{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:40:33Z","timestamp":1760143233455,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council of Taiwan","award":["112-2320-B-038-045"],"award-info":[{"award-number":["112-2320-B-038-045"]}]},{"name":"Higher Education Sprout Project by the Ministry of Education (MOE)","award":["112-2320-B-038-045"],"award-info":[{"award-number":["112-2320-B-038-045"]}]},{"name":"Sunny Brain Tumor and Brain Disease Research and Development Foundation","award":["112-2320-B-038-045"],"award-info":[{"award-number":["112-2320-B-038-045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>A 50-year-old male presented to the emergency room after experiencing sudden right upper limb facial numbness and dysphasia, followed by full recovery. A brain CT scan showed hyperdense lesions within the left hemispheric sulcus, which raised suspicion of spontaneous subarachnoid hemorrhage. A T1-weighted MRI showed multiple tiny leptomeningeal enhancements in the same area, and a digital subtraction angiography showed no signs of vascular abnormality. Cerebrospinal fluid cytology revealed atypical melanin-containing cells with minimal pleomorphism. One month later, the patient developed sixth nerve palsy, which was determined to be due to intracranial hypertension. Multiple giant nevi on the legs, trunk, and scalp were also observed. A skin biopsy showed well-defined and symmetrical proliferation of melanocytic nevus cell nests in the dermis. An open biopsy was performed due to the suspicious leptomeningeal lesions, which surprisingly revealed diffuse and thick black-colored tissue infiltration of the leptomeninges. Pathology confirmed the diagnosis of meningeal melanocytosis. A ventriculoperitoneal shunt was then placed, and the patient\u2019s neurological symptoms gradually improved. Based on the presence of multiple giant nevi on the patient\u2019s skin and the finding of diffuse meningeal melanocytosis during the open biopsy, the patient was diagnosed with neurocutaneous melanosis. The patient received 6 cycles triweekly of Ipilimumab and Nivolumab 8 months after initial diagnosis. Unfortunately, the disease progressed and the patient passed away 14 months after initial diagnosis.<\/jats:p>","DOI":"10.3390\/life14010139","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T06:41:22Z","timestamp":1705560082000},"page":"139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurocutaneous Melanosis with Meningeal Melanocytosis: A Rare Case of Intracranial Hypertension and Cutaneous Manifestations"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-0167","authenticated-orcid":false,"given":"Hsien-Chung","family":"Chen","sequence":"first","affiliation":[{"name":"Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei 110, Taiwan"},{"name":"Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Taipei Neuroscience Institute, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-7740","authenticated-orcid":false,"given":"Tsung-I","family":"Hsu","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei 110, Taiwan"},{"name":"TMU Research Center of Neuroscience, Taipei Medical University, Taipei 110, Taiwan"},{"name":"International Master Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan"},{"name":"TMU Research Center of Cancer Translational Medicine, Taipei 110, Taiwan"},{"name":"Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsu-Yi","family":"Chao","sequence":"additional","affiliation":[{"name":"Cancer Center, Attending Physician, Division of Hematology-Oncology, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Tai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Taipei Neuroscience Institute, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12659\/MSM.891279","article-title":"Giant congenital melanocytic nevi: Selected aspects of diagnostics and treatment","volume":"21","author":"Sawicka","year":"2015","journal-title":"Med. 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Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/pde.13804","article-title":"Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression","volume":"36","author":"Schaff","year":"2019","journal-title":"Pediatr. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Akay, S., Pollard, J.H., Saad Eddin, A., Alatoum, A., Kandemirli, S., Gholamrezanezhad, A., Menda, Y., Graham, M.M., and Shariftabrizi, A. (2023). PET\/CT Imaging in Treatment Planning and Surveillance of Sinonasal Neoplasms. Cancers, 15.","DOI":"10.3390\/cancers15153759"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101212","DOI":"10.1016\/j.adro.2023.101212","article-title":"Positron Emission Tomography (PET)\/Computed Tomography (CT) Imaging in Radiation Therapy Treatment Planning: A Review of PET Imaging Tracers and Methods to Incorporate PET\/CT","volume":"8","author":"Trotter","year":"2023","journal-title":"Adv. Radiat. 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Med."},{"key":"ref_16","first-page":"13","article-title":"Diagnostic and prognostic biomarkers in melanoma","volume":"7","author":"Weinstein","year":"2014","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e235772","DOI":"10.1136\/bcr-2020-235772","article-title":"Symptomatic neurocutaneous melanosis: Mild clinical onset in a teenager","volume":"13","author":"Vanood","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.12998\/wjcc.v10.i15.5025","article-title":"Neurocutaneous melanosis with an intracranial cystic-solid meningeal melanoma in an adult: A case report and review of literature","volume":"10","author":"Liu","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.wneu.2018.02.007","article-title":"Neurocutaneous Melanosis in an Adult Patient with Intracranial Primary Malignant Melanoma: Case Report and Review of the Literature","volume":"114","author":"Ma","year":"2018","journal-title":"World Neurosurg."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/1\/139\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:49:38Z","timestamp":1760104178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/1\/139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["life14010139"],"URL":"https:\/\/doi.org\/10.3390\/life14010139","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2024,1,18]]}}}