00001721-200203000-00005","article-title":"Cytokines in Coagulation and Thrombosis: A Preclinical and Clinical Review","volume":"13","author":"Joseph","year":"2002","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1038\/s41598-022-12793-2","article-title":"Adipokine Human Resistin Promotes Obesity-Associated Inflammatory Intervertebral Disc Degeneration via pro-Inflammatory Cytokine Cascade Activation","volume":"12","author":"Shin","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/ITT.S73223","article-title":"The Role of Adipokines in Chronic Inflammation","volume":"5","author":"Mancuso","year":"2016","journal-title":"Immunotargets Ther."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1111\/febs.15322","article-title":"Resistin in Metabolism, Inflammation, and Disease","volume":"287","author":"Tripathi","year":"2020","journal-title":"FEBS J."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5114\/pjp.2017.67583","article-title":"Expression of Resistin in the Liver of Patients with Non-Alcoholic Fatty Liver Disease","volume":"68","author":"Gierej","year":"2017","journal-title":"Pol. J. Pathol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"286","DOI":"10.5604\/01.3001.0010.8660","article-title":"Clinical Significance of Serum Adiponectin and Resistin Levels in Liver Cirrhosis","volume":"17","author":"Correa","year":"2018","journal-title":"Ann. Hepatol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.3748\/wjg.v19.i28.4475","article-title":"Resistin Mediates the Hepatic Stellate Cell Phenotype","volume":"19","author":"Dong","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1007\/s10620-021-07105-z","article-title":"A Decreased Response to Resistin in Mononuclear Leukocytes Contributes to Oxidative Stress in Nonalcoholic Fatty Liver Disease","volume":"67","author":"Garcia","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3389\/fphys.2019.01399","article-title":"Relation of Circulating Resistin to Insulin Resistance in Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis","volume":"10","author":"Su","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_235","first-page":"193","article-title":"Resistin: A New Hormone That Links Obesity with Type 2 Diabetes","volume":"322","author":"Berger","year":"2001","journal-title":"BMJ"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/0971-6580.84272","article-title":"Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome","volume":"18","author":"Gupta","year":"2011","journal-title":"Toxicol. Int."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1007\/BF03347059","article-title":"Resistin Level Is Positively Correlated with Thrombotic Complications in Southern Chinese Metabolic Syndrome Patients","volume":"34","author":"Fang","year":"2011","journal-title":"J. Endocrinol. Investig."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Pablo-Moreno, J.A.D., Serrano, L.J., Revuelta, L., S\u00e1nchez, M.J., and Liras, A. (2022). The Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158283"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jvs.2004.12.046","article-title":"Adipocyte-Derived Cytokine Resistin Causes Endothelial Dysfunction of Porcine Coronary Arteries","volume":"41","author":"Kougias","year":"2005","journal-title":"J. Vasc. Surg."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"H2997","DOI":"10.1152\/ajpheart.01035.2005","article-title":"Resistin Impairs Endothelium-Dependent Dilation to Bradykinin, but Not Acetylcholine, in the Coronary Circulation","volume":"291","author":"Dick","year":"2006","journal-title":"Am. J. Physiol.\u2014Heart Circ. Physiol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cardiores.2006.01.015","article-title":"Adipokine Resistin Promotes in Vitro Angiogenesis of Human Endothelial Cells","volume":"70","author":"Mu","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/01.CIR.0000084503.91330.49","article-title":"Resistin Promotes Endothelial Cell Activation","volume":"108","author":"Verma","year":"2003","journal-title":"Circulation"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/jcp.22555","article-title":"Resistin Induces Monocyte\u2013Endothelial Cell Adhesion by Increasing ICAM-1 and VCAM-1 Expression in Endothelial Cells via p38MAPK-Dependent Pathway","volume":"226","author":"Hsu","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Jamaluddin, M.S., Yan, S., L\u00fc, J., Liang, Z., Yao, Q., and Chen, C. (2013). Resistin Increases Monolayer Permeability of Human Coronary Artery Endothelial Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0084576"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1440-1681.2010.05430.x","article-title":"Increased Tissue Factor Activity in Monocytes from Obese Young Adults","volume":"37","author":"Ayer","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"H193","DOI":"10.1152\/ajpheart.00431.2009","article-title":"Resistin Decreases Expression of Endothelial Nitric Oxide Synthase through Oxidative Stress in Human Coronary Artery Endothelial Cells","volume":"299","author":"Chen","year":"2010","journal-title":"Am. J. Physiol.\u2014Heart Circ. Physiol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2010.11.011","article-title":"Distinct Role and Location of the Endothelial Isoform of Nitric Oxide Synthase in Regulating Platelet Aggregation in Males and Females in Vivo","volume":"651","author":"Moore","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1001-9294(09)60082-1","article-title":"High Serum Resistin Level May Be an Indicator of the Severity of Coronary Disease in Acute Coronary Syndrome","volume":"24","author":"Wang","year":"2009","journal-title":"Chin. Med. Sci. J."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/00029330-200705020-00004","article-title":"Plasma Resistin Is Increased in Patients with Unstable Angina","volume":"120","author":"Hu","year":"2007","journal-title":"Chin. Med. J."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cca.2020.11.010","article-title":"Resistin: Potential Biomarker and Therapeutic Target in Atherosclerosis","volume":"512","author":"Zhou","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"830061","DOI":"10.3389\/fimmu.2022.830061","article-title":"Resistin Associated with Cytokines and Endothelial Cell Adhesion Molecules Is Related to Worse Outcome in COVID-19","volume":"13","author":"Ebihara","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1161\/01.CIR.0000147825.97879.E7","article-title":"Resistin Promotes Smooth Muscle Cell Proliferation Through Activation of Extracellular Signal\u2013Regulated Kinase 1\/2 and Phosphatidylinositol 3-Kinase Pathways","volume":"110","author":"Calabro","year":"2004","journal-title":"Circulation"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mad.2019.01.004","article-title":"Resistin: A Reappraisal","volume":"178","author":"Acquarone","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Rasineni, K., Kubik, J.L., Knight, K.L., Hall, L., Casey, C.A., and Kharbanda, K.K. (2020). Ghrelin Regulates Adipose Tissue Metabolism: Role in Hepatic Steatosis. Chem. Biol. Interact., 322.","DOI":"10.1016\/j.cbi.2020.109059"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41366-020-00711-3","article-title":"Gastric Ghrelin Cells in Obese Patients Are Hyperactive","volume":"45","author":"Castorina","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin Is a Growth-Hormone-Releasing Acylated Peptide from Stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: Structure and Function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/liv.12286","article-title":"Ghrelin Contributes to Protection of Hepatocellular Injury Induced by Ischaemia\/Reperfusion","volume":"34","author":"Qin","year":"2014","journal-title":"Liver Int."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/hep.23421","article-title":"Ghrelin Attenuates Hepatocellular Injury and Liver Fibrogenesis in Rodents and Influences Fibrosis Progression in Humans","volume":"51","author":"Moreno","year":"2010","journal-title":"Hepatology"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2011.05.010","article-title":"Hepatoprotective Effect of Ghrelin on Carbon Tetrachloride-Induced Acute Liver Injury in Rats","volume":"171","author":"Cetin","year":"2011","journal-title":"Regul. Pept."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.regpep.2010.10.009","article-title":"Protective Role of Ghrelin against Carbon Tetrachloride (CCl\u2084)-Induced Coagulation Disturbances in Rats","volume":"166","author":"Cetin","year":"2011","journal-title":"Regul. Pept."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1016\/j.peptides.2010.08.009","article-title":"Protective Effect of Ghrelin on Acetaminophen-Induced Liver Injury in Rat","volume":"31","author":"Nabavizadeh","year":"2010","journal-title":"Peptides"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"21911","DOI":"10.3390\/ijms160921911","article-title":"Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-\u03921 Expression and Autophagy","volume":"16","author":"Mao","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12020-012-9761-5","article-title":"Administration of Ghrelin Improves Inflammation, Oxidative Stress, and Apoptosis during and after Non-Alcoholic Fatty Liver Disease Development","volume":"43","author":"Li","year":"2013","journal-title":"Endocrine"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2478\/jtim-2021-0025","article-title":"Effects of Des-Acyl Ghrelin on Insulin Sensitivity and Macrophage Polarization in Adipose Tissue","volume":"9","author":"Yuan","year":"2021","journal-title":"J. Transl. Int. Med."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"e22508","DOI":"10.1096\/fj.202200634R","article-title":"Potential Role of Ghrelin in the Regulation of Inflammation","volume":"36","author":"Ma","year":"2022","journal-title":"FASEB J."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Ma, X., Lin, L., Yue, J., Wu, C.-S., Guo, C.A., Wang, R., Yu, K.-J., Devaraj, S., Murano, P., and Chen, Z. (2017). Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061302"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.3748\/wjg.v21.i11.3214","article-title":"Ghrelin-Ghrelin O-Acyltransferase System in the Pathogenesis of Nonalcoholic Fatty Liver Disease","volume":"21","author":"Zhang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"233","DOI":"10.15403\/jgld-2703","article-title":"The Leu72Met (Rs696217 G>T) Polymorphism of the Ghrelin Gene Might Be a Protective Factor for Nonalcoholic Fatty Liver Disease","volume":"30","author":"Tabaeian","year":"2021","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_270","first-page":"342","article-title":"The \u201cGG\u201d Genotype of Rs26802 Variant in the Ghrelin Gene Is a Potential Protective Factor against Nonalcoholic Fatty Liver Disease","volume":"108","author":"Rezamand","year":"2021","journal-title":"Physiol. Int."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF03344083","article-title":"Ghrelin Tissue Distribution: Comparison between Gene and Protein Expression","volume":"29","author":"Ghelardoni","year":"2006","journal-title":"J. Endocrinol. Investig."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cardiores.2005.09.001","article-title":"Functional and Immunocytochemical Evidence for a Role of Ghrelin and Des-Octanoyl Ghrelin in the Regulation of Vascular Tone in Man","volume":"69","author":"Kleinz","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1083\/jcb.200207165","article-title":"Ghrelin and Des-Acyl Ghrelin Inhibit Cell Death in Cardiomyocytes and Endothelial Cells through ERK1\/2 and PI 3-Kinase\/AKT","volume":"159","author":"Baldanzi","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10741-020-10032-2","article-title":"Heal the Heart through Gut (Hormone) Ghrelin: A Potential Player to Combat Heart Failure","volume":"26","author":"Gupta","year":"2021","journal-title":"Heart Fail. Rev."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/157340310790231662","article-title":"Ghrelin and Cardiovascular Diseases","volume":"6","author":"Zhang","year":"2010","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00395-018-0671-4","article-title":"Cardioprotective Effect of Ghrelin against Myocardial Infarction-Induced Left Ventricular Injury via Inhibition of SOCS3 and Activation of JAK2\/STAT3 Signaling","volume":"113","author":"Eid","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"170921","DOI":"10.1016\/j.peptides.2022.170921","article-title":"The Effects and Mechanisms of Ghrelin upon Angiogenesis in Human Coronary Artery Endothelial Cells under Hypoxia","volume":"160","author":"Wang","year":"2023","journal-title":"Peptides"},{"key":"ref_278","first-page":"29","article-title":"Reduced Ghrelin in Endothelial Cells Plays Important Mechanistic Role in Aging-Related Impairment of Angiogenesis","volume":"60","author":"Ahluwalia","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1161\/01.CIR.0000127956.43874.F2","article-title":"Ghrelin Inhibits Proinflammatory Responses and Nuclear Factor-kappaB Activation in Human Endothelial Cells","volume":"109","author":"Li","year":"2004","journal-title":"Circulation"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.peptides.2011.11.001","article-title":"Ghrelin Stimulates Angiogenesis via GHSR1a-Dependent MEK\/ERK and PI3K\/Akt Signal Pathways in Rat Cardiac Microvascular Endothelial Cells","volume":"33","author":"Wang","year":"2012","journal-title":"Peptides"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/CBI20100139","article-title":"Effects and Mechanisms of Ghrelin on Cardiac Microvascular Endothelial Cells in Rats","volume":"35","author":"Wang","year":"2011","journal-title":"Cell Biol. Int."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1161\/CIRCULATIONAHA.105.553883","article-title":"Ghrelin Improves Endothelial Function in Patients with Metabolic Syndrome","volume":"112","author":"Tesauro","year":"2005","journal-title":"Circulation"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1161\/HYPERTENSIONAHA.109.137729","article-title":"Ghrelin Restores the Endothelin 1\/Nitric Oxide Balance in Patients with Obesity-Related Metabolic Syndrome","volume":"54","author":"Tesauro","year":"2009","journal-title":"Hypertension"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5482\/HAMO-14-11-0075","article-title":"Endothelium and Haemostasis","volume":"35","author":"Aird","year":"2015","journal-title":"Hamostaseologie"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1179\/acb.2006.036","article-title":"The Pivotal Role of the Endothelium in Haemostasis and Thrombosis","volume":"61","author":"Verhamme","year":"2006","journal-title":"Acta Clin. Belg."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ajh.21582","article-title":"Endothelial Nitric Oxide Synthase and Nitric Oxide Regulate Endothelial Tissue Factor Expression in Vivo in the Sickle Transgenic Mouse","volume":"85","author":"Solovey","year":"2010","journal-title":"Am. J. Hematol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1055\/s-0037-1613355","article-title":"Regulation by Nitric Oxide of Endotoxin-Induced Tissue Factor and Plasminogen Activator Inhibitor-1 in Endothelial Cells","volume":"88","author":"Montes","year":"2002","journal-title":"Thromb. Haemost."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.thromres.2015.04.018","article-title":"Suppression of Plasminogen Activator Inhibitor-1 by Inhaled Nitric Oxide Attenuates the Adverse Effects of Hyperoxia in a Rat Model of Acute Lung Injury","volume":"136","author":"Chen","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1046\/j.1432-1327.2000.01086.x","article-title":"Dual Regulatory Effects of Nitric Oxide on Plasminogen Activator Inhibitor Type 1 Expression in Endothelial Cells","volume":"267","author":"Swiatkowska","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"9497","DOI":"10.1073\/pnas.1918761117","article-title":"Unbiased Proteomics Identifies Plasminogen Activator Inhibitor-1 as a Negative Regulator of Endothelial Nitric Oxide Synthase","volume":"117","author":"Garcia","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_291","first-page":"MC13","article-title":"Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion","volume":"8","author":"Khatib","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"187","DOI":"10.14310\/horm.2002.11183","article-title":"Changes in Prothrombin and Activated Partial Thromboplastin Time during Replacement Therapy with Human Recombinant Growth Hormone in Growth Hormone Deficient Adults","volume":"5","author":"Miljic","year":"2006","journal-title":"Hormones"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1007\/s11695-017-2779-2","article-title":"Metabolic Effects of Sleeve Gastrectomy and Laparoscopic Greater Curvature Plication: An 18-Month Prospective, Observational, Open-Label Study","volume":"27","author":"Hauptman","year":"2017","journal-title":"Obes. Surg."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/gidisord5040036","article-title":"Scientific and Public Interest in Bariatric Surgery for Obesity: The Italian Scenario","volume":"5","author":"Mazzone","year":"2023","journal-title":"Gastrointest. Disord."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/13813455.2018.1489849","article-title":"Hemostatic Effect of Acylated Ghrelin in Control and Sleeve Gastrectomy-Induced Rats: Mechanisms of Action","volume":"126","author":"Morsy","year":"2020","journal-title":"Arch. Physiol. 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