{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:28:52Z","timestamp":1768832932950,"version":"3.49.0"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"institute\u2019s budget"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>While several studies have shown associations between hearing disorders and congenital toxoplasmosis, the present study investigated the impact of chronic, latent Toxoplasma gondii (T. gondii) infection on hearing loss. We used a regression analysis to explore whether latent T. gondii infection modulates changes in hearing thresholds over an age range from 20 to 70 years. We analyzed audiometric data of 162 T. gondii IgG-positive and 430 T. gondii-negative participants, collected in the Dortmund Vital Study (DVS, ClinicalTrials.gov Identifier: NCT05155397), a prospective study on healthy cognitive aging. The regression analysis indicated that latent toxoplasmosis was associated with an accelerated development in hearing loss over the observed age range. Hearing loss was less frequent in IgG-positive than in IgG-negative participants up to the age of about 40 for a low (0.125\u20131 kHz)-frequency range. For high (2\u20138 kHz) frequencies, this pattern reversed for ages above 65 years. We discuss these findings on hearing function in the context of a recently proposed model, suggesting that latent toxoplasmosis can differentially affect brain functions across a lifespan.<\/jats:p>","DOI":"10.3390\/life14020194","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:11:27Z","timestamp":1706515887000},"page":"194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic Toxoplasma gondii Infection Modulates Hearing Ability across the Adult Life Span"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-0183","authenticated-orcid":false,"given":"Stephan","family":"Getzmann","sequence":"first","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), D-44139 Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0954-3805","authenticated-orcid":false,"given":"Klaus","family":"Golka","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), D-44139 Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-704X","authenticated-orcid":false,"given":"Peter","family":"Br\u00f6de","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), D-44139 Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-7849","authenticated-orcid":false,"given":"J\u00f6rg","family":"Reinders","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), D-44139 Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thura","family":"Kadhum","sequence":"additional","affiliation":[{"name":"Clinic for Psychosomatic Rehabilitation, Mittelrhein-Klinik, D-56154 Boppard-Bad Salzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.","family":"Hengstler","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), D-44139 Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-9767","authenticated-orcid":false,"given":"Edmund","family":"Wascher","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), D-44139 Dortmund, Germany"},{"name":"German Center for Mental Health (DZPG), Partner Site Bochum\/Marburg, 44787 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8240-1702","authenticated-orcid":false,"given":"Patrick D.","family":"Gajewski","sequence":"additional","affiliation":[{"name":"Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), D-44139 Dortmund, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Daher, D., Shaghlil, A., Sobh, E., Hamie, M., Hassan, M.E., Moumneh, M.B., Itani, S., Hajj, R.E., Tawk, L., and Sabban, M.E. 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