{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T15:52:18Z","timestamp":1794498738757,"version":"4.9.1"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disease, usually presented in the third trimester with pruritus, elevated transaminase, and serum total bile acids. Evidence shows that it can be developed in the first trimester, more commonly after in vitro fertilization (IVF) procedures, with the presence of ovarian hyperstimulation syndrome (OHSS). Methods: A literature search was conducted in the PubMed\/MEDLINE database of case reports\/studies reporting early-onset ICP in spontaneous and IVF pregnancies published until July 2023. Results: Thirty articles on early-onset ICP were included in the review analysis, with 19 patients who developed ICP in spontaneous pregnancy and 15 patients who developed ICP in IVF pregnancies with or without OHSS. Cases of 1st and 2nd trimester ICP in terms of \u201cearly-onset\u201d ICP were pooled to gather additional findings. Conclusions: Proper monitoring should be applied even before expected pregnancy and during IVF procedures in patients with known risk factors for OHSS and ICP development (patient and family history), with proper progesterone supplementation dosage and genetic testing in case of ICP recurrence.<\/jats:p>","DOI":"10.3390\/life14010129","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:37:18Z","timestamp":1705405038000},"page":"129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Severe Early-Onset Intrahepatic Cholestasis of Pregnancy Following Ovarian Hyperstimulation Syndrome with Pulmonary Presentation after In Vitro Fertilization: Case Report and Systematic Review of Case Reports"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-5394","authenticated-orcid":false,"given":"Stipe","family":"Duman\u010di\u0107","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Hospital Center Split, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1365-8704","authenticated-orcid":false,"given":"Mislav","family":"Miku\u0161","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Hospital Center Zagreb, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenka","family":"Pal\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Hospital Center Split, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-7064","authenticated-orcid":false,"given":"Dubravko","family":"Habek","sequence":"additional","affiliation":[{"name":"School of Medicine, Catholic University of Croatia, Ilica 242, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Te\u0161anovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, General Hospital Dubrovnik, 20 000 Dubrovnik, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko Dra\u017een","family":"Mimica","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Hospital Center Split, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-8896","authenticated-orcid":false,"given":"Jelena","family":"Maru\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Hospital Center Split, 21 000 Split, Croatia"},{"name":"School of Medicine, University of Split, Soltanska 2, 21 000 Split, Croatia"},{"name":"University Department of Health Studies, University of Split, R. Boskovica 35, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/AOG.0000000000000346","article-title":"Intrahepatic cholestasis of pregnancy","volume":"124","author":"Williamson","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1080\/14767058.2017.1397124","article-title":"Diagnosis and prognosis of early-onset intrahepatic cholestasis of pregnancy: A prospective study","volume":"32","author":"Lin","year":"2019","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5005\/jp-journals-10018-1232","article-title":"Intrahepatic Cholestasis of Pregnancy: Spontaneous vs in vitro Fertilization","volume":"7","author":"Bolukbas","year":"2017","journal-title":"Euroasian J. 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